Improvements in whole muscle and myocellular function are limited with high-intensity resistance training in octogenarian women
Open accessAbstract
Advanced sarcopenia is prevalent among octogenarian women; yet little is known about myocellular quality and plasticity in this cohort. The aim of this investigation was to examine single muscle fiber contractile function and whole muscle characteristics before and after 12 wk of high-intensity progressive resistance training (PRT) in very old (85 ± 1 yr) women (OW, n = 6). Young women [YW (21 ± 2 yr old), n = 9] were included as a control group. Whole muscle strength [1 repetition maximum (RM)] and size (CT scans) were assessed before and after PRT. Functional experiments (size, peak force, velocity, and power) were performed on vastus lateralis myosin heavy chain (MHC) I and IIa muscle fibers before and after PRT. With PRT, 1-RM strength increased ( P < 0.05) in YW (36%) and OW (26%). Thigh muscle cross-sectional area increased (5%) in YW ( P < 0.05), but thigh muscle did not hypertrophy in OW. Before PRT, there were no differences in single-fiber parameters between YW and OW. With PRT, MHC IIa fiber size (28%), peak force (31%), and power (28%) improved, but no changes were observed in MHC I fibers, in YW ( P < 0.05). There were no improvements in MHC I or IIa single-fiber function in OW. These data show that the myocellular functional profile in OW is similar to that in YW but that OW have a blunted hypertrophic response to PRT at the whole muscle and myocellular level. The limited myocellular plasticity in OW with PRT contrasts with that in YW and previous PRT studies in elderly women only a decade younger. These data suggest that attempts to greatly enhance skeletal muscle mass and function should begin before 80 yr of age.
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The hypertrophic response of aging skeletal muscle may be blunted.
“observations that the hypertrophic response of aging skeletal muscle may be blunted [40–43]”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [41]
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BackgroundHuman skeletal muscle-specific atrophy with aging: a comprehensive review
Naruse, M., Trappe, S. W., & Trappe, T. A. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00768.2022 · Cited by 132 · see citing works
Self-citationNoone, J., Mucinski, J. M., DeLany, J. P., Sparks, L. M., & Goodpaster, B. H. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.025 · Cited by 128 · see citing works
Aging impairs the recovery in mechanical muscle function following 4days of disuse
Hvid, L. G., Suetta, C., Nielsen, J., Jensen, M. M., Frandsen, U., Ørtenblad, N., Kjær, M., & Aagaard, P. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.012 · Cited by 122 · see citing works
“2008), accompanied by an even slower rate of training-induced recovery as observed in human training studies comprising very old individuals (Laroche et al., 2008; Raue et al., 2009).”
Arthur, S. T., & Cooley, I. D. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4262 · Cited by 119 · see citing works
“It should be noted that some investigators report that training has deleterious effects on aged muscle function (228, 241, 242).”
BackgroundCharacterization and Regulation of Mechanical Loading‐Induced Compensatory Muscle Hypertrophy
Adams, G. R., & Bamman, M. M. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110066 · Cited by 114 · see citing works
Blunting of adaptive responses to resistance exercise training in women over 75y
Greig, C. A., Gray, C. D., Rankin, D., Young, A., Mann, V., Noble, B., & Atherton, P. J. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.07.010 · Cited by 104 · see citing works
“In contrast, our findings are much more striking in terms of muscle loss in older women than the 23% previously reported (Raue et al. 2009).”
Reid, K. F., Doros, G., Clark, D. J., Patten, C., Carabello, R. J., Cloutier, G. J., Phillips, E. M., Krivickas, L. S., Frontera, W. R., & Fielding, R. A. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2200-0 · Cited by 100 · see citing works
“This observation is consistent with previous studies reporting the elimination of age-related diVerences in single Wber contractile performance after adjustment for Wber or cell size (Frontera et al. 2000b, 2008; Raue et al. 2009; Slivka et al. 2008; Trappe et al. 2003).”
