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Cited by 79Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeural and Behavioral Psychology Studies

Persistent non-verbal memory impairment in remitted major depression — Caused by encoding deficits?

Behnken, Andreas, Schöning, Sonja, Gerß, Joachim, Konrad, Carsten, de Jong-Meyer, Renate, Zwanzger, Peter, Arolt, Volker·2010·Journal of Affective Disorders
DOI 10.1016/j.jad.2009.07.010
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Abstract

Background While neuropsychological impairments are well described in acute phases of major depressive disorders (MDD), little is known about the neuropsychological profile in remission. There is evidence for episodic memory impairments in both acute depressed and remitted patients with MDD. Learning and memory depend on individuals' ability to organize information during learning. This study investigates non-verbal memory functions in remitted MDD and whether nonverbal memory performance is mediated by organizational strategies whilst learning.Methods 30 well-characterized fully remitted individuals with unipolar MDD and 30 healthy controls matching in age, sex and education were investigated. Non-verbal learning and memory were measured by the Rey-Osterrieth-Complex-Figure-Test (RCFT). The RCFT provides measures of planning, organizational skills, perceptual and non-verbal memory functions. For assessing the mediating effects of organizational strategies, we used the Savage Organizational Score.Results Compared to healthy controls, participants with remitted MDD showed more deficits in their non-verbal memory function. Moreover, participants with remitted MDD demonstrated difficulties in organizing non-verbal information appropriately during learning. In contrast, no impairments regarding visual-spatial functions in remitted MDD were observed.Limitations Except for one patient, all the others were taking psychopharmacological medication. The neuropsychological function was solely investigated in the remitted phase of MDD.Conclusions Individuals with MDD in remission showed persistent non-verbal memory impairments, modulated by a deficient use of organizational strategies during encoding. Therefore, our results strongly argue for additional therapeutic interventions in order to improve these remaining deficits in cognitive function.

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  • A significant proportion of major depressive disorder patients continue to experience significant cognitive impairment despite conventional antidepressants.

    “However, a significant proportion of MDD patients continue to experience significant cognitive impairment.”

    From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [18]

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Authors
Behnken, A., Schöning, S., Gerß, J., Konrad, C., de Jong-Meyer, R., Zwanzger, P., & Arolt, V.
Affiliations
  • University of Münster (DE)
  • Philipps University of Marburg (DE)
Corresponding author
Behnken, Andreas
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2010-04
Volume
122
Issue
1-2
Pages
144-148
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2009.07.010
OpenAlex
W2030380365
Cited by
79
References
38
Citations by year
2025: 3 · 2024: 4 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 10 · 2015: 8 · 2014: 9 · 2013: 4 · 2012: 10
FWCI
3.85
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
nonverbal memory, episodic memory, memory encoding, organizational strategy, Rey-Osterrieth Complex Figure Test, visuospatial memory, cognitive deficits in depression, neuropsychological profile
MeSH terms
Adult, Attention, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Pattern Recognition, Visual, Psychometrics, Psychomotor Performance, Reference Values, Retention, Psychology, Reproducibility of Results, Executive Function

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