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Cited by 84Adipokines, Inflammation, and Metabolic DiseasesPhysical Activity and HealthCardiovascular and exercise physiology

The association between cardiorespiratory fitness and C-reactive protein in subjects with the metabolic syndrome

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Aronson, Doron, Sella, Ron, Sheikh-Ahmad, Muhammad, Kerner, Arthur, Avizohar, Ophir, Rispler, Shmuel, Bartha, Peter, Markiewicz, Walter +2 more·2004·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2004.08.030
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Abstract

Objectives We sought to study relationship between cardiorespiratory fitness and C-reactive protein (CRP) in subjects with the metabolic syndrome.Background Recent studies have shown an association between the metabolic syndrome and chronic subclinical inflammation, as determined by elevated CRP. Cardiorespiratory fitness is associated with a lower risk of diabetes and improved insulin resistance.Methods Physical fitness was assessed in 1,640 subjects using the Bruce treadmill protocol and expressed as maximal metabolic equivalents. The level of CRP was measured using a high-sensitivity assay.Results Geometric mean CRP was calculated across quartiles of fitness after adjustment for age, gender, smoking, use of medications, and coronary disease. A strong inverse trend toward decreasing CRP levels with increasing fitness quartiles was present in subjects without metabolic abnormalities, subjects with one or two metabolic abnormalities, and subjects with the metabolic syndrome (all p <or= 0.001). The effect of fitness was particularly robust among subjects with the metabolic syndrome. The adjusted mean CRP in subjects in the upper and lower fitness quartiles was 1.48 versus 0.93 mg/dl in subjects without metabolic abnormalities, 2.40 versus 1.66 mg/dl in subjects with one or two metabolic abnormalities, and 4.62 versus 2.20 mg/l in subjects with the metabolic syndrome (p = 0.049 for the interaction between fitness and number of metabolic abnormalities).Conclusions Subjects with the metabolic syndrome who maintain a high fitness level have markedly lower CRP concentrations, as compared with those with a low fitness level.

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  • Several training interventions did not change basal IL-6 or CRP concentrations.

    “Several training interventions have not produced changes in basal IL-6 or CRP concentrations (213 -218) , while significant reductions in inflammatory markers have been observed following training without changes in BMI or body fat in elderly participants (219,220) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [218]

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Authors
Aronson, D., Sella, R., Sheikh-Ahmad, M., Kerner, A., Avizohar, O., Rispler, S., Bartha, P., Markiewicz, W., Levy, Y., & Brook, G. J.
Affiliations
Rambam Health Care Campus (IL)
Corresponding author
Aronson, Doron
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2004-11
Volume
44
Issue
10
Pages
2003-2007
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2004.08.030
OpenAlex
W2124035752
Cited by
84
References
14
Citations by year
2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 6 · 2012: 5
FWCI
7.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
cardiorespiratory fitness, C-reactive protein, metabolic syndrome, subclinical inflammation, Bruce protocol, insulin resistance, diabetes risk, physical fitness
MeSH terms
C-Reactive Protein, Cardiovascular System, Exercise Test, Female, Humans, Male, Middle Aged, Physical Fitness, Respiratory System, Metabolic Syndrome

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