Exosome engineering: Current progress in cargo loading and targeted delivery

Shedding light on the cell biology of extracellular vesicles

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Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

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Liposomal drug delivery systems: From concept to clinical applications

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Diffusion of univalent ions across the lamellae of swollen phospholipids

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Metal-organic frameworks

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Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery

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Exosomes

Pegtel, D. M., & Gould, S. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111902 · Cited by 2,682

Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.

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Exosomes as drug delivery vehicles for Parkinson’s disease therapy

Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009

Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy

Tariq, H., Bukhari, S. Z., An, R., Dong, J., Ihsan, A., & Younis, M. R. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101440 · Cited by 18

Plant-Derived Exosomes: Nano-Inducers of Cross-Kingdom Regulations

Rehman, T. U., Li, H., Martuscelli, M., Aiello, F., Esposito, L., Ashraf, K., Mastrocola, D., Guo, M., & Mohsin, A. (2025) · Pharmaceuticals · doi:10.3390/ph18071005 · Cited by 21

Cancer-derived exosomes: mediators of immune crosstalk and emerging targets for immunotherapy

Mahamed, R., Monchusi, B. A., Penny, C. B., & Mirza, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1679934 · Cited by 18

Recent advances in PDEVs as nanocarriers for drug delivery: loading techniques, engineering strategies and future directions

Rajasekaran, B., Lo, K.-J., & Pan, M. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2593981 · Cited by 18

Interleukin-4 Receptor Targeting Peptide Decorated Extracellular Vesicles as a Platform for In Vivo Drug Delivery to Thyroid Cancer

Gangadaran, P., Gunassekaran, G. R., Rajendran, R. L., Oh, J. M., Vadevoo, S. M. P., Lee, H., Hong, C. M., Lee, B.-H., Lee, J., & Ahn, B. (2022) · Biomedicines · doi:10.3390/biomedicines10081978 · Cited by 17

Potential of Milk-Derived Extracellular Vesicles as Carriers for Oral Delivery of Active Phytoconstituents

Jiang, Q., Liu, Y., Si, X., Wang, L., Gui, H., Tian, J., Cui, H., Jiang, H., Dong, W., & Li, B. (2024) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-072023-034354 · Cited by 17

Exosome-like Systems: From Therapies to Vaccination for Cancer Treatment and Prevention—Exploring the State of the Art

Hossein, H. H. S., Iommelli, F., Pietro, N. D., Curia, M. C., Piattelli, A., Palumbo, R., Roviello, G. N., & Rosa, V. D. (2024) · Vaccines · doi:10.3390/vaccines12050519 · Cited by 17

Exosomes as a Therapeutic Strategy in Cancer: Potential Roles as Drug Carriers and Immune Modulators

Abedi, A., Moghaddam, M. M., Kachuei, R., & Fooladi, A. A. I. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189238 · Cited by 18

A High Throughput Approach Based on Dynamic High Pressure for the Encapsulation of Active Compounds in Exosomes for Precision Medicine

Romano, E., Netti, P. A., & Torino, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189896 · Cited by 17

Development and single‐particle analysis of hybrid extracellular vesicles fused with liposomes using viral fusogenic proteins

Ishikawa, R., Yoshida, S., Sawada, S., Sasaki, Y., & Akiyoshi, K. (2022) · FEBS Open Bio · doi:10.1002/2211-5463.13406 · Cited by 18

Modulating osteoclasts with nanoparticles: A path for osteoporosis management?

Rouco, H., García‐García, P., Briffault, E., & Díaz‐Rodríguez, P. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1885 · Cited by 16

Drug delivery of extracellular vesicles: Preparation, delivery strategies and applications

Lin, S.-W., Tsai, J., & Shyong, Y. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123185 · Cited by 16

State-of-the-Art of Synthesized Exosomes and NPs-Based Biomimetic Nanoparticles for Wound Rehabilitation: A Review

Issaka, E. (2023) · Biomedical Materials & Devices · doi:10.1007/s44174-023-00112-w · Cited by 16

Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment

Lee, E. S., Ko, H., Kim, C. H., Kim, H.-C., Choi, S., Jeong, S. W., Lee, S.-G., Lee, S., Na, H., Park, J. H., et al. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00418-2 · Cited by 20

