Exosome engineering: Current progress in cargo loading and targeted delivery

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

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Liposomal drug delivery systems: From concept to clinical applications

Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.037 · Cited by 4,839

Diffusion of univalent ions across the lamellae of swollen phospholipids

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Metal-organic frameworks

James, S. L. (2003) · Chemical Society Reviews · doi:10.1039/b200393g · Cited by 3,616

Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery

Tang, F., Li, L., & Chen, D. (2012) · Advanced Materials · doi:10.1002/adma.201104763 · Cited by 2,898

Exosomes

Pegtel, D. M., & Gould, S. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111902 · Cited by 2,682

Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.

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Exosomes as drug delivery vehicles for Parkinson’s disease therapy

Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009

Withdrawn: Plant-Derived Exosomes: Nano-Inducers of Cross Kingdom RegulationsPreprint

Rehman, T. U., Li, H., Martuscelli, M., Aiello, F., Esposito, L., Ashraf, K., Mastrocola, D., Guo, M., & Mohsin, A. (2024) · Preprints.org · doi:10.20944/preprints202407.2048.v1

Theranostics exosomes mediated drug delivery

Gebologlu, I. K., & Öncel, S. Ş. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22044-9.00026-7

Exosomes in cancer therapeutic delivery

Karmakar, A., Khairnar, Y. N., & Kumar, L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29052-7.00015-5

Current applications of new generations of exosomes nanovesicles

Sharma, D., Mudgal, R., Arora, S., & Gugulothu, D. B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29052-7.00017-9

Exploring extracellular vesicles: Understanding exosomes and beyond

Laxmi, L., Golmei, P., Gugulothu, D. B., Sharma, A., & Kumar, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29052-7.00002-7

Improving cargo loading and release strategies for exosomes nanovesicles

Gupta, S., Singla, K., Garima, G., Kaur, G., Gugulothu, D. B., & Mittal, N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29052-7.00004-0

Production of exosomal nanoparticles containing antigenic peptides LACK, KMP11, TSA and LmSTI1 of L. major and evaluation of their immunoprophylactic effect against L. major infection in a murine infection model

Sangani, G. S., Farash, B. R. H., Khamesipour, A., Bandehpour, M., Sangani, P. S., Jajarmi, V., & Mohebali, M. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107316

Preparation and Evaluation of Exosomes Loaded with Combined Drugs against Colon Cancer

Panigrahi, A. R., Samal, S. S., & Lankalapalli, S. (2025) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.20250014

Extracellular Vesicles as Therapeutic Tools against Infectious Diseases

Ezeuko, C. C., Wijerathne, S. V. T., & Matthews, Q. L. (2025) · Biocell · doi:10.32604/biocell.2025.065474

Engineering Cell Membrane-Derived Nanovesicles for Advanced Biomedical Applications

Hussain, Z., Ahmed, W., Gao, T., Zhang, Y., & Pei, R. (2025) · Springer eBooks · doi:10.1007/978-3-031-93425-4_2

Extracellular Vesicle–Liposome Hybrid Nanoparticles Delivery of CRISPR/Cas9 Induces a Unique DNA Repair Pattern in the HGF Gene of Stem Cells from Apical Papilla

Yazdani, R., Nasr‐Esfahani, M. H., Eghbalsaied, S., & Karamali, F. (2025) · DNA and Cell Biology · doi:10.1177/10445498251370554

The effect of exosomes on oocyte maturation

Barut, T., Darıcı, H., & Akpolat, M. (2025) · Ege Tıp Dergisi · doi:10.19161/etd.1653074

Probing hydrogel microstructure and porosity with fluorinated liquid NMR nanocapsules

Bochert, I., Betancourt, C. M. V., Missirlis, D., Moreno-Gómez, N., & Fischer, P. (2025) · Soft Matter · doi:10.1039/d5sm00756a

Ovarian oncosomes

Parmar, N. B., Desai, M. K., Parekh, P. S., Patel, R. B., Shah, D. D., Chorawala, M. R., Shah, P. A., & Bhupendra, G. P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33536-5.00012-2

Cytostatic Drugs Delivery to MCF-7 Cells Using Horse Milk Exosomes

Timofeeva, A. M., Cherenko, V., Sedykh, S. E., & Nevinsky, G. A. (2025) · Physiology · doi:10.5772/intechopen.1013407