Skeletal muscle signature of a champion sprint runner
Trappe, S. W., Luden, N. D., Minchev, K., Raue, U., Jemioło, B., & Trappe, T. A. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00037.2015 · Cited by 100 · see citing works
Self-citationKirby, T. J., Lee, J. D., England, J. H., Chaillou, T., Esser, K. A., & McCarthy, J. J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00296.2015 · Cited by 89 · see citing works
“HUMAN AND RODENT STUDIES HAVE reported that skeletal muscle hypertrophy is significantly diminished with old age (8, 14, 16, 26, 28, 30, 33).”
BackgroundEffects of ageing on single muscle fibre contractile function following short‐term immobilisation
Hvid, L. G., Ørtenblad, N., Aagaard, P., Kjaer, M., & Suetta, C. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.215434 · Cited by 88 · see citing works
“Journal compilation C© 2011 The Physiological Society quadriceps muscle CSA (Trappe et al. 2003; Frontera et al. 2008; Raue et al. 2009).”
BackgroundThe effect of vitamin D on sarcopenia depends on the level of physical activity in older adults
Yang, A., Lv, Q., Chen, F., Wang, Y., Liu, Y., Shi, W., Liu, Y., & Wang, D. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12545 · Cited by 88 · see citing works
Skeletal muscle size, function, and adiposity with lifelong aerobic exercise
Chambers, T. L., Burnett, T. R., Raue, U., Lee, G. A., Finch, W. H., Graham, B. M., Trappe, T. A., & Trappe, S. W. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00426.2019 · Cited by 76 · see citing works
Self-citationVenturelli, M., Saggin, P., Muti, E., Naro, F., Cancellara, L., Toniolo, L., Tarperi, C., Calabria, E., Richardson, R. S., Reggiani, C., et al. (2015) · Acta Physiologica · doi:10.1111/apha.12524 · Cited by 75 · see citing works
“85 years) (Trappe et al. 2003, Raue et al. 2009).”
BackgroundResultDietary Protein, Muscle and Physical Function in the Very Old
Franzke, B., Neubauer, O., Cameron‐Smith, D., & Wagner, K. (2018) · Nutrients · doi:10.3390/nu10070935 · Cited by 74 · see citing works
“Available data in octogenarians suggest that muscular adaptations to resistance training might be limited at a very old age [59,60].”
BackgroundSkeletal muscle fibre diversity and the underlying mechanisms
Canepari, M., Pellegrino, M. A., D’Antona, G., & Bottinelli, R. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02118.x · Cited by 71 · see citing works
“Although it is generally believed that ageing impairs both P0/CSA and V0 of muscle fibres, contradictory results suggesting no change in such parameters have been reported (Frontera et al. 2000a, Trappe et al. 2003, Raue et al. 2009).”
BackgroundMethodKarlsen, A., Bechshøft, R. L., Malmgaard‐Clausen, N. M., Andersen, J. L., Schjerling, P., Kjær, M., & Mackey, A. L. (2019) · Acta Physiologica · doi:10.1111/apha.13271 · Cited by 70 · see citing works
Zullo, A., Fleckenstein, J., Schleip, R., Hoppe, K., Wearing, S. C., & Klingler, W. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00592 · Cited by 70 · see citing works
Murias, J. M., Kowalchuk, J. M., Ritchie, D., Hepple, R. T., Doherty, T. J., & Paterson, D. H. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr096 · Cited by 64 · see citing works
Single muscle fibre contractile function with ageing
Grosicki, G. J., Zepeda, C. S., & Sundberg, C. W. (2022) · The Journal of Physiology · doi:10.1113/jp282298 · Cited by 65 · see citing works
“However, it is worth noting that even in circumstances where no age-related differences inMHC II fibre size were observed, a limited capacity for growth in the MHC II fibres fromolder comparedwith youngermuscle fibres has been documented (Raue et al., 2009).”
