The DOI matches its Crossref record; 204 of the 204 references it cites were found in a registry or an index.
Exosome engineering: Current progress in cargo loading and targeted delivery
Open accessAbstract
Exosomes, a class of small bilayer vesicles derived from virtually all eukaryotic cells, have been exploited as a promising natural delivery platform due to their low toxicity, excellent structural stability, nanoscale size, cargo loading ability, and editable surface structure. To load therapeutic or diagnostic cargos (drugs, nucleic acids, proteins, peptides, and nanomaterials) into exosomes, multiple techniques have been developed, such as incubating cargos with exosomes or exosome-secreting cells, transfection, physical treatments (sonication, electroporation, extrusion, freeze-thaw, surfactant treatment, and dialysis), and in situ synthesis. Moreover, homing-molecules with high receptor binding affinity, acidic milieu responsiveness, or magnetic properties have been assembled on exosomal surface by transfection or chemical modification, conferring the targeting capacity to exosomes. In this review, we summarize the biogenesis, contents and functions of natural exosomes, and provide a comprehensive discussion for the strategies of exosomal cargo loading and membrane modification for targeted delivery.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Another standard method for direct engineering of EV surfaces includes the chemical modification of ligands onto the EV surface [226].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [226]
Citations
Cites
Shedding light on the cell biology of extracellular vesicles
van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.
Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., RINGOLD, G. M., & Danielsen, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7413 · Cited by 4,954
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930
Liposomal drug delivery systems: From concept to clinical applications
Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.037 · Cited by 4,839
Diffusion of univalent ions across the lamellae of swollen phospholipids
Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80093-6 · Cited by 4,664
James, S. L. (2003) · Chemical Society Reviews · doi:10.1039/b200393g · Cited by 3,616
Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
Tang, F., Li, L., & Chen, D. (2012) · Advanced Materials · doi:10.1002/adma.201104763 · Cited by 2,898
Pegtel, D. M., & Gould, S. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111902 · Cited by 2,682
Szoka, F. C., & Papahadjopoulos, D. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4194 · Cited by 2,350
Exosomes as drug delivery vehicles for Parkinson’s disease therapy
Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009
Flagged first, then by citations
Cited by
Sorted by citations
Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake
Kimiz-Gebologlu, I., & Oncel, S. S. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.027 · Cited by 722
Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics
Tenchov, R., Sasso, J. M., Wang, X., Liaw, W., Chen, C., & Zhou, Q. A. (2022) · ACS Nano · doi:10.1021/acsnano.2c08774 · Cited by 642
Exosome engineering in cell therapy and drug delivery
Sadeghi, S., Tehrani, F. R., Tahmasebi, S., Shafiee, A., & Hashemi, S. M. (2023) · Inflammopharmacology · doi:10.1007/s10787-022-01115-7 · Cited by 351
Exosomes, a New Star for Targeted Delivery
Chen, H., Wang, L., Zeng, X., Schwarz, H., Nanda, H. S., Peng, X., & Zhou, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.751079 · Cited by 349
Zou, J., Yang, W., Cui, W., Li, C., Ma, C., Ji, X., Hong, J., Qu, Z., Chen, J., Liu, A., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01778-6 · Cited by 325
Bella, M. A. D. (2022) · Biology · doi:10.3390/biology11060804 · Cited by 322
Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading
Rädler, J., Gupta, D., Zickler, A. M., & Andaloussi, S. E. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.02.013 · Cited by 298