Physio-chemical Modifications to Re-engineer Small Extracellular Vesicles for Targeted Anticancer Therapeutics Delivery and Imaging

Asfiya, R., Xu, L., Paramanantham, A., Kabytaev, K., Chernatynskaya, A., McCully, G., Yang, H., & Srivastava, A. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01404 · Cited by 18

Tackling exosome and nuclear receptor interaction: an emerging paradigm in the treatment of chronic diseases

Aswani, B. S., Hegde, M., Vishwa, R., Alqahtani, M. S., Abbas, M., Almubarak, H. A., Sethi, G., & Kunnumakkara, A. B. (2024) · Military Medical Research · doi:10.1186/s40779-024-00564-1 · Cited by 17

From bench to bedside: the research status and application opportunity of extracellular vesicles and their engineering strategies in the treatment of skin defects

Cui, L., Song, Y., Hou, Z., Yang, L., Guo, S., & Wang, C. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03461-4 · Cited by 18

Cell primitive-based biomimetic nanomaterials for Alzheimer's disease targeting and therapy

Yin, T., Liu, Y., He, B., Gong, B., Chu, J., Gao, C., Liang, W., Hao, M., Sun, W., Zhuang, J., et al. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100789 · Cited by 16

Engineered Exosomes as Theranostic Platforms for Cancer Treatment

Yang, X., Xie, X., Liu, S., Ma, W., Zheng, Z., Wei, H., & Yu, C. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00745 · Cited by 17

Hypoxic regulation of extracellular vesicles: Implications for cancer therapy

Yoo, S., Choi, S., Kim, I., & Kim, I. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.034 · Cited by 15

Engineering Exosomes for CNS Disorders: Advances, Challenges, and Therapeutic Potential

Lee, E. C., Choi, D., Lee, D.-H., & Oh, J. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073137 · Cited by 17

Exosomes in Age-Related Cognitive Decline: Mechanistic Insights and Improving Outcomes

Duggan, M. R., Lu, A., Foster, T. C., Wimmer, M. E., & Parikh, V. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.834775 · Cited by 15

Bioengineering of Extracellular Vesicles: Exosome-Based Next-Generation Therapeutic Strategy in Cancer

Saha, P., Datta, S., Ghosh, S., Samanta, A., Ghosh, P., & Sinha, D. (2021) · Bioengineering · doi:10.3390/bioengineering8100139 · Cited by 15

Extracellular Vesicles in Coronary Artery Disease

Buntsma, N. C., van der Pol, E., Nieuwland, R., & Gąsecka, A. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-1443-2_6 · Cited by 14

The pathological and therapeutically role of mesenchymal stem cell (MSC)-derived exosome in degenerative diseases; Particular focus on LncRNA and microRNA

Al‐Dhalimy, A. M. B., Salim, H. M., Shather, A. H., Naser, I. H., Hizam, M. M., & Alshujery, M. K. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154778 · Cited by 17

Nature vs. Manmade: Comparing Exosomes and Liposomes for Traumatic Brain Injury

Hennigan, K., & Lavik, E. (2023) · The AAPS Journal · doi:10.1208/s12248-023-00849-8 · Cited by 14

Biomembrane-Derived Nanoparticles in Alzheimer’s Disease Therapy: A Comprehensive Review of Synthetic Lipid Nanoparticles and Natural Cell-Derived Vesicles

Gao, C., Liu, Y., Zhang, T., Luo, Y., Gao, J., Chu, J., Gong, B., Chen, X., Yin, T., Zhang, J., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s436774 · Cited by 16

Exosomes in Vascular/Neurological Disorders and the Road Ahead

Alzahrani, F. A., Riza, Y. M., Eid, T. M., Almotairi, R., Scherschinski, L., Contreras, J., Nadeem, M., Perez, S. E., Raikwar, S. P., Jha, R. M., et al. (2024) · Cells · doi:10.3390/cells13080670 · Cited by 15

Approaches to Characterize and Quantify Extracellular Vesicle Surface Conjugation Efficiency

Goldbloom‐Helzner, L., Bains, H., & Wang, A. (2024) · Life · doi:10.3390/life14040511 · Cited by 15

