Evidence for continuing neuropsychological impairments in depression
Abstract
Background Neuropsychological deficits have been reported in patients with major depressive disorder (MDD) during an acute episode of MDD. Little is known whether these abnormalities persist when patients are remitted. The purpose of the present study was to describe the neuropsychological functioning of fully remitted, unmedicated patients with a history of MDD by focusing on tasks related to prefrontal cortex functioning.Methods Twenty-eight young to middle-aged, unmedicated, fully remitted patients with MDD were compared to 23 healthy control subjects on tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) and the California Verbal Learning Test (CVLT).Results Patients with remitted MDD relative to controls were impaired on tasks of rapid visual information processing (RVIP), psychomotor performance and spatial working memory (SWM). After correction for residual depressive symptoms, deficits in sustained attention remained significant.Limitations CANTAB tasks are not equated for difficulty, and difficulty differences between the CANTAB tasks and the CVLT are not known.Conclusions These findings suggest deficits in sustained attention as vulnerability marker for MDD. The functional importance of this finding and the neuronal networks involved remain to be elucidated.
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There are many reports of cognitive impairments that remain following antidepressant treatment that successfully reduces depressive symptomatology, even when remission of depressive symptoms is obtained.
“In contrast, there are many reports of cognitive impairments that remain following antidepressant treatment that successfully reduces depressive symptomatology [19–21], even when remission of depressive symptoms is obtained [22–24].”
Different domains of global cognition might be negatively affected by class-specific antidepressant side effects.
“Despite evidence of cognitive impairment in medication-free individuals with MDD [83], different domains of global cognition might be negatively affected by class-specific antidepressant side effects.”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [83]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
An analysis of variance test for normality (complete samples)
SHAPIRO, S. S., & WILK, M. B. (1965) · Biometrika · doi:10.1093/biomet/52.3-4.591 · Cited by 23,480 · see citing works
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
Wechsler Abbreviated Scale of Intelligence
Wechsler, D. (1999) · PsycTESTS Dataset · doi:10.1037/t15170-000 · Cited by 4,681 · see citing works
Planning and spatial working memory following frontal lobe lesions in man
Owen, A. M., Downes, J. J., Sahakian, B. J., Polkey, C. E., & Robbins, T. W. (1990) · Neuropsychologia · doi:10.1016/0028-3932(90)90137-d · Cited by 1,241 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Preedy, V., & Watson, R. (2010) · Springer eBooks · doi:10.1007/978-0-387-78665-0_5485 · Cited by 1,146 · see citing works
Depression and memory impairment: A meta-analysis of the association, its pattern, and specificity.
Burt, D. B., Zembar, M. J., & Niederehe, G. (1995) · Psychological Bulletin · doi:10.1037/0033-2909.117.2.285 · Cited by 903 · see citing works
Psychomotor symptoms of depression
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.1.4 · Cited by 662 · cited 1× · see citing works
“So far, these studies have exclusively involved patients during the acute phase of MDD, and the results suggest that MDD is associated with cognitive deficits in domains of psychomotor speed (Sobin and Sackeim, 1997), memory (Burt et al.”