BackgroundStrasser, B., Keinrad, M., Haber, P., & Schobersberger, W. (2009) · Wiener klinische Wochenschrift · doi:10.1007/s00508-009-1273-9 · Cited by 65 · see citing works
“763 wkw 23–24/2009 Springer-Verlag Efficacy of systemic endurance and resistance training on muscle strength RT at the whole muscle and myocellular level [37].”
BackgroundSingle Muscle Fiber Gene Expression with Run Taper
Murach, K. A., Raue, U., Wilkerson, B. S., Minchev, K., Jemioło, B., Bagley, J. R., Luden, N. D., & Trappe, S. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108547 · Cited by 61 · see citing works
“Acute resistance exercise elicits differential MHC I and IIa proteolytic mRNA responses [11] and activates a distinct MHC IIa transcriptome that precedes resistance training-induced increases in MHC IIa single fiber cross sectional area [6,9].”
BackgroundInfluentialSelf-citationLavin, K. M., Coen, P. M., Baptista, L. C. P., Bell, M. B., Drummer, D. J., Harper, S. A., Lixandrão, M. E., McAdam, J. S., O’Bryan, S. M., Ramos, S. V., et al. (2022) · Comprehensive physiology · doi:10.1002/cphy.c200033 · Cited by 74 · see citing works
Human skeletal muscle size with ultrasound imaging: a comprehensive review
Naruse, M., Trappe, S. W., & Trappe, T. A. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00041.2022 · Cited by 58 · see citing works
Self-citationMyocellular basis for tapering in competitive distance runners
Luden, N. D., Hayes, E., Galpin, A. J., Minchev, K., Jemioło, B., Raue, U., Trappe, T. A., Harber, M. P., Bowers, T., & Trappe, S. W. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00045.2010 · Cited by 58 · see citing works
Self-citationTrappe, T. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-041 · Cited by 56 · see citing works
“Surprisingly, studies show the intrinsic power producing ability of muscle does not change with aging (Raue et al. 2009; Trappe et al. 2003) (Fig.”
BackgroundDNA methylation assessment from human slow- and fast-twitch skeletal muscle fibers.
Begue, G., Raue, U., Jemioło, B., & Trappe, S. (2017) · Journal of applied physiology · doi:10.1152/japplphysiol.00867.2016 · Cited by 47 · see citing works
“Studies have also reported fiber type-specific changes in fiber size, force, power, and metabolic properties after prolonged spaceflight (18, 76) or with aging (10, 34, 47, 60, 61, 77).”
BackgroundInfluentialSelf-citationResistance Exercise, Skeletal Muscle FOXO3A, and 85-Year-Old Women
Williamson, D. L., Raue, U., Slivka, D. R., & Trappe, S. W. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq005 · Cited by 54 · see citing works
Self-citationAging and the Skeletal Muscle Angiogenic Response to Exercise in Women
Gavin, T. P., Kraus, R. M., Carrithers, J. A., Garry, J. P., & Hickner, R. C. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu138 · Cited by 53 · see citing works
“In skeletal muscle, resistance exerciseinduced hypertrophy is maintained in septuagenarian (47), but not octogenarian women (48).”
BackgroundJones, R. G., Dimet‐Wiley, A., Haghani, A., da Silva, F. M., Brightwell, C. R., Lim, S., Khadgi, S., Wen, Y., Dungan, C. M., Brooke, R. T., et al. (2022) · The Journal of Physiology · doi:10.1113/jp283836 · Cited by 47 · see citing works
“Perhaps an attenuated MYC response in muscle fibres of very old humans and animals (Alway, 1997) explains diminished adaptability to exercise, specifically in glycolytic type 2 muscle fibres (Grosicki et al., 2022; Raue et al., 2009; Slivka et al., 2008).”