Extracellular vesicles as missiles for enhanced anti-tumor efficacy of oncolytic viruses: from disseminating oncolysis and anti-tumor immunity to targeted delivery

Safarzadeh, M., Saadat, N., Abbasi-Molaei, S., & Rastegari‐Pouyani, M. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02283-z · Cited by 14

Exosomes carrying immune checkpoints, a promising therapeutic approach in cancer treatment

Rasihashemi, S. Z., Sahrai, H., Rezazadeh‐Gavgani, E., Yazdani, Y., Khalaji, A., & Lotfinejad, P. (2022) · Medical Oncology · doi:10.1007/s12032-022-01781-1 · Cited by 14

Therapeutic potential of extracellular vesicles in neurodegenerative disorders

Roudi, S., Rädler, J., & Andaloussi, S. E. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-323-85555-6.00017-5 · Cited by 14

From Polyphenols to Prodrugs: Bridging the Blood–Brain Barrier with Nanomedicine and Neurotherapeutics

Tanaka, M., Araujo, A. C., Valenti, V. E., Guiguer, E. L., Catharin, V. C. S., Gualhardi, C. M., de Souza Bastos Mazuqueli Pereira, E., de Alvares Goulart, R., de Argolo Haber, R. S., de Carvalho, A. C. A., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052370 · Cited by 13

Extracellular vesicles in chronic wound therapy: engineering strategies and advanced delivery systems for enhanced regeneration

Ding, L., Zhang, T., Pan, Y., Liu, J., Ma, T., Zhou, H., Zhu, Q., Tai, Z., & Chen, Z. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102298 · Cited by 14

Engineered small extracellular vesicles as bioactive materials: Integrating engineering strategies for cargo loading and targeted delivery systems

Xu, H., Liu, R., Zhou, H., Kong, B., Shen, K., Zhao, T., Du, X., Zhang, H., Song, H., Guo, D., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.12.029 · Cited by 15

Surface engineering of extracellular vesicles: trends, strategies, and applications in diagnosis and therapy

Hong, Y., Hu, S., Yu, Z., Yang, Y., & Yang, H. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04404-3 · Cited by 15

Exosomes: Recent Advances and Challenges as Targeted Therapeutic Delivery Vesicles

Jadhav, S., Kumar, A., & Gulbake, A. (2023) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.2022044495 · Cited by 13

Surface-Bioengineered Extracellular Vesicles Seeking Molecular Biotargets in Lung Cancer Cells

Kowalczyk, A., Dziubak, D., Kasprzak, A., Sobczak, K., Ruzycka-Ayoush, M., Bamburowicz‐Klimkowska, M., Sęk, S., Ríos-Mondragón, I., Żołek, T., Rundén‐Pran, E., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c04265 · Cited by 13

Trends in Developing Extracellular Vesicle-Based Therapeutics

Lee, J. (2024) · Brain Tumor Research and Treatment · doi:10.14791/btrt.2024.0027 · Cited by 14

Extracellular Vesicles Comprising Carborane Prepared by a Host Exchanging Reaction as a Boron Carrier for Boron Neutron Capture Therapy

Kawasaki, R., Oshige, A., Kono, N., Yamana, K., Hirano, H., Miura, Y., Yorioka, R., Bando, K., Tabata, A., Yasukawa, N., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c07650 · Cited by 13

Drug Delivery Systems Based on Dendritic-Cell-Derived Exosomes

Chen, L., Zhang, J., Huang, Y., Zhang, X., Zhang, G., Kong, S., Gao, J., Zhang, X., & Ding, B. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030326 · Cited by 15

Fusogenic Hybrid Extracellular Vesicles with PD-1 Membrane Proteins for the Cytosolic Delivery of Cargos

Ishikawa, R., Yoshida, S., Sawada, S., Sasaki, Y., & Akiyoshi, K. (2022) · Cancers · doi:10.3390/cancers14112635 · Cited by 14

Chemical Advances in Therapeutic Application of Exosomes and Liposomes

Chew, B. C., Liew, F. F., Tan, H. W., & Chung, I. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220221094044 · Cited by 13

Evaluation of exosomes encapsulated recombinant Interleukin-29 for its in vitro anticancer studies

