The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
Dimensions in major depressive disorder and their relevance for treatment outcome
Open accessAbstract
Background Major depressive disorder (MDD) is a heterogeneous disease. More homogeneous psycho(patho)logical dimensions would facilitate MDD research as well as clinical practice. The first aim of this study was to find potential dimensions within a broad psychopathological assessment in depressed patients. Second, we aimed at examining how these dimensions predicted course in MDD.Methods Ten psychopathological variables were assessed in 75 MDD inpatients. Factor and regression analyses assessed putative relations between psychopathological factors and depression severity and outcome after 8 weeks of treatment.Results A 3-factor model (eigenvalue: 54.4%) was found, representing a psychomotor change, anhedonia and negative affect factor. Anhedonia and negative affect predicted depression severity (R(2)=0.37, F=20.86, p<0.0001). Anhedonia predicted non-response (OR 6.00, CI 1.46-24.59) and both negative affect (OR 5.69, CI 1.19-27.20) and anhedonia predicted non-remission (OR 9.28, CI 1.85-46.51).Limitations The sample size of the study was relatively modest, limiting the number of variables included in the analysis.Conclusions Results confirm that psychomotor change, anhedonia and negative affect are key MDD dimensions, two of which are related to treatment outcome.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Furthermore, it was shown that anhedonia is a negative prognostic factor for treatment outcome both in adolescents (McMakin et al., 2012) and adults (Spijker et al., 2001; Vrieze et al., 2014).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Vrieze et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067
The Structured Clinical Interview for DSM-III-R (SCID): I: History, Rationale, and Description
Spitzer, R. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080032005 · Cited by 4,336
Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979
THE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION
Kessler, R. C. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.191 · Cited by 2,111 · cited 1×
“Environmental factors play an important role in MDD and it is generally assumed that stress is key feature in the etiology of MDD (Kessler, 1997).”
A scale for the assessment of hedonic tone the Snaith-Hamilton pleasure scale
Snaith, R. P., Hamilton, M., Morley, S., Humayan, A., Hargreaves, D., & Trigwell, P. (1995) · British Journal of Psychiatry · doi:10.1192/bjp.167.1.99 · Cited by 1,778
Revised NEO Personality Inventory (NEO PI-R) and NEO Five-Factor Inventory (NEO-FFI)
Costa, P. T., & McCrea, R. B. (1992) · Medical Entomology and Zoology · Cited by 1,758
Watson, D., Weber, K., Assenheimer, J. S., Clark, L. A., Strauss, M. E., & McCormick, R. A. (1995) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.104.1.3 · Cited by 1,423
Depression and cortisol responses to psychological stress: A meta-analysis
Burke, H. M., Davis, M. C., Otte, C., & Mohr, D. C. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.02.010 · Cited by 1,194
Diagnostic and Statistical Manual of Mental Disorders
Preedy, V., & Watson, R. (2010) · Springer eBooks · doi:10.1007/978-0-387-78665-0_5485 · Cited by 1,146
Discovering Endophenotypes for Major Depression
Hasler, G., Drevets, W. C., Manji, H. K., & Charney, D. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300506 · Cited by 1,123
Shafer, A. B. (2006) · Journal of Clinical Psychology · doi:10.1002/jclp.20213 · Cited by 837 · cited 1×
“The most commonly identified factors in MDD are a depression severity factor and a somatic factor (Shafer, 2006).”
Kendler, K. S., Kuhn, J., & Prescott, C. A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.631 · Cited by 799
Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task
Pizzagalli, D. A., Iosifescu, D., Hallett, L. A., Ratner, K. G., & Fava, M. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.001 · Cited by 780
Toward an objective characterization of an anhedonic phenotype: A signal-detection approach
Pizzagalli, D. A., Jahn, A. L., & O’Shea, J. P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.026 · Cited by 738
Psychomotor symptoms of depression
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.1.4 · Cited by 662 · cited 2×
“…the psychomotor change factor was not associated with depression severity at baseline and did not play a significant role in predicting clinical outcome, raising the possibility that psychomotor symptoms are more a state characteristic in MDD (Parker et al., 2000; Sobin and Sackeim, 1997).”
The Neural Correlates of Anhedonia in Major Depressive Disorder
Keedwell, P. A., Andrew, C., Williams, S. C. R., Brammer, M. J., & Phillips, M. L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.019 · Cited by 650
Reward and Punishment Processing in Depression
Eshel, N., & Roiser, J. P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.01.027 · Cited by 575
Behavioral activation and inhibition systems and the severity and course of depression.