Biodistribution of Exosomes and Engineering Strategies for Targeted Delivery of Therapeutic Exosomes
Choi, H., Choi, Y., Yim, H. Y., Mirzaaghasi, A., Yoo, J., & Choi, C. (2021) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-021-00361-0 · Cited by 295
Exosome-Based Drug Delivery: Translation from Bench to Clinic
Koh, H. B., Kim, H. J., Kang, S.-W., & Yoo, T.-H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082042 · Cited by 259
Huda, M. N., Nafiujjaman, M., Deaguero, I. G., Okonkwo, J., Hill, M. L., Kim, T. H., & Nurunnabi, M. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00217 · Cited by 268
Engineered Exosome for Drug Delivery: Recent Development and Clinical Applications
Tian, J., Han, Z., Song, D., Peng, Y., Xiong, M., Chen, Z., Duan, S., & Zhang, L. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s444582 · Cited by 246
Butreddy, A., Kommineni, N., & Dudhipala, N. R. (2021) · Nanomaterials · doi:10.3390/nano11061481 · Cited by 215
Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities
Nagelkerke, A., Ojansivu, M., van der Koog, L., Whittaker, T. E., Cunnane, E. M., da Silva, A. M., Dekker, N., & Stevens, M. M. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.013 · Cited by 211
Bovine Milk-Derived Exosomes as a Drug Delivery Vehicle for miRNA-Based Therapy
del Pozo‐Acebo, L., Hazas, M. L. D. L., Tomé‐Carneiro, J., Gil-Cabrerizo, P., San-Cristóbal, R., Busto, R., García‐Ruiz, A., & Dávalos, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031105 · Cited by 191
Exosomes as natural nanocarrier-based drug delivery system: recent insights and future perspectives
Sen, S., Xavier, J., Kumar, N., Ahmad, M. Z., & Ranjan, O. P. (2023) · 3 Biotech · doi:10.1007/s13205-023-03521-2 · Cited by 195
Plant-derived extracellular vesicles as oral drug delivery carriers
Fang, Z., & Liu, K. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.046 · Cited by 178
Cao, H., Chen, M., Cui, X., Liu, Y., Liu, Y., Deng, S., Yuan, T., Fan, Y., Wang, Q., & Zhang, X. (2023) · ACS Nano · doi:10.1021/acsnano.3c01612 · Cited by 172
Liang, Y., Iqbal, Z., Lu, J., Wang, J., Zhang, H., Chen, X., Duan, L., & Xia, J. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2022.10.008 · Cited by 162
Exosomes Engineering and Their Roles as Therapy Delivery Tools, Therapeutic Targets, and Biomarkers
Kučuk, N., Primožič, M., Knez, Ž., & Leitgeb, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179543 · Cited by 161
Optimised Electroporation for Loading of Extracellular Vesicles with Doxorubicin
Lennaárd, A. J., Mamand, D. R., Wiklander, R. J., Andaloussi, S. E., & Wiklander, O. P. B. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics14010038 · Cited by 162
Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications
Akbar, A., Malekian, F., Baghban, N., Kodam, S. P., & Ullah, M. (2022) · Cells · doi:10.3390/cells11020186 · Cited by 156
Clinical Translation of Extracellular Vesicles
Ghodasara, A. A., Raza, A., Wolfram, J., Salomón, C., & Popat, A. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301010 · Cited by 165
Milk exosomes: Nature's abundant nanoplatform for theranostic applications
Adriano, B., Cotto, N. M., Chauhan, N., Jaggi, M., Chauhan, S. C., & Yallapu, M. M. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.01.009 · Cited by 154
Recent progresses in exosome-based systems for targeted drug delivery to the brain
Bashyal, S., Chhitij, T., & Lee, S. K. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.06.011 · Cited by 130
Protein corona and exosomes: new challenges and prospects
Heidarzadeh, M., Zarebkohan, A., Rahbarghazi, R., & Sokullu, E. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01089-1 · Cited by 140
Hosseini, N. F., Amini, R., Ramezani, M., Saidijam, M., Hashemi, S. M., & Najafi, R. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113690 · Cited by 126
Clinical delivery of circular RNA: Lessons learned from RNA drug development
Young, T. L., Wang, K. C., Varley, A., & Li, B. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114826 · Cited by 130
Exosome-powered neuropharmaceutics: unlocking the blood-brain barrier for next-gen therapies