BackgroundOwen, A. M., Roberts, A. C., Hodges, J. R., & Robbins, T. W. (1993) · Brain · doi:10.1093/brain/116.5.1159 · Cited by 639 · see citing works
Coull, J. T., Frith, C. D., Frackowiak, R. S. J., & Grasby, P. M. (1996) · Neuropsychologia · doi:10.1016/0028-3932(96)00029-2 · Cited by 566 · see citing works
Sustained attention deficit in bipolar disorder
Clark, L., Iversen, S. D., & Goodwin, G. M. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.180.4.313 · Cited by 539 · see citing works
Neurocognitive impairment in drug-free patients with major depressive disorder
Porter, R. J., Gallagher, P., Thompson, J. M., & Young, A. H. (2003) · British Journal of Psychiatry · doi:10.1192/bjp.182.3.214 · Cited by 519 · see citing works
Functional neuroimaging studies of depression: The anatomy of melancholia
Drevets, W. C. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.341 · Cited by 500 · see citing works
Sahakian, B. J., Jones, G., Levy, R., Gray, J. A., & Warburton, D. M. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.154.6.797 · Cited by 494 · see citing works
Elliott, R., Sahakian, B. J., McKay, A. P., Herrod, J. J., Robbins, T. W., & Paykel, E. S. (1996) · Psychological Medicine · doi:10.1017/s0033291700035303 · Cited by 469 · see citing works
Sweeney, J. A., Kmiec, J. A., & Kupfer, D. J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00910-0 · Cited by 460 · see citing works
Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed
Beats, B. C., Sahakian, B. J., & Levy, R. (1996) · Psychological Medicine · doi:10.1017/s0033291700035662 · Cited by 457 · see citing works
Cornblatt, B. A., Lenzenweger, M. F., & Erlenmeyer-Kimling, L. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90188-1 · Cited by 399 · see citing works
Effort and Cognition in Depression
Cohen, R. M. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290050061012 · Cited by 383 · see citing works
Cognitive function in major depression
Austin, M., Ross, M. C., Murray, C. L., O’Carroll, R. E., Ebmeier, K. P., & Goodwin, G. M. (1992) · Journal of Affective Disorders · doi:10.1016/0165-0327(92)90089-o · Cited by 320 · see citing works
Cognitive disturbance in outpatient depressed younger adults: evidence of modest impairment
Grant, M. M., Thase, M. E., & Sweeney, J. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01072-6 · Cited by 319 · see citing works
Cognitive function in depression: a distinct pattern of frontal impairment in melancholia?
Austin, M., Mitchell, P. B., Wilhelm, K. A., Parker, G. B., Hickie, I. B., Brodaty, H., CHAN, J., Eyers, K., MILIC, M., & Hadži-Pavlović, D. (1999) · Psychological Medicine · doi:10.1017/s0033291798007788 · Cited by 293 · see citing works
Neuropsychological function in young patients with unipolar major depression
PURCELL, R., MARUFF, P., KYRIOS, M., & PANTELIS, C. (1997) · Psychological Medicine · doi:10.1017/s0033291797005448 · Cited by 281 · see citing works
Prefrontal Cortical Dysfunction in Depression Determined by Wisconsin Card Sorting Test Performance
Merriam, E. P., Thase, M. E., Haas, G. L., Keshavan, M. S., & Sweeney, J. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.780 · Cited by 278 · see citing works
A Neuropsychological Investigation of Prefrontal Cortex Involvement in Acute Mania
Clark, L., Iversen, S. D., & Goodwin, G. M. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.10.1605 · Cited by 277 · see citing works
Nebes, R. D., Pollock, B. G., Houck, P. R., Butters, M. A., Mulsant, B. H., Zmuda, M. D., & Reynolds, C. F. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(02)00085-7 · Cited by 275 · see citing works
Neuropsychological evidence for frontostriatal dysfunction in schizophrenia
Elliott, R., McKenna, P. J., Robbins, T. W., & Sahakian, B. J. (1995) · Psychological Medicine · doi:10.1017/s0033291700033523 · Cited by 267 · see citing works
Chen, W. J., Liu, S. K., Chang, C., Lien, Y.-J., Chang, Y., & Hwu, H. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.9.1214 · Cited by 260 · see citing works
Neuropsychological function in nonpsychotic unipolar major depression.
