Cited by 3,806Immune cells in cancerInflammatory mediators and NSAID effectsCancer Immunotherapy and Biomarkers

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Inflammation and Cancer: Triggers, Mechanisms, and Consequences

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Greten, Florian R., Grivennikov, Sergei I.·2019·Immunity

DOI 10.1016/j.immuni.2019.06.025PMC PMC6831096

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Abstract

Inflammation predisposes to the development of cancer and promotes all stages of tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage in well-orchestrated reciprocal interactions to form an inflammatory tumor microenvironment (TME). Cells within the TME are highly plastic, continuously changing their phenotypic and functional characteristics. Here, we review the origins of inflammation in tumors, and the mechanisms whereby inflammation drives tumor initiation, growth, progression, and metastasis. We discuss how tumor-promoting inflammation closely resembles inflammatory processes typically found during development, immunity, maintenance of tissue homeostasis, or tissue repair and illuminate the distinctions between tissue-protective and pro-tumorigenic inflammation, including spatiotemporal considerations. Defining the cornerstone rules of engagement governing molecular and cellular mechanisms of tumor-promoting inflammation will be essential for further development of anti-cancer therapies.

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Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989
Cancer-related inflammation
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Self-citation
Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Origin and physiological roles of inflammation
Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474
Understanding the tumor immune microenvironment (TIME) for effective therapy
Binnewies, M., Roberts, E. W., Kersten, K., Chan, V., Fearon, D. F., Merad, M., Coussens, L. M., Gabrilovich, D. I., Ostrand-Rosenberg, S., Hedrick, C. C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0014-x · Cited by 6,145
The future of immune checkpoint therapy
Sharma, P., & Allison, J. P. (2015) · Science · doi:10.1126/science.aaa8172 · Cited by 4,878
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632 · cited 2×
“However, inducers of TEI in microbial-rich versus “sterile” tumors may be different (Hanahan and Coussens, 2012; Mantovani et al., 2008).”
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Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19
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Shen, L., Zhou, Y., He, H., Chen, W., Lenahan, C., Li, X., Deng, Y., Shao, A., & Huang, J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8865791 · Cited by 92
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Jia, Y., Wang, L., Hu, G.-S., Zhang, Y., Du, J., Ding, J., Ji, X., Shen, H., Huang, H., Ye, F., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022112408 · Cited by 92
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Zhang, F., Wang, K., Du, P., Yang, W., He, Y., Li, T. X., & Mei, Z. (2020) · Neurology · doi:10.1212/wnl.0000000000011264 · Cited by 84
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Yang, T., Hao, L., Yang, X., Luo, C., Wang, G., Cai, C. L., Qi, S., & Li, Z. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-049123 · Cited by 70
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Wu, Q., Tu, H., & Li, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.914730 · Cited by 68
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Wang, F., Niu, Y., Chen, K., Yuan, X., Qin, Y., Zheng, F., Cui, Z., Lü, W., Wu, Y., & Xia, D. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0410 · Cited by 69
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Butner, J. D., Dogra, P., Chung, C. D., Pasqualini, R., Arap, W., Lowengrub, J. S., Vittorio Cristini, C., & Wang, Z. (2022) · Nature Computational Science · doi:10.1038/s43588-022-00377-z · Cited by 71
Isoliquiritigenin, a potential therapeutic agent for treatment of inflammation-associated diseases
Chen, Z., Ding, W., Yang, X., Lu, T., & Liu, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117059 · Cited by 71
SERPINE1 associated with remodeling of the tumor microenvironment in colon cancer progression: a novel therapeutic target
Wang, S., Pang, L., Liu, Z., & Meng, X. (2021) · BMC Cancer · doi:10.1186/s12885-021-08536-7 · Cited by 65
Heterogeneous Myeloid Cells in Tumors
Dou, A., & Fang, J. (2021) · Cancers · doi:10.3390/cancers13153772 · Cited by 68
Exosome-based nanomedicine for cancer treatment by targeting inflammatory pathways: Current status and future perspectives
Ansari, M. A., Thiruvengadam, M., Venkidasamy, B., Alomary, M. N., Salawi, A., Chung, I.-M., Shariati, M. A., & Rebezov, M. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.04.005 · Cited by 63
Relationship between gut microbiota and colorectal cancer: Probiotics as a potential strategy for prevention
Lee, S. Y., Lee, D. Y., Kang, J. H., Kim, J. H., Jeong, J. W., Kim, H. W., Oh, D. H., Yoon, S. H., & Hur, S. J. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111327 · Cited by 69
Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer
Liu, Q., Niu, X., Li, Y., Zhang, J.-R., Zhu, S., Yang, Q.-Y., Zhang, W., & Li, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.863317 · Cited by 66
Elucidation of interleukin-19 as a therapeutic target for breast cancer by computational analysis and experimental validation
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Giordo, R., Wehbe, Z., Paliogiannis, P., Eid, A. H., Mangoni, A. A., & Pintus, G. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.03.001 · Cited by 67
How does fascin promote cancer metastasis?
Lin, S., Taylor, M. D., Singh, P. K., & Yang, S. (2020) · FEBS Journal · doi:10.1111/febs.15484 · Cited by 65
Leptin, Both Bad and Good Actor in Cancer
Jiménez‐Cortegana, C., López-Saavedra, A., Sánchez-Jiménez, F., Pérez‐Pérez, A., Castiñeiras, J., Virizuela-Echaburu, J. A., de la Cruz‐Merino, L., & Sánchez‐Margalet, V. (2021) · Biomolecules · doi:10.3390/biom11060913 · Cited by 69
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Wang, Y., Xu, C., Meng, M., Lin, L., Hu, Y., Hao, K., Shu, S., Zhang, S., Wu, J., Liu, F., et al. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101266 · Cited by 64
The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms
Frigerio, S., Lartey, D. A., D’Haens, G., & Grootjans, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312739 · Cited by 66
BCL-2 expression promotes immunosuppression in chronic lymphocytic leukemia by enhancing regulatory T cell differentiation and cytotoxic T cell exhaustion
Liu, L., Cheng, X., Yang, H., Lian, S., Jiang, Y., Liang, J., Chen, X., Mo, S., Shi, Y., Zhao, S., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01516-w · Cited by 68
NF-κB: A Druggable Target in Acute Myeloid Leukemia
Francesco, B. D., Verzella, D., Capece, D., Vecchiotti, D., Nolfi, M. D. V., Flati, I., Cornice, J., Padova, M. D., Angelucci, A., Alesse, E., et al. (2022) · Cancers · doi:10.3390/cancers14143557 · Cited by 64
Prognostic Value of the Baseline Systemic Immune-Inflammation Index in HER2-Positive Metastatic Breast Cancer: Exploratory Analysis of Two Prospective Trials
Pang, J., Ding, N., Liu, X., He, X., Zhou, W., Xie, H., Feng, J., Li, Y., He, Y., Wang, S., et al. (2024) · Annals of Surgical Oncology · doi:10.1245/s10434-024-16454-8 · Cited by 64
Canakinumab in combination with docetaxel compared with docetaxel alone for the treatment of advanced non-small cell lung cancer following platinum-based doublet chemotherapy and immunotherapy (CANOPY-2): A multicenter, randomized, double-blind, phase 3 trial
Paz-Ares, L. G., Goto, Y., Lim, W., Halmos, B., Cho, B. C., Cobo, M., González-Larriba, J. L., Zhou, C., Demedts, I., Atmaca, A., et al. (2024) · Lung Cancer · doi:10.1016/j.lungcan.2023.107451 · Cited by 63