BackgroundTrappe, T. A., Ratchford, S. M., Brower, B. E., Liu, S. Z., Lavin, K. M., Carroll, C. C., Jemioło, B., & Trappe, S. W. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv231 · Cited by 50 · see citing works
Self-citationHicks, G. E., Sions, J. M., Velasco, T. O., & Manal, T. J. (2016) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000348 · Cited by 49 · see citing works
“(11.1) Numeric pain rating (0-10) 3.9 (2.6) 3.7 (2.1) Tampa Scale of Kinesiophobia (17-68) 23.0 (7.5) 23.8 (4.8) Outcomes at 6mo Timed Up and Go (s) 7.8 (2.4) 7.5 (3.9) Gait speed (m/s) 1.09 (0.26) 1.14 (0.24) Oswestry LBP Questionnaire (0-100) 27.8 (10.1) 23.1 (14.4) Numeric pain rating (0-10) 3.5 (1.9) 3.2 (2.3) Tam…”
InfluentialSingle and combined influence of ACE and ACTN3 genotypes on muscle phenotypes in octogenarians
Garatachea, N., Fiuza‐Luces, C., Torres‐Luque, G., Yvert, T. P., Santiago, C., Gómez‐Gallego, F., Ruiz, J. R., & Lucía, A. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2217-4 · Cited by 47 · see citing works
Marzuca-Nassr, G. N., Alegría-Molina, A., SanMartín-Calísto, Y., Artigas-Arias, M., Huard, N., SAPUNAR, J., Salazar, L. A., Verdijk, L. B., & van Loon, L. J. C. (2023) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2023-0087 · Cited by 47 · see citing works
Skeletal Muscle Function in the Oldest-Old: The Role of Intrinsic and Extrinsic Factors
Venturelli, M., Reggiani, C., Richardson, R. S., & Schena, F. F. (2018) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000155 · Cited by 45 · see citing works
Straight, C. R., Fedewa, M. V., Toth, M. J., & Miller, M. S. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00170.2020 · Cited by 46 · see citing works
“Whereas skeletal muscle hypertrophy is often purported as a chronic adaptation to RT, studies investigating its effects on single fiber size in older adults have yielded inconsistent results, ranging from hypertrophy in one fiber type (12, 26, 47, 54, 60, 93, 95, 97, 98), both (5, 33, 39, 42, 52, 96), neither (15, 32,…”
BackgroundRaue, U., Jemioło, B., Yang, Y., & Trappe, S. W. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00759.2014 · Cited by 44 · see citing works
Self-citationLiu, S. Z., Jemioło, B., Lavin, K. M., Lester, B. E., Trappe, S. W., & Trappe, T. A. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00396.2015 · Cited by 43 · see citing works
“types are fundamentally different (7, 35, 44) and respond differently to aging and 256 exercise training (11, 32, 35, 45).”
Self-citationNeuroprotective effects of exercise on the aging human neuromuscular system
Allen, M. D., Dalton, B. H., Gilmore, K. J., McNeil, C. J., Doherty, T. J., Rice, C. L., & Power, G. A. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111465 · Cited by 45 · see citing works
Dankel, S. J., Kang, M., Abe, T., & Loenneke, J. P. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-4022-9 · Cited by 41 · see citing works
Rubenstein, A. B., Hinkley, J. M., Nair, V. D., Nudelman, G., Standley, R. A., Yi, F., Yu, G., Trappe, T. A., Bamman, M. M., Trappe, S. W., et al. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00378.2021 · Cited by 40 · see citing works
Self-citationBallak, S. B., Jaspers, R. T., Deldicque, L., Chalil, S., Peters, E. L., HAAN, A. D., & Degens, H. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.12.020 · Cited by 39 · see citing works
“, 2013), the hypertrophic response to resistance training or overload may be blunted in old humans (Grimby et al., 1992; Kosek et al., 2006; Martel et al., 2006; Raue et al., 2009; Slivka et al., 2008) and rodents (Alway et al.”
