The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Antidepressants and dementia
Abstract
Background It has been suggested that antidepressants may have neuroprotective abilities but it has newer been investigated lately whether treatment with antidepressants reduces the risk of dementia. Method Linkage of registers of all prescribed antidepressants and diagnoses of dementia in Denmark during a period from 1995 to 2005. Results Persons who purchased antidepressants once (N=687,552) had an increased rate of dementia compared to persons unexposed to antidepressants (N=779,831). Nevertheless, the rate of dementia changed over time; thus during the initial prescription periods the rate increased with the number of prescriptions but continued long-term antidepressants treatment was associated with a reduction in the rate of dementia, however, not to the same level as the rate for the general population. This pattern was found for all classes of antidepressants (SSRIs, newer non-SSRI antidepressants and older antidepressants). All findings were replicated in sub-analyses with Alzheimer's disease as outcome. Limitations Methodological reasons for the findings cannot be excluded due to the non-randomized nature of data. Conclusions Continued long-term antidepressant treatment was associated with a reduced rate of dementia, however, not to the same level as the rate for the general population.
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In the citing paper
“Several studies have found that SSRIs reduce risk of AD in depressed individuals.”
From Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans (2011) · cites this paper as [47]
In the citing paper
“A recent retrospective study of over 1.4 million people in Denmark over a 10-y period suggested that depressed individuals who were treated only once, or for only a short period, had a greater risk of AD than those who had chronic antidepressant use (47); chronic antidepressant use lowered the risk toward that of the general population.”
From Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans (2011) · cites this paper as [47]
In the citing paper
“A recent retrospective study of over 1.4 million people in Denmark over a 10-y period suggested that depressed individuals who were treated only once, or for only a short period, had a greater risk of AD than those who had chronic antidepressant use (47); chronic antidepressant use lowered the risk toward that of the general population.”
From Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans (2011) · cites this paper as [47]
In the citing paper
“Another study using a nationwide database in Denmark revealed that continued long-term antidepressant treatment was associated with a reduced rate of dementia [55].”
From Risk analysis of use of different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan (2017) · cites this paper as [55]
In the citing paper
“In contrast, other studies did link antidepressant use to increased dementia risk. 4,8-14”
From Antidepressant use in relation to dementia risk, cognitive decline, and brain atrophy (2024) · cites this paper as [13]
In the citing paper
“Long-term observational data are needed, but cohort studies to date have produced contrasting results. While various studies observed increased risk of dementia in antidepressant users, 4,8-14 several others did not. 15-19”
From Antidepressant use in relation to dementia risk, cognitive decline, and brain atrophy (2024) · cites this paper as [13]
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Cognitive impairment in the remitted state of unipolar depressive disorder: A systematic review
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“4 million people in Denmark over a 10-y period suggested that depressed individuals who were treated only once, or for only a short period, had a greater risk ofAD than thosewho had chronic antidepressant use (47); chronic antidepressant use lowered the risk toward that of the general population.”
BackgroundDepression—an underrecognized target for prevention of dementia in Alzheimer’s disease
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“In clinical studies, long-term treatment with SSRIs is associated with reduced rates of dementia and delayed AD progression (Bartels et al., 2018; Kessing et al., 2009).”
Background
Metadata
- Authors
- Kessing, L. V., Søndergård, L., Forman, J. L., & Andersen, P. K.
- Affiliations
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- University of Copenhagen (DK)
- Corresponding author
- Kessing, Lars Vedel
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 117
- Issue
- 1-2
- Pages
- 24-29
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2015172698
- Cited by
- 113
- References
- 27
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 6 · 2019: 10 · 2018: 12 · 2017: 5 · 2016: 9 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 8
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- antidepressants, dementia, Alzheimer's disease, long-term antidepressant treatment, neuroprotection, selective serotonin reuptake inhibitors, prescribing patterns, dementia risk
- MeSH terms
- Adult, Aged, Alzheimer Disease, Antidepressive Agents, Dementia, Denmark, Depressive Disorder, Female, Humans, Male, Middle Aged, Registries, Risk, Time, Comorbidity, Prevalence, Age Distribution
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