The DOI matches its Crossref record; 78 of the 80 references it cites were found in a registry or an index.
SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
Open accessPublished version of a preprint
Abstract
Epidemiological studies of the COVID-19 pandemic have revealed evidence of cardiac involvement and documented that myocardial injury and myocarditis are predictors of poor outcomes. Nonetheless, little is understood regarding SARS-CoV-2 tropism within the heart and whether cardiac complications result directly from myocardial infection. Here, we develop a human engineered heart tissue model and demonstrate that SARS-CoV-2 selectively infects cardiomyocytes. Viral infection is dependent on expression of angiotensin-I converting enzyme 2 (ACE2) and endosomal cysteine proteases, suggesting an endosomal mechanism of cell entry. After infection with SARS-CoV-2, engineered tissues display typical features of myocarditis, including cardiomyocyte cell death, impaired cardiac contractility, and innate immune cell activation. Consistent with these findings, autopsy tissue obtained from individuals with COVID-19 myocarditis demonstrated cardiomyocyte infection, cell death, and macrophage-predominate immune cell infiltrate. These findings establish human cardiomyocyte tropism for SARS-CoV-2 and provide an experimental platform for interrogating and mitigating cardiac complications of COVID-19.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263
WGCNA: an R package for weighted correlation network analysis
Langfelder, P., & Horvath, S. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-559 · Cited by 27,252
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286
Salmon provides fast and bias-aware quantification of transcript expression
Patro, R., Duggal, G., Love, M. I., Irizarry, R. A., & Kingsford, C. (2017) · Nature Methods · doi:10.1038/nmeth.4197 · Cited by 12,700
Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China
Shi, S., Qin, M., Shen, B., Cai, Y., Liu, T., Yang, F., Gong, W., Liu, X., Liang, J., Zhao, Q., et al. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.0950 · Cited by 4,349
Wan, Y., Shang, J., Graham, R., Baric, R. S., & Li, F. (2020) · Journal of Virology · doi:10.1128/jvi.00127-20 · Cited by 4,341
Letko, M., Marzi, A., & Munster, V. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0688-y · Cited by 3,109
RSeQC: quality control of RNA-seq experiments
Wang, L., Wang, S., & Li, W. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts356 · Cited by 2,753
Pathview: an R/Bioconductor package for pathway-based data integration and visualization
Luo, W., & Brouwer, C. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt285 · Cited by 2,297
Püntmann, V. O., Carerj, M. L., Wieters, I., Fahim, M., Arendt, C. T., Hoffmann, J., Shchendrygina, A., Escher, F., Vasa‐Nicotera, M., Zeiher, A. M., et al. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.3557 · Cited by 2,228
The Architecture of SARS-CoV-2 Transcriptome
Kim, D., Lee, J.-Y., Yang, J.-S., Kim, J. W., Kim, V. N., & Chang, H. (2020) · Cell · doi:10.1016/j.cell.2020.04.011 · Cited by 2,123
Monteil, V., Kwon, H., Prado, P., Hagelkrüys, A., Wimmer, R. A., Stahl, M., Leopoldi, A., Garreta, E., Hurtado del Pozo, C., Prosper, F., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.004 · Cited by 2,122
Hoffmann, M., Kleine-Weber, H., & Pöhlmann, S. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.04.022 · Cited by 1,852
Potential Effects of Coronaviruses on the Cardiovascular System
Madjid, M., Safavi‐Naeini, P., Solomon, S. D., & Vardeny, O. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.1286 · Cited by 1,850
Multiorgan and Renal Tropism of SARS-CoV-2
Puelles, V. G., Lütgehetmann, M., Lindenmeyer, M. T., Sperhake, J. P., Wong, M. N., Allweiss, L., Chilla, S., Heinemann, A., Wanner, N., Liu, S., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2011400 · Cited by 1,775 · cited 1×
“These findings are consistent with prior reports highlighting infiltration of monocytes, lymphocytes, and plasma cells in an endomyocardial biopsy specimen from a patient with suspected COVID-19 myocarditis and viral RNA within the myocardium of COVID-19 autopsy specimens (33,34).”