Landrø, N. I., Stiles, T. C., & Sletvold, H. (2001) · PubMed · Cited by 241 · see citing works
Data Analysis for Research Designs
Ziegel, E. R., Keppel, G., & Zedick, C. (1992) · Technometrics · doi:10.2307/1269590 · Cited by 239 · see citing works
Albus, M., Hubmann, W., Wahlheim, C., Sobizack, N., Franz, U., & Mohr, F. (1996) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1996.tb09830.x · Cited by 200 · see citing works
Prefrontal and Cerebellar Abnormalities in Major Depression: Evidence from Oculomotor Studies
Sweeney, J. A., Strojwas, M., Mann, J. J., & Thase, M. E. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00485-x · Cited by 130 · see citing works
Nelson, E. B., Sax, K. W., & Strakowski, S. M. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.1.137 · Cited by 104 · see citing works
Cognitive impairments in depression
Golinkoff, M., & Sweeney, J. A. (1989) · Journal of Affective Disorders · doi:10.1016/0165-0327(89)90032-3 · Cited by 100 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cognitive impairment in depression: a systematic review and meta-analysis
Rock, P. L., Roiser, J. P., Riedel, W. J., & Blackwell, A. D. (2014) · Psychological Medicine · doi:10.1017/s0033291713002535 · Cited by 2,161 · see citing works
Snyder, H. R. (2013) · Psychological Bulletin · doi:10.1037/a0028727 · Cited by 1,667 · see citing works
Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response
Pizzagalli, D. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.166 · Cited by 945 · see citing works
Cognitive impairment in euthymic major depressive disorder: a meta-analysis
Bora, E., Harrison, B. J., Yücel, M., & Pantelis, C. (2013) · Psychological Medicine · doi:10.1017/s0033291712002085 · Cited by 551 · see citing works
Cognitive functioning in major depression – a summary
Hammar, Å. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.026.2009 · Cited by 491 · see citing works
Attention and executive functions in remitted major depression patients
Paelecke-Habermann, Y., Pohl, J., & Leplow, B. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.09.006 · Cited by 487 · see citing works
Methamphetamine use: A comprehensive review of molecular, preclinical and clinical findings
Panenka, W. J., Procyshyn, R. M., Lecomte, T., MacEwan, G. W., Flynn, S. W., Honer, W. G., & Barr, A. M. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.11.016 · Cited by 432 · see citing works
Toward constructing an endophenotype strategy for bipolar disorders
Hasler, G., Drevets, W. C., Gould, T. D., Gottesman, I. I., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.006 · Cited by 423 · see citing works
Hinwood, M., Morandini, J., Day, T. A., & Walker, F. R. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr229 · Cited by 420 · see citing works
Cognitive impairment in the remitted state of unipolar depressive disorder: A systematic review
Hasselbalch, B. J., Knorr, U., & Kessing, L. V. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.11.011 · Cited by 406 · see citing works
Cognitive dysfunction in depression: Neurocircuitry and new therapeutic strategies
Murrough, J. W., Iacoviello, B., Neumeister, A., Charney, D. S., & Iosifescu, D. V. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.06.006 · Cited by 307 · see citing works
Self-citationCognitive dysfunction in unipolar depression: Implications for treatment
Trivedi, M. H., & Greer, T. L. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.09.012 · Cited by 294 · see citing works
Cognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works
Sleep and circadian functioning: critical mechanisms in the mood disorders?
