Exosome engineering: Current progress in cargo loading and targeted delivery

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Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

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Liposomal drug delivery systems: From concept to clinical applications

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Metal-organic frameworks

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Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery

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Exosomes

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Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.

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Exosomes as drug delivery vehicles for Parkinson’s disease therapy

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Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

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Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

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Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and Nanomedicine

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A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

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Biogenesis and secretion of exosomes

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Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

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New Technologies for Analysis of Extracellular Vesicles

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Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

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A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

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Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

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Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

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Extracellular vesicles for drug delivery.

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Exosome-Mediated Metastasis: Communication from a Distance

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Exosome Theranostics: Biology and Translational Medicine

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Engineering exosomes as refined biological nanoplatforms for drug delivery

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Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties

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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

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Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

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Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

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Bovine milk-derived exosomes for drug delivery

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Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

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Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

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Biogenesis and function of extracellular vesicles in cancer

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Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

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Clinical Translation of Nanomedicine

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Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases

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Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

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Exosome Function: From Tumor Immunology to Pathogen Biology

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NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

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Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

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Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

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Engineering hybrid exosomes by membrane fusion with liposomes

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Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

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Saponins as cytotoxic agents: a review

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Exosome-Based Cell-Cell Communication in the Tumor Microenvironment

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Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

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Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

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Exosome–Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

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Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

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Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

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Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain

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Exosomes for targeted siRNA delivery across biological barriers

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Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

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Milk-derived exosomes for oral delivery of paclitaxel

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Surface Functionalization of Exosomes Using Click Chemistry

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Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

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Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury

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Amorphous TiO 2 Shells: A Vital Elastic Buffering Layer on Silicon Nanoparticles for High‐Performance and Safe Lithium Storage

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Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

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Exosomes are natural carriers of exogenous siRNA to human cells in vitro

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The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities

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Mesenchymal stem cell-derived exosomes for clinical use

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Application of Various Types of Liposomes in Drug Delivery Systems

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Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

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Pseudotyping exosomes for enhanced protein delivery in mammalian cells

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Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

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Display of GPI‐anchored anti‐EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

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KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

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Exosome Biochemistry and Advanced Nanotechnology for Next‐Generation Theranostic Platforms

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The acidic tumor microenvironment: a target for smart cancer nano-theranostics

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Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

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In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles

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Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)

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Increased miR‐124‐3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons

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Exosome-SIRPα, a CD47 blockade increases cancer cell phagocytosis

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Exosome-based tumor antigens–adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA

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Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

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RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer’s disease

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Liposomes with a large trapping capacity prepared by freezing and thawing of sonicated phospholipid mixtures

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GROWTH FACTORS AND CANCER

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Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

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Elevated expression of IL-3Rα in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis

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Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway

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Transfer of extracellular vesicles during immune cell‐cell interactions

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In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9

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A Nanodrug Consisting Of Doxorubicin And Exosome Derived From Mesenchymal Stem Cells For Osteosarcoma Treatment In Vitro

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Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease

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Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis

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Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes

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Targeted exosome‐encapsulated erastin induced ferroptosis in triple negative breast cancer cells

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Maximizing exosome colloidal stability following electroporation

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Gemcitabine loaded autologous exosomes for effective and safe chemotherapy of pancreatic cancer

Li, Y., Wu, J., Wang, J., Hu, X.-B., Cai, J., & Xiang, D. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.10.022 · Cited by 295

Extracellular vesicles in renal disease

Karpman, D., Ståhl, A.-L., & Arvidsson, I. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.98 · Cited by 294

Exosomes Increase the Therapeutic Index of Doxorubicin in Breast and Ovarian Cancer Mouse Models

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Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

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Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2.

