Cited by 193Lipoproteins and Cardiovascular HealthCancer, Lipids, and MetabolismAcute Myocardial Infarction Research

Optimizing cholesterol treatment in patients with muscle complaints

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Rosenson, Robert S., Baker, Steven, Banach, Maciej, Borow, Kenneth M., Braun, Lynne T., Bruckert, Eric, Brunham, Liam R., Catapano, Alberico L. +11 more·2017·Journal of the American College of Cardiology

Abstract

Statins are highly effective for preventing cardiovascular events by reducing low-density lipoprotein cholesterol (LDL-C). However, many patients taking statins report muscle-related symptoms that prevent the use of guideline recommended doses. Patients with reported intolerance to statins have a high risk of cardiovascular events. Clinical strategies that optimize cardiovascular risk reduction through LDL-C lowering need to be applied in patients experiencing intolerable side effects that they attribute to statins. In this paper, the authors review definitions of statin intolerance, propose algorithms to better define statin intolerance, and describe approaches to optimize cardiovascular risk reduction among individuals reporting statin-associated muscle symptoms.

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Crossref · 10.1016/j.jacc.2017.07.752

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  • For most patients with statin-associated muscle symptoms, even up to 95%, statins can still be used with a step-by-step approach, because complete statin intolerance affects only 3% to 5% of patients.

    “Moreover, for most (even 95%) of the patients with SAMS, it is still possible to use statins using a step-bystep approach, as complete statin intolerance affects only 3% to 5% patients (10)(11)(12).”

    From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [10]

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Authors
Rosenson, R. S., Baker, S., Banach, M., Borow, K. M., Braun, L. T., Bruckert, E., Brunham, L. R., Catapano, A. L., Elam, M. B., Mancini, G. B. J., Moriarty, P. M., Morris, P. B., Muntner, P., Ray, K. K., Stroes, E. S., Taylor, B. A., Taylor, V. H., Watts, G. F., & Thompson, P. D.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • McMaster University (CA)
  • Medical University of Lodz (PL)
  • Rush University Medical Center (US)
  • University of Milan (IT)
  • University of Tennessee Health Science Center (US)
  • University of British Columbia (CA)
  • University of Kansas Medical Center (US)
  • Medical University of South Carolina (US)
  • University of Alabama at Birmingham (US)
  • Imperial College London (GB)
  • Amsterdam UMC Location University of Amsterdam (NL)
  • Hartford Hospital (US)
  • University of Toronto (CA)
  • The University of Western Australia (AU)
Corresponding author
Rosenson, Robert S.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2017-09
Volume
70
Issue
10
Pages
1290-1301
ISSN
0735-1097 (ISSN-L)
OpenAlex
W2745511617
Cited by
193
References
78
Citations by year
2026: 8 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 27 · 2020: 42 · 2019: 29 · 2018: 38 · 2017: 11
FWCI
6.96
Type
journal article
Language
en
Open access
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • HAL (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Keywords
statin intolerance, statin-associated muscle symptoms, statins, LDL cholesterol lowering, cardiovascular risk reduction, hypercholesterolemia, diagnostic algorithm
MeSH terms
Anticholesteremic Agents, Cardiovascular Diseases, Cholesterol, Humans, Muscular Diseases, Risk Factors, Muscle, Skeletal, Hydroxymethylglutaryl-CoA Reductase Inhibitors

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