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Baroreflex Activation Therapy Lowers Blood Pressure in Patients With Resistant Hypertension
Open accessAbstract
Objectives We sought to determine the effect of baroreflex activation therapy (BAT) on systolic blood pressure (SBP) in patients with resistant hypertension.Background The Rheos Pivotal Trial evaluated BAT for resistant hypertension in a double-blind, randomized, prospective, multicenter, placebo-controlled Phase III clinical trial.Methods This was a double-blind randomized trial of 265 subjects with resistant hypertension implanted and subsequently randomized (2:1) 1 month after implantation. Subjects received either BAT (Group A) for the first 6 months or delayed BAT initiation following the 6-month visit (Group B). The 5 coprimary endpoints were: 1) acute SBP responder rate at 6 months; 2) sustained responder rate at 12 months; 3) procedure safety; 4) BAT safety; and 5) device safety.Results The trial showed significant benefit for the endpoints of sustained efficacy, BAT safety, and device safety. However, it did not meet the endpoints for acute responders or procedural safety. A protocol-specified ancillary analysis showed 42% (Group A) versus 24% (Group B) achieving SBP ≤140 mm Hg at 6 months (p = 0.005), with both groups achieving over 50% at 12 months, at which point Group B had received 6 months of BAT.Conclusions A clinically meaningful measure, those achieving a SBP of ≤140 mm Hg, yielded a significant difference between the groups. The weight of the overall evidence suggests that over the long-term, BAT can safely reduce SBP in patients with resistant hypertension. Future clinical trials will address the limitations of this study and further define the therapeutic benefit of BAT.
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“This was the development of two device-based therapies targeting the sympathetic nervous system, the surgically implanted barostimulator device117 and catheter-based renal denervation20,118.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [117]
In the citing paper
“Despite the widespread availability and prescribing of angiotensin converting enzyme-inhibitors, angiotensin receptor blockers, diuretics and calcium channel blockers, in a substantial minority of patients with essential hypertension, perhaps 10%116, goal blood pressure were not achieved.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [116]
In the citing paper
“In a large-scale, double-blind study, the Rheos device was implanted in 265 patients who were subsequently randomised (2:1) to immediate baroreceptor stimulation for the first 6 months (n=181), or deferred stimulation after 6 months (n=84)117.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [117]
In the citing paper
“At 6 months, blood pressure fell in the group receiving immediate treatment, but the primary efficacy endpoint was not reached, partly because blood pressure likewise decreased in many control subjects117.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [117]
In the citing paper
“The first results from a large randomized trial in 322 participants with RH410 failed to meet the primary end point of the trial, a composite of 5 individual efficacy and safety end points.”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [410]
Citations
Cites
Law, M. R., Morris, J. K., & Wald, N. J. (2009) · BMJ · doi:10.1136/bmj.b1665 · Cited by 2,775
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.189141 · Cited by 2,240
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Ferguson, G. G., Eliasziw, M., Barr, H. W. K., Clagett, G. P., Barnes, R. W., Wallace, M. C., Taylor, D. W., Haynes, R. B., Finan, J. W., Hachinski, V., et al. (1999) · Stroke · doi:10.1161/01.str.30.9.1751 · Cited by 1,498
Heusser, K., Tank, J., Engeli, S., Diedrich, A., Menne, J., Eckert, S., Peters, T., Sweep, F. C. G. J., Haller, H., Pichlmaier, A. M., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.140665 · Cited by 433
Novel Baroreflex Activation Therapy in Resistant Hypertension
Scheffers, I. J. M., Kroon, A. A., Schmidli, J., Jordan, J., Tordoir, J. H. M., Mohaupt, M. G., Luft, F. C., Haller, H. G., Menne, J., Engeli, S., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.089 · Cited by 356
Self-citationSarafidis, P. A., & Bakris, G. L. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.08.036 · Cited by 336
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Grassi, G. M. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.154 · Cited by 225