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Engineered Exosome-Mediated Near-Infrared-II Region V2C Quantum Dot Delivery for Nucleus-Target Low-Temperature Photothermal Therapy

Cao, Y., Wu, T., Zhang, K., Meng, X., Dai, W., Wang, D., Dong, H., & Zhang, X. (2019) · ACS Nano · doi:10.1021/acsnano.8b07224 · Cited by 281

Aptamer-functionalized exosomes from bone marrow stromal cells target bone to promote bone regeneration

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Exosomal formulation enhances therapeutic response of celastrol against lung cancer

Aqil, F., Kausar, H., Agrawal, A. K., Jeyabalan, J., Kyakulaga, A.-H., Munagala, R., & Gupta, R. C. (2016) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2016.05.013 · Cited by 273

The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

Matsumoto, J., Stewart, T., Banks, W. A., & Zhang, J. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612823666170913164738 · Cited by 267

Competitive Interactions of Cancer Cells and Normal Cells via Secretory MicroRNAs

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Engineering Exosomes for Cancer Therapy

Gilligan, K., & Dwyer, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061122 · Cited by 266

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells

Chen, L., Charrier, A., Zhou, Y., Chen, R., Yu, B., Agarwal, K., Tsukamoto, H., Lee, J. L., Paulaitis, M. E., & Brigstock, D. R. (2013) · Hepatology · doi:10.1002/hep.26768 · Cited by 264

Stimulus-responsive nanopreparations for tumor targeting

Zhu, L., & Torchilin, V. P. (2012) · Integrative Biology · doi:10.1039/c2ib20135f · Cited by 263

Exosome as a Novel Shuttle for Delivery of Therapeutics across Biological Barriers

Das, C. K., Jena, B. C., Banerjee, I., Das, S., Parekh, A., Bhutia, S. K., & Mandal, M. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00901 · Cited by 262

Superparamagnetic nanoarchitectures for disease-specific biomarker detection

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Macrophage-Derived Extracellular Vesicles as Drug Delivery Systems for Triple Negative Breast Cancer (TNBC) Therapy

Haney, M. J., Zhao, Y., Jin, Y. S., Li, S. M., Bagó, J. R., Klyachko, N. L., Kabanov, A. V., & Batrakova, E. V. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09884-9 · Cited by 252

A platform for actively loading cargo RNA to elucidate limiting steps in EV‐mediated delivery

Hung, M. E., & Leonard, J. N. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.31027 · Cited by 251

Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges

Kibria, G., Ramos, E. K., Wan, Y., Gius, D. R., & Liu, H. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00277 · Cited by 244

Engineered Exosomes for Targeted Transfer of siRNA to HER2 Positive Breast Cancer Cells

Khodashenas, S., Moghadam, M. F., Moazzeni, S. M., Gomari, H., & Salimi, F. (2018) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-018-2813-4 · Cited by 243

Mesenchymal stem cells as natural biofactories for exosomes carrying miR-124a in the treatment of gliomas

Lang, F., Hossain, A., Gumin, J., Momin, E. N., Shimizu, Y., Ledbetter, D., Shahar, T., Yamashita, S., Kerrigan, B. C. P., Fueyo-Margareto, J., et al. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox152 · Cited by 242

Exosome: emerging biomarker in breast cancer

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Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutics and as a Drug Delivery Platform

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Treatment of neurodegenerative disorders through the blood–brain barrier using nanocarriers

Poovaiah, N., Davoudi, Z., Peng, H., Schlichtmann, B. W., Mallapragada, S. K., Narasimhan, B., & Wang, Q. (2018) · Nanoscale · doi:10.1039/c8nr04073g · Cited by 231

Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer

Nie, H., Xie, X., Zhang, D., Zhou, Y., Li, B., Li, F., Li, F., Cheng, Y., Mei, H., Meng, H., et al. (2019) · Nanoscale · doi:10.1039/c9nr09011h · Cited by 230

Exosomes in inflammation and role as biomarkers

Console, L., Scalise, M., & Indiveri, C. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.11.009 · Cited by 225

A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer

Li, Y., Gao, Y., Gong, C., Wang, Z., Xia, Q., Gu, F., Hu, C., Zhang, L., Guo, H., & Gao, S. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2018.05.020 · Cited by 224

Extracellular vesicles: the next generation of biomarkers for liquid biopsy-based prostate cancer diagnosis

Pang, B., Zhu, Y., Ni, J., Thompson, J. E., Malouf, D. J., Bucci, J. A., Graham, P., & Li, Y. (2020) · Theranostics · doi:10.7150/thno.39486 · Cited by 221

