MicroRNAs as critical biomarkers of major depressive disorder: a comprehensive perspective
Open accessAbstract
Major Depressive Disorder (MDD) represents a major global health concern, a body-mind malady of rising prevalence worldwide nowadays. The complex network of mechanisms involved in MDD pathophysiology is subjected to epigenetic changes modulated by microRNAs (miRNAs). Serum free or vesicles loaded miRNAs have starred numerous publications, denoting a key role in cell-cell communication, systematically and in brain structure and neuronal morphogenesis, activity and plasticity. Upregulated or downregulated expression of these signaling molecules may imply the impairment of genes implicated in pathways of MDD etiopathogenesis (neuroinflammation, brain-derived neurotrophic factor (BDNF), neurotransmitters, hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, circadian rhythms...). In addition, these miRNAs could serve as potential biomarkers with diagnostic, prognostic and predictive value, allowing to classify severity of the disease or to make decisions in clinical management. They have been considered as promising therapy targets as well and may interfere with available antidepressant treatments. As epigenetic malleable regulators, we also conclude emphasizing lifestyle interventions with physical activity, mindfulness and diet, opening the door to new clinical management considerations.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dysregulated microRNA expression is linked to synaptic plasticity, neuroinflammation, and stress response.
“Dysregulated microRNA expression is also linked to synaptic plasticity, neuroinflammation, and stress response (Ortega et al., 2021; Elhag and Al Khodor, 2023).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Ortega et al., 2021
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
3 retracted
Yang, Y., Hu, Z., Du, X., Davies, H., Huo, X., & Fang, M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00428 · Cited by 90 · see citing works
RetractedRETRACTED: Individual Differences in Response to Antidepressants
Maslej, M. M., Furukawa, T. A., Cipriani, A., Andrews, P. W., & Mulsant, B. H. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.4815 · Cited by 65 · see citing works
RetractedPei, G., Xu, L., Huang, W., & Yin, J. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106076 · Cited by 26 · see citing works
RetractedDiagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · cited 8× · see citing works
“Predictive: Paroxetine may lead to decreased serum levels of miR-221-3p, which is related to decreased HAM-D score Therapy: ERK pathway regulates miR-221 expression [124,187,194,195,246,277] Biomedicines 2021, 9, 1659 25 of 38 Table 1.”
BackgroundInfluentialExtracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099 · see citing works
Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462 · see citing works
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287 · see citing works
MicroRNA genes are transcribed by RNA polymerase II
Lee, Y., Kim, M., Han, J., Yeom, K.-H., Lee, S., Baek, S. H., & Kim, V. N. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600385 · Cited by 4,355 · see citing works
The MicroRNA Spectrum in 12 Body Fluids
Weber, J. A., Baxter, D. H., Zhang, S., Huang, D. Y. C., Huang, K., Lee, M., Galas, D. J., & Wang, K. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.147405 · Cited by 2,754 · see citing works
The Microprocessor complex mediates the genesis of microRNAs
Gregory, R. I., Yan, K.-P., Amuthan, G., Chendrimada, T. P., Doratotaj, B., Cooch, N. S., & Shiekhattar, R. (2004) · Nature · doi:10.1038/nature03120 · Cited by 2,724 · see citing works
The Epidemiology of Depression Across Cultures
Kessler, R. C., & Bromet, E. J. (2013) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031912-114409 · Cited by 2,657 · see citing works
Lu, T. X., & Rothenberg, M. E. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.08.034 · Cited by 2,425 · see citing works
Towards a molecular understanding of microRNA-mediated gene silencing
Jonas, S., & Izaurralde, E. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3965 · Cited by 1,872 · see citing works
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works
The Economic Burden of Adults With Major Depressive Disorder in the United States (2005 and 2010)
Greenberg, P. E., Fournier, A.-A., Sisitsky, T., Pike, C. T., & Kessler, R. C. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09298 · Cited by 1,779 · see citing works
Ownby, R. L., Crocco, E., Acevedo, A., John, V., & Loewenstein, D. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.5.530 · Cited by 1,493 · see citing works
Recent progress in the biology and physiology of sirtuins
Finkel, T., Deng, C., & Mostoslavsky, R. (2009) · Nature · doi:10.1038/nature08197 · Cited by 1,484 · see citing works
Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427 · see citing works
RNA polymerase III transcribes human microRNAs
Borchert, G. M., Lanier, W., & Davidson, B. L. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1167 · Cited by 1,397 · see citing works
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278 · see citing works
The increasing burden of depression
Briley, M., & Lépine (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s19617 · Cited by 1,222 · see citing works
Severity classification on the Hamilton depression rating scale
Zimmerman, M., Martinez, J. H., Young, D., Chelminski, I., & Dalrymple, K. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.04.028 · Cited by 1,199 · see citing works
Neuroinflammation and depression: A review
Troubat, R., Barone, P., Leman, S., Desmidt, T., Cressant, A., Atanasova, B., Brizard, B., El Hage, W., Surget, A., Belzung, C., et al. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14720 · Cited by 1,107 · see citing works
MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions.