The role of exosomal long non-coding RNAs in head, neck and thyroid cancers

Güzel, E., Kilinc, Z., Adiguzel, S., Uzun, F. R., & Ayla, I. N. (2025) · Medical Oncology · doi:10.1007/s12032-025-03203-4

Coconut milk exosomal formulation of curcumin analog targets head and neck cancer progression through alterations in the HABP1 signaling mechanism

Pande, K., K, B. B., & Kannan, A. (2026) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2026.101102

Modified tumor uptake and biodistribution of nanoparticles coated with small extracellular vesicle membranes derived from distinct tumor cell lines

Jenkins, S. V., Carlton, H., Scott, B., Stahr, S., Vinson, W., Fletcher, G., Jamshidi-Parsian, A., Hsu, P.-C., Dings, R. P. M., Huitink, D., et al. (2026) · International Journal of Hyperthermia · doi:10.1080/02656736.2026.2624448

Vesicular Systems for Anticancer Drug Delivery

Garanin, A., Плевако, Д. С., Васильева, О. А., & Malek, A. V. (2025) · Nanobiotechnology Reports · doi:10.1134/s2635167625600506

Extracellular Vesicles in Neurodegenerative Diseases: Tools for Therapy and Regeneration

Bakr, M., Gobba, F., Sabry, M., & Salama, M. (2026) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-032-12705-1_3

Glutathione-responsive milk-derived exosomes for safe and efficient sonodynamic cancer therapy

Lee, D. G., Choi, J. H., Gwak, S., Cao, T. G. N., Tram, L. T. H., Rhee, W. J., Kim, B. C., & Shim, M. S. (2026) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-026-00275-5

Extracellular vesicle delivery of Myricetin suppresses ovarian cancer through mitochondrial dynamics by downregulating the ECM1/NF-κB/TGFβ signaling pathway

Pande, K., Singh, S. A., & Kannan, A. (2026) · Scientific Reports · doi:10.1038/s41598-026-46901-3 · Cited by 1

Drug loading techniques for extracellular vesicles for biomedical applications

Chaudhary, U., Rana, D., Benival, D. M., & Garkhal, K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36641-3.00003-6

Engineered iNK cell-derived exosomes with sequential chitosan-galactose coating for ASGR1-targeted therapy of nonalcoholic steatohepatitis

Oh, H., Hong, S., Kwon, J.-H., Lee, Y., Son, P., Kim, H., Lee, E. J., Ki, Y. W., Hwang, D. W., Jung, K. O., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.177060

Exploring electroporation for miRNA mimic delivery into cells with milk-derived extracellular vesicles

Ou, H., Csuth, T. I., Molnár, A., Czömpöly, T., & Kvell, K. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.126968

Exosome engineering: The promise and peril of targeted delivery for treating ocular diseases

Sharif, E., Hashemi, N., Eskandari, F., Shams, F., & Rekabgardan, M. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103664

Engineered exosomes and hybrid nanosystems for cancer theranostics: mechanisms, strategies, and translational hurdles

Iqbal, A., Ali, S., Summer, M., Riaz, S., Ashraf, R., & Bibi, R. (2026) · Emergent Materials · doi:10.1007/s42247-026-01438-z · Cited by 1

Targeted Stimulation of Dendritic Cells via MDK-ALK -STAT3 Inhibition by Dendritic Cell-derived Exosomes

Ren, G., Zheng, X., Zou, X., & Zuo, H. (2026) · BIO Web of Conferences · doi:10.1051/bioconf/202623701013

Metal Nanoparticle-Loaded Exosomes for Cancer Theranostics

Abdulrehman, T., Al-Haik, M. Y., & Haik, Y. (2026) · BioNanoScience · doi:10.1007/s12668-026-02643-0

Engineered small extracellular vesicles in hematologic malignancies: mechanisms, therapeutic strategies, and translational challenges

Hsu, C., Saidaloevich, M. S., Zubair, S. M., Abohassan, M., Patel, P. N., Singh, G., Arora, V., Nayak, P. P., Iqbal, M. S., & Abbas, Z. K. (2026) · Clinical and Experimental Medicine · doi:10.1007/s10238-026-02216-1

