Cited by 57MicroRNA in disease regulationTreatment of Major DepressionTryptophan and brain disorders

MicroRNAs as critical biomarkers of major depressive disorder: a comprehensive perspective

Open access
Ortega, Miguel A., Alvarez-Mon, Miguel Angel, García-Montero, Cielo, Fraile-Martinez, Oscar, Lahera, Guillermo, Monserrat, Jorge, Muñoz-Merida, Luis, Mora, Fernando +4 more·2021·Biomedicines

Abstract

Major Depressive Disorder (MDD) represents a major global health concern, a body-mind malady of rising prevalence worldwide nowadays. The complex network of mechanisms involved in MDD pathophysiology is subjected to epigenetic changes modulated by microRNAs (miRNAs). Serum free or vesicles loaded miRNAs have starred numerous publications, denoting a key role in cell-cell communication, systematically and in brain structure and neuronal morphogenesis, activity and plasticity. Upregulated or downregulated expression of these signaling molecules may imply the impairment of genes implicated in pathways of MDD etiopathogenesis (neuroinflammation, brain-derived neurotrophic factor (BDNF), neurotransmitters, hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, circadian rhythms...). In addition, these miRNAs could serve as potential biomarkers with diagnostic, prognostic and predictive value, allowing to classify severity of the disease or to make decisions in clinical management. They have been considered as promising therapy targets as well and may interfere with available antidepressant treatments. As epigenetic malleable regulators, we also conclude emphasizing lifestyle interventions with physical activity, mindfulness and diet, opening the door to new clinical management considerations.

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Authors
Ortega, M. A., Alvarez-Mon, M. A., García-Montero, C., Fraile-Martinez, O., Lahera, G., Monserrat, J., Muñoz-Merida, L., Mora, F., Rodríguez-Jiménez, R., Fernandez-Rojo, S., Quintero, J., & Álvarez-Mon, M.
Affiliations
  • Universidad de Alcalá (ES)
  • Department of Medicine and Medical Specialities, University of Alcala, 28801 Alcalá de Henares, Spain
  • Universidad Complutense de Madrid (ES)
  • Department of Legal Medicine and Psychiatry, Complutense University, 28040 Madrid, Spain
  • Cancer Registry and Pathology Department, Hospital Universitario Principe de Asturias, 28806 Alcalá de Henares, Spain
Venue
Biomedicines
Publisher
MDPI AG
Published
2021-11-10
Volume
9
Issue
11
Pages
1659
ISSN
2227-9059 (ISSN-L)
OpenAlex
W3211397738
Cited by
57
References
286
Citations by year
2026: 13 · 2025: 14 · 2024: 11 · 2023: 10 · 2022: 9
FWCI
0.90
Type
journal article
Language
en
Open access
Locations
  • Biomedicines (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Instituto de Salud Carlos III (PI18/01726)
  • Comunidad de Madrid (B2017/BMD3804)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
major depressive disorder, microRNA, biomarkers, epigenetics, serum microRNA, extracellular vesicles, neuroinflammation, brain-derived neurotrophic factor, hypothalamic-pituitary-adrenal axis, oxidative stress, circadian rhythm, antidepressant targets, lifestyle intervention, physical activity, mindfulness, diet

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