Shukla, G. C., Singh, J., & Barik, S. (2011) · PubMed · Cited by 821 · see citing works
Towfighi, A., Ovbiagele, B. I., Husseini, N. E., Hackett, M. L., Jorge, R. E., D, B. M. K. M., Mitchell, P. H., Skolarus, L. E., Whooley, M. A., & Williams, L. S. (2016) · Stroke · doi:10.1161/str.0000000000000113 · Cited by 783 · see citing works
MicroRNA functions in stress responses
Leung, A. K. L., & Sharp, P. A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.027 · Cited by 765 · see citing works
Dopamine system dysregulation in major depressive disorders
Belujon, P., & Grace, A. A. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx056 · Cited by 754 · see citing works
Antoniuk, S., Bijata, M., Ponimaskin, E., & Wlodarczyk, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.12.002 · Cited by 750 · see citing works
Duman, R. S., & Voleti, B. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.004 · Cited by 714 · see citing works
Epigenetics in health and disease
Zhang, L., Lu, Q., & Chang, C. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-15-3449-2_1 · Cited by 689 · see citing works
(2000) · PubMed · Cited by 685 · see citing works
Stubbs, B., Vancampfort, D., Rosenbaum, S., Firth, J., Cosco, T., Veronese, N., Salum, G. A., & Schuch, F. B. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2016.12.020 · Cited by 666 · cited 1× · see citing works
“Physical exercise is considered a perfect anxiolytic for mental disorders [248].”
BackgroundBrites, D., & Fernandes, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00476 · Cited by 599 · cited 1× · see citing works
“Hence exercise can be considered as a neuroprotector now that it can repress the expression of certain microRNAs related to damage in brain [253,254] and age-related hippocampal deterioration and depressive symptoms.”
BackgroundExtracellular miRNAs: the mystery of their origin and function
Turchinovich, A. A., Weiz, L., & Burwinkel, B. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.08.003 · Cited by 520 · see citing works
Central monoamines and their role in major depression
Elhwuegi, A. S. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.11.018 · Cited by 504 · see citing works
Prognosis and improved outcomes in major depression: a review
Kraus, C., Kadriu, B., Lanzenberger, R., Zarate, C. A., & Kasper, S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0460-3 · Cited by 482 · see citing works
Yu, J.-T., Xu, W., Tan, C.-C., Andrieu, S., Suckling, J., Evangelou, E., Pan, A., Zhang, C., Jia, J., Feng, L., et al. (2020) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-321913 · Cited by 482 · see citing works
MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants
Baudry, A., Mouillet-Richard, S., Schneider, B., Launay, J.-M., & Kellermann, O. (2010) · Science · doi:10.1126/science.1193692 · Cited by 480 · see citing works
Neurobiological mechanisms in major depressive disorder
Rot, M. A. H., Mathew, S. J., & Charney, D. S. (2009) · Canadian Medical Association Journal · doi:10.1503/cmaj.080697 · Cited by 473 · see citing works
Prevalence and correlates of major depressive disorder: a systematic review
Gutiérrez-Rojas, L., Porras‐Segovia, A., Dunne, H., Andrade‐González, N., & Cervilla, J. A. (2020) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-0650 · Cited by 459 · see citing works
Montero, C. G., Fraile‐Μartinez, O., Gomez-Lahoz, A. M., Pekarek, L., Castellanos, A. J., Noguerales-Fraguas, F., Coca, S., Guijarro, L. G., García‐Honduvilla, N., Asúnsolo, Á., et al. (2021) · Nutrients · doi:10.3390/nu13020699 · Cited by 452 · see citing works
Self-citationStress, stress hormones, and adult neurogenesis
Schoenfeld, T. J., & Gould, E. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.01.008 · Cited by 425 · see citing works
Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA
Hendrickson, D. G., Hogan, D. J., McCullough, H. L., Myers, J. W., Herschlag, D., Ferrell, J. E., & Brown, P. O. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000238 · Cited by 418 · see citing works
The excess costs of depression: a systematic review and meta-analysis
König, H., König, H.-H., & Konnopka, A. (2019) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796019000180 · Cited by 411 · see citing works
Neural basis of major depressive disorder: Beyond monoamine hypothesis
Boku, S., Nakagawa, S., Toda, H., & Hishimoto, A. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12604 · Cited by 402 · see citing works
Tafet, G. E., & Nemeroff, C. B. (2016) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.15030053 · Cited by 393 · cited 1× · see citing works
“Simultaneously, there is a cognitive and emotional vulnerability derived from all these factors that eventually may lead to the appearance of depression [95].”
BackgroundThe Non-Canonical Aspects of MicroRNAs: Many Roads to Gene Regulation
Stavast, C. J., & Erkeland, S. J. (2019) · Cells · doi:10.3390/cells8111465 · Cited by 379 · see citing works
Understanding the Complex of Suicide in Depression: from Research to Clinics
Orsolini, L., Latini, R., Pompili, M., Serafini, G., Volpe, U., Vellante, F., Fornaro, M., Valchera, A., Tomasetti, C., Fraticelli, S., et al. (2020) · Psychiatry Investigation · doi:10.30773/pi.2019.0171 · Cited by 373 · see citing works
Circulating miRNAs: cell–cell communication function?
Turchinovich, A. A., Samatov, T. R., Tonevitsky, A., & Burwinkel, B. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00119 · Cited by 370 · see citing works
NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings
Kaufmann, F. N., Costa, A. P., Ghisleni, G., Diaz, A. P., Rodrigues, A. L. S., Peluffo, H., & Kaster, M. P. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.002 · Cited by 370 · see citing works
Brain-derived neurotrophic factor: role in depression and suicide
Dwivedi, Y. (2009) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s5700 · Cited by 355 · see citing works
The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.