Divergent Results Using Clinic and Ambulatory Blood Pressures
Bakris, G. L., Lindholm, L. H., Black, H. R., Krum, H., Linas, S. L., Linseman, J. V., Arterburn, S., Sager, P. T., & Weber, M. A. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.156976 · Cited by 197
Self-citationBeckett, L., & Godwin, M. S. (2005) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-5-18 · Cited by 175
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2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,739
2018 ESC/ESH Guidelines for the management of arterial hypertension
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy339 · Cited by 10,286
Self-citationWhelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000065 · Cited by 7,391
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.006 · Cited by 6,616
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., et al. (2013) · Journal of Hypertension · doi:10.1097/01.hjh.0000431740.32696.cc · Cited by 5,655
Mancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003480 · Cited by 3,473
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001940 · Cited by 2,885
Oparil, S., Acelajado, M. C., Bakris, G. L., Berlowitz, D. R., Cífková, R., Dominiczak, A. F., Grassi, G., Jordan, J., Poulter, N. R., Rodgers, A., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.14 · Cited by 1,167
Self-citationDiabetic kidney disease: a report from an ADA Consensus Conference
Tuttle, K. R., Bakris, G. L., Bilous, R. W., Chiang, J. L., de Boer, I. H., Goldstein-Fuchs, J., Hirsch, I. B., Kalantar-Zadeh, K., Narva, A. S., Navaneethan, S. D., et al. (2014) · Diabetes Care · doi:10.2337/dc14-1296 · Cited by 1,153
Self-citationCarey, R. M., Calhoun, D. A., Bakris, G. L., Brook, R. D., Daugherty, S. L., Dennison-Himmelfarb, C. R., Egan, B. M., Flack, J. M., Gidding, S. S., Judd, E., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000084 · Cited by 1,153
Self-citationWhelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000596 · Cited by 1,127
Diabetic Kidney Disease: A Report From an ADA Consensus Conference
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Self-citationDaskalopoulou, S. S., Rabi, D. M., Zarnke, K. B., Dasgupta, K., Nerenberg, K. A., Cloutier, L., Gelfer, M., Lamarre-Cliché, M., Milot, A., Bolli, P., et al. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.02.016 · Cited by 690
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Grassi, G., Mark, A., & Esler, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303604 · Cited by 616
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Brook, R. D., Appel, L. J., Rubenfire, M., Ogedegbe, G. G., Bisognano, J. D., Elliott, W. J., Fuchs, F. D., Hughes, J. W., Lackland, D. T., Staffileno, B. A., et al. (2013) · Hypertension · doi:10.1161/hyp.0b013e318293645f · Cited by 604
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Mancia, G., Fagard, R. H., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T. C., Cífková, R., Backer, G. D., Dominiczak, A. F., et al. (2013) · Blood Pressure · doi:10.3109/08037051.2013.812549 · Cited by 430
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Paton, J. F. R., Sobotka, P. A., Fudim, M., Engelman, Z. J., Hart, E. C., McBryde, F. D., Abdala, A. P., Marina, N., Gourine, A. V., Mel, L. O. B. O., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.00064 · Cited by 305
Hoppe, U. C., Brandt, M. C., Wachter, R., Beige, J., Rump, L. C., Kroon, A. A., Cates, A. W., Lovett, E. G., & Haller, H. G. (2012) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2012.04.004 · Cited by 292
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Oparil, S., & Schmieder, R. E. (2015) · Circulation Research · doi:10.1161/circresaha.116.303603 · Cited by 276
Jonas, D. E., Amick, H. R., Feltner, C., Weber, R. P., Arvanitis, M., Stine, A., Lux, L., & Harris, R. P. (2017) · JAMA · doi:10.1001/jama.2016.19635 · Cited by 267
Bakris, G. L., Nadim, M. K., Haller, H. G., Lovett, E. G., Schafer, J. E., & Bisognano, J. D. (2012) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2012.01.003 · Cited by 246
Self-citationNocturnal blood pressure and cardiovascular disease: a review of recent advances
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Chiang, C., Wang, T., Ueng, K.-C., Lin, T., Yeh, H., Chen, C.-Y., Wu, Y.-J., Tsai, W., Chao, T., Chen, C.-H., et al. (2014) · Journal of the Chinese Medical Association · doi:10.1016/j.jcma.2014.11.005 · Cited by 203
The crosstalk between autonomic nervous system and blood vessels.
