Cited by 92Treatment of Major DepressionEpigenetics and DNA MethylationGenomics and Chromatin Dynamics

β-hydroxybutyrate alleviates depressive behaviors in mice possibly by increasing the histone3-lysine9-β-hydroxybutyrylation

Chen, Li, Miao, Zhigang, Xu, Xingshun·2017·Biochemical and Biophysical Research Communications

Abstract

Epigenetics regulation has been considered a mechanistic interface between environmental stress stimuli and altered functioning of underlying gene network. Metabolite changes in vivo after stress contribute to histone modification. Histone3-lysine9-β-hydroxybutyrylation (H3k9bhb), a novel histone modification mark induced by β-hydroxybutyrate, may participate in the development of depression. To examine the role of H3k9bhb in depression, experiments were performed on mice and cells. H3k9bhb were reduced in the brain of depressive mice. Exogenous β-hydroxybutyrate ameliorated depressive behaviors and reversed the reduction of H3K9bhb and BDNF. We showed that H3k9bhb played a role in depression, and firstly linked BHB and BDNF via H3k9bhb. Our findings emphasized the crucial role of metabolic regulation on epigenetics in depression.

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Crossref · 10.1016/j.bbrc.2017.05.184

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Authors
Chen, L., Miao, Z., & Xu, X.
Affiliations
  • Second Affiliated Hospital of Soochow University (CN)
  • Soochow University (CN)
Corresponding author
Xu, Xingshun
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2017-08
Volume
490
Issue
2
Pages
117-122
ISSN
0006-291X (ISSN-L)
OpenAlex
W2621268123
Cited by
92
References
37
Citations by year
2026: 10 · 2025: 15 · 2024: 10 · 2023: 16 · 2022: 7 · 2021: 14 · 2020: 10 · 2019: 6 · 2018: 4
FWCI
3.82
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Science Foundation of China (81601154)
  • Priority Academic Program Development of Jiangsu Higher Education Institutions of China
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
beta-hydroxybutyrate, depression, histone modifications, brain-derived neurotrophic factor, epigenetic regulation, metabolic regulation, depression-like behavior, brain
MeSH terms
Animals, Behavior, Animal, Depression, Histones, Lysine, Male, Mice, Inbred ICR, 3-Hydroxybutyric Acid, Mice

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