Chemically Edited Exosomes with Dual Ligand Purified by Microfluidic Device for Active Targeted Drug Delivery to Tumor Cells

Wang, J., Li, W., Zhang, L., Ban, L., Chen, P., Du, W., Feng, X., & Liu, B. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b06464 · Cited by 218

Exosome-coated metal–organic framework nanoparticles: an efficient drug delivery platform

Illes, B., Hirschle, P., Barnert, S., Cauda, V., Wuttke, S., & Engelke, H. (2017) · Chemistry of Materials · doi:10.1021/acs.chemmater.7b02358 · Cited by 215

Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity

Bryniarski, K., Ptak, W., Jayakumar, A., Püellmann, K., Caplan, M. J., Chairoungdua, A., Lü, J., Adams, B. D., Sikora, E., Nazimek, K., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.048 · Cited by 214

Nanotechnology applications for improved delivery of antiretroviral drugs to the brain

Wong, H. L., Chattopadhyay, N., Wu, X. Y., & Bendayan, R. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.020 · Cited by 214

Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology

Izco, M., Blesa, J., Schleef, M., Schmeer, M., Porcari, R., Al‐Shawi, R., Ellmerich, S., de Toro, M., Gardiner, C., Seow, Y., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.08.010 · Cited by 213

Molecular Recognition-Based DNA Nanoassemblies on the Surfaces of Nanosized Exosomes

Wan, S., Zhang, L., Wang, S., Liu, Y., Wu, C. S., Cui, C., Sun, H. R., Shi, M., Jiang, Y. Y., Li, L., et al. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b00319 · Cited by 210

Long noncoding RNAs and exosomal lncRNAs: classification, and mechanisms in breast cancer metastasis and drug resistance

Yousefi, H., Maheronnaghsh, M., Molaei, F., Mashouri, L., Aref, A. R., Momeny, M., & Alahari, S. K. (2019) · Oncogene · doi:10.1038/s41388-019-1040-y · Cited by 207

Post Isolation Modification of Exosomes for Nanomedicine Applications

Hood, J. L. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0102 · Cited by 203

Exosomes from Cardiomyocyte Progenitor Cells and Mesenchymal Stem Cells Stimulate Angiogenesis Via EMMPRIN

Vrijsen, K. R., Maring, J. A., Chamuleau, S. A. J., Verhage, V., Mol, E. A., Deddens, J. C., Metz, C. H. G., Lodder, K., van Eeuwijk, E. C. M., van Dommelen, S. M., et al. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600308 · Cited by 203

miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury

Wei, Z., Qiao, S., Zhao, J., Liu, Y., Li, Q., Wei, Z., Dai, Q., Kang, L., & Xu, B. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116632 · Cited by 202

Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents

Xia, X., Wang, Y., Huang, Y., Zhang, H., Lu, H., & Zheng, J. C. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101694 · Cited by 202

Exosomes derived from gastric cancer cells activate NF-κB pathway in macrophages to promote cancer progression

Wu, L., Zhang, X., Zhang, B., Shi, H., Yuan, X., Sun, Y., Pan, Z., Qian, H., & Xu, W. (2016) · Tumor Biology · doi:10.1007/s13277-016-5071-5 · Cited by 189

Targeted cancer therapy using engineered exosome as a natural drug delivery vehicle

Gomari, H., Moghadam, M. F., & Soleimani, M. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s173110 · Cited by 189

Designer Exosomes for Active Targeted Chemo‐Photothermal Synergistic Tumor Therapy

Wang, J., Dong, Y., Li, Y., Li, W., Cheng, K., Qian, Y., Xu, G., Zhang, X., Hu, L., Chen, P., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201707360 · Cited by 187

Enhanced Loading of Functional miRNA Cargo via pH Gradient Modification of Extracellular Vesicles

Jeyaram, A., Lamichhane, T. N., Wang, S., Zou, L., Dahal, E., Kronstadt, S. M., Levy, D. H., Parajuli, B., Knudsen-Palmer, D. R., Chao, W., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.12.007 · Cited by 187

Exosomes Derived from miR-126-modified MSCs Promote Angiogenesis and Neurogenesis and Attenuate Apoptosis after Spinal Cord Injury in Rats