Engineered extracellular vesicles and their mimics for chronic wounds: strategies and delivery systems

Yang, W., Tang, Z., Hou, K., Zou, X., Zhao, C., Xing, Z., & Wang, J. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.178679

Extracellular vesicles (EVs) in neurodevelopment: The emerging role of lipids

Germelli, L., Daniele, S., Martini, C., & Pozzo, E. D. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118175

Current perspectives of next-generation nanomedicine deploying green-based nanoparticles and nanorobots for precise cancer therapies

Leong, K. Y., Pong, L. Y., Tham, S. K., & Poh, C. L. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108637

Microfluidic nanochips for rapid exosome isolation and multiplex biomarker profiling from a single blood drop: Toward sample‐to‐answer liquid biopsy

Uti, D. E., Alum, E. U., Egbung, J. E., Aggad, W. S., Almohaimeed, H. M., Mohammedsaleh, Z. M., Kaur, M., & Ealla, K. K. R. (2026) · Clinical and Translational Discovery · doi:10.1002/ctd2.70170

Therapeutic strategies for downregulating isocitrate dehydrogenase in the treatment of glioblastoma multiforme

Ifham, A. (2026) · Biomedical Letters · doi:10.47262/bl/12.1.20260304

Exosome-mediated precision immunotherapy in lung cancer: Harnessing smart drug delivery vehicles

Quadri, S. N., Malik, S. S., & Abdin, M. Z. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44585-9.00003-2

Extracellular Vesicles Meet Inorganic Nanoparticles: Production, Characterization, and Evaluation

Lin, X., Cao, Y., Ngo, C. H. L., Wang, Y., & Lu, Y. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6c07602

Exosome-mimetic nanoparticles versus natural exosomes as drug delivery vehicles: The identity crisis of biomimetic therapeutics - addressing the scientific gaps in production, cargo fidelity, and clinical translation

Prajapati, A., & Pimple, P. M. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108949

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Singh, R. D., Calvoli, M., & Kim, K. K. (2026) · Advanced Science · doi:10.1002/advs.77370

Exosomes: The Elixir or the Trojan Horse

Khosravipour, A., Mansoori, M., Aboutalebi, H., Hashemi, F., & Vafaei, S. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119957

Biomimetic and Natural Exosomes in Drug Delivery: A Critical Review

Robles-Anda, N., Jabardo, R. G., Ladero, M., & Gallardo, M. E. (2026) · Biomimetics · doi:10.3390/biomimetics11100747

Engineering exosome-based delivery of IL-37 to enhance cytokine stability and antitumor activity in vitro and in vivo

Abbas, Z., Fujimura, N., Afzal, S., Akram, M., Tahir, S., & Ahmed, N. (2026) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2026.103041

Genetically reprogrammed exosomes for targeted prostate cancer immunotherapy

Kao, G., Zhang, L., Kim, S. H., He, Q., Zhang, Z., Shen, K., Shi, J., Dai, Z., Albanese, A., Seidler, P. M., et al. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.10.042

Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives

Ahmed, W., Mushtaq, A., Ali, S., Khan, N., Liang, Y., & Duan, L. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00856 · Cited by 56

Exosomes as Advanced Nanocarriers for Targeted Drug Delivery: Recent Progress, Engineering Strategies and Translational Challenges

Tanuja Jadhav*, K. K. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.23019162

Nanoengineering of Exosomal Surfaces for Precision Targeting and Payload Delivery at the Molecular Level

Singh, D., Singh, S., & Tandon, N. (2025) · Assay and Drug Development Technologies · doi:10.1177/1540658x251369691 · Cited by 5

Exosomes as Targeted Delivery Drug System: Advances in Exosome Loading, Surface Functionalization and Potential for Clinical Application

Guo, Z. Y., Tang, Y., & Cheng, Y. C. (2022) · Current Drug Delivery · doi:10.2174/1567201819666220613150814 · Cited by 47

Exosomal targeting and its potential clinical application

He, J., Ren, W., Wang, W., Han, W., Jiang, L., Zhang, D., & Guo, M. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01087-1 · Cited by 210