Harvey, A. G. (2011) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032210-104550 · Cited by 237 · see citing works
Decreased hippocampal volume in healthy girls at risk of depression
Chen, M. C., Hamilton, J. P., & Gotlib, I. H. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.202 · Cited by 220 · see citing works
Reppermund, S., Ising, M., Lucae, S., & Zihl, J. (2009) · Psychological Medicine · doi:10.1017/s003329170800411x · Cited by 219 · see citing works
Longitudinal Assessment of Neuropsychological Function in Major Depression
Douglas, K. M., & Porter, R. J. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048670903279887 · Cited by 217 · see citing works
Nikolin, S., Tan, Y. Y., Schwaab, A., Moffa, A., Loo, C. K., & Martin, D. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.01.084 · Cited by 205 · see citing works
Cognitive Deficits in Depression and Functional Specificity of Regional Brain Activity
Levin, R. L., Heller, W., Mohanty, A., Herrington, J. D., & Miller, G. A. (2007) · Cognitive Therapy and Research · doi:10.1007/s10608-007-9128-z · Cited by 187 · see citing works
Woo, Y. S., Rosenblat, J. D., Kakar, R., Bahk, W.-M., & McIntyre, R. S. (2016) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2016.14.1.1 · Cited by 183 · see citing works
Wagner, S., Doering, B., Helmreich, I., Lieb, K., & Tadić, A. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01762.x · Cited by 180 · see citing works
Cognitive dysfunction in major depressive disorder: a state-of-the-art clinical review
Bortolato, B., Carvalho, A., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203823 · Cited by 181 · see citing works
Hayward, G., Goodwin, G. M., Cowen, P. J., & Harmer, C. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.016 · Cited by 162 · see citing works
Herrera-Guzmán, I., Gudayol-Ferré, E., Herrera-Guzmán, D., Guàrdia-Olmos, J., Hinojosa-Calvo, E., & Herrera-Abarca, J. E. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.10.015 · Cited by 160 · see citing works
Cognitive functioning in patients with affective disorders and schizophrenia: a meta-analysis
Stefanopoulou, E., Manoharan, A., Landau, S., Geddes, J. R., Goodwin, G., & Frangou, S. (2009) · International Review of Psychiatry · doi:10.1080/09540260902962149 · Cited by 141 · see citing works
Abnormal neural filtering of irrelevant visual information in depression
Desseilles, M., Balteau, E., Sterpenich, V., Dang-Vu, T. T., Darsaud, A., Vandewalle, G., Albouy, G., Salmon, E., Peters, F., Schmidt, C., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3341-08.2009 · Cited by 129 · see citing works
Cognitive deficits in the euthymic phase of unipolar depression
Preiss, M., Kucerova, H., Lukavsky, J., Stepankova, H., Sos, P., & Kawaciukova, R. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.06.042 · Cited by 127 · see citing works
Identifying a cognitive impairment subgroup in adults with mood disorders
Iverson, G. L., Brooks, B. L., Langenecker, S. A., & Young, A. H. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.001 · Cited by 124 · see citing works
Herrera-Guzmán, I., Herrera-Abarca, J. E., Gudayol-Ferré, E., Herrera-Guzmán, D., Gómez-Carbajal, L., Peña-Olvira, M., Villuendas-González, E., & Joan, G.-O. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.03.006 · Cited by 120 · see citing works
Memory impairment in patients with late-onset major depression: The effect of antidepressant therapy
Gallassi, R., Di Sarro, R., Morreale, A., & Amore, M. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.01.018 · Cited by 118 · see citing works
Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target
Goeldner, C., Ballard, T. M., Knoflach, F., Wichmann, J., Gatti, S., & Umbricht, D. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.08.001 · Cited by 96 · see citing works
Herrera-Guzmán, I., Gudayol-Ferré, E., Herrera-Abarca, J. E., Herrera-Guzmán, D., Montelongo-Pedraza, P., Padrós Blázquez, F., Peró-Cebollero, M., & Guàrdia-Olmos, J. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.10.009 · Cited by 94 · see citing works
Lim, J., Oh, I. K., Han, C., Huh, Y. J., Jung, I.-K., Patkar, A. A., Steffens, D. C., & Jang, B.-H. (2013) · International Psychogeriatrics · doi:10.1017/s1041610213000689 · Cited by 81 · see citing works
Working‐memory fMRI reveals cingulate hyperactivation in euthymic major depression
Schöning, S., Zwitserlood, P., Engelien, A., Behnken, A., Kugel, H., Schiffbauer, H., Lipina, K., Pachur, C., Kersting, A., Dannlowski, U., et al. (2009) · Human Brain Mapping · doi:10.1002/hbm.20702 · Cited by 81 · see citing works
Persistent non-verbal memory impairment in remitted major depression — Caused by encoding deficits?
