Cited by 423Posttraumatic Stress Disorder ResearchStress Responses and CortisolChild Abuse and Trauma

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Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: A meta-analysis

Kitayama, Noriyuki, Vaccarino, Viola, Kutner, Michael, Weiss, Paul, Bremner, J. Douglas·2005·Journal of Affective Disorders

DOI 10.1016/j.jad.2005.05.014

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Abstract

Background Studies in animals showed that the hippocampus, a brain area involved in learning and memory, is sensitive to stress. Although several MRI studies showed smaller hippocampal volume in adults with chronic PTSD, others did not show significant differences from controls. These studies are typified by small sample sizes which may limit the ability to show significant differences. We therefore performed a meta-analytic study of all of these studies to clarify the role of hippocampal structural changes in subjects with PTSD. Methods Nine studies with a total of 133 adult subjects with chronic PTSD, 148 healthy controls, and 53 traumatized controls were included in the meta-analysis. Results There was significantly smaller volume in both right and left hippocampi in adult subjects with chronic PTSD in comparison with both healthy controls and traumatized controls. Conclusion These findings are consistent with smaller hippocampal volume in adult subjects with chronic PTSD.

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Authors: Kitayama, N., Vaccarino, V., Kutner, M., Weiss, P., & Bremner, J. D.
Affiliations: Emory University (US)
Corresponding author: Kitayama, Noriyuki
ORCID: Vaccarino, Viola
Kutner, Michael
Bremner, J. Douglas
Venue: Journal of Affective Disorders
Publisher: Elsevier BV
Published: 2005-09
Volume: 88
Issue: 1
Pages: 79-86
ISSN: 0165-0327 (ISSN-L)
DOI: 10.1016/j.jad.2005.05.014
OpenAlex: W2145267709
Cited by: 423
References: 49
Citations by year: 2026: 9 · 2025: 7 · 2024: 16 · 2023: 13 · 2022: 16 · 2021: 13 · 2020: 20 · 2019: 22 · 2018: 24 · 2017: 28 · 2016: 27 · 2015: 26 · 2014: 29 · 2013: 36 · 2012: 19
FWCI: 2.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Affective Disorders (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: post-traumatic stress disorder, hippocampal volume, hippocampal atrophy, chronic PTSD, brain structural changes, trauma exposure, hippocampus
MeSH terms: Adult, Chronic Disease, Dominance, Cerebral, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Reference Values, Stress Disorders, Post-Traumatic

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Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: A meta-analysis

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