Appleton, J. (2018) · Europe PMC (PubMed Central) · Cited by 337 · see citing works
miR-212/132 expression and functions: within and beyond the neuronal compartment
Wanet, A., Tacheny, A., Arnould, T., & Renard, P. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks151 · Cited by 331 · see citing works
Smalheiser, N. R., Lugli, G., Rizavi, H. S., Torvik, V. I., Turecki, G., & Dwivedi, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033201 · Cited by 324 · see citing works
Issler, O., Haramati, S., Paul, E. D., Maeno, H., Navon, I., Zwang, R., Gil, S., Mayberg, H. S., Dunlop, B. W., Menke, A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.042 · Cited by 318 · see citing works
Zhou, R., Yuan, P., Wang, Y., Hunsberger, J. G., Elkahloun, A. G., Wei, Y., Damschroder-Williams, P. J., Du, J., Chen, G., & Manji, H. K. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.131 · Cited by 313 · see citing works
Recent Advances in miRNA Delivery Systems
Dasgupta, I., & Chatterjee, A. (2021) · Methods and Protocols · doi:10.3390/mps4010010 · Cited by 312 · see citing works
DSM-5 Criteria and Depression Severity: Implications for Clinical Practice
Tolentino, J. C., & Schmidt, S. L. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00450 · Cited by 311 · see citing works
Determining the role of microRNAs in psychiatric disorders
Issler, O., & Chen, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3879 · Cited by 309 · see citing works
Lopez, J. P., Lim, R., Cruceanu, C., Crapper, L., Fasano, C., Labonte, B., Maussion, G., Yang, J. P., Yerko, V., Vigneault, E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3582 · Cited by 308 · see citing works
Where in the Brain Is Depression?
Pandya, M. A., Altinay, M. I., Malone, D. A., & Anand, A. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0322-7 · Cited by 302 · see citing works
The burden of severe depression: A review of diagnostic challenges and treatment alternatives
Nemeroff, C. B. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.05.008 · Cited by 295 · see citing works
Lekman, M., Laje, G., Charney, D., Rush, A. J., Wilson, A. F., Sorant, A. J. M., Lipsky, R., Wisniewski, S. R., Manji, H., McMahon, F. J., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.026 · Cited by 284 · see citing works
Carrozzino, D., Patierno, C., Fava, G. A., & Guidi, J. (2020) · Psychotherapy and Psychosomatics · doi:10.1159/000506879 · Cited by 271 · see citing works
Clinical Practice Guidelines for the management of Depression
Grover, S., Gautam, S., Jain, A., Gautam, M., & Vahia, V. (2017) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.196973 · Cited by 269 · see citing works
The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
Raison, C. L., & Miller, A. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.2 · Cited by 253 · see citing works
Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders
van den Berg, M. M. J., Krauskopf, J., Ramaekers, J. G., Kleinjans, J. C. S., Prickaerts, J., & Briedé, J. J. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101732 · Cited by 253 · see citing works
Sex differences in glutamate receptor gene expression in major depression and suicide
Gray, A. L., Hyde, T. M., Deep-Soboslay, A., Kleinman, J. E., & Sodhi, M. S. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.91 · Cited by 250 · see citing works
Belzeaux-R, R., Bergon, A., Jeanjean, V., Loriod, B., Formisano‐Tréziny, C., Verrier, L., Loundou, A., Baumstarck, K., Boyer, L., Gall, V., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.112 · Cited by 222 · see citing works
Oxidative Stress and Major Depression
Bajpai, A. (2014) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2014/10258.5292 · Cited by 222 · see citing works
Jiménez‐Fernández, S., Manuel Gurpegui, A., Díaz-Atienza, F., Pérez-Costillas, L., Gerstenberg, M., & Correll, C. U. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14r09179 · Cited by 220 · see citing works
Recent progress in microRNA-based delivery systems for the treatment of human disease
Fu, Y., Chen, J., & Huang, Z. (2019) · ExRNA · doi:10.1186/s41544-019-0024-y · Cited by 213 · see citing works
Gee, B., Orchard, F., Clarke, E., Joy, A., Clarke, T., & Reynolds, S. (2019) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.09.004 · Cited by 212 · cited 1× · see citing works
“In addition, a wide variety of non-medical complementary approaches are being explored in the clinical management of MDD, showing promising results including the use of nutraceuticals [13], mindfulness-based interventions [14] physical activity [15] and sleep interventions [16].”