Fujimura, N. A., Fatima, S., Ahmed, N., Akram, M., Tahir, S., Khan, M. A., Amirzada, M. I., Nadeem, T., Bashir, H., & Malik, K. A. (2023) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2023.06.008 · Cited by 12

New Origins of Yeast, Plant and Bacterial-Derived Extracellular Vesicles to Expand and Advance Compound Delivery

Fernández‐Rhodes, M., Lorca, C., Lisa, J., Batalla, I., Ramos‐Miguel, A., Gallart‐Palau, X., & Serra, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137151 · Cited by 13

Ligand‐Tethered Extracellular Vesicles Mediated RNA Therapy for Liver Fibrosis

Liu, Y., Chen, S., Huang, H., Midgley, A. C., Han, Z., Han, Z., Li, Q., & Li, Z. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202403068 · Cited by 13

Review of mesenchymal stem cell-derived exosomes and their potential therapeutic roles in treating rheumatoid arthritis

Aghajani, S., Maboudi, S. A., Seyhoun, I., NIa, R., Shabestari, A. N., Sharif, S., Daneshi, M., & Verdi, J. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10290-z · Cited by 12

Engineered extracellular vesicles: a breakthrough approach to overcoming sperm cryopreservation challenges

Esmaeili, A., Esmaeili, V., Shahverdi, A., & Eslaminejad, M. B. (2025) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-025-01407-x · Cited by 12

Synergistic strategies in tissue engineering: The role of exosomes and decellularized extracellular matrix hydrogels

Soltanmohammadi, F., Gharehbaba, A. M., & Javadzadeh, Y. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118200 · Cited by 14

Bioengineering exosomes for treatment of organ ischemia-reperfusion injury

Toghiani, R., Abolmaali, S. S., Najafi, H., & Tamaddon, A. M. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120654 · Cited by 12

Preparation of Nanoparticle-Loaded Extracellular Vesicles Using Direct Flow Filtration

Mansur, S., Habib, S., Hawkins, M., Brown, S. R., Weinman, S. T., & Bao, Y. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051551 · Cited by 12

Exosomes: Their role in the diagnosis, progression, metastasis, and treatment of glioblastoma

Mousavikia, S. N., Darvish, L., Toossi, M. T. B., & Azimian, H. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122743 · Cited by 14

Mesenchymal stem cells from biology to therapy

Kuntin, D., & Genever, P. G. (2021) · Emerging Topics in Life Sciences · doi:10.1042/etls20200303 · Cited by 13

Antibiotic-loaded Lactobacillus-derived extracellular vesicles enhance the bactericidal efficacy against Staphylococcus species

Lee, Y., Cho, H., & Kim, K.-S. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.106607 · Cited by 12

Biogenesis mechanisms, regulatory strategies, and applications of bacterial extracellular vesicles

Huang, C. R., Cao, W., Zhou, S., & Deng, Y. (2025) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2025.2496300 · Cited by 11

Exosomes in Alzheimer’s disease: From pathogenesis to therapeutics—A comprehensive review of diagnostic and drug delivery applications

Shahlaei, M., Afkhami, H., Ahmadieh-Yazdi, A., Mirmazloumi, S. H., Sahraei, S. S., Akbari, M., Yang, P., Manoochehri, H., Tanzadehpanah, H., Mahaki, H., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118548 · Cited by 11

The emerging roles of long noncoding RNAs in lymphatic vascular development and disease

Ivanov, K. I., Samuilova, O. V., & Zamyatnin, A. A. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04842-4 · Cited by 11

Enhancement of Chondrogenic Markers by Exosomes Derived from Cultured Human Synovial Fluid-Derived Cells: A Comparative Analysis of 2D and 3D Conditions

Han, B., FANG, W. H., Yang, Z. G., Wang, Y., Zhao, S., Hoang, B. X., & Vangsness, C. T. (2023) · Biomedicines · doi:10.3390/biomedicines11123145 · Cited by 11

On the Feasibility of SERS-Based Monitoring of Drug Loading Efficiency in Exosomes for Targeted Delivery

Liu, J., Srivastava, S., Li, T., Moujane, F., Lee, J. Y., Chen, Y., Liu, H. H., Deng, S. X., & Xie, Y. (2025) · Biosensors · doi:10.3390/bios15030141 · Cited by 13