Behnken, A., Schöning, S., Gerß, J., Konrad, C., de Jong-Meyer, R., Zwanzger, P., & Arolt, V. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.07.010 · Cited by 79 · see citing works
Herrera-Guzmán, I., Gudayol-Ferré, E., Lira-Mandujano, J., Herrera-Abarca, J., Herrera-Guzmán, D., Montoya-Pérez, K., & Guardia-Olmos, J. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2007.04.012 · Cited by 78 · see citing works
Severity of generalized social anxiety disorder correlates with low executive functioning
Fujii, Y., Kitagawa, N., Shimizu, Y., Mitsui, N., Toyomaki, A., Hashimoto, N., Kako, Y., Tanaka, T., Asakura, S., Koyama, T., et al. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.02.059 · Cited by 72 · see citing works
Silton, R. L., Heller, W., Engels, A. S., Towers, D. N., Spielberg, J. M., Edgar, J. C., Sass, S. M., Stewart, J. L., Sutton, B. P., Banich, M. T., et al. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0023204 · Cited by 70 · see citing works
Greer, T. L., Sunderajan, P., Grannemann, B. D., Kurian, B. T., & Trivedi, M. H. (2014) · Depression Research and Treatment · doi:10.1155/2014/627863 · Cited by 63 · see citing works
Soczynska, J. K., Ravindran, L. N., Styra, R., McIntyre, R. S., Cyriac, A., Manierka, M. S., & Kennedy, S. H. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.06.053 · Cited by 60 · see citing works
Relationships Among Neurocognition, Symptoms, and Functioning in Treatment-Resistant Depression
Gupta, M., Holshausen, K., Best, M. W., Jokic, R., Milev, R., Bernard, T., Gou, L., & Bowie, C. R. (2013) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/act002 · Cited by 53 · see citing works
Nagane, A., Baba, H., Nakano, Y., Maeshima, H., Hukatsu, M., Ozawa, K., Suzuki, T., & Arai, H. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.04.013 · Cited by 49 · see citing works
Cortical organization of inhibition-related functions and modulation by psychopathology
Warren, S. L., Crocker, L. D., Spielberg, J. M., Engels, A. S., Banich, M. T., Sutton, B. P., Miller, G. A., & Heller, W. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00271 · Cited by 48 · see citing works
Miskowiak, K., Vinberg, M., Christensen, E. M., & Kessing, L. V. (2012) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2012.658862 · Cited by 43 · see citing works
Neuromodulation of Attentional Control in Major Depression: A Pilot DeepTMS Study
Naim-Feil, J., Bradshaw, J. L., Sheppard, D. M., Rosenberg, O., Levkovitz, Y., Dannon, P., Fitzgerald, P. B., Isserles, M., & Zangen, A. (2016) · Neural Plasticity · doi:10.1155/2016/5760141 · Cited by 33 · see citing works
He, Z.-H., & Yin, W.-G. (2016) · The Journal of Genetic Psychology · doi:10.1080/00221325.2016.1218322 · Cited by 28 · see citing works
Almarzouki, A. F., Alghamdi, R. A., Nassar, R., Aljohani, R. R., Nasser, A., Bawadood, M., & Almalki, R. H. (2022) · Behavioral Sciences · doi:10.3390/bs12010016 · Cited by 22 · see citing works
- Authors
- Weiland-Fiedler, P., Erickson, K., Waldeck, T., Luckenbaugh, D. A., Pike, D., Bonne, O., Charney, D. S., & Neumeister, A.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Neumeister, Alexander
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 82
- Issue
- 2
- Pages
- 253-258
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2132838344
- Cited by
- 314
- References
- 34
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 17 · 2019: 8 · 2018: 14 · 2017: 11 · 2016: 18 · 2015: 24 · 2014: 21 · 2013: 26 · 2012: 20
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, remitted depression, neuropsychological deficits, sustained attention, prefrontal cortex, spatial working memory, rapid visual information processing, psychomotor performance, vulnerability indicators, residual depressive symptoms, unmedicated patients
- MeSH terms
- Adult, Attention, Cognition Disorders, Major Depressive Disorder, Diagnosis, Computer-Assisted, Female, Follow-Up Studies, Humans, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Pattern Recognition, Visual, Psychometrics, Psychomotor Performance, Reaction Time, Remission, Spontaneous, Prefrontal Cortex
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