Cited by 65Dementia and Cognitive Impairment ResearchAdvanced Neuroimaging Techniques and ApplicationsAlzheimer's disease research and treatments

White matter integrity linked to functional impairments in aging and early Alzheimer’s disease

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Kavcic, Voyko, Ni, Hongyan, Zhu, Tong, Zhong, Jianhui, Duffy, Charles J.·2008·Alzheimer's & Dementia

Abstract

Background: Alzheimer's disease (AD) is associated with changes in cerebral white matter (WM), but the functional significance of such findings is not yet established. We hypothesized that diffusion tensor imaging (DTI) might reveal links between regional WM changes and specific neuropsychologically and psychophysically defined impairments in early AD. Methods: Older adult control subjects (OA, n = 18) and mildly impaired AD patients (n = 14) underwent neuropsychological and visual perceptual testing along with DTI of cerebral WM. DTI yielded factional anisotropy (FA) and mean diffusivity (〈D〉) maps for nine regions of interest in three brain regions that were then compared with the performance measures. Results: AD patients exhibited nonsignificant trends toward lower FAs in the posterior region's callosal and subcortical regions of interest. However, posterior callosal FA was significantly correlated with verbal fluency and figural memory impairments, whereas posterior subcortical FA was correlated with delayed verbal memory, figural memory, and optic flow perceptual impairments. Conclusions: WM changes in early AD are concentrated in posterior cerebral areas, with distributions that correspond to specific functional impairments. DTI can be used to assess regional pathology related to individual's deficits in early AD.

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Crossref · 10.1016/j.jalz.2008.07.001

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  • Lower FADTI and higher MDDTI are most frequently reported in studies of AD.

    “Lower FADTI and higher MDDTI are most frequently reported in studies of AD (Kavcic et al., 2008; Clerx et al., 2012; Nir et al., 2013; Maggipinto et al., 2017; Mayo et al., 2017)”

    From Diffusion MRI Indices and Their Relation to Cognitive Impairment in Brain Aging: The Updated Multi-protocol Approach in ADNI3 (2019) · cites this paper as Kavcic et al., 2008

    The Results (Linking Performance and DTI; page unavailable) identify decreased FA in posterior regions as distinguishing the AD and older-adult groups. But the DTI Analyses report no statistically significant group difference in either FA or mean diffusivity after correction. The paper does not establish that higher mean diffusivity is a frequent finding across AD studies. (LLM, conf=0.82)

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Research works printed but not linked: 5

  1. [11]Kantarci K Jack CR Jr Xu YC Mild cognitive impairment and Alzheimer disease: regional diffusivity of water Radiology 2001 Apr 219 1 101 107 11274543 PMC2771587
  2. [16]Naggara O Oppenheim C Rieu D Diffusion tensor imaging in early Alzheimer's disease Psychiatry Res 2006 Apr 30 146 3 243 249 16520023
  3. [26]Mori Sususu Wakana Setsu Nagae-Poetcher Lidia M Van Zijl Peter CM MRI Atlasof Human White Matter Elsevier 2005
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Authors
Kavcic, V., Ni, H., Zhu, T., Zhong, J., & Duffy, C. J.
Affiliations
  • University of Rochester Medicine (US)
  • Tianjin First Center Hospital (CN)
Corresponding author
Kavcic, Voyko
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2008-11
Volume
4
Issue
6
Pages
381-389
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
OpenAlex
W2161291535
Cited by
65
References
58
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 6 · 2012: 6
FWCI
4.22
Type
journal article
Language
en
Open access
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Alzheimer's Association (NIRG‐04‐1074)
  • National Institute on Aging (AG17596)
  • National Eye Institute (EY10287)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, early Alzheimer's disease
MeSH terms
Aged, Aged, 80 and over, Aging, Alzheimer Disease, Brain, Cognition Disorders, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Logistic Models, Case-Control Studies

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