Mehdizadeh, S., Mamaghani, M., Hassanikia, S., Pilehvar‐Soltanahmadi, Y., & Ertaş, Y. N. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03352-8 · Cited by 138
Kim, G., Lee, Y., Ha, J., Han, S., & Lee, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.12.053 · Cited by 120
Exosomes for mRNA delivery: a novel biotherapeutic strategy with hurdles and hope
Aslan, C., Kiaie, S. H., Zolbanin, N. M., Lotfinejad, P., Ramezani, R., Kashanchi, F., & Jafari, R. (2021) · BMC Biotechnology · doi:10.1186/s12896-021-00683-w · Cited by 113
Research Advances of Engineered Exosomes as Drug Delivery Carrier
Huang, L., Wu, E., Liao, J., Wei, Z., Wang, J., & Chen, Z. (2023) · ACS Omega · doi:10.1021/acsomega.3c04479 · Cited by 113
Sanadgol, N., Abedi, M., Hashemzaei, M., Kamran, Z., Khalseh, R., Beyer, C., & Voelz, C. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03528-2 · Cited by 112
Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade
Moghassemi, S., Dadashzadeh, A., Sousa, M. J., Vlieghe, H., Yang, J., León-Félix, C. M., & Amorim, C. A. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.02.021 · Cited by 113
Novel antitumor therapeutic strategy using CD4+ T cell-derived extracellular vesicles
Shin, S., Jung, I., Jung, D., Kim, C. S. K., Kang, S., Ryu, S., Choi, S.-J., Noh, S., Jeong, J., Lee, B. Y., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121765 · Cited by 101
Shafiei, M., Ansari, M. N. M., Razak, S. I. A., & Khan, M. U. A. (2021) · Polymers · doi:10.3390/polym13152529 · Cited by 100
Piffoux, M., Volatron, J., Cherukula, K., Aubertin, K., Wilhelm, C., Silva, A., & Gazeau, F. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113972 · Cited by 107
Factors Affecting Extracellular Vesicles Based Drug Delivery Systems
Gaurav, I., Thakur, A., Iyaswamy, A., Wang, X., Chen, X., & Yang, Z. (2021) · Molecules · doi:10.3390/molecules26061544 · Cited by 97
Exosome-Based Carrier for RNA Delivery: Progress and Challenges
Lu, Y., Huang, W. C., Li, M., & Zheng, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020598 · Cited by 103
Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies
Mallick, R., Basak, S., Chowdhury, P., Bhowmik, P., Das, R. K., Banerjee, A., Paul, S., Pathak, S., & Duttaroy, A. K. (2025) · Pharmaceuticals · doi:10.3390/ph18010104 · Cited by 108
Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases
Xia, X., Wang, Y., & Zheng, J. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00330-0 · Cited by 97
Self-citationEngineering exosome-based biomimetic nanovehicles for wound healing
Joorabloo, A., & Liu, T. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.03.013 · Cited by 93
Acoustofluidics for simultaneous nanoparticle-based drug loading and exosome encapsulation
Wang, Z., Rich, J. T., Hao, N., Gu, Y., Chen, C., Yang, S., Zhang, P., & Huang, T. J. (2022) · Microsystems & Nanoengineering · doi:10.1038/s41378-022-00374-2 · Cited by 92
Therapeutic Application of Exosomes in Inflammatory Diseases
Suh, J. H., Joo, H. S., Hong, E. B., Lee, H. J., & Lee, J. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031144 · Cited by 91
Isolation of high-purity and high-stability exosomes from ginseng
Jang, J.-W., Jeong, H., Jang, E., Kim, E., Yoon, Y., Jang, S., Jeong, H., & Jang, G. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2022.1064412 · Cited by 94
Enhanced effect of autologous EVs delivering paclitaxel in pancreatic cancer
Faruque, H. A., Choi, E., Kim, J., & Kim, E. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.012 · Cited by 86
Exosome/Liposome-like Nanoparticles: New Carriers for CRISPR Genome Editing in Plants
Alghuthaymi, M. A., Ahmad, A., Khan, Z., Khan, S. H., Ahmed, F. K., Faiz, S., Nepovimova, E., Kuča, K., & Abd-Elsalam, K. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147456 · Cited by 83
“Interestingly, recently reported artificial multi-layer NPs exhibited considerable delivery efficiency with CRISPR/Cas9 systems, demonstrating the superiorities of multi-layer structures in delivering CRISPR cargos [19].”