Extracellular Vesicles as Biomarkers and Therapeutics for Inflammatory Eye Diseases

Louie, H. H., Mugisho, O. O., Chamley, L. W., & Rupenthal, I. D. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00414 · Cited by 11

Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes

Nair, S., Ormazábal, V., Carrión, F., Handberg, A., McIntyre, D. H., & Salomón, C. (2023) · Clinical Science · doi:10.1042/cs20220150 · Cited by 13

Released bacterial ATP shapes local and systemic inflammation during abdominal sepsisPreprint

Spari, D., Schmid, A., Sánchez‐Taltavull, D., Murugan, S., Keller, K., Ennaciri, N., Salm, L., Stroka, D., & Beldi, G. (2024) · eLife · doi:10.7554/elife.96678 · Cited by 11

Advances in Intranasal Delivery of Exosomes for Central Nervous System Disorders

Arjmand, B., Mojavezi, A. R., Kamroo, A., Yazdi, R. K., Rezaei–Tavirani, M., & Vahedi, M.-S. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05563-4 · Cited by 12

Improvement of biomedical properties of PEO-treated titanium with flurbiprofen and exosome conjugation

Tavakoli, E., Yarmand, B., Soleimannejad, M., & Saeidifar, M. (2024) · Surfaces and Interfaces · doi:10.1016/j.surfin.2024.104429 · Cited by 10

The roles and therapeutic approaches of MSC-derived exosomes in colorectal cancer

Yang, J., & Zhang, L. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-021-02750-2 · Cited by 10

Superparamagnetic Iron Oxide Nanoparticle-Labeled Extracellular Vesicles for Magnetic Resonance Imaging of Ischemic Stroke

Helsper, S., Yuan, X., Jeske, R., Bhagu, J., Esmonde, C., Duke, L. C., Sun, L. J., Li, Y., & Grant, S. C. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c04888 · Cited by 9

Quantifying extracellular vesicle heterogeneity: the effect of process conditions on protein cargo for skin therapy

Combe, M., Isaac, K. S., Plews, J. R., & Sokolenko, S. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04279-5 · Cited by 9

The Recent Applications of Stem Cell-Derived Exosomes and Hydrogels in Neurological Disorders

Ajwad, N., Mustapha, M., Idris, Z., & Lee, S. (2025) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2024.0353 · Cited by 9

Extracellular vesicle-based targeted RNA therapies against cancer

Wang, Z., Xing, H., Huang, Y., & Lu, M. (2025) · Extracellular Vesicle · doi:10.1016/j.vesic.2025.100083 · Cited by 10

Extracellular vesicles as the drug delivery vehicle for gene-based therapy

Aquino, A. D., Rubinstein, A., Кудрявцев, И. В., Yakovlev, A. A., & Головкин, А. С. (2025) · Applied Physics Reviews · doi:10.1063/5.0255519 · Cited by 9

Extracellular Vesicles as Potential Therapeutic Messengers in Cancer Management

Almeida, C., Teixeira, A. L., Dias, F., Morais, M., & Medeiros, R. (2023) · Biology · doi:10.3390/biology12050665 · Cited by 9

miR ‐125b‐5p impacts extracellular vesicle biogenesis, trafficking, and EV subpopulation release in the porcine trophoblast by regulating ESCRT ‐dependent pathway

Guzewska, M. M., Witek, K. J., Karnas, E., Rawski, M., Zuba‐Surma, E. K., & Kaczmarek, M. M. (2023) · The FASEB Journal · doi:10.1096/fj.202300710r · Cited by 9

Smart nano-sized extracellular vesicles for cancer therapy: Potential theranostic applications in gastrointestinal tumors

Lucchetti, D., Colella, F., Artemi, G., Haque, S., Sgambato, A., Pellicano, R., & Fagoonee, S. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104121 · Cited by 9

Therapeutic potential of exosomes in spermatogenesis regulation and male infertility

Mohammadi, A., Shabani, R., Bashiri, Z., Rafiei, S., Asgari, H. R., & Koruji, M. (2024) · Biology of the Cell · doi:10.1111/boc.202300127 · Cited by 9

