Inflammatory bowel disease and bipolar disorder: A population-based cross-sectional study
Abstract
Background To date, some experimental studies showed that inflammatory bowel disease (IBD) and bipolar disorder (BD) may share similar biological pathways. Nevertheless, only a few western studies have attempted to demonstrate the potential association between IBD and BD, and relevant findings are still conflicting. Therefore, this cross-sectional study aimed to evaluate the relationship between IBD and BD using a nationwide database in Taiwan.Method This study used data from the National Health Insurance Research Database. In total, 3590 patients with IBD and 14,360 propensity score-matched comparison patients without IBD were included in this study. Conditional logistic regressions were performed to evaluate the association between BD and IBD.Results Results showed that BD was found in 26 (0.72%) patients with IBD and in 49 (0.34%) matched comparison patients without IBD. After adjustment, the adjusted odds ratio (OR) of BD for IBD patients was 2.10 (95% confidence interval (CI): 1.30∼3.38) compared to the comparison group. Additionally, this study showed that adjusted OR of BD for ulcerative colitis patients were 2.23 (95% CI: 1.31∼3.82) compared to the comparison group.Limitations we could not precisely determine the causal association between BD and IBD.Conclusions We concluded that patients with IBD were more likely to have BD than those comparison patients without IBD.
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A national cohort study conducted in Denmark presented a higher risk of bipolar disorder only in patients with CD.
“a national cohort study conducted in Denmark presented a higher risk of bipolar disorder only in patients with CD [109,110].”
From Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood (2023) · cites this paper as [110]
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- Authors
- Kao, L.-T., Lin, H.-C., & Lee, H.-C.
- Affiliations
- Tri-Service General Hospital (TW)
- Taipei Medical University Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Corresponding author
- Lee, Hsin-Chien
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 247
- Pages
- 120-124
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2909335506
- Cited by
- 36
- References
- 33
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 11 · 2022: 3 · 2021: 3 · 2020: 7
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Taipei Medical University (107TMU-SHH-14)
- Shuang-Ho Hospital
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- inflammatory bowel disease, bipolar disorder, ulcerative colitis, comorbidities, shared biological pathways, Taiwan
- MeSH terms
- Adult, Bipolar Disorder, Colitis, Ulcerative, Crohn Disease, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Risk Factors, Taiwan, Inflammatory Bowel Diseases, Logistic Models, Odds Ratio, Databases, Factual
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