Huang, J., Xu, Y., Yin, X.-M., & Lin, F. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.10.043 · Cited by 180

Exosomes as Drug Carriers for Cancer Therapy

Pullan, J. E., Confeld, M. I., Osborn, J., Kim, J., Sarkar, K., & Mallik, S. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00104 · Cited by 179

Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model

Jeong, K., Yu, Y. J., You, J. Y., Rhee, W. J., & Kim, J. A. (2020) · Lab on a Chip · doi:10.1039/c9lc00958b · Cited by 178

Exosomes and Their Noncoding RNA Cargo Are Emerging as New Modulators for Diabetes Mellitus

Chang, W., & Wang, J. (2019) · Cells · doi:10.3390/cells8080853 · Cited by 176

Efficient encapsulation of theranostic nanoparticles in cell-derived exosomes: leveraging the exosomal biogenesis pathway to obtain hollow gold nanoparticle-hybrids

Sancho‐Albero, M., Encabo-Berzosa, M. D. M., Beltrán‐Visiedo, M., Fernández‐Messina, L., Sebastián, V., Sánchez‐Madrid, F., Arruebo, M., Santamarı́a, J., & Martín-Duque, P. (2019) · Nanoscale · doi:10.1039/c9nr06183e · Cited by 175

Combining magnetic nanoparticles with cell derived microvesicles for drug loading and targeting

Silva, A., Luciani, N., Gazeau, F., Aubertin, K., Bonneau, S., Chauvierre, C., Letourneur, D., & Wilhelm, C. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.11.009 · Cited by 174

Passion fruit-like exosome-PMA/Au-BSA@Ce6 nanovehicles for real-time fluorescence imaging and enhanced targeted photodynamic therapy with deep penetration and superior retention behavior in tumor

Pan, S., Pei, L., Zhang, A., Zhang, Y., Zhang, C., Huang, M., Huang, Z., Liu, B., Wang, L., Ma, L., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119606 · Cited by 172

Magnetic and Folate Functionalization Enables Rapid Isolation and Enhanced Tumor-Targeting of Cell-Derived Microvesicles

Zhang, W., Yu, Z., Wu, M. Y., Ren, J., Xia, H.-F., Sa, G., Zhu, J., Pang, D., Zhao, Y., & Chen, G. (2016) · ACS Nano · doi:10.1021/acsnano.6b05630 · Cited by 171

miR-1246 and miR-4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer

Machida, T., Tomofuji, T., Maruyama, T., Yoneda, T., Ekuni, D., Azuma, T., Miyai, H., Mizuno, H., Kato, H., Tsutsumi, K., et al. (2016) · Oncology Reports · doi:10.3892/or.2016.5021 · Cited by 170

Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach

Kooijmans, S. A. A., Gitz-Francois, J. J., Schiffelers, R. M., & Vader, P. (2018) · Nanoscale · doi:10.1039/c7nr06966a · Cited by 169

Therapeutic use of curcumin‐encapsulated and curcumin‐primed exosomes

Nosrati‐Oskouie, M., Aghili‐Moghaddam, N. S., Butler, A. E., Zamani, P., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27615 · Cited by 166

Reduction of the therapeutic dose of silencing RNA by packaging it in extracellular vesicles via a pre-microRNA backbone

Reshke, R., Taylor, J. A., Savard, A., Guo, H., Rhym, L. H., Kowalski, P. S., Trung, M. T., Campbell, C. M., Little, W., Anderson, D. G., et al. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0502-4 · Cited by 165

Tumor‐Exocytosed Exosome/Aggregation‐Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy

Zhu, D., Duo, Y., Suo, M., Zhao, Y., Xia, L., Zheng, Z., Yang, L., & Tang, B. Z. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202003672 · Cited by 164

Exosome-Based Delivery of miR-124 in a Huntington’s Disease Model

Lee, S.-T., Im, W., Ban, J.-J., Lee, M., Jung, K.-H., Lee, S. K., Chu, K., & Kim, M. (2017) · Journal of Movement Disorders · doi:10.14802/jmd.16054 · Cited by 164