Kasch, K. L., Rottenberg, J., Arnow, B. A., & Gotlib, I. H. (2002) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.111.4.589 · Cited by 551
Affective neuroscience and psychophysiology: Toward a synthesis
Davidson, R. J. (2003) · Psychophysiology · doi:10.1111/1469-8986.00067 · Cited by 535
Reduced Reward Learning Predicts Outcome in Major Depressive Disorder
Vrieze, E., Pizzagalli, D. A., Demyttenaere, K., Hompes, T., Sienaert, P. A., de Boer, P., Schmidt, M. E., & Claes, S. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.014 · Cited by 463
The continuity of depression in clinical and nonclinical samples.
Flett, G. L., Vredenburg, K., & Krames, L. (1997) · Psychological Bulletin · doi:10.1037/0033-2909.121.3.395 · Cited by 374
Franken, I. H. A., Rassin, E., & Muris, P. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.08.020 · Cited by 373
Meta-review of depressive subtyping models
Harald, B., & Gordon, P. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.07.015 · Cited by 328 · cited 1×
“In the past, several studies have used factor analytic strategies to identify subdimensions of MDD, based on clinical rating scales for depression and other symptom measures reflecting DSM-IV criteria (e.g., Carragher et al., 2009; Cassano et al., 2009; Harald and Gordon, 2012).”
Maternal neglect: oxytocin, dopamine and the neurobiology of attachment
Strathearn, L. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02228.x · Cited by 268 · cited 2×
“…have suggested the involvement of both oxytocinergic and dopaminergic reward systems as the neurobiological basis of neglect in childhood, associating behaviors such as anhedonia to the development of the attachment system in childhood on a neurobiological level (Strathearn, 2011; Rilling, 2013).”
Draijer, N., & Langeland, W. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.3.379 · Cited by 259
Psychomotor symptoms in depression: A diagnostic, pathophysiological and therapeutic tool
Schrijvers, D. L., Hulstijn, W., & Sabbe, B. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.10.019 · Cited by 247
The neural and hormonal bases of human parentalcare
Rilling, J. K. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.12.017 · Cited by 230
Subtypes of depression in a nationally representative sample
Carragher, N., Adamson, G., Bunting, B. P., & McCann, S. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.05.015 · Cited by 225
Konkle, A. T. M., Baker, S. L., Kentner, A. C., Barbagallo, L. S.-M., Merali, Z., & Bielajew, C. H. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.047 · Cited by 208
Defining Melancholia: Properties of a Refined Sign-Based Measure
Parker, G. B., Hadži-Pavlović, D., Wilhelm, K. A., Hickie, I. B., Brodaty, H., Boyce, P. M., Mitchell, P. B., & Eyers, K. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.164.3.316 · Cited by 185
Vulnerability to depression: A model centered on anhedonia
Loas, G. (1996) · Journal of Affective Disorders · doi:10.1016/0165-0327(96)00065-1 · Cited by 184
Genetic risk of depression and stress-induced negative affect in daily life
Wichers, M., Myin‐Germeys, I., Jacobs, N., Peeters, F. P. M. L., Kenis, G., Derom, C. A., VLIETINCK, R. F., Delespaul, P., & van Os, J. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.032201 · Cited by 179
Chen, L.-S., Eaton, W. W., Gallo, J. J., & Nestadt, G. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00132-9 · Cited by 149
Wichers, M., Schrijvers, D., Geschwind, N., Jacobs, N., Myin-Germeys, I., Thiery, E., Derom, C., Sabbe, B., Peeters, F., Delespaul, P., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291708004388 · Cited by 131
Geschwind, N., Nicolson, N. A., Peeters, F., van Os, J., Barge-Schaapveld, D., & Wichers, M. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.11.004 · Cited by 119
Insel, T. R., & Charney, D. S. (2003) · JAMA · doi:10.1001/jama.289.23.3167 · Cited by 117
Common and specific dimensions of self-reported anxiety and depression: A replication.