BackgroundImmune-Cell-Derived Exosomes for Cancer Therapy
Zhao, Y., Liu, T., & Zhou, M. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00407 · Cited by 83
Soltanmohammadi, F., Gharehbaba, A. M., Zangi, A. R., Adibkia, K., & Javadzadeh, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117248 · Cited by 87
CRISPR-Cas9 delivery strategies with engineered extracellular vesicles
Lu, Y., Godbout, K., Lamothe, G., & Tremblay, J. P. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.102040 · Cited by 90
Functional Extracellular Vesicles for Regenerative Medicine
Kim, H. Y., Kwon, S., Um, W., Shin, S., Kim, C. H., Park, J. H., & Kim, B. (2022) · Small · doi:10.1002/smll.202106569 · Cited by 81
The exosome: a review of current therapeutic roles and capabilities in human reproduction
Dimik, M., Abeysinghe, P., Logan, J., & Mitchell, M. D. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01225-3 · Cited by 86
Extracellular Vesicles as Next-Generation Diagnostics and Advanced Therapy Medicinal Products
Stawarska, A., Bamburowicz‐Klimkowska, M., Rundén‐Pran, E., Dušinská, M., Cimpan, M. R., Ríos-Mondragón, I., & Grudziński, I. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126533 · Cited by 89
Native and Bioengineered Exosomes for Ischemic Stroke Therapy
Khan, H. L., Pan, J., Li, Y.-F., Zhang, Z., & Yang, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.619565 · Cited by 79
Sun, Z., Yang, J., Li, H., Wang, C., Fletcher, C., Li, J., Zhan, Y., Du, L., Wang, F., & Jiang, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120873 · Cited by 74
Cao, T. G. N., Hoang, Q. T., Kang, J. H., Kang, S. J., Ravichandran, V., Rhee, W. J., Lee, M., Ko, Y. T., & Shim, M. S. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122242 · Cited by 76
mRNA – A game changer in regenerative medicine, cell-based therapy and reprogramming strategies
Chabanovska, O., Galow, A.-M., David, R., & Lemcke, H. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114002 · Cited by 81
In vivo fate and intracellular trafficking of vaccine delivery systems
Lee, J., Kim, D., Byun, J., Wu, Y., Park, J.-W., & Oh, Y. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114325 · Cited by 72
Milk Exosomes: Next-Generation Agents for Delivery of Anticancer Drugs and Therapeutic Nucleic Acids
Timofeeva, A. M., Paramonik, A. P., Sedykh, S. E., & Nevinsky, G. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210194 · Cited by 75
Chiral Graphene Quantum Dots Enhanced Drug Loading into Small Extracellular Vesicles
Zhang, Y., Kim, G., Zhu, Y., Wang, C., Zhu, R., Lü, X., Chang, H., & Wang, Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c00305 · Cited by 74
Self-citationConverting extracellular vesicles into nanomedicine: loading and unloading of cargo
Joshi, B. S., Ortíz-Rios, D., & Zuhorn, I. S. (2021) · Materials Today Nano · doi:10.1016/j.mtnano.2021.100148 · Cited by 71
Raghav, A., & Jeong, G. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01219-2 · Cited by 72
Exosome engineering for efficient and targeted drug delivery: Current status and future perspective
Malekian, F., Shamsian, A., Kodam, S. P., & Ullah, M. (2022) · The Journal of Physiology · doi:10.1113/jp282799 · Cited by 71
Extracellular vesicles for the delivery of gene therapy
Ianni, E. D., Obuchi, W., Breyne, K., & Breakefield, X. O. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-025-00277-7 · Cited by 83
Exosomal-long non-coding RNAs journey in colorectal cancer: Evil and goodness faces of key players
Rizk, N. I., Abulsoud, A. I., Kamal, M. M., Kassem, D. H., & Hamdy, N. Μ. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120325 · Cited by 67
Chen, B., Zhao, Y., Zhang, Y., Pan, Y.-J., Xia, H., Kankala, R. K., Wang, S., Liu, G., & Chen, A. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.07.023 · Cited by 66
The role of Extracellular Vesicles during CNS development