Exosomes: A new delivery system for tumor antigens in cancer immunotherapy

Cho, J., Yeo, D.-J., Son, H., Kim, H., Jung, D., Ko, J., Koh, J. S., Kim, Y.-N., & Kim, C. (2004) · International Journal of Cancer · doi:10.1002/ijc.20757 · Cited by 160

pH-sensitive Liposomes for Drug Delivery in Cancer Treatment

Ferreira, D. S., Lopes, S. C. D. A., Franco, M. S., & Oliveira, M. C. (2013) · Therapeutic Delivery · doi:10.4155/tde.13.80 · Cited by 158

Focused ultrasound-augmented targeting delivery of nanosonosensitizers from homogenous exosomes for enhanced sonodynamic cancer therapy

Liu, Y., Bai, L., Guo, K., Jia, Y., Zhang, K., Liu, Q., Wang, P., & Wang, X. (2019) · Theranostics · doi:10.7150/thno.33183 · Cited by 158

Engineered extracellular vesicles with synthetic lipids via membrane fusion to establish efficient gene delivery

Jhan, Y., Prasca-Chamorro, D., Zuniga, G. P., Moore, D. M., Kumar, S. A., Gaharwar, A. K., & Bishop, C. J. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118802 · Cited by 157

Exosomes in Alzheimer's disease

Malm, T., Loppi, S. H., & Kanninen, K. M. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.04.011 · Cited by 152

siRNA based drug design, quality, delivery and clinical translation

Subhan, M. A., & Torchilin, V. P. (2020) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2020.102239 · Cited by 152

Virus‐Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes

Yang, Y., Hong, Y., Nam, G., Chung, J. H., Koh, E., & Kim, I. (2017) · Advanced Materials · doi:10.1002/adma.201605604 · Cited by 151

Drug-loaded exosomal preparations from different cell types exhibit distinctive loading capability, yield, and antitumor efficacies: a comparative analysis

Kanchanapally, R., Deshmukh, S. K., Chavva, S. R., Tyagi, N., Srivastava, S. K., Patel, G. K., Singh, A. P., & Singh, S. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s191313 · Cited by 151

pH-responsive hyaluronate-anchored extracellular vesicles to promote tumor-targeted drug delivery

Lee, H., Park, H., Noh, G. J., & Lee, E. S. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.08.141 · Cited by 150

SPION decorated exosome delivery of TNF-α to cancer cell membranes through magnetism

Zhuang, M., Chen, X., Du, D., Shi, J., Deng, M., Qian, L., Yin, X., Wang, Y., & Rao, L. (2019) · Nanoscale · doi:10.1039/c9nr05865f · Cited by 150

Bone marrow mesenchymal stem cell-secreted exosomes carrying microRNA-125b protect against myocardial ischemia reperfusion injury via targeting SIRT7

Chen, Q., Liu, Y., Ding, X., Li, Q., Qiu, F., Wang, M., Shen, Z., Zheng, H., & Fu, G. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03671-z · Cited by 146

Exosomal DNA Aptamer Targeting α-Synuclein Aggregates Reduced Neuropathological Deficits in a Mouse Parkinson’s Disease Model

Ren, X., Zhao, Y., Xue, F., Zheng, Y., Huang, H., Wang, W., Chang, Y., Yang, H., & Zhang, J. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.07.008 · Cited by 143

Exosomes Mediate Epithelium–Mesenchyme Crosstalk in Organ Development

Jiang, N., Xiang, L., He, L., Yang, G., Zheng, J., Wang, C., Zhang, Y., Wang, S., Zhou, Y., Sheu, T.-J., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b01087 · Cited by 142

Liposome triggering of innate immune responses: A perspective on benefits and adverse reactions

Szebeni, J., & Moghimi, S. M. (2009) · Journal of Liposome Research · doi:10.1080/08982100902792855 · Cited by 128

A novel method for encapsulation of macromolecules in liposomes

Shew, R. L., & Deamer, D. W. (1985) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(85)90386-4 · Cited by 128

Exosome as a Vehicle for Delivery of Membrane Protein Therapeutics, PH20, for Enhanced Tumor Penetration and Antitumor Efficacy