Steer, R. A., Clark, D. A., Beck, A. T., & Ranieri, W. F. (1995) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.104.3.542 · Cited by 98
Wichers, M., Lothmann, C., Simons, C. J. P., Nicolson, N. A., & Peeters, F. (2012) · British Journal of Clinical Psychology · doi:10.1111/j.2044-8260.2011.02021.x · Cited by 89
Psychomotor retardation and anhedonia in depression
Lemke, M. R., Puhl, P., Koethe, N., & Winkler, T. (1999) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1999.tb07221.x · Cited by 88
Restoring melancholia in the classification of mood disorders
Taylor, M. A., & Fink, M. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.05.023 · Cited by 77
Nutrition, growth, and development
Tizard, J. (1976) · Psychological Medicine · doi:10.1017/s003329170000742x · Cited by 70
Measuring extrastriatal dopamine release during a reward learning task
Vrieze, E., Ceccarini, J., Pizzagalli, D. A., Bormans, G. M., Vandenbulcke, M., Demyttenaere, K., Laere, K. V., & Claes, S. J. (2011) · Human Brain Mapping · doi:10.1002/hbm.21456 · Cited by 65
Differences between anhedonic and normally hedonic depressive states
FAWCETT, J. A., Clark, D. C., Scheftner, W. A., & Hedeker, D. (1983) · American Journal of Psychiatry · doi:10.1176/ajp.140.8.1027 · Cited by 48
The factor structure of lifetime depressive spectrum in patients with unipolar depression
Cassano, G. B., Benvenuti, A., Miniati, M., Calugi, S., Mula, M., Maggi, L., Rucci, P., Fagiolini, A. M., Perris, F., & Frank, E. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.09.006 · Cited by 48
Setting Boundaries for Psychiatric Disorders
Kendler, K. S. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.12.1845 · Cited by 37
Subtyping depression by clinical features:the Australasian database
Parker, G. B., Roy, K. T., Hadzi‐Pavlovic, D., Mitchell, P. B., Wilhelm, K. A., Menkes, D. B., Snowdon, J. A., Loo, C. K. A., & Schweitzer, I. (2000) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2000.101001021.x · Cited by 23
Anhedonia and Increased Stress Sensitivity: Two Promising Endophenotypes for Major Depression
Vrieze, E., & Claes, S. J. (2009) · Current Psychiatry Reviews · doi:10.2174/157340009788971083 · Cited by 15
Psychiatric Screening with the Comrey Personality Scales
Comrey, A. L., Soufi, A., & Backer, T. E. (1978) · Psychological Reports · doi:10.2466/pr0.1978.42.3c.1127 · Cited by 5
Introduction: Selecting an Antidepressant
Zimmerman, M. A. (2009) · CNS Spectrums · doi:10.1017/s1092852900026341 · Cited by 1
Cited by
Sorted by citations
Setiawan, E., Wilson, A. A., Mizrahi, R., Rusjan, P. M., Miler, L., Rajkowska, G., Suridjan, I., Kennedy, J. L., Rekkas, P. V., Houle, S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2427 · Cited by 939
Felger, J. C., Li, Z., Haroon, E., Woolwine, B. J., Jung, M. Y., Hu, X., & Miller, A. H. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.168 · Cited by 620
Circuit Mechanisms of Reward, Anhedonia, and Depression
Höflich, A., Michenthaler, P., Kasper, S., & Lanzenberger, R. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy081 · Cited by 253
Kessler, R. C., van Loo, H. M., Wardenaar, K. J., Bossarte, R. M., Brenner, L. A., Cai, T., Ebert, D. D., Hwang, I., Li, J. J., de Jonge, P., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.198 · Cited by 263
Anhedonia and the Brain Reward Circuitry in Depression
Heshmati, M., & Russo, S. J. (2015) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-015-0044-3 · Cited by 254
Metadata
- Authors
- Vrieze, E., Demyttenaere, K., Bruffaerts, R., Hermans, D., Pizzagalli, D. A., Sienaert, P., Hompes, T., de Boer, P., Schmidt, M., & Claes, S.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- KU Leuven (BE)
- Harvard University (US)
- Janssen (Belgium) (BE)
- Corresponding author
- Vrieze, Elske
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 155
- Pages
- 35-41
- ISSN
- 0165-0327 (ISSN-L)
- PMC
- PMC3932031
- OpenAlex
- W2102019801
- Cited by
- 138
- References
- 53
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 13 · 2023: 7 · 2022: 19 · 2021: 12 · 2020: 8 · 2019: 7 · 2018: 17 · 2017: 12 · 2016: 11 · 2015: 7 · 2014: 4
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Lirias (submittedVersion)
- Funders
- Johnson and Johnson
- National Institute of Mental Health (R01MH068376, R21MH078979, R01 MH68376)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- major depressive disorder, psychopathological dimensions, anhedonia, negative affect, psychomotor changes, treatment outcomes, treatment non-response, depression severity, hospitalized patients
- MeSH terms
- Adult, Affect, Major Depressive Disorder, Factor Analysis, Statistical, Female, Humans, Male, Middle Aged, Psychopathology, Regression Analysis, Severity of Illness Index, Treatment Outcome, Anhedonia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