Effects of Age and Rest Interval on Strength Recovery
Bottaro, M., Ernesto, C., Celes, R. S., Farinatti, P., Brown, L. E., & Oliveira, R. J. (2009) · International Journal of Sports Medicine · doi:10.1055/s-0029-1239497 · Cited by 39 · see citing works
Physical exercise: An inducer of positive oxidative stress in skeletal muscle aging
Thirupathi, A., Pinho, R. A., & Chang, Y. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117630 · Cited by 39 · see citing works
Improved single muscle fiber quality in the oldest-old
Grosicki, G. J., Standley, R. A., Murach, K. A., Raue, U., Minchev, K., Coen, P. M., Newman, A. B., Cummings, S. R., Harris, T. B., Kritchevsky, S. B., et al. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00479.2016 · Cited by 38 · see citing works
“Our laboratory previously reported comparable MHC IIa quality in a cohort of octogenarian and younger sedentary women (53).”
BackgroundResultInfluentialSelf-citationAas, S. N., Seynnes, O., Benestad, H. B., & Raastad, T. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01234-2 · Cited by 38 · see citing works
Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation in women
Lavin, K. M., Perkins, R. K., Jemioło, B., Raue, U., Trappe, S. W., & Trappe, T. A. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00655.2020 · Cited by 36 · see citing works
“Older women may demonstrate blunted hypertrophy in response to a resistance exercise regimen, especially with advancing age (18, 60).”
BackgroundSelf-citationSingle-muscle fiber contractile properties in lifelong aerobic exercising women
Gries, K. J., Minchev, K., Raue, U., Grosicki, G. J., Begue, G., Finch, W. H., Graham, B., Trappe, T. A., & Trappe, S. W. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00459.2019 · Cited by 35 · see citing works
“To date, the effects of various short-term exercise paradigms to improve the function and health profile of the fast-twitch muscle fibers in older individuals ( 70 yr) have been mixed (24, 25, 43, 45, 46, 56, 60).”
BackgroundMethodInfluentialSelf-citationMusculoskeletal adaptations to strength training in frail elderly: a matter of quantity or quality?
Aas, S. N., Breit, M., Karsrud, S., Aase, O. J., Rognlien, S. H., Cumming, K. T., Reggiani, C., Seynnes, O., Rossi, A. P., Toniolo, L., et al. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12543 · Cited by 37 · see citing works
Simon, C. B., & Hicks, G. E. (2018) · Physical Therapy · doi:10.1093/ptj/pzy028 · Cited by 34 · see citing works
Determinants of Skeletal Muscle Hypertrophy and the Attenuated Hypertrophic Response at Old Age
Degens, H. (2012) · Journal of Sports Medicine & Doping Studies · doi:10.4172/2161-0673.s1-003 · Cited by 33 · see citing works
“It has been shown in both human [68-70] and animal muscles [66,71-75] that the hypertrophic response is attenuated at old age.”
Kwon, I., Kim, J., Shin, C., Park, Y., & Kim, J.-H. (2019) · Physical Activity and Nutrition · doi:10.20463/jenb.2019.0023 · Cited by 29 · see citing works
Tavoian, D., Russ, D. W., Consitt, L. A., & Clark, B. C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00799 · Cited by 26 · see citing works
Thomas, M. M., Vigna, C., Betik, A. C., Tupling, A. R., & Hepple, R. T. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00663.2009 · Cited by 28 · see citing works
“In general, our results are consistent with a growing body of evidence showing that skeletal muscle plasticity becomes severely compromised in senescence (3, 36, 44), suggesting that additional adjuncts may be necessary to restore the adaptive muscle response to contractile activity at very advanced age.”