BackgroundAlterations of Serum Levels of BDNF-Related miRNAs in Patients with Depression
Li, Y., Xu, M., Zong-hua, G., Wang, Y., Yue, Z., Zhang, Y.-X., Li, X., Zhang, C. M., Xie, S., & Wang, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063648 · Cited by 204 · see citing works
Notch Signaling, Brain Development, and Human Disease
Lasky, J. L., & Wu, H. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000159632.70510.3d · Cited by 203 · see citing works
Lopez, J. P., Fiori, L. M., Cruceanu, C., Lin, R., Labonte, B., Cates, H. M., Heller, E. A., Vialou, V., Ku, S. M., Gerald, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms15497 · Cited by 201 · see citing works
Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder
Roy, B., Dunbar, M., Shelton, R. C., & Dwivedi, Y. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.175 · Cited by 199 · see citing works
Desvignes, T., Batzel, P., Berezikov, E., Eilbeck, K. L., Eppig, J. T., McAndrews-Hill, M., Singer, A., & Postlethwait, J. H. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.09.002 · Cited by 198 · see citing works
MiR-137: an important player in neural development and neoplastic transformation
Mahmoudi, E., & Cairns, M. J. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.150 · Cited by 198 · see citing works
Bai, M., Zhu, X., Zhang, Y., Zhang, S., Zhang, L., Xue, L., Yi, J., Yao, S., & Zhang, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046921 · Cited by 195 · see citing works
Zucchi, F. C. R., Yao, Y., Ward, I. D., Ilnytskyy, Y., Olson, D. M., Benzies, K., Kovalchuk, I., Kovalchuk, O., & Metz, G. A. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056967 · Cited by 193 · see citing works
Effects of Physical Exercise on Neuroinflammation, Neuroplasticity, Neurodegeneration, and Behavior
Svensson, M., Lexell, J. E., & Deierborg, T. (2014) · Neurorehabilitation and neural repair · doi:10.1177/1545968314562108 · Cited by 189 · see citing works
Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses
Matsuda, S., Ikeda, Y., Murakami, M., Nakagawa, Y., Tsuji, A., & Kitagishi, Y. (2019) · Diseases · doi:10.3390/diseases7010022 · Cited by 189 · see citing works
Wan, Y., Liu, Y., Wang, X., Wu, J., Liu, K., Zhou, J., Liu, L., & Zhang, C. (2015) · PLOS ONE · doi:10.1371/journal.pone.0121975 · Cited by 182 · see citing works
Peripheral whole blood microRNA alterations in major depression and bipolar disorder
Maffioletti, E., Cattaneo, A., Rosso, G., Maina, G., Maj, C., Gennarelli, M., Tardito, D., & Bocchio-Chiavetto, L. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.021 · Cited by 181 · see citing works
Microbial regulation of microRNA expression in the amygdala and prefrontal cortex
Hoban, A. E., Stilling, R. M., M. Moloney, G., Moloney, R. D., Shanahan, F., Dinan, T. G., Cryan, J. F., & Clarke, G. (2017) · Microbiome · doi:10.1186/s40168-017-0321-3 · Cited by 177 · see citing works
Emerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implications
Dwivedi, Y. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.1/ydwivedi · Cited by 169 · see citing works
Antidepressants and the placebo effect
Kirsch, I. (2014) · Zeitschrift für Psychologie · doi:10.1027/2151-2604/a000176 · Cited by 164 · see citing works
Saus, E., Soria, V., Escaramís, G., Vivarelli, F., Crespo, J. M., Kagerbauer, B., Menchón, J. M., Urretavizcaya, M., Gratacòs, M., & Estivill, X. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq316 · Cited by 163 · see citing works
Physical Exercise in Major Depression: Reducing the Mortality Gap While Improving Clinical Outcomes
Belvederi Murri, M., Ekkekakis, P., Magagnoli, M., Zampogna, D., Cattedra, S., Capobianco, L., Serafini, G., Calcagno, P., Zanetidou, S., & Amore, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00762 · Cited by 163 · see citing works
Update on non-canonical microRNAs
Abdelfattah, A. M., Park, C., & Choi, M. Y. (2014) · BioMolecular Concepts · doi:10.1515/bmc-2014-0012 · Cited by 157 · see citing works
MicroRNAs in the Pathobiology and Therapy of Atherosclerosis
Laffont, B., & Rayner, K. J. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.01.001 · Cited by 151 · see citing works
Sheline, Y. I., Liston, C. M., & McEwen, B. S. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.01.011 · Cited by 149 · see citing works
MicroRNA mediators of early life stress vulnerability to depression and suicidal behavior
Allen, L., & Dwivedi, Y. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0597-8 · Cited by 148 · see citing works
Brain-specific knockdown of miR-29 results in neuronal cell death and ataxia in mice
Roshan, R., Shridhar, S., Sarangdhar, M. A., Banik, A., Chawla, M., Garg, M., Singh, V. P., & Pillai, B. (2014) · RNA · doi:10.1261/rna.044008.113 · Cited by 146 · see citing works
Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective
Eyre, H. A., Papps, E., & Baune, B. T. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00003 · Cited by 144 · see citing works
MicroRNAs as biomarkers for major depression: a role for let-7b and let-7c
Gururajan, A., Naughton, M., Scott, K. A., O’Connor, R. M., Moloney, G. M., Clarke, G. A., Dowling, J. L., Walsh, A. E. L., Ismail, M. F., Shorten, G., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.131 · Cited by 144 · see citing works
The Microbiota-Inflammasome Hypothesis of Major Depression
Inserra, A., Rogers, G. B., Licinio, J., & Wong, M. (2018) · BioEssays · doi:10.1002/bies.201800027 · Cited by 134 · see citing works