Sheng, Y., & Zhu, L. (2018) · PubMed Central · Cited by 196
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Rossignol, P., Massy, Z. A., Azizi, M., Bakris, G., Ritz, E., Covic, A., Goldsmith, D., Heine, G. H., Jager, K. J., Kanbay, M., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00418-3 · Cited by 194
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Plachta, D. T. T., Gierthmuehlen, M., Cota, O. F., Espinosa, N., Boeser, F., Herrera, T. C., Stieglitz, T., & Zentner, J. (2014) · Journal of Neural Engineering · doi:10.1088/1741-2560/11/3/036011 · Cited by 187
Evidence for a critical role of the sympathetic nervous system in hypertension
Grassi, G. M., & Ram, V. S. (2016) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2016.02.015 · Cited by 193
Kumbhani, D. J., Steg, P. G., Cannon, C. P., Eagle, K. A., Smith, S. C., Crowley, K., Goto, S., Ohman, E. M., Bakris, G. L., Perlstein, T. S., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs368 · Cited by 186
Self-citationLobo, M. D., Sobotka, P. A., Stanton, A. V., Cockcroft, J., Sulke, N., Dolan, E., van der Giet, M., Hoyer, J. D., FURNISS, S. S., Foran, J. P., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)62053-5 · Cited by 177
Grassi, G. M., Seravalle, G., & Mancia, G. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12553 · Cited by 177
Translational neurocardiology: preclinical models and cardioneural integrative aspects
Ardell, J. L., Andresen, M. C., Armour, J. A., Billman, G. E., Chen, P., Foreman, R. D., Herring, N., O’Leary, D. S., Sabbah, H. N., Schultz, H. D., et al. (2016) · The Journal of Physiology · doi:10.1113/jp271869 · Cited by 176
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Kaur, J., Young, B., & Fadel, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081682 · Cited by 168
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Lansdown, A., & Rees, A. (2012) · Clinical Endocrinology · doi:10.1111/cen.12003 · Cited by 167
Kandzari, D. E., Kario, K., Mahfoud, F., Cohen, S. A., Pilcher, G., Pocock, S., Townsend, R. R., Weber, M. A., & Böhm, M. (2015) · American Heart Journal · doi:10.1016/j.ahj.2015.08.021 · Cited by 153
Jordan, J., Yumuk, V., Schlaich, M. P., Nilsson, P. M., Zahorska‐Markiewicz, B., Grassi, G. M., Schmieder, R. E., Engeli, S., & Finer, N. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283537347 · Cited by 156
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Laurent, S., Schlaich, M. P., & Esler, M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60825-3 · Cited by 151
van Bilsen, M., Patel, H. C., Bauersachs, J. K., Böhm, M., Borggrefe, M. M., Brutsaert, D. L., Coats, A. J. S., de Boer, R. A., Keulenaer, G. W. D., Filippatos, G. S., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.921 · Cited by 153
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Carthy, E. R. (2013) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2013.11.002 · Cited by 143
Oxlund, C. S., Henriksen, J. E., Tarnow, L., Schousboe, K., Gram, J., & Jacobsen, I. A. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283638b1a · Cited by 138
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Lohmeier, T. E., & Iliescu, R. (2015) · Physiology · doi:10.1152/physiol.00035.2014 · Cited by 126
Esler, M. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.06.001 · Cited by 129
Sustained Reduction of Blood Pressure With Baroreceptor Activation Therapy
de Leeuw, P. W., Bisognano, J. D., Bakris, G. L., Nadim, M. K., Haller, H. G., & Kroon, A. A. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09086 · Cited by 125
Self-citationMahfoud, F., Schmieder, R. E., Azizi, M., Pathak, A., Sievert, H., Tsioufis, C. P., Zeller, T., Bertog, S. C., Blankestijn, P. J., Böhm, M., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx215 · Cited by 124
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Lauder, L., Azizi, M., Kirtane, A. J., Böhm, M., & Mahfoud, F. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0364-1 · Cited by 126
Spiering, W., Williams, B., der Heyden, J. V., van Kleef, M. E. A. M., Lo, R. H., Versmissen, J., Moelker, A. D., Kroon, A. A., Reuter, H., Ansel, G. M., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32337-1 · Cited by 121
Self-citationShould the sympathetic nervous system be a target to improve cardiometabolic risk in obesity?