Authors: Greten, F. R., & Grivennikov, S. I.
Affiliations: Goethe University Frankfurt (DE)
Fox Chase Cancer Center (US)
Corresponding author: Greten, Florian R.
Grivennikov, Sergei I.
ORCID: Greten, Florian R.
Grivennikov, Sergei I.
Venue: Immunity
Publisher: Elsevier BV
Published: 2019-07
Volume: 51
Issue: 1
Pages: 27-41
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2019.06.025
PMC: PMC6831096
OpenAlex: W2959497269
Cited by: 3,806
References: 178
Citations by year: 2026: 457 · 2025: 640 · 2024: 753 · 2023: 715 · 2022: 664 · 2021: 397 · 2020: 163 · 2019: 16
FWCI: 26.79
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 381 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (R01CA227629, CA218133)
Pew Scholar in Biomedical Sciences
US-Israel BSF
NIH (P30 CA-006927)
Georg-Speyer-Haus
LOEWE Center Frankfurt Cancer Institute (III L 5 - 519/03/03.001 - (0015), FOR2438: Gr1916/11-1, SFB 815, 1177, 1292)
German Federal Ministry of Health
Ministry of Higher Education, Research and the Arts of the State of Hessen
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: tumor inflammation, tumor inflammatory microenvironment, carcinogenesis, tumor initiation, tumor progression, metastasis, tumor-stroma interactions, cellular plasticity, tissue homeostasis, tissue repair, cancer therapy
MeSH terms: Animals, Chronic Disease, Homeostasis, Humans, Infections, Inflammation, Neoplasms, Neovascularization, Pathologic, Wound Healing, Autoimmunity, Tumor Microenvironment, Carcinogenesis

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