Hong, Y., Nam, G., Koh, E., Jeon, S., Kim, G. B., Jeong, C., Kim, D. H., Yang, Y., & Kim, I.-S. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201703074 · Cited by 126

Glycan modification of glioblastoma‐derived extracellular vesicles enhances receptor‐mediated targeting of dendritic cells

Dusoswa, S. A., Horrevorts, S. K., Ambrosini, M., Kalay, H., Paauw, N. J., Nieuwland, R., Pegtel, D. M., Würdinger, T., van Kooyk, Y., & García-Vallejo, J. J. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1648995 · Cited by 126

Neonatal Subventricular Zone Neural Stem Cells Release Extracellular Vesicles that Act as a Microglial Morphogen

Morton, M. C., Neckles, V. N., Seluzicki, C. M., Holmberg, J. C., & Feliciano, D. M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.037 · Cited by 122

Functional extracellular vesicles engineered with lipid-grafted hyaluronic acid effectively reverse cancer drug resistance

Liu, J., Ye, Z., Xiang, M., Chang, B., Cui, J., Ji, T., Zhao, L., Li, Q., Deng, Y., Xu, L., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119475 · Cited by 121

Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small metastatic lung tumors

Lara, P., Palma-Florez, S., Salas‐Huenuleo, E., Polakovičová, I., Guerrero, S., Lobos‐González, L., Campos, A. V., Muñoz, L., Jorquera‐Cordero, C., Varas‐Godoy, M., et al. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-0573-0 · Cited by 118

Stellate Plasmonic Exosomes for Penetrative Targeting Tumor NIR-II Thermo-Radiotherapy

Zhu, D., Lyu, M., Huang, Q., Suo, M., Liu, Y., Jiang, W., Duo, Y., & Fan, K. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c09969 · Cited by 117

Mannose‐Modified Serum Exosomes for the Elevated Uptake to Murine Dendritic Cells and Lymphatic Accumulation

Choi, E. S., Song, J., Kang, Y. Y., & Mok, H. (2019) · Macromolecular Bioscience · doi:10.1002/mabi.201900042 · Cited by 112

Human mesenchymal stem cell-derived iron oxide exosomes allow targeted ablation of tumor cells via magnetic hyperthermia

Altanerova, U., Babincová, M., Babinec, P., Benejova, K., Jakubechova, J., Altanerová, V., Zdurienčíková, M., Repiská, V., & Altaner, Č. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s145096 · Cited by 110

Extracellular vesicles based self-grown gold nanopopcorn for combinatorial chemo-photothermal therapy

Zhang, D., Qin, X., Wu, T., Qiao, Q., Song, Q., & Zhang, Z. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.01.024 · Cited by 107

Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a

Ma, Y., Li, C., Huang, Y., Wang, Y., Xia, X., & Zheng, J. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0418-3 · Cited by 105

Effects of exosome-mediated delivery of myostatin propeptide on functional recovery of mdx mice

Ran, N., Gao, X., Dong, X., Li, J., Lin, C., Geng, M., & Yin, H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119826 · Cited by 100

Synthetic and Biological Vesicular Nano-Carriers Designed for Gene Delivery

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Magnetoliposomes as Multimodal Contrast Agents for Molecular Imaging and Cancer Nanotheragnostics

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High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesicles

Longatti, A., Schindler, C., Collinson, A., Jenkinson, L., Matthews, C., FitzPatrick, L., Blundy, M., Minter, R., Vaughan, T. J., Shaw, M., et al. (2018) · Nanoscale · doi:10.1039/c8nr03970d · Cited by 96

Aspirin-loaded nanoexosomes as cancer therapeutics

Tran, P. H. L., Wang, T., Yin, W., Tran, T. T. D., Nguyen, T. N.-G., Lee, B., & Duan, W. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118786 · Cited by 96

Engineered Cell‐Derived Microparticles Bi2Se3/DOX@MPs for Imaging Guided Synergistic Photothermal/Low‐Dose Chemotherapy of Cancer

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Delivery of High Mobility Group Box-1 siRNA Using Brain-Targeting Exosomes for Ischemic Stroke Therapy