ResultAngiotensin-converting enzyme 2 is an essential regulator of heart function
Crackower, M. A., Sarao, R., Oudit, G. Y., Yagil, C., Kozieradzki, I., Scanga, S. E., Oliveira-dos-Santos, A. J., da Costa, J., Zhang, L., Pei, Y., et al. (2002) · Nature · doi:10.1038/nature00786 · Cited by 1,733
Lian, X., Hsiao, C., Wilson, G., Zhu, K., Hazeltine, L. B., Azarin, S. M., Raval, K. K., Zhang, J., Kamp, T. J., & Palecek, S. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200250109 · Cited by 1,717
SARS-CoV-2 productively infects human gut enterocytes
Lamers, M. M., Beumer, J., van der Vaart, J., Knoops, K., Puschhof, J., Breugem, T. I., Ravelli, R. B. G., Paul van Schayck, J., Mykytyn, A. Z., Duimel, H. Q., et al. (2020) · Science · doi:10.1126/science.abc1669 · Cited by 1,573
Agostini, M. L., Andres, E. L., Sims, A. M., Graham, R. L., Sheahan, T. P., Lu, X., Smith, E. C., Case, J. B., Feng, J. Y., Jordan, R., et al. (2018) · mBio · doi:10.1128/mbio.00221-18 · Cited by 1,418
GAGE: generally applicable gene set enrichment for pathway analysis
Luo, W., Friedman, M. S., Shedden, K., Hankenson, K. D., & Woolf, P. J. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-161 · Cited by 1,333
Cooper, L. T. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0800028 · Cited by 1,325
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Yin, W., Mao, C., Luan, X., Shen, D.-D., Shen, Q., Su, H., Wang, X., Zhou, F., Zhao, W., Gao, M., et al. (2020) · Science · doi:10.1126/science.abc1560 · Cited by 1,219
Chen, L., Li, X., Chen, M., Feng, Y., & Xiong, C. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa078 · Cited by 1,163 · cited 2×
“Among myocardial cell types, cardiomyocytes and pericytes express ACE2 mRNA (19).”
BackgroundResultThe pathogenicity of SARS-CoV-2 in hACE2 transgenic mice
Bao, L., Deng, W., Huang, B., Gao, H., Liu, J., Ren, L., Wei, Q., Yu, P., Xu, Y., Qi, F., et al. (2020) · Nature · doi:10.1038/s41586-020-2312-y · Cited by 1,126
Self-citationGordon, C. J., Tchesnokov, E. P., Woolner, E., Perry, J. K., Feng, J. Y., Porter, D., & Götte, M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013679 · Cited by 995
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
Zang, R., Castro, M. F. G., McCune, B. T., Zeng, Q., Rothlauf, P. W., Sonnek, N. M., Liu, Z., Brulois, K. F., Wang, X., Greenberg, H. B., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abc3582 · Cited by 982
Self-citationMyocardial Localization of Coronavirus in COVID-19 Cardiogenic Shock
Tavazzi, G., Pellegrini, C., Maurelli, M., Belliato, M., Sciutti, F., Bottazzi, A., Sepe, P. A., Resasco, T., Camporotondo, R., Bruno, R., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1828 · Cited by 932
Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases
Lindner, D., Fitzek, A., Bräuninger, H., Aleshcheva, G., Edler, C., Meissner, K., Scherschel, K., Kirchhof, P., Escher, F., Schultheiss, H.-P., et al. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.3551 · Cited by 827
Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Karbassi, E., Fenix, A. M., Marchianò, S., Muraoka, N., Nakamura, K., Yang, X., & Murry, C. E. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0331-x · Cited by 796
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
Johnson, B. A., Xie, X., Bailey, A. L., Kalveram, B., Lokugamage, K. G., Muruato, A., Zou, J., Zhang, X., Juelich, T., Smith, J. K., et al. (2021) · Nature · doi:10.1038/s41586-021-03237-4 · Cited by 694
Self-citationCoronavirus fulminant myocarditis treated with glucocorticoid and human immunoglobulin
Hu, H., Ma, F., Wei, X. C., & Fang, Y. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa190 · Cited by 687
An Infectious cDNA Clone of SARS-CoV-2
Xie, X., Muruato, A., Lokugamage, K. G., Narayanan, K., Zhang, X., Zou, J., Liu, J., Schindewolf, C., Bopp, N. E., Aguilar, P. V., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.04.004 · Cited by 647
Self-citationYang, L., Han, Y., Nilsson-Payant, B. E., Gupta, V., Wang, P., Duan, X., Tang, X., Zhu, J., Zhao, Z., Jaffré, F., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.06.015 · Cited by 645
Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
Hinson, J. T., Chopra, A., Nafissi, N., Polacheck, W. J., Benson, C. C., Swist, S., Gorham, J., Yang, L., Schafer, S., Sheng, C. C., et al. (2015) · Science · doi:10.1126/science.aaa5458 · Cited by 638
Self-citationter Meulen, J., van den Brink, E. N., Poon, L. L. M., Marissen, W. E., Leung, C. S.-W., Cox, F., Cheung, C. Y., Bakker, A. Q., Bogaards, J. A., van Deventer, E., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030237 · Cited by 599
Huang, L., Zhao, P., Tang, D., Zhu, T., Han, R., Zhan, C., Liu, W., Zeng, H., Tao, Q., & Xia, L. (2020) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2020.05.004 · Cited by 592
Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses
Liu, R., Holik, A. Z., Su, S., Jansz, N., Chen, K., Leong, H. S., Blewitt, M. E., Asselin-Labat, M.-L., Smyth, G. K., & Ritchie, M. E. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv412 · Cited by 583
Infection of bat and human intestinal organoids by SARS-CoV-2
Zhou, J., Li, C., Liu, X., Chiu, M. C., Zhao, X., Wang, D., Wei, Y., Lee, A. C.-Y., Zhang, J., Chu, H., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0912-6 · Cited by 545
Rajpal, S., Tong, M., Borchers, J. R., Zaręba, K. M., Obarski, T. P., Simonetti, O. P., & Daniels, C. J. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.4916 · Cited by 530
Simmons, G., Zmora, P., Gierer, S., Heurich, A., & Pöhlmann, S. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2013.09.028 · Cited by 429
COVID-19 and cardiac arrhythmias
Bhatla, A., Mayer, M. M., Adusumalli, S., Hyman, M. C., Oh, E. J., Tierney, A. M., Moss, J., Chahal, C. A. A., Anesi, G. L., Denduluri, S., et al. (2020) · Heart Rhythm · doi:10.1016/j.hrthm.2020.06.016 · Cited by 407
Ultrastructural Characterization of SARS Coronavirus
Goldsmith, C. S., Tatti, K. M., Ksiazek, T. G., Rollin, P. E., Comer, J. A., Lee, W. W., Rota, P. A., Bankamp, B., Bellini, W. J., & Zaki, S. R. (2004) · Emerging infectious diseases · doi:10.3201/eid1002.030913 · Cited by 400
Advanced Heat Map and Clustering Analysis Using Heatmap3
Zhao, S., Guo, Y. P., Sheng, Q., & Shyr, Y. (2014) · BioMed Research International · doi:10.1155/2014/986048 · Cited by 333
Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms
Tersalvi, G., Vicenzi, M., Calabretta, D., Biasco, L., Pedrazzini, G. B., & Winterton, D. (2020) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2020.04.009 · Cited by 331
Lian, X. L., Bao, X., Al-Ahmad, A. J., Liu, J., Wu, Y., Dong, W., Dunn, K. K., Shusta, E. V., & Palecek, S. P. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.09.005 · Cited by 321
Self-citationDifferentiation of cardiomyocytes and generation of human engineered heart tissue
Breckwoldt, K., Letuffe-Brenière, D., Mannhardt, I., Schulze, T., Ulmer, B., Werner, T., Benzin, A., Klampe, B., Reinsch, M. C., Laufer, S., et al. (2017) · Nature Protocols · doi:10.1038/nprot.2017.033 · Cited by 272
SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes
Bojkova, D., Wagner, J. U. G., Shumliakivska, M., Aslan, G. S., Saleem, U., Hansen, A., Luxán, G., Günther, S., Pham, M. D., Krishnan, J., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa267 · Cited by 257
Engineering Cardiac Muscle Tissue
Weinberger, F., Mannhardt, I., & Eschenhagen, T. (2017) · Circulation Research · doi:10.1161/circresaha.117.310738 · Cited by 234
Growth, detection, quantification, and inactivation of SARS-CoV-2
Case, J. B., Bailey, A. L., Kim, A. S., Chen, R. E., & Diamond, M. (2020) · Virology · doi:10.1016/j.virol.2020.05.015 · Cited by 234
Self-citationElectron microscopy of SARS-CoV-2: a challenging task
Goldsmith, C. S., Miller, S., Martines, R. B., Bullock, H. A., & Zaki, S. R. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31188-0 · Cited by 217
Meder, B., Haas, J., Sedaghat‐Hamedani, F., Kayvanpour, E., Frese, K., Lai, A., Nietsch, R., Scheiner, C., Mester, S., Bordalo, D. M., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.027355 · Cited by 192
Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids
Bartok, E., & Hartmann, G. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.014 · Cited by 190
Zhang, H., Tian, L., Shen, M., Tu, C., Wu, H., Gu, M., Paik, D. T., & Wu, J. C. (2019) · Circulation Research · doi:10.1161/circresaha.119.315491 · Cited by 187
Furin Cleavage Site Is Key to SARS-CoV-2 PathogenesisPreprint
Johnson, B. A., Xie, X., Kalveram, B., Lokugamage, K. G., Muruato, A. E., Zou, J., Zhang, X., Juelich, T. L., Smith, J. K., Zhang, L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.26.268854 · Cited by 186
Self-citationAnimal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathology
Cleary, S. J., Pitchford, S. C., Amison, R. T., Carrington, R., Cabrera, C. L. R., Magnen, M., Looney, M. R., Gray, E., & Page, C. P. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15143 · Cited by 169
Kumar, S. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.34 · Cited by 146
Michaud, K., Basso, C., d’Amati, G., Giordano, C., Kholová, I., Preston, S., Rizzo, S., Sabatasso, S., Sheppard, M. N., Vink, A., et al. (2019) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-019-02662-1 · Cited by 143
Tucker, N. R., Chaffin, M. D., Bedi, K. C., Papangeli, I., Akkad, A.-D., Arduini, A., Hayat, S., Eraslan, G., Muus, C., Bhattacharyya, R. P., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.047911 · Cited by 119
The spectrum of myocarditis: from pathology to the clinics
Leone, O., Pieroni, M., Rapezzi, C., & Olivotto, I. (2019) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-019-02615-8 · Cited by 116
Sharma, A., Li, G., Rajarajan, K., Hamaguchi, R., Burridge, P. W., & Wu, S. M. (2015) · Journal of Visualized Experiments · doi:10.3791/52628 · Cited by 110
TBK1, a central kinase in innate immune sensing of nucleic acids and beyond
Zhou, R., Zhang, Q., & Xu, P. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa051 · Cited by 104
A single human keratin 18 gene is expressed in diverse epithelial cells of transgenic mice.
Abe, M., & Oshima, R. G. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.3.1197 · Cited by 100
Early markers for myocardial ischemia and sudden cardiac death
Sabatasso, S., Mangin, P. J., Fracasso, T., Moretti, M., Docquier, M., & Djonov, V. (2016) · International Journal of Legal Medicine · doi:10.1007/s00414-016-1401-9 · Cited by 72
Bos, J. M., Hebl, V. B., Oberg, A. L., Sun, Z., Herman, D. S., Teekakirikul, P., Seidman, J. G., Seidman, C. E., dos Remedios, C. G., Maleszewski, J. J., et al. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.04.028 · Cited by 64
Clippinger, S. R., Cloonan, P. E., Greenberg, L., Ernst, M., Stump, W. T., & Greenberg, M. J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910962116 · Cited by 62
Self-citationWijnker, P. J. M., Friedrich, F. W., Dutsch, A., Reischmann, S., Eder, A., Mannhardt, I., Mearini, G., Thomas Eschenhagen, A., van der Velden, J., & Carrier, L. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.03.003 · Cited by 58
Truitt, R., Mu, A., Corbin, E. A., Vite, A., Brandimarto, J., Ky, B., & Margulies, K. B. (2018) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2017.12.007 · Cited by 56
Greenberg, M. J., Daily, N., Wang, A., Conway, M. K., & Wakatsuki, T. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00120 · Cited by 22
Self-citationDutsch, A., Wijnker, P. J. M., Schlossarek, S., Friedrich, F. W., Krämer, E., Braren, I., Hirt, M. N., Brenière‐Letuffe, D., Rhoden, A., Mannhardt, I., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-54665-2 · Cited by 20
Dege, C., & Sturgeon, C. M. (2017) · Journal of Visualized Experiments · doi:10.3791/55196 · Cited by 19
Khan, A. A., Lauer, E., Lenglet, S., Grabherr, S., Fracasso, T., Augsburger, M. P., Sabatasso, S., & Thomas, A. (2018) · International Journal of Legal Medicine · doi:10.1007/s00414-018-1813-9 · Cited by 13
COVID-19 ARTIC v3 Illumina library construction and sequencing protocol v4Preprint
