The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
2010 Alzheimer's disease facts and figures
Abstract
Alzheimer's disease (AD) is the seventh leading cause of all deaths in the United States and is virtually tied with the sixth leading cause of death—diabetes. AD is the fifth leading cause of death in Americans aged 65 and older. Although other major causes of death have been on the decrease, deaths because of AD have been rising dramatically. Between 2000 and 2006, heart disease deaths decreased 11.1%, stroke deaths decreased 18.2%, and prostate cancer–related deaths decreased 8.7%, whereas deaths because of AD increased 46.1%. Older African‐Americans and Hispanics are more likely than older white Americans to have AD or other dementia. Current estimates are that African‐Americans are about 2 times more likely, and Hispanics about 1.5 times more likely, than their white counterparts to have these conditions. However, the relationship of race and ethnicity to the development of AD and other dementias is complex and not fully understood. In 2009, nearly 11 million family and other unpaid caregivers provided an estimated 12.5 billion hours of care to persons with AD and other dementias; this care is valued at nearly $144 billion. Medicare payments for services to beneficiaries aged 65 years and older with AD and other dementias are three times higher than for beneficiaries without these conditions. Total payments for 2010 for health care and long‐term care services for people aged 65 and older with AD and other dementias are expected to be $172 billion (not including the contributions of unpaid caregivers). An estimated 5.3 million Americans have AD; approximately 200,000 persons under age 65 with AD comprise the younger‐onset AD population. Every 70 seconds, someone in America develops AD; by 2050 the time of every 70 seconds is expected to decrease to every 33 seconds. Over the coming decades, the baby boom population is projected to add 10 million people to these numbers. In 2050, the incidence of AD is expected to approach nearly a million people per year, with a total estimated prevalence of 11–16 million people. Dramatic increases in the numbers of “oldest old” (aged 85 years and older) across all racial and ethnic groups will also significantly affect the numbers of people living with AD. This report provides information to increase understanding of the public health effect of AD, including incidence and prevalence, mortality, costs of care, and effect on caregivers and society in general. This report also sets the stage for better understanding the relationship between race and ethnicity and the development of AD and other dementias.
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Citations
Cites
Mixed brain pathologies account for most dementia cases in community-dwelling older persons
Schneider, J. A., Arvanitakis, Z., Bang, W., & Bennett, D. A. (2007) · Neurology · doi:10.1212/01.wnl.0000271090.28148.24 · Cited by 1,992
Prevalence of Dementia in the United States: The Aging, Demographics, and Memory Study
Plassman, B. L., Langa, K. M., Fisher, G. G., Heeringa, S. G., Weir, D. R., Ofstedal, M. B., Burke, J. R., Hurd, M. D., Potter, G. G., Rodgers, W. L., et al. (2007) · Neuroepidemiology · doi:10.1159/000109998 · Cited by 1,932
Is caregiving hazardous to one’s physical health? A meta-analysis
Vitaliano, P. P., Zhang, J., & Scanlan, J. M. (2003) · Psychological Bulletin · doi:10.1037/0033-2909.129.6.946 · Cited by 1,734 · cited 1×
“Family and other unpaid caregivers of people with AD and other dementias are more likely than noncaregivers to report that their health is fair or poor [64,65].”
Influence of education and occupation on the incidence of Alzheimer's disease
Stern, Y. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03510370056032 · Cited by 1,434
Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease
Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., Helkala, E.-L., Tuomilehto, J., Soininen, H., & Nissinen, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1556 · Cited by 1,291
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function
Arvanitakis, Z., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.661 · Cited by 1,258
Slowing of wound healing by psychological stress
Kiecolt-Glaser, J. K., Marucha, P. T., Mercado, A. M., Malarkey, W. B., & Glaser, R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92899-5 · Cited by 1,104
Patient and Caregiver Characteristics and Nursing Home Placement in Patients With Dementia
Yaffe, K. (2002) · JAMA · doi:10.1001/jama.287.16.2090 · Cited by 903
Dementia and Alzheimer Disease Incidence: A Prospective Cohort Study
Kukull, W. A., Higdon, R., Bowen, J. D., McCormick, W. C., Teri, L., Schellenberg, G. D., van Belle, G., Jolley, L., & Larson, E. B. (2002) · Archives of Neurology · doi:10.1001/archneur.59.11.1737 · Cited by 806
Vascular risk factors for Alzheimer’s disease:
Breteler, M. M. B. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00110-4 · Cited by 664
Solomon, A., Kivipelto, M., Wolozin, B., Zhou, J., & Whitmer, R. A. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000231980 · Cited by 557
Mortality after the Hospitalization of a Spouse
Christakis, N. A., & Allison, P. D. (2006) · New England Journal of Medicine · doi:10.1056/nejmsa050196 · Cited by 501
A Path Model of Chronic Stress, the Metabolic Syndrome, and Coronary Heart Disease
Vitaliano, P. P., Scanlan, J. M., Zhang, J., Savage, M. V., Hirsch, I. B., & Siegler, I. C. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200205000-00006 · Cited by 481 · cited 1×
“Family and other unpaid caregivers of people with AD or other dementia are more likely than non-caregivers to have high levels of stress hormones [66–68], reduced immune function [66,69], slow wound healing [70], new hypertension [71], and new coronary heart disease [72].”