Exosomal Bupivacaine: Integrating Nerve Barrier Penetration Capability and Sustained Drug Release for Enhanced Potency in Peripheral Nerve Block and Reduced Toxicity

Cai, Y., Li, Q., Wesselmann, U., & Zhao, C. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202406876 · Cited by 8

Exosome-based platforms for treatment of multiple sclerosis

Zonouz, A. M., Rahbardar, M. G., & Alibolandi, M. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111256 · Cited by 9

The multifaceted roles of extracellular vesicles in osteonecrosis of the femoral head

Li, H., Liu, H., Zhou, Y., Cheng, L., Wang, B., & Ma, J. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.03.009 · Cited by 8

Potential of mesenchymal stem cells and exosomes in tissue engineering: Emerging strategies for skin regeneration and advanced wound healing

Mahheidari, N., Alizadeh, M., Rashidi, M., & Rezakhani, L. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103201 · Cited by 8

Therapeutic potential of extracellular vesicles in Parkinson’s disease

Teixeira, M. R., Alievi, A. L., da Costa, V. R., Pinto, J. R. D., & Araldi, R. P. (2023) · Exploration of neuroscience · doi:10.37349/en.2023.00016 · Cited by 8

Exosomes Derived from Metastatic Colon Cancer Cells Induced Oncogenic Transformation and Migratory Potential of Immortalized Human Cells

Kesavan, Y., Sahabudeen, S. M., & Ramalingam, S. (2023) · International Journal of experimental research and review · doi:10.52756/ijerr.2023.v36.003 · Cited by 8

Multiplexed targeting of microRNA in stem cell-derived extracellular vesicles for regenerative medicine

Song, B., Oh, S., & Chang, W. (2022) · BMB Reports · doi:10.5483/bmbrep.2022.55.2.182 · Cited by 8

A vivid outline demonstrating the benefits of exosome-mediated drug delivery in CNS-associated disease environments

Ray, R., Chowdhury, S. G., & Karmakar, P. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.109906 · Cited by 8

Regulatory Immune Cell-derived Exosomes: Modes of Action and Therapeutic Potential in Transplantation

León, C. G. A.-D., & Thomson, A. W. (2025) · Transplantation · doi:10.1097/tp.0000000000005309 · Cited by 7

Biomanufacturing and Curcumin-Loading of Human Choroid Plexus Organoid-Derived Extracellular Vesicles from a Vertical-Wheel Bioreactor to Alleviate Neuro-Inflammation

Ene, J., Muok, L., Gonzalez, V., Sanchez, N., Nathani, A., Syed, F., Liu, Z. L., Singh, M., Driscoll, T. P., & Li, Y. (2025) · Biomedicines · doi:10.3390/biomedicines13051069 · Cited by 7

Recent Breakthroughs in Exosome-Based Drug Delivery: A Comprehensive Review for Cancer Therapy

Shah, D., Gandhi, S., Shah, S., & Patel, K. (2025) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2025.0050 · Cited by 8

Critical evaluation of saponin as a permeabilizer for anandamide encapsulation in extracellular vesicles

Auquière, M., Terrasi, R., Gratpain, V., Vanderstraeten, J., Andrade, A. C., Mozaheb, N., Mingeot‐Leclercq, M., Rieux, A. D., & Muccioli, G. G. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01951-4 · Cited by 9

Current Applications and Future Challenges of Mesenchymal Stem Cell-Extracellular Vesicles in Tissue Engineering: A Bibliometric Analysis

Chen, S., Di, J., Zhang, Z., Guo, Z., Tian, Z., Qin, Y., Long, Y., Xu, J., Xiang, C., & Cao, F. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s549684 · Cited by 9

The Role of Exosomes as Endogenous Nanocarriers for Targeted Drug Delivery: Isolation, Engineering, and Clinical Progress in Neurological and Other Diseases

Liu, X.-Q. N., & Sheng, R. N. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin47443 · Cited by 9

Targeted expression of a designed fusion protein containing BMP2 into the lumen of exosomes

Masjedi, M. N.-K., Sadroddiny, E., Ai, J., Balalaie, S., & Asgari, Y. (2023) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2023.130505 · Cited by 7