Kim, M., Kim, G., Hwang, D. W., & Lee, M. (2019) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2019.2866 · Cited by 92

Delivery of LNA-antimiR-142-3p by Mesenchymal Stem Cells-Derived Exosomes to Breast Cancer Stem Cells Reduces Tumorigenicity

Naseri, Z., Oskuee, R. K., Forouzandeh‐Moghadam, M., & Jaafari, M. R. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09944-w · Cited by 91

Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release

Gao, G., Li, C., Zhu, J., Wang, Y., Huang, Y., Zhao, S., Sheng, S., Song, Y., Ji, C., Li, C., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00161 · Cited by 90

Nanoparticle‐Induced Exosomes Target Antigen‐Presenting Cells to Initiate Th1‐Type Immune Activation

Zhu, M., Tian, X., Song, X. J., Li, Y., Tian, Y., Zhao, Y., & Nie, G. (2012) · Small · doi:10.1002/smll.201200381 · Cited by 89

In vitro evaluation of endothelial exosomes as carriers for small interfering ribonucleic acid delivery

He, J., Banizs, A. B., Huang, T., Dryden, K. A., Berr, S. S., Stone, J. R., Nakamoto, R. K., & Shi, W. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s64267 · Cited by 86

Exosome is a mechanism of intercellular drug transfer: Application of quantitative pharmacology

Wang, J., Yeung, B. Z., Cui, M., Peer, C. J., Lu, Z., Figg, W. D., Wientjes, M. G., Woo, S., & Au, J. L. ‐. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.10.020 · Cited by 85

Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease

Gao, G., Zhao, S., Xia, X., Li, C., Li, C., Ji, C., Sheng, S., Tang, Y., Zhu, J., Wang, Y., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00264 · Cited by 85

Smart Drug Delivery Systems in Cancer Therapy

Ünsoy, G., & Gündüz, U. (2016) · Current Drug Targets · doi:10.2174/1389450117666160401124624 · Cited by 83

SPION‐Decorated Exosome Delivered BAY55‐9837 Targeting the Pancreas through Magnetism to Improve the Blood GLC Response

Zhuang, M., Du, D., Pu, L., Song, H., Deng, M., Qian, L., Yin, X., Wang, Y., & Rao, L. (2019) · Small · doi:10.1002/smll.201903135 · Cited by 82

Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus

Temchura, V., Tenbusch, M., Nchinda, G., Nabi, G., Tippler, B. G., Zelenyuk, M., Wildner, O., Überla, K., & Kuate, S. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.04.069 · Cited by 82

Differential effects of alkali metal chlorides on formation of giant liposomes by freezing and thawing and by dialysis

Oku, N., & MacDonald, R. C. (1983) · Biochemistry · doi:10.1021/bi00273a023 · Cited by 77

A pH and thermosensitive choline phosphate-based delivery platform targeted to the acidic tumor microenvironment

Yu, X., Yang, X., Horte, S. A., Kizhakkedathu, J. N., & Brooks, D. E. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.052 · Cited by 72

Exosome as a Vehicle for Delivery of Membrane Protein Therapeutics, PH20, for Enhanced Tumor Penetration and Antitumor Efficacy

Hong, Y., Nam, G., Koh, E., Jeon, S., Kim, G. B., Jeong, C., Kim, D., Yang, Y., & Kim, I. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201801301 · Cited by 69

Exosome-delivered syndecan-1 rescues acute lung injury via a FAK/p190RhoGAP/RhoA/ROCK/NF-κB signaling axis and glycocalyx enhancement

Zhang, C., Guo, F., Chang, M., Zhou, Z., Yi, L., Gao, C., Huang, X., & Huan, J. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111596 · Cited by 67

Folate-Engineered Microvesicles for Enhanced Target and Synergistic Therapy toward Breast Cancer

Zhu, L. Q., Dong, D., Yu, Z., Zhao, Y., Pang, D., & Zhang, Z. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b14633 · Cited by 64

Extracellular vesicles-based drug delivery system for cancer treatment

Balachandran, B., & Yuana, Y. (2019) · Cogent Medicine · doi:10.1080/2331205x.2019.1635806 · Cited by 64