Annual Incidence of Alzheimer Disease in the United States Projected to the Years 2000 Through 2050
Hebert, L. E., Beckett, L. A., Scherr, P. A., & Evans, D. A. (2001) · Alzheimer Disease and Associated Disorders · doi:10.1097/00002093-200110000-00002 · Cited by 467
Prevalence of Dementia in Older Japanese-American Men in Hawaii: The Honolulu-Asia Aging Study
White, L. (1996) · JAMA · doi:10.1001/jama.1996.03540120033030 · Cited by 437
Evans, D. A., Hebert, L. E., Beckett, L. A., Scherr, P. A., Albert, M. S., Chown, M. J., Pilgrim, D. M., & Taylor, J. O. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550230066019 · Cited by 435
Vascular risk factors and dementia: How to move forward?
Viswanathan, A., Rocca, W. A., & Tzourio, C. (2009) · Neurology · doi:10.1212/01.wnl.0000341271.90478.8e · Cited by 414
Long-term Care Placement of Dementia Patients and Caregiver Health and Well-being
Schulz, R. (2004) · JAMA · doi:10.1001/jama.292.8.961 · Cited by 388
Evans, D. A., Bennett, D. A., Wilson, R. S., Bienias, J. L., Morris, M. C., Scherr, P. A., Hebert, L. E., Aggarwal, N., Beckett, L. A., Joglekar, R., et al. (2003) · Archives of Neurology · doi:10.1001/archneur.60.2.185 · Cited by 370
Is the Risk of Developing Alzheimer's Disease Greater for Women than for Men?
Hebert, L. E., Scherr, P. A., McCann, J. J., Beckett, L. A., & Evans, D. A. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.2.132 · Cited by 331
The NIH Cognitive and Emotional Health Project: Report of the Critical Evaluation Study Committee
Hendrie, H. C., Albert, M. S., Butters, M. A., Gao, S., Knopman, D. S., Launer, L. J., Yaffe, K., Cuthbert, B. N., Edwards, E., & Wagster, M. V. (2006) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2005.11.004 · Cited by 323
Life stress, mood disturbance, and elevated interleukin-6 in healthy older women
Lutgendorf, S. K., Garand, L., Buckwalter, K. C., Reimer, T. T., Hong, S.-Y., & Lubaroff, D. M. (1999) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/54.9.m434 · Cited by 305 · cited 1×
“Family and other unpaid caregivers of people with AD or other dementia are more likely than non-caregivers to have high levels of stress hormones [66–68], reduced immune function [66,69], slow wound healing [70], new hypertension [71], and new coronary heart disease [72].”
Potter, G. G., Plassman, B. L., Burke, J. R., Kabeto, M. U., Langa, K. M., Llewellyn, D. J., Rogers, M. A. M., & Steffens, D. C. (2009) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2009.04.1234 · Cited by 209
Determinants of vascular dementia in the Cardiovascular Health Cognition Study
Kuller, L. H., Lopez, O. L., Jagust, W. J., Becker, J. T., DeKosky, S. T., Lyketsos, C., Kawas, C., Breitner, J. C. S., Fitzpatrick, A., & Dulberg, C. (2005) · Neurology · doi:10.1212/01.wnl.0000160115.55756.de · Cited by 179 · cited 1×
“High blood pressure and diabetes are treatable conditions, and many researchers and clinicians have proposed that treatment of these diseases, especially if it were begun in people who have the conditions in midlife, could reduce the prevalence of AD and other dementias [29,127,129,130,134,137].”
Gender, cognitive decline, and risk of AD in older persons
Barnes, L. L., Wilson, R. S., Schneider, J. A., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2003) · Neurology · doi:10.1212/01.wnl.0000065892.67099.2a · Cited by 173
Rocca, W. A., Cha, R. H., Waring, S. C., & Kokmen, E. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009560 · Cited by 160
Port, C. L., Zimmerman, S., Williams, C. S., Dobbs, D., Preisser, J. S., & Williams, S. W. (2005) · The Gerontologist · doi:10.1093/geront/45.suppl_1.87 · Cited by 144
Diagnosis and assessment of Alzheimer's disease in diverse populations
Dilworth‐Anderson, P., Hendrie, H. C., Manly, J. J., Khachaturian, A. S., & Fazio, S. (2008) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2008.03.001 · Cited by 139
Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124
Ives, D. G., Samuel, P., Psaty, B. M., & Kuller, L. H. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02056.x · Cited by 108
Acute Care Utilization by Dementia Caregivers Within Urban Primary Care Practices
Schubert, C. C., Boustani, M., Callahan, C. M., Perkins, A. J., Hui, S., & Hendrie, H. C. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0711-0 · Cited by 107
Cited by
Epidemiology of Alzheimer disease
Reitz, C., Brayne, C., & Mayeux, R. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.2 · Cited by 1,675
Monetary Costs of Dementia in the United States
Hurd, M. D., Martorell, P., Delavande, A., Mullen, K. J., & Langa, K. M. (2013) · New England Journal of Medicine · doi:10.1056/nejmsa1204629 · Cited by 1,484
Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences
Mielke, M., Vemuri, P., & Rocca, W. (2014) · Clinical Epidemiology · doi:10.2147/clep.s37929 · Cited by 1,021
Oxidative Stress and the Pathogenesis of Alzheimer's Disease
Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855
Molecular mechanisms of neurodegeneration in Alzheimer's disease
Crews, L., & Masliah, E. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq160 · Cited by 772
Metadata
- Authors
- Alzheimer's Association
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2010-03
- Volume
- 6
- Issue
- 2
- Pages
- 158-194
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W4243693606
- Cited by
- 684
- References
- 31
- FWCI
- 59.42
- Type
- journal article
- Language
- en
- Open access
- closed
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