Sangani, N. B., Gomes, A. R., Curfs, L., & Reutelingsperger, C. P. M. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102124 · Cited by 68
Exosomes for Regulation of Immune Responses and Immunotherapy
Hussain, M. W. A., Jahangir, S. R. T., Ghosh, B., Yesmin, F., Anis, A., Satil, S. N., Anwar, F., & Rashid, M. H. (2022) · Journal of Nanotheranostics · doi:10.3390/jnt3010005 · Cited by 64
Advances and prospects of RNA delivery nanoplatforms for cancer therapy
Attia, M. S., Kijanka, G. S., Nguyen, N., Zhang, J., & An, H. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.09.009 · Cited by 64
Choi, H., Kim, M.-Y., Kim, D., Yun, H., Oh, B.-K., Kim, S.-B., Song, I.-H., Park, H.-S., Kim, S.-E., Park, C., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061118 · Cited by 60
Mesenchymal stem cells and their derived exosomes to combat Covid–19
Dehbidi, M. Y., Goodarzi, N., Azhdari, M. H., & Doroudian, M. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2281 · Cited by 61
Extracellular Vesicle-Based Therapy for COVID-19: Promises, Challenges and Future Prospects
Karn, V., Ahmed, S., Tsai, L.-W., Dubey, R., Ojha, S. K., Singh, H. N., Kumar, M., Gupta, P. K., Sadhu, S., Jha, N. K., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9101373 · Cited by 58
Gabaran, S. G., Ghasemzadeh, N., Rahnama, M., Karataş, E., Akbari, A., & Rezaie, J. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02268-y · Cited by 60
Ahmed, F., Tamma, M., Pathigadapa, U., Reddanna, P., & Yenuganti, V. R. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00182 · Cited by 57
Inorganic Nanoparticle-Loaded Exosomes for Biomedical Applications
Barjesteh, T., Mansur, S., & Bao, Y. (2021) · Molecules · doi:10.3390/molecules26041135 · Cited by 57
Cao, Q., Huang, C., Chen, X., & Pollock, C. A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.816656 · Cited by 58
Gomes, P., Tzouanou, F., Skolariki, K., Vamvaka-Iakovou, A., Nogueras‐Ortiz, C. J., Tsirtsaki, K., Waites, C. L., Vlamos, P., Sousa, N., Costa‐Silva, B., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114183 · Cited by 57
Hade, M. D., Suire, C. N., & Suo, Z. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c20728 · Cited by 56
Deng, S., Cao, H., Cui, X., Fan, Y., Wang, Q., & Zhang, X. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.09.023 · Cited by 60
Impact of the Drug Loading Method on the Drug Distribution and Biological Efficacy of Exosomes
Kumar, D. N., Chaudhuri, A., Kumar, D., Singh, S. K., & Agrawal, A. K. (2023) · AAPS PharmSciTech · doi:10.1208/s12249-023-02624-6 · Cited by 55
Biomimetic and cell-based nanocarriers – New strategies for brain tumor targeting
Mendanha, D., de Castro, J. V., Ferreira, H., & Neves, N. M. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.07.047 · Cited by 56
Abesekara, M. S., & Chau, Y. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.972790 · Cited by 56
Ahmed, W., Mushtaq, A., Ali, S., Khan, N., Liang, Y., & Duan, L. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00856 · Cited by 56
Extracellular Vesicles and the Stress System
Makrygianni, E. A., & Chrousos, G. P. (2022) · Neuroendocrinology · doi:10.1159/000527182 · Cited by 59
Kumar, A., Zhou, L., Zhi, K., Raji, B., Pernell, S., Tadrous, E., Kodidela, S., Nookala, A. R., Kochat, H., & Kumar, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010138 · Cited by 54
Tracking tools of extracellular vesicles for biomedical research
Liu, Q., Huang, J., Xia, J., Liang, Y., & Li, G. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.943712 · Cited by 56
Exosomes: a potential diagnostic and treatment modality in the quest for counteracting cancer
Patel, G., Agnihotri, T. G., Gitte, M., Shinde, T., Gomte, S. S., Goswami, R., & Jain, A. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00810-z · Cited by 53
Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review