Gorinski, N., Bijata, M., Prasad, S., Wirth, A., Galil, D. A., Zeug, A., Базовкина, Д. В., Kondaurova, E. M., Kulikova, E. A., Ilchibaeva, T. V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11876-5 · Cited by 134 · see citing works
Dwivedi, Y., Roy, B., Lugli, G., Rizavi, H. S., Zhang, H., & Smalheiser, N. R. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.175 · Cited by 133 · see citing works
Brown, R. A. M., Epis, M. R., Horsham, J. L., Kabir, T. D., Richardson, K. L., & Leedman, P. J. (2018) · BMC Biotechnology · doi:10.1186/s12896-018-0421-6 · Cited by 132 · see citing works
MicroRNAs and Cellular Phenotypy
Kosik, K. S. (2010) · Cell · doi:10.1016/j.cell.2010.09.008 · Cited by 123 · see citing works
Monoamine Theories of Depression: Historical Impact on Biomedical Research
Mulinari, S. (2012) · Journal of the History of the Neurosciences · doi:10.1080/0964704x.2011.623917 · Cited by 122 · see citing works
Differential Allelic Expression of Dopamine D1 Receptor Gene (DRD1) Is Modulated by microRNA miR-504
Huang, W., & Li, M. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.024 · Cited by 121 · see citing works
The diagnosis of depression: current and emerging methods
Smith, K., Renshaw, P. F., & Bilello, J. A. (2012) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2012.06.006 · Cited by 121 · see citing works
Disease-Induced Neuroinflammation and Depression
Benatti, C., Blom, J. M. C., Rigillo, G., Alboni, S., Zizzi, F., Torta, R., Brunello, N., & Tascedda, F. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160321104749 · Cited by 121 · see citing works
Liu, J., Buisman-Pijlman, F., & Hutchinson, M. R. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00309 · Cited by 119 · see citing works
Hu, Z., Yu, D., Gu, Q.-H., Yang, Y., Tu, K., Zhu, J., & Li, Z. (2014) · Nature Communications · doi:10.1038/ncomms4263 · Cited by 117 · see citing works
Smalheiser, N. R., Lugli, G., Rizavi, H. S., Zhang, H., Torvik, V. I., Pandey, G. N., Davis, J. M., & Dwivedi, Y. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001628 · Cited by 115 · see citing works
Camkurt, M. A., Acar, Ş. T., Coşkun, S., Güneş, M., Güneş, S., Yılmaz, M. F., Görür, A., & Tamer, L. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.07.023 · Cited by 115 · see citing works
The Prevalence of Depression in Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Chi, S., Wang, C., Jiang, T., Zhu, X., Yu, J., & Tan, L. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150204124310 · Cited by 115 · see citing works
Rohan, K. J., Rough, J. N., Evans, M., Ho, S.-Y., Meyerhoff, J., Roberts, L. M., & Vacek, P. M. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.01.051 · Cited by 114 · see citing works
Song, M.-F., Dong, J., Wang, Y.-W., He, J., Ju, X., Zhang, L., Zhang, Y., Shi, J., & Lv, Y.-Y. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.02.022 · Cited by 111 · see citing works
Effects of gut microbiota on the microRNA and mRNA expression in the hippocampus of mice
Chen, J.-J., Zeng, B.-H., Li, W.-W., Zhou, C.-J., Fan, S.-H., Cheng, K., Zeng, L., Zheng, P., Fang, L., Wei, H., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.01.021 · Cited by 111 · see citing works
COVID-19 and Alzheimer’s Disease
Ciaccio, M., Sasso, B. L., Scazzone, C., Gambino, C. M., Ciaccio, A. M., Bivona, G., Piccoli, T., Giglio, R. V., & Agnello, L. (2021) · Brain Sciences · doi:10.3390/brainsci11030305 · Cited by 111 · see citing works
Surget, A., & Belzung, C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01136-8 · Cited by 110 · see citing works
Sustained activation of ERK1/2 by NGF induces microRNA‐221 and 222 in PC12 cells
Terasawa, K., Ichimura, A., Sato, F., Shimizu, K., & Tsujimoto, G. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07041.x · Cited by 109 · see citing works
Evidence demonstrating role of microRNAs in the etiopathology of major depression
Dwivedi, Y. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.04.002 · Cited by 107 · see citing works
Role and possible mechanisms of Sirt1 in depression
Lu, G., Li, J., Zhang, H., Zhao, X., Yan, L.-J., & Yang, X. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8596903 · Cited by 106 · see citing works
Circulating microRNA-144-5p is associated with depressive disorders
Wang, X., Sundquist, K., Hedelius, A., Palmér, K., Memon, A. A., & Sundquist, J. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0099-8 · Cited by 102 · see citing works
MicroRNA132 associated multimodal neuroimaging patterns in unmedicated major depressive disorder
Qi, S., Yang, X., Zhao, L.-S., Calhoun, V., Perrone-Bizzozero, N., Liu, S., Jiang, R.-T., Jiang, T., Sui, J., & Ma, X.-H. (2018) · Brain : a journal of neurology · doi:10.1093/brain/awx366 · Cited by 102 · see citing works
O'Connor, R. M., Grenham, S., Dinan, T. G., & Cryan, J. F. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000448 · Cited by 101 · see citing works
Circadian Rhythms, Melatonin and Depression
A. Quera Salva, M., Hartley, S., Barbot, F., C. Alvarez, J., Lofaso, F., & Guilleminault, C. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211796197188 · Cited by 100 · see citing works
Xu, Y., Liu, H., Li, F., Sun, N., Ren, Y., Liu, Z., Cao, X., Wang, Y., Liu, P., & Zhang, K. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.05.019 · Cited by 99 · see citing works
Exploiting Circulating MicroRNAs as Biomarkers in Psychiatric Disorders
Roy, B., Yoshino, Y., McKibben, L. A., Prall, K., Schell, G., & Dwivedi, Y. (2020) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-020-00464-9 · Cited by 95 · see citing works
miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction
