β-hydroxybutyrate alleviates depressive behaviors in mice possibly by increasing the histone3-lysine9-β-hydroxybutyrylation
Abstract
Epigenetics regulation has been considered a mechanistic interface between environmental stress stimuli and altered functioning of underlying gene network. Metabolite changes in vivo after stress contribute to histone modification. Histone3-lysine9-β-hydroxybutyrylation (H3k9bhb), a novel histone modification mark induced by β-hydroxybutyrate, may participate in the development of depression. To examine the role of H3k9bhb in depression, experiments were performed on mice and cells. H3k9bhb were reduced in the brain of depressive mice. Exogenous β-hydroxybutyrate ameliorated depressive behaviors and reversed the reduction of H3K9bhb and BDNF. We showed that H3k9bhb played a role in depression, and firstly linked BHB and BDNF via H3k9bhb. Our findings emphasized the crucial role of metabolic regulation on epigenetics in depression.
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Metabolite changes after stress contribute to histone modification.
“This study emphasized that metabolite changes after stress contribute to histone modification.191”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [191]
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- Authors
- Chen, L., Miao, Z., & Xu, X.
- Affiliations
- Second Affiliated Hospital of Soochow University (CN)
- Soochow University (CN)
- Corresponding author
- Xu, Xingshun
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 490
- Issue
- 2
- Pages
- 117-122
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2621268123
- Cited by
- 92
- References
- 37
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 10 · 2023: 16 · 2022: 7 · 2021: 14 · 2020: 10 · 2019: 6 · 2018: 4
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of China (81601154)
- Priority Academic Program Development of Jiangsu Higher Education Institutions of China
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- beta-hydroxybutyrate, depression, histone modifications, brain-derived neurotrophic factor, epigenetic regulation, metabolic regulation, depression-like behavior, brain
- MeSH terms
- Animals, Behavior, Animal, Depression, Histones, Lysine, Male, Mice, Inbred ICR, 3-Hydroxybutyric Acid, Mice
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