Extracellular Vesicles–Encapsulated MicroRNA-125b Produced in Genetically Modified Mesenchymal Stromal Cells Inhibits Hepatocellular Carcinoma Cell Proliferation

Baldari, S., Rocco, G. D., Magenta, A., Picozza, M., & Toietta, G. (2019) · Cells · doi:10.3390/cells8121560 · Cited by 62

Functionalized extracellular vesicles as advanced therapeutic nanodelivery systems

Lu, M., Xing, H., Xun, Z., Yang, T., Zhao, X., Cai, C., Wang, D., & Ding, P. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.05.001 · Cited by 56

Chemical Modulation of Bioengineered Exosomes for Tissue‐Specific Biodistribution

Hwang, D. W., Jo, M. J., Lee, J. H., Kang, H., Bao, K., Hu, S., Baek, Y., Moon, H. G., Lee, D. S., Kashiwagi, S., et al. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201900111 · Cited by 55

Exosome-Mediated Transfer of Anti-miR-33a-5p from Transduced Endothelial Cells Enhances Macrophage and Vascular Smooth Muscle Cell Cholesterol Efflux

Stamatikos, A., Knight, E., Vojtech, L. N., Bi, L., Wacker, B. K., Tang, C., & Dichek, D. A. (2019) · Human Gene Therapy · doi:10.1089/hum.2019.245 · Cited by 54

Induced neural progenitor cells abundantly secrete extracellular vesicles and promote the proliferation of neural progenitors via extracellular signal–regulated kinase pathways

Ma, Y., Wang, K., Pan, J., Fan, Z., Tian, C.-H., Deng, X., Ma, K.-M., Xia, X.-H., Huang, Y.-L., & Zheng, J.-L. C. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.12.003 · Cited by 53

Biomimetic Carriers Based on Giant Membrane Vesicles for Targeted Drug Delivery and Photodynamic/Photothermal Synergistic Therapy

Luo, C., Hu, X., Peng, R., Huang, H., Liu, Q., & Tan, W. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b11223 · Cited by 48

Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake

Kimiz-Gebologlu, I., & Oncel, S. S. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.027 · Cited by 722

Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics

Tenchov, R., Sasso, J. M., Wang, X., Liaw, W., Chen, C., & Zhou, Q. A. (2022) · ACS Nano · doi:10.1021/acsnano.2c08774 · Cited by 642

Exosome engineering in cell therapy and drug delivery

Sadeghi, S., Tehrani, F. R., Tahmasebi, S., Shafiee, A., & Hashemi, S. M. (2023) · Inflammopharmacology · doi:10.1007/s10787-022-01115-7 · Cited by 351

Exosomes, a New Star for Targeted Delivery

Chen, H., Wang, L., Zeng, X., Schwarz, H., Nanda, H. S., Peng, X., & Zhou, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.751079 · Cited by 349

Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon–bone healing

Zou, J., Yang, W., Cui, W., Li, C., Ma, C., Ji, X., Hong, J., Qu, Z., Chen, J., Liu, A., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01778-6 · Cited by 325

Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives

Ahmed, W., Mushtaq, A., Ali, S., Khan, N., Liang, Y., & Duan, L. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00856 · Cited by 56

Exosomes as Advanced Nanocarriers for Targeted Drug Delivery: Recent Progress, Engineering Strategies and Translational Challenges

Tanuja Jadhav*, K. K. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.23019162

Nanoengineering of Exosomal Surfaces for Precision Targeting and Payload Delivery at the Molecular Level

Singh, D., Singh, S., & Tandon, N. (2025) · Assay and Drug Development Technologies · doi:10.1177/1540658x251369691 · Cited by 5

Exosomes as Targeted Delivery Drug System: Advances in Exosome Loading, Surface Functionalization and Potential for Clinical Application

Guo, Z. Y., Tang, Y., & Cheng, Y. C. (2022) · Current Drug Delivery · doi:10.2174/1567201819666220613150814 · Cited by 47

Exosomal targeting and its potential clinical application

He, J., Ren, W., Wang, W., Han, W., Jiang, L., Zhang, D., & Guo, M. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01087-1 · Cited by 210