Woodbury, M. E., Freilich, R. W., Cheng, C. J., Asai, H., Ikezu, S., Boucher, J. D., Slack, F. J., & Ikezu, T. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4790-14.2015 · Cited by 94 · see citing works
Slattery, D. A., & Neumann, I. D. (2010) · Pharmaceuticals · doi:10.3390/ph3030702 · Cited by 94 · see citing works
He, S., Liu, X., Jiang, K., Peng, D., Hong, W., Fang, Y., Qian, Y., Yu, S., & Li, H. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.03.015 · Cited by 94 · see citing works
Serafini, G., Pompili, M., Hansen, K. F., Obrietan, K. H., Dwivedi, Y., Shomron, N., & Girardi, P. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-9997-5 · Cited by 93 · see citing works
Seo, H. A., Moeng, S., Sim, S., Kuh, H. J., Choi, S. Y., & Park, J. K. (2019) · Cells · doi:10.3390/cells9010029 · Cited by 93 · see citing works
Role of Inflammation in Depression and Treatment Implications
Felger, J. C. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_166 · Cited by 92 · see citing works
Díez-Sainz, E., Lorente‐Cebrián, S., Aranaz, P., Riezu‐Boj, J. I., Martínez, J. A., & Milagro, F. I. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.586564 · Cited by 92 · see citing works
Balakathiresan, N. S., Chandran, R., Bhomia, M., Jia, M., Li, H., & Maheshwari, R. K. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.05.020 · Cited by 91 · see citing works
Notch signaling in the brain: In good and bad times
Alberi, L. A., Hoey, S. E., Brai, E., Scotti, A. L., & Marathe, S. V. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.03.004 · Cited by 90 · see citing works
exercise influence on hippocampal function: possible involvement of orexin-A
Chieffi, S., Messina, G., Villano, I., Messina, A., Esposito, M., Monda, V., Valenzano, A., Moscatelli, F., Esposito, T., Carotenuto, M., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00085 · Cited by 90 · see citing works
Fang, Y., Qiu, Q., Zhang, S., Sun, L., Li, G., Xiao, S., & Li, X. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.090 · Cited by 90 · see citing works
Li, Y., Fan, C., Wang, L., Lan, T., Gao, R., Wang, W., & Yu, S. Y. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148853 · Cited by 90 · see citing works
Su, M., HONG, J., ZHAO, Y., Liu, S., & XUE, X. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4104 · Cited by 89 · see citing works
miR-323a regulates ERBB4 and is involved in depression
Fiori, L. M., Kos, A., Lin, R., Théroux, J.-F., Lopez, J. P., Kühne, C., Eggert, C., Holzapfel, M., Huettl, R.-E., Mechawar, N., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00953-7 · Cited by 88 · see citing works
Transcriptome profiling of human hippocampus dentate gyrus granule cells in mental illness
Kohen, R., Dobra, A., Tracy, J. H., & Haugen, E. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.9 · Cited by 87 · see citing works
Serum-based microRNA biomarkers for major depression: MiR-16, miR-135a, and miR-1202
Gheysarzadeh, A., Sadeghifard, N., Afraidooni, L., Pooyan, F., Mofid, M. R., Valadbeigi, H., Bakhtiari, H., & Keikhavani, S. (2018) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_879_17 · Cited by 86 · see citing works
Álvarez-Mon, M. Á., Gomez-Lahoz, A. M., Orozco, A., Lahera, G., Sosa-Reina, M. D., Díaz, D., Aubá, E., Albillos, A., Monserrat, J., & Álvarez‐Mon, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00812 · Cited by 86 · see citing works
Self-citationMicroRNA nomenclature and the need for a revised naming prescription
Budak, H., Bulut, R., Kantar, M., & Alptekin, B. (2015) · Briefings in Functional Genomics · doi:10.1093/bfgp/elv026 · Cited by 84 · see citing works
Zhang, Y., Zhu, X., Bai, M., Zhang, L., Xue, L., & Yi, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069934 · Cited by 83 · see citing works
microRNA-124 targets glucocorticoid receptor and is involved in depression-like behaviors
Wang, S., Mu, R.-H., Li, C., Dong, S., Geng, D., Liu, Q., & Yi, L. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.024 · Cited by 80 · see citing works
Hung, Y.-Y., Wu, M., Tsai, M.-C., Huang, Y., & Kang, H. (2019) · Cells · doi:10.3390/cells8070647 · Cited by 80 · see citing works
Azevedo, J. A., Carter, B. S., Meng, F., Turner, D. L., Dai, M., Schatzberg, A. F., Barchas, J. D., Jones, E. G., Bunney, W. E., Myers, R., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.012 · Cited by 79 · see citing works
Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress
Volk, N., Pape, J. C., Engel, M., Zannas, A. S., Cattane, N., Cattaneo, A., Binder, E. B., & Chen, A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.038 · Cited by 79 · see citing works
MiR-218: a molecular switch and potential biomarker of susceptibility to stress
Torres-Berrío, A., Nouel, D., Cuesta, S., Parise, E. M., Restrepo-Lozano, J. M., Larochelle, P., Nestler, E. J., & Flores, C. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0421-5 · Cited by 79 · see citing works
MicroRNAs in depression and suicide: Recent insights and future perspectives
Dwivedi, Y. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.07.075 · Cited by 77 · see citing works
Sun, N., Lei, L., Wang, Y., Yang, C., Liu, Z., Li, X., & Zhang, K. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.01.017 · Cited by 74 · see citing works
Role of endoplasmic reticulum stress in depression (Review)
Mao, J., Hu, Y., Ruan, L., Ji, Y., & Lou, Z. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10789 · Cited by 74 · see citing works
Mendes‐Silva, A. P., Pereira, K. S., Araújo, G. T. T., Nicolau, E. D. S., Silva-Ferreira, C. M., Teixeira, A. L., & Diniz, B. S. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.07.017 · Cited by 73 · see citing works