D, D. P. R., Farr, B., Rajan, D., Dawson, E., Shirley, L., Quail, M., Park, N., Redshaw, N., Bronner, I. F., Aigrain, L., et al. (2020) · doi:10.17504/protocols.io.bgxjjxkn · Cited by 9
Flagged first, then by citations
2 of the 80 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Proal, A. D., & VanElzakker, M. B. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.698169 · Cited by 921
COVID-19 and Cardiovascular Disease
Chung, M. K., Zidar, D. A., Bristow, M. R., Cameron, S. J., Chan, T. A.-T., Harding, C. V., Kwon, D. H., Singh, T. K., Tilton, J. C., Tsai, E. J., et al. (2021) · Circulation Research · doi:10.1161/circresaha.121.317997 · Cited by 377
Pérez-Bermejo, J. A., Kang, S., Rockwood, S. J., Simoneau, C. R., Joy, D. A., Silva, A. C., Ramadoss, G. N., Flanigan, W., Fozouni, P., Li, H., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abf7872 · Cited by 256
Three-Dimensional Cell Cultures: The Bridge between In Vitro and In Vivo Models
Urzì, O., Gasparro, R., Costanzo, E., Luca, A. D., Giavaresi, G., Fontana, S., & Alessandro, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512046 · Cited by 258
COVID-19, Myocarditis and Pericarditis
Fairweather, D., Beetler, D. J., Di Florio, D. N., Musigk, N., Heidecker, B., & Cooper, L. T. (2023) · Circulation Research · doi:10.1161/circresaha.123.321878 · Cited by 194
Metadata
- Authors
- Bailey, A. L., Dmytrenko, O., Greenberg, L., Bredemeyer, A. L., Ma, P., Liu, J., Penna, V., Winkler, E. S., Sviben, S., Brooks, E., Nair, A. P., Heck, K. A., Rali, A. S., Simpson, L., Saririan, M., Hobohm, D., Stump, W. T., Fitzpatrick, J. A., Xie, X., Zhang, X., Shi, P.-Y., Hinson, J. T., Gi, W.-T., Schmidt, C., Leuschner, F., Lin, C.-Y., Diamond, M. S., Greenberg, M. J., & Lavine, K. J.
- Affiliations
- Washington University in St. Louis (US)
- University of Wisconsin–Madison (US)
- Baylor College of Medicine (US)
- Vanderbilt University (US)
- Creighton University (US)
- The University of Texas Medical Branch at Galveston (US)
- The Jackson Laboratory for Genomic Medicine (US)
- Heidelberg University (DE)
- Corresponding author
- Lavine, Kory J.
- ORCID
- Bailey, Adam L.
- Dmytrenko, Oleksandr
- Greenberg, Lina
- Bredemeyer, Andrea L.
- Ma, Pan
- Liu, Jing
- Penna, Vinay
- Winkler, Emma S.
- Sviben, Sanja
- Brooks, Erin
- Nair, Ajith P.
- Rali, Aniket S.
- Simpson, Leo
- Saririan, Mehrdad
- Fitzpatrick, James A.
- Xie, Xuping
- Zhang, Xianwen
- Shi, Pei-Yong
- Hinson, J. Travis
- Gi, Weng-Tein
- Schmidt, Constanze
- Leuschner, Florian
- Lin, Chieh-Yu
- Diamond, Michael S.
- Greenberg, Michael J.
- Lavine, Kory J.
- Venue
- JACC: Basic to Translational Science
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 6
- Issue
- 4
- Pages
- 331-345
- ISSN
- 2452-302X (ISSN-L)
- PMC
- PMC7909907
- OpenAlex
- W3134776434
- Cited by
- 193
- References
- 80
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 37 · 2023: 50 · 2022: 42 · 2021: 43
- FWCI
- 29.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- JACC Basic to Translational Science (publishedVersion, cc-by-nc-nd)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by-nc-nd)
- PubMed Central (submittedVersion)
- Digital Commons-TMC (Texas Medical Center) (submittedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- Foundation for Barnes-Jewish Hospital
- Center for Cellular Imaging, Washington University
- National Institutes of Health (75N93019C00062, R01 AI127828, R01 HL138466, R01 HL139714, R01 HL141086)
- St. Louis Children's Hospital (CDI-CORE-2015-505, CDI-CORE-2019-813)
- Defense Advanced Research Projects Agency (HR001117S0019)
- Burroughs Wellcome Fund (1014782)
- March of Dimes Foundation (FY18-BOC-430198)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- SARS-CoV-2, COVID-19 myocarditis, engineered heart tissue, cardiac complications of COVID-19, sarcomere disassembly, cytokine production, cardiomyocyte contractile dysfunction, cell death, viral pathogenesis, myocardial pathology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