ResultDrummond, M. J., Marcus, R. L., & LaStayo, P. C. (2012) · Journal of Aging Research · doi:10.1155/2012/486930 · Cited by 28 · see citing works
“For example, work from the Trappe Laboratory [21, 22] reported, in older men and women > 80 years old, an impaired ability to stimulate muscle fiber hypertrophy compared to younger adults following a resistance exercise training program.”
BackgroundChoi, S.-J., Shively, C. A., Register, T. C., Feng, X., Stehle, J., High, K. P., Ip, E. H., Kritchevsky, S. B., Nicklas, B. J., & Delbono, O. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls143 · Cited by 27 · see citing works
“The specific force recorded in this study ranged from 67 to 138 kN/m(2), in good agreement with previous studies conducted under similar experimental conditions in humans (21,22,49,50).”
BackgroundResultSingle muscle fibre contractile characteristics with lifelong endurance exercise
Grosicki, G. J., Gries, K. J., Minchev, K., Raue, U., Chambers, T. L., Begue, G., Finch, H., Graham, B., Trappe, T. A., & Trappe, S. W. (2021) · The Journal of Physiology · doi:10.1113/jp281666 · Cited by 27 · see citing works
Self-citationClark, L. A., Russ, D. W., Tavoian, D., Arnold, W. D., Law, T., France, C. R., & Clark, B. C. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111437 · Cited by 26 · see citing works
The Aging Athlete: Paradigm of Healthy Aging
Gries, K. J., & Trappe, S. W. (2022) · International Journal of Sports Medicine · doi:10.1055/a-1761-8481 · Cited by 32 · see citing works
“Normalized power of fast muscle fibers is maintained or improved with advanced age [108, 138].”
BackgroundSelf-citationThomas, M. M., Khan, W., Betik, A. C., Wright, K. J., & Hepple, R. T. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.07.003 · Cited by 26 · see citing works
Age-dependent Muscle Adaptation after Chronic Stretch-shortening Contractions in Rats
Rader, E. P., Layner, K. N., Triscuit, A. M., Chetlin, R. D., Ensey, J. S., & Baker, B. A. (2016) · Aging and Disease · doi:10.14336/ad.2015.0920 · Cited by 26 · see citing works
“A substantial amount of research has been focused on comparing two age groups, typically an old age group vs a much younger age group, in regards to age-related deficiencies in performance [4, 5, 8, 10, 16, 17].”
BackgroundResultInfluentialMethodological considerations in measuring specific force in human single skinned muscle fibres
Kalakoutis, M., Giulio, I. D., Douiri, A., Ochala, J., Harridge, S. D. R., & WOLEDGE, R. C. (2021) · Acta Physiologica · doi:10.1111/apha.13719 · Cited by 24 · see citing works
Skeletal Muscle Fiber Size and Gene Expression in the Oldest-Old With Differing Degrees of Mobility
Naro, F., Venturelli, M., Monaco, L., Toniolo, L., Muti, E., Milanese, C., Zhao, J., Richardson, R. S., Schena, F. F., & Reggiani, C. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00313 · Cited by 22 · see citing works
Choi, S.-J. (2016) · Integrative Medicine Research · doi:10.1016/j.imr.2016.05.004 · Cited by 21 · see citing works
Lavin, K. M., Coen, P. M., Baptista, L. C. P., Bell, M. B., Drummer, D. J., Harper, S. A., Lixandrão, M. E., McAdam, J. S., O’Bryan, S. M., Ramos, S. V., et al. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00211.x · Cited by 20 · see citing works
Xia, Z., Cholewa, J. M., Zhao, Y., Yang, Y., Shang, H., Jiang, H., Su, Q., & Zanchi, N. E. (2017) · Food & Function · doi:10.1039/c7fo01181d · Cited by 19 · see citing works
Rader, E. P., Naimo, M. A., Layner, K. N., Triscuit, A. M., Chetlin, R. D., Ensey, J. S., & Baker, B. A. (2016) · Rejuvenation Research · doi:10.1089/rej.2016.1816 · Cited by 17 · see citing works
Exercise-Induced MYC as an Epigenetic Reprogramming Factor That Combats Skeletal Muscle Aging
Jones, R. G., von Walden, F., & Murach, K. A. (2024) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000333 · Cited by 15 · see citing works
“A dysregulated molecular response to resistance exercise characterizes aging (3), and the anabolic effects of resistance training may be attenuated or delayed beyond age 80 in both men and women (4,5).”