ENĂTESCU, V. R., Papavă, I., Enătescu, I., Antonescu, M., Anghel, A., Șeclăman, E. P., Sîrbu, I. O., & Marian, C. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.5.549 · Cited by 73 · see citing works
Circulating microRNA 134 sheds light on the diagnosis of major depressive disorder
Zhang, H., Liu, X., Chen, J., Cheng, K., Bai, S., Zheng, P., Zhou, C., Wang, W., Wang, H., Zhong, L., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0773-2 · Cited by 73 · see citing works
MicroRNA-dependent control of neuroplasticity in affective disorders
Martins, H. C., & Schratt, G. M. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01379-7 · Cited by 73 · see citing works
Fiori, L. M., Lopez, J. P., Richard-Devantoy, S., Berlim, M., Chachamovich, E., Jollant, F., Foster, J., Rotzinger, S., Kennedy, S. H., & Turecki, G. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx034 · Cited by 71 · see citing works
Kuang, W.-H., Dong, Z.-Q., Tian, L.-T., & Li, J. (2018) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20187212 · Cited by 70 · see citing works
Wingo, T. S., Yang, J., Fan, W., Canon, S. M., Gerasimov, E. S., Lori, A., Logsdon, B. A., Yao, B., Seyfried, N. T., Lah, J. J., et al. (2020) · npj Genomic Medicine · doi:10.1038/s41525-019-0113-8 · Cited by 70 · see citing works
Liu, X., Zhang, L., Cheng, K., Wang, X., Ren, G., & Xie, P. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.12.035 · Cited by 69 · see citing works
Dysregulation of Inflammasome Priming and Activation by MicroRNAs in Human Immune-Mediated Diseases
Boxberger, N., Hecker, M., & Zettl, U. K. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801416 · Cited by 69 · see citing works
Coordinated Messenger RNA/MicroRNA Changes in Fibroblasts of Patients with Major Depression
Garbett, K. A., Vereczkei, A., Kálmán, S., Brown, J. A., Taylor, W. D., Faludi, G., Korade, Ž., Shelton, R. C., & Mirnics, K. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.05.015 · Cited by 68 · see citing works
Yoshino, Y., Roy, B., & Dwivedi, Y. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00861-y · Cited by 68 · see citing works
Oved, K., Morag, A., Pasmanik-Chor, M., Oron-Karni, V., Shomron, N., Rehavi, M., Stingl, J. C., & Gurwitz, D. (2012) · Pharmacogenomics · doi:10.2217/pgs.12.93 · Cited by 66 · see citing works
Wang, Y. Y., Li, X., Zheng, W., Xu, Z., Ng, C. H., Ungvari, G. S., Yuan, Z., & Xiang, Y. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.12.093 · Cited by 66 · see citing works
Millan, M. J. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.01.008 · Cited by 63 · see citing works
Fan, C., Zhu, X., Song, Q., Wang, P., Liu, Z., & Yu, S. Y. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.009 · Cited by 63 · see citing works
Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions
Zhao, Y., Zeng, Y., Zeng, D., Wang, H., Zhou, M., Sun, N., Xin, J., Khalique, A., Rajput, D. S., Pan, K., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.604462 · Cited by 63 · see citing works
MicroRNAs and psychiatric disorders: From aetiology to treatment
Luoni, A., & Riva, M. A. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.006 · Cited by 62 · see citing works
Strategies to use microRNAs as therapeutic targets
Krützfeldt, J. (2016) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2016.07.004 · Cited by 62 · see citing works
Prognosis and Improved Outcomes in Major Depression: A Review
Kraus, C., Kadriu, B., Lanzenberger, R. R., Zarate, C. A., & Kasper, S. F. (2020) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.18205 · Cited by 62 · see citing works
Epigenetics and Depression: An Update
Lin, E., & Tsai, S. (2019) · Psychiatry Investigation · doi:10.30773/pi.2019.07.17.2 · Cited by 61 · see citing works
Prefrontal cortex miR-29b-3p plays a key role in the antidepressant-like effect of ketamine in rats
Wan, Y.-Q., Feng, J.-G., Li, M., Wang, M.-Z., Liu, L., Liu, X., Duan, X.-X., Zhang, C.-X., & Wang, X.-B. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0164-4 · Cited by 60 · see citing works
Guerrera, C. S., Furneri, G., Grasso, M., Caruso, G., Castellano, S., Drago, F., Nuovo, S. D., & Caraci, F. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00857 · Cited by 60 · see citing works
Xu, J., Wang, R., Liu, Y., Wang, W., Liu, D., Jiang, H., & Pan, F. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.11.008 · Cited by 59 · see citing works
Karen, C., Shyu, D. J. H., & Rajan, K. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.719933 · Cited by 59 · see citing works
Moya, P. R., Wendland, J. R., Salemme, J., Fried, R. L., & Murphy, D. L. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000454 · Cited by 58 · see citing works
miR-124 ameliorates depressive-like behavior by targeting STAT3 to regulate microglial activation
Lou, D., Wang, J., & Wang, X. (2019) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2019.101470 · Cited by 58 · see citing works
Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression
Wei, Y. B., Liu, J. J., Villaescusa, J. C., Åberg, E., Brené, S., Wegener, G., Mathé, A. A., & Lavebratt, C. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.136 · Cited by 57 · see citing works
Alvarez-Mon, M. A., Gómez-Lahoz, A. M., Orozco, A., Lahera, G., Diaz, D., Ortega, M. A., Albillos, A., Quintero, J., Aubá, E., Monserrat, J., et al. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11030220 · Cited by 57 · see citing works
