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Cited by 13Genetic Associations and EpidemiologyMental Health Research TopicsAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

A population based family study of symptoms of anxiety and depression

Czajkowski, Nikolai, Røysamb, Espen, Reichborn-Kjennerud, Ted, Tambs, Kristian·2010·Journal of Affective Disorders
DOI 10.1016/j.jad.2010.01.006
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Abstract

Objective To estimate an upper limit on the heritability of self-reported symptoms of anxiety and depression in a large and population representative nuclear family sample. Method The ten-item symptom checklist (SCL-10) was administered as part of a health survey in a Norwegian county. The SCL-10 is a shortened version of the SCL-25, assessing symptoms of anxiety and depression. In all, 46,064 people responded, and with data from Statistics Norway, responses of first-degree relatives could be linked. Polychoric correlations between family members score on SCL-10 were calculated, and a structural equation model was fitted to these correlations using the software package R. Results All correlations between nuclear family members were in the range of 0.12 to 0.16, indicating small but significant familial influences on SCL-10. In the best fitting model, heritability was estimated at 0.25 (95% CI=0.22-0.27), and sibling specific environmental effects could be discarded. Conclusions The estimated upper level heritability for SCL-10 in our sample was lower than what has been reported in twin studies of similar measures.

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  • The heritability estimate for one-year depression risk was slightly lower than the estimate reported by Kendler and Gardner (2017), but close to heritability estimates for depressive symptoms in the past year and in the past two weeks.

    “The heritability estimate for one-year depression risk was slightly lower than the estimate reported by Kendler and Gardner (2017), but close to heritability estimates for depressive symptoms in the past year (Matthews et al., 2016) and in the past two weeks (Czajkowski, Røysamb, Reichborn-Kjennerud, & Tambs, 2010).”

    From Stressful life events increase the risk of major depressive episodes: A population-based twin study (2023) · cites this paper as Czajkowski, Røysamb, Reichborn-Kjennerud, & Tambs, 2010

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Authors
Czajkowski, N., Røysamb, E., Reichborn-Kjennerud, T., & Tambs, K.
Affiliations
Norwegian Institute of Public Health (NO)
Corresponding author
Czajkowski, Nikolai
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2010-09
Volume
125
Issue
1-3
Pages
355-360
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2010.01.006
OpenAlex
W157084806
Cited by
13
References
44
Citations by year
2025: 1 · 2023: 2 · 2022: 1 · 2020: 2 · 2015: 1 · 2014: 3 · 2012: 2
FWCI
0.54
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
Research Council of Norway
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
heritability, anxiety symptoms, depressive symptoms, family-based genetic study, nuclear family, familial aggregation, environmental effects
MeSH terms
Adult, Anxiety Disorders, Cross-Sectional Studies, Depressive Disorder, Female, Humans, Male, Middle Aged, Norway, Nuclear Family, Pedigree, Personality Inventory, Phenotype, Psychometrics, Sex Factors, Statistics as Topic, Genetic Predisposition to Disease, Young Adult

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