Cited by 315Genetics, Aging, and Longevity in Model OrganismsT-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

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An evolutionary perspective on the mechanisms of immunosenescence

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Shanley, Daryl P., Aw, Danielle, Manley, Nancy R., Palmer, Donald B.·2009·Trends in Immunology

DOI 10.1016/j.it.2009.05.001

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Abstract

There is an accumulating body of evidence that a decline in immune function with age is common to most if not all vertebrates. For instance, age-associated thymic involution seems to occur in all species that possess a thymus, indicating that this process is evolutionary ancient and conserved. The precise mechanisms regulating immunosenescence remain to be resolved, but much of what we do know is consistent with modern evolutionary theory. In this review, we assess our current knowledge from an evolutionary perspective on the occurrence of immunosenescence, we show that life history trade-offs play a key role and we highlight the possible advantages of the age-related decline in thymic function.

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Authors: Shanley, D. P., Aw, D., Manley, N. R., & Palmer, D. B.
Affiliations: Newcastle University (GB)
Royal Veterinary College (GB)
University of Georgia (US)
Corresponding author: Shanley, Daryl P.
Palmer, Donald B.
ORCID: Shanley, Daryl P.
Manley, Nancy R.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2009-07
Volume: 30
Issue: 7
Pages: 374-381
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2009.05.001
OpenAlex: W2045107302
Cited by: 315
References: 119
Citations by year: 2026: 13 · 2025: 23 · 2024: 28 · 2023: 13 · 2022: 17 · 2021: 26 · 2020: 24 · 2019: 16 · 2018: 16 · 2017: 23 · 2016: 18 · 2015: 19 · 2014: 11 · 2013: 22 · 2012: 20
FWCI: 1.43
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion, cc-by)
PubMed (publishedVersion)
RVC Research Online (Royal Veterinary College) (submittedVersion, cc-by)
Newcastle University ePrints (Newcastle Univesity)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: immunosenescence, thymic involution, aging, immune function decline, life-history trade-offs, evolutionary immunology, thymus, vertebrates
MeSH terms: Aging, Animals, Biological Evolution, Humans, Immunity, Innate, Reproduction, Thymus Gland, T-Lymphocyte Subsets

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An evolutionary perspective on the mechanisms of immunosenescence

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