Hybrid Milk Extracellular Vesicles as Potential Systems for Oral Delivery of siRNA

Zhang, Y., Luo, X., Ding, N., Belaid, M., Thanou, M., & Vllasaliu, D. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202300335 · Cited by 7

An effective cell-penetrating peptide-based loading method to extracellular vesicles and enhancement in cellular delivery of drugs

Zhang, J., Su, N., Liu, W., Li, M., Zheng, H., Li, B., Jin, X., Gao, M., & Zhang, X. (2025) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-025-05742-1 · Cited by 7

Exosomes derived from natural killer cells: transforming immunotherapy for aggressive breast cancer

Altamimi, A. S. A., Babu, M. A., Afzal, M., Bishoyi, A. K., Roopashree, R., Saini, S., Sharma, R. K., Pathak, P. K., Chauhan, A. S., Goyal, K., et al. (2025) · Medical Oncology · doi:10.1007/s12032-025-02647-y · Cited by 8

Turning adversity into opportunity: Small extracellular vesicles as nanocarriers for tumor‐associated macrophages re‐education

Meneses, D. D., Figueroa‐Valdés, A. I., Georges, N., Tobar, H. E., & Alcayaga‐Miranda, F. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10349 · Cited by 7

Tumor-originated pH-responsive nanovaccine mixture to treat heterogeneous tumors

Park, J., Lee, E., & Lee, E. S. (2022) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-022-00585-9 · Cited by 7

Roles of extracellular vesicles derived from immune cells in atherosclerosis

Qiao, K., Cui, X., Gao, J., Yu, F., Liu, H., Dai, Y., Liu, J., Yang, Y., Xian, X., Hu, J.-M., et al. (2023) · Extracellular Vesicle · doi:10.1016/j.vesic.2023.100028 · Cited by 4

Exosomes: Friends or Foes in Microbial Infections?

Teymouri, S., Pourhajibagher, M., & Bahador, A. (2024) · Infectious Disorders - Drug Targets · doi:10.2174/0118715265264388231128045954 · Cited by 8

Plant-Based Exosomes: Insights and Therapeutic Applications

BODALA, C. K., Parveen, A., Gogireddy, B. L., Priya, S., & Lankalapalli, S. (2025) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.2025057676 · Cited by 7

Engineered mesenchymal stem cell-derived exosomes: A revolutionary approach to unlocking liver disease treatment

Kheirkhah, A. H., Sheykhhasan, M., Hosseinzadeh, F., & Fath-Bayati, L. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102313 · Cited by 7

Harnessing nanomedicine to target NF-κB signalling in cancer: at the intersection of inflammatory signalling, metabolic reprogramming, and therapeutic innovation

BharathwajChetty, B., Aswani, B. S., Shinde, S. S., Alqahtani, M. S., Abbas, M., Sethi, G., Ma, Z., & Kunnumakkara, A. B. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-025-02554-9 · Cited by 7

Generation, Characterization, and Count of Fluorescent Extracellular Vesicles

Ferrantelli, F., Tirelli, V., Barreca, V., & Manfredi, F. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2341-1_15 · Cited by 6

Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives

Ahmed, W., Mushtaq, A., Ali, S., Khan, N., Liang, Y., & Duan, L. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00856 · Cited by 56

Exosomes as Advanced Nanocarriers for Targeted Drug Delivery: Recent Progress, Engineering Strategies and Translational Challenges

Tanuja Jadhav*, K. K. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.23019162

Nanoengineering of Exosomal Surfaces for Precision Targeting and Payload Delivery at the Molecular Level

Singh, D., Singh, S., & Tandon, N. (2025) · Assay and Drug Development Technologies · doi:10.1177/1540658x251369691 · Cited by 5

Exosomes as Targeted Delivery Drug System: Advances in Exosome Loading, Surface Functionalization and Potential for Clinical Application

Guo, Z. Y., Tang, Y., & Cheng, Y. C. (2022) · Current Drug Delivery · doi:10.2174/1567201819666220613150814 · Cited by 47

Exosomal targeting and its potential clinical application

He, J., Ren, W., Wang, W., Han, W., Jiang, L., Zhang, D., & Guo, M. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01087-1 · Cited by 210