Ng, C. Y., Chai, J. Y., Foo, J. B., Yahaya, N. H. M., Yang, Y., Ng, M. H., & Law, J. X. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s327059 · Cited by 52
Native and engineered exosomes for inflammatory disease
Ma, X., Liu, B., Fan, L., Liu, Y., Zhao, Y., Ren, T., Li, Y., & Li, Y. (2022) · Nano Research · doi:10.1007/s12274-022-5275-5 · Cited by 52
Exosomes for angiogenesis induction in ischemic disorders
Moeinabadi‐Bidgoli, K., Rezaee, M., Hossein‐Khannazer, N., Babajani, A., Aghdaei, H. A., Arki, M. K., Afaghi, S., Niknejad, H., & Vosough, M. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17689 · Cited by 51
Role of Acute Myeloid Leukemia (AML)-Derived exosomes in tumor progression and survival
Amin, A. H., Sharifi, L. M. A., Kahharov, A., Opulencia, M. J. C., Alsaikhan, F., Bokov, D. O., Majdi, H. S., Jawad, M. A., Hammid, A. T., Shalaby, M. N., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113009 · Cited by 50
Goo, J., Lee, Y., Lee, J., Kim, I., & Jeong, C. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16030311 · Cited by 51
Human plasma derived exosomes: Impact of active and passive drug loading approaches on drug delivery
Gul, R., Bashir, H., Sarfraz, M., Shaikh, A. J., Jardan, Y. A. B., Hussain, Z., Asad, M. H. H. B., Gulzar, F., Guan, B., Nazir, I., et al. (2024) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2024.102096 · Cited by 50
Li, C., Zheng, J., Lu, Y., Lin, P., Lin, Y., Zheng, Y., Xu, R., Mai, Z., Guo, B., & Zhao, X. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02443-2 · Cited by 53
Self-citationHuman Epidural AD–MSC Exosomes Improve Function Recovery after Spinal Cord Injury in Rats
Sung, S., Seo, M., Kim, Y., Kang, K., Choi, J.-H., Lee, S., Sung, M. K., Yim, S., Lim, J., Seok, H.-G., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10030678 · Cited by 46
Exosomes-Based Nanomedicine for Neurodegenerative Diseases: Current Insights and Future Challenges
Cano, A. C., Muñoz-Morales, Á., Sánchez‐López, E., Ettcheto, M., Souto, E. B., Camins, A., Boada, M., & Ruiz, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010298 · Cited by 48
Villanueva, J. P., Agudo, J. T., & Borau, J. M. (2013) · Biology · doi:10.3390/biology · Cited by 44
Exosomes: Insights and therapeutic applications in cancer
Panigrahi, A. R., Lankalapalli, S., & Panda, J. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101439 · Cited by 46
Bheri, S., Brown, M. E., Park, H.-J., Brazhkina, O., Takaesu, F., & Davis, M. E. (2023) · ACS Nano · doi:10.1021/acsnano.3c01534 · Cited by 43
Engineered mRNA Delivery Systems for Biomedical Applications
Wang, J., Zhu, H., Gan, J., Liang, G., Li, L., & Zhao, Y. (2023) · Advanced Materials · doi:10.1002/adma.202308029 · Cited by 46
Emerging roles of extracellular vesicles in COVID‐19, a double‐edged sword?
Xia, X., Yuan, P., Liu, Y., Wang, Y., Cao, W., & Zheng, J. (2021) · Immunology · doi:10.1111/imm.13329 · Cited by 44
Self-citation
Metadata
- Authors
- Fu, S., Wang, Y., Xia, X., & Zheng, J. C.
- Affiliations
- Tongji University (CN)
- Corresponding author
- Xia, Xiaohuan
- Zheng, Jialin C.
- Venue
- NanoImpact
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 20
- Pages
- 100261
- ISSN
- 2452-0748 (ISSN-L)
- OpenAlex
- W3092146157
- Cited by
- 444
- References
- 204
- Citations by year
- 2026: 47 · 2025: 94 · 2024: 93 · 2023: 91 · 2022: 68 · 2021: 46 · 2020: 3
- FWCI
- 16.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- NanoImpact (publishedVersion, cc-by-nc-nd)
- Funders
- Foundation for the National Institutes of Health
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- exosomes, exosome engineering, cargo loading, targeted delivery, exosome biogenesis, membrane modification, nucleic acid delivery, drug delivery, in situ synthesis, electroporation, sonication, freeze-thaw
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
