Cited by 614Immune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative MechanismsAdvanced Glycation End Products research

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Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox

Rubartelli, Anna, Lotze, Michael T.·2007·Trends in Immunology

DOI 10.1016/j.it.2007.08.004

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Abstract

Immune responses are initiated and perpetuated by molecules derived from microorganisms pathogen-associated molecular-pattern molecules or from the damage or death of host cells [damage-associated molecular-pattern (DAMP) molecules]. Many DAMPs are nuclear or cytosolic proteins with defined intracellular function that, when released outside the cell following tissue injury, move from a reducing to an oxidizing milieu resulting in their functional denaturation. Here, we discuss the consequences of DAMP oxidation on the outcome of acute inflammation. We also suggest that, outside the cell, DAMPs might adopt novel conformations or alter the redox of the extracellular environment to more closely mimic the internal one, thereby avoiding oxidation-mediated inactivation and promoting pathology. We propose that chronic inflammation associated with autoimmunity, chronic viral infection and cancer is probably mediated by persistent release and function of DAMPs, promoting and promoted by a disordered redox environment.

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Authors: Rubartelli, A., & Lotze, M. T.
Affiliations: UPMC Hillman Cancer Center (US)
Corresponding author: Rubartelli, Anna
ORCID: Rubartelli, Anna
Lotze, Michael T.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2007-10
Volume: 28
Issue: 10
Pages: 429-436
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2007.08.004
OpenAlex: W2104414795
Cited by: 614
References: 67
Citations by year: 2026: 8 · 2025: 18 · 2024: 26 · 2023: 25 · 2022: 28 · 2021: 32 · 2020: 35 · 2019: 38 · 2018: 33 · 2017: 43 · 2016: 19 · 2015: 54 · 2014: 42 · 2013: 50 · 2012: 39
FWCI: 2.19
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Pennsylvania Department of Health
National Cancer Institute (P01CA101944)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Keywords: damage-associated molecular patterns, redox conditions, acute inflammation, chronic inflammation, autoimmunity, chronic viral infection, cancer, protein denaturation, tissue damage, innate immunity
MeSH terms: Humans, Immunity, Innate, Inflammation, Neoplasms, Oxidation-Reduction, Proteins, Cytokines, Inflammation Mediators

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Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox

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