Self-citationZhou, M., Wang, M.-H., Wang, X., Liu, K., Wan, Y., Li, M., Liu, L., & Zhang, C. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0365-6 · Cited by 56 · see citing works
MicroRNA overexpression increases cortical neuronal vulnerability to injury
Truettner, J. S., Motti, D., & Dietrich, W. D. (2013) · Brain Research · doi:10.1016/j.brainres.2013.08.011 · Cited by 55 · see citing works
Knockdown of miR-124 Reduces Depression-like Behavior by Targeting CREB1 and BDNF
Yang, W., Liu, M., Zhang, Q., Zhang, J., Chen, J., Chen, Q., & Suo, L. (2020) · Current Neurovascular Research · doi:10.2174/1567202617666200319141755 · Cited by 55 · see citing works
Individual Differences in Response to Antidepressants
Maslej, M. M., Furukawa, T. A., Cipriani, A., Andrews, P. W., Sanches, M., Tomlinson, A., Volkmann, C., McCutcheon, R. A., Howes, O. D., Guo, X., et al. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.4564 · Cited by 55 · see citing works
MiR-221 is involved in depression by regulating Wnt2/CREB/BDNF axis in hippocampal neurons
Lian, N., Niu, Q., Lei, Y., Li, X., Li, Y., & Song, X. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1556060 · Cited by 54 · see citing works
miR-182 (microRNA-182) suppression in the hippocampus evokes antidepressant-like effects in rats
Li, Y., Li, S., Yan, J., Wang, D., Yin, R.-G., Zhao, L., Zhu, Y., & Zhu, X. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.09.004 · Cited by 53 · see citing works
MicroRNA as therapeutic targets for treatment of depression
Obrietan, K. H., & Hansen, K. F. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s34811 · Cited by 53 · see citing works
MicroRNA-155 deletion reduces anxiety- and depressive-like behaviors in mice
Fonken, L. K., Gaudet, A. D., Gaier, K. R., Nelson, R. J., & Popovich, P. G. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.10.019 · Cited by 53 · see citing works
Roy, B., Dunbar, M., Agrawal, J., Allen, L., & Dwivedi, Y. (2019) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyz071 · Cited by 53 · see citing works
Qu, H., Liu, R., Chen, J., Zheng, L., & Chen, R. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17082676 · Cited by 53 · see citing works
Paramasivam, P., Poongothai, S., Shanthirani, C. S., Anjana, R. M., Mohan, V., & Balasubramanyam, M. (2020) · Acta Diabetologica · doi:10.1007/s00592-020-01486-9 · Cited by 52 · see citing works
Simpson, E. H., Winiger, V., Biezonski, D. K., Haq, I., Kandel, E. R., & Kellendonk, C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.023 · Cited by 51 · see citing works
Satyanarayanan, S. K., Shih, Y.-H., Wen, Y., Palani, M., Lin, Y., Su, H., Gałecki, P., & Su, K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.190 · Cited by 50 · see citing works
Khandelwal, N., Dey, S. K., Chakravarty, S., & Kumar, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00188 · Cited by 49 · see citing works
Zhao, Y., Wang, S., Chu, Z., Dang, Y., Zhu, J.-X., & Su, X. (2017) · Brain Research · doi:10.1016/j.brainres.2017.05.020 · Cited by 48 · see citing works
MicroRNAs as Biomarkers for Psychiatric Conditions: A Review of Current Research.
Narahari, A., Hussain, M., & Sreeram, V. (2017) · PubMed Central · Cited by 47 · see citing works
Kim, H. K., Tyryshkin, K., Elmi, N., Dharsee, M., Evans, K., Good, J. L., Javadi, M., McCormack, S., Vaccarino, A. L., Zhang, X., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.12.007 · Cited by 46 · see citing works
Dietary Bioactive Compounds and Human Health and Disease
González, S. (2020) · Nutrients · doi:10.3390/nu12020348 · Cited by 45 · see citing works
microRNA-124: a putative therapeutic target and biomarker for major depression
Dwivedi, Y. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1328501 · Cited by 44 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lv, L.-Z., Wang, Z.-D., Ren, J.-J., Li, L.-H., Liu, X.-B., Li, J.-L., Zhu, H., Jiang, B., Han, Y.-P., Zhou, X.-M., et al. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2025.1722453 · Cited by 7 · see citing works
“Dysregulated microRNA expression is also linked to synaptic plasticity, neuroinflammation, and stress response (Ortega et al., 2021; Elhag and Al Khodor, 2023).”
- Authors
- Ortega, M. A., Alvarez-Mon, M. A., García-Montero, C., Fraile-Martinez, O., Lahera, G., Monserrat, J., Muñoz-Merida, L., Mora, F., Rodríguez-Jiménez, R., Fernandez-Rojo, S., Quintero, J., & Álvarez-Mon, M.
- Affiliations
- Universidad de Alcalá (ES)
- Department of Medicine and Medical Specialities, University of Alcala, 28801 Alcalá de Henares, Spain
- Universidad Complutense de Madrid (ES)
- Department of Legal Medicine and Psychiatry, Complutense University, 28040 Madrid, Spain
- Cancer Registry and Pathology Department, Hospital Universitario Principe de Asturias, 28806 Alcalá de Henares, Spain
- ORCID
- Venue
- Biomedicines
- Publisher
- MDPI AG
- Published
- 2021-11-10
- Volume
- 9
- Issue
- 11
- Pages
- 1659
- ISSN
- 2227-9059 (ISSN-L)
- PMC
- PMC8615526
- OpenAlex
- W3211397738
- Cited by
- 57
- References
- 286
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 11 · 2023: 10 · 2022: 9
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Instituto de Salud Carlos III (PI18/01726)
- Comunidad de Madrid (B2017/BMD3804)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, microRNA, biomarkers, epigenetics, serum microRNA, extracellular vesicles, neuroinflammation, brain-derived neurotrophic factor, hypothalamic-pituitary-adrenal axis, oxidative stress, circadian rhythm, antidepressant targets, lifestyle intervention, physical activity, mindfulness, diet
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review