BackgroundRubenstein, A. B., Smith, G. R., Zhang, Z., Chen, X., Chambers, T. L., Ruf-Zamojski, F. M., Mendelev, N., Cheng, W. S., Zamojski, M., Amper, M. A. S., et al. (2025) · Genome Research · doi:10.1101/gr.280051.124 · Cited by 14 · see citing works
“…lip-idmetabolism,andlactateproduction(Hultmanetal.1991;Romijn etal.1993,2000;Greenhaffet al.1994;Bottinelli et al.1999;Trappe et al. 2003, 2006; Kosek et al. 2006; Luden et al. 2008; Raue et al. 2009; Dickinson et al. 2010; Jensen et al. 2020; Hokken et al. 2021; Egan and Sharples 2023).”
Self-citationTargeting Intramyocellular Lipids to Improve Aging Muscle Function
Russ, D. W., Manickam, R., & Tipparaju, S. M. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02622-6 · Cited by 15 · see citing works
Inactivity, age, and exercise: single-muscle fiber power generation
Kim, J., & Thompson, L. V. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00525.2012 · Cited by 13 · see citing works
Kurosawa, T., Minato, K., Ikemoto‐Uezumi, M., Hino, J., Tsuchida, K., & Uezumi, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910246 · Cited by 12 · see citing works
“Studies measuring both in vivo muscle strength and in vitro myofiber contractile properties demonstrated that, although the in vivo muscle strength is compromised by aging and further exacerbated by disuse, the contractile force generated by single myofibers in vitro is unaffected even in the non-ambulatory oldest old…”
BackgroundFast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise
Raue, U., Begue, G., Minchev, K., Jemioło, B., Gries, K. J., Chambers, T. L., Rubenstein, A. B., Zaslavsky, E., Sealfon, S. C., Trappe, T. A., et al. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00442.2023 · Cited by 12 · see citing works
Self-citationCharacterization and Regulation of Mechanical Loading‐Induced Compensatory Muscle Hypertrophy
Adams, G. R., & Bamman, M. M. (2012) · Comprehensive physiology · doi:10.1002/j.2040-4603.2012.tb00474.x · Cited by 12 · see citing works
“For example, Gundersen et al. (189) have expressed technical concerns with the majority of the literature with regard to assessing myonuclear domain size.”
Delaire, L., Courtay, A., Humblot, J., Vidal, H., Bonnefoy, M., & Meugnier, E. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70162 · Cited by 11 · see citing works
- Authors
- Raue, U., Slivka, D., Minchev, K., & Trappe, S.
- Affiliations
- Ball State University (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2009-05
- Volume
- 106
- Issue
- 5
- Pages
- 1611-1617
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- PMC
- PMC2681332
- OpenAlex
- W2090562582
- Cited by
- 166
- References
- 60
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 8 · 2020: 8 · 2019: 15 · 2018: 9 · 2017: 9 · 2016: 11 · 2015: 11 · 2014: 8 · 2013: 6 · 2012: 15
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Applied Physiology (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 18409, R01AG018409)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- high-intensity resistance training, progressive resistance training, sarcopenia, muscle hypertrophy, myosin heavy chain, vastus lateralis, muscle strength, muscle cross-sectional area, muscle power
- MeSH terms
- Adaptation, Physiological, Aged, 80 and over, Aging, Female, Humans, Isometric Contraction, Male, Sex Factors, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal, Myosin Light Chains, Myosin Heavy Chains, Lower Extremity, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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