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Fagard, R. H. (2011) · Heart · doi:10.1136/heartjnl-2011-300741 · Cited by 104
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Carotid baroreflex activation therapy for resistant hypertension
Victor, R. G. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.96 · Cited by 98
2019 Chinese guideline for the management of hypertension in the elderly.
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Bangalore, S., Fayyad, R., Laskey, R., DeMicco, D. A., Deedwania, P., Kostis, J. B., & Messerli, F. H. (2014) · The American Journal of Medicine · doi:10.1016/j.amjmed.2013.07.038 · Cited by 93
Wallbach, M., Lehnig, L.-Y., Schroer, C., Lüders, S., Böhning, E., Muller, G. A., Wachter, R., & Koziolek, M. J. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06717 · Cited by 91
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Heusser, K., Tank, J., Brinkmann, J., Menne, J., Kaufeld, J. K., Linnenweber-Held, S., Beige, J., Wilhelmi, M. H., Diedrich, A., Haller, H. G., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06486 · Cited by 85
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Bertog, S. C., Sobotka, P. A., & Sievert, H. (2012) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2011.12.011 · Cited by 86
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Feltner, C., Wallace, I., Aymes, S. E., Middleton, J. C., Hicks, K. L., Coker-Schwimmer, M. J. L., Baker, C., Balio, C. P., Moore, D., Voisin, C. E., et al. (2022) · JAMA · doi:10.1001/jama.2022.18357 · Cited by 91
Ohya, Y., Arakawa, K., Arata, N., Arima, S., Arima, H., Asayama, K., Dohi, Y., Fukami, A., Furuhashi, M., Goto, K., et al. (2026) · Hypertension Research · doi:10.1038/s41440-025-02462-y · Cited by 91
Non-pharmacological modulation of the autonomic tone to treat heart failure
Singh, J. P., Kandala, J., & Camm, A. J. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht436 · Cited by 72
Maryam, M., Varghese, T. P., & Tazneem, B. (2024) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2024.102411 · Cited by 81
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de Leeuw, P. W., Alnima, T., Lovett, E. G., Sica, D. A., Bisognano, J. D., Haller, H. G., & Kroon, A. A. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04492 · Cited by 72
Self-citationKück, K., Bordachar, P., Borggrefe, M., Boriani, G., Burri, H., Leyva, F., SCHAUERTE, P. N., Theuns, D. A. M. J., Thibault, B., Reviewers, D., et al. (2013) · EP Europace · doi:10.1093/europace/eut311 · Cited by 70
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Metadata
- Authors
- Bisognano, J. D., Bakris, G., Nadim, M. K., Sanchez, L., Kroon, A. A., Schafer, J., de Leeuw, P. W., & Sica, D. A.
- Affiliations
- University of Rochester Medicine (US)
- University of Chicago (US)
- University of Southern California (US)
- Maastricht University Medical Centre (NL)
- Virginia Commonwealth University (US)
- Corresponding author
- Bisognano, John D.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 58
- Issue
- 7
- Pages
- 765-773
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W167701172
- Cited by
- 600
- References
- 16
- Citations by year
- 2026: 16 · 2025: 18 · 2024: 29 · 2023: 31 · 2022: 20 · 2021: 19 · 2020: 30 · 2019: 32 · 2018: 34 · 2017: 46 · 2016: 53 · 2015: 62 · 2014: 71 · 2013: 61 · 2012: 64
- FWCI
- 45.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- CVRx
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- baroreflex activation therapy, resistant hypertension, systolic blood pressure, blood pressure reduction, device safety, procedural safety, antihypertensive therapy
- MeSH terms
- Blood Pressure, Carotid Sinus, Double-Blind Method, Electrodes, Implanted, Electric Stimulation Therapy, Female, Humans, Hypertension, Male, Middle Aged, Baroreflex
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