Incidence of Dementia and Alzheimer's Disease: A Reanalysis of Data from Rochester, Minnesota, 1975-1984
Abstract
For both dementia and Alzheimer's disease (AD), data regarding incidence rates in the oldest old and time trends in incidence are limited. The authors reanalyzed previously reported data on the incidence of dementia and AD in Rochester, Minnesota, from 1975 through 1984, using three new strategies. First, incidence rates were corrected by removing age-, sex-, and calendar year-specific prevalent cases from the census-derived denominator figures. Second, incidence figures for persons above age 84 years were disaggregated. Third, time trends were investigated graphically using age-specific curves and birth cohort curves. Dementia diagnosis and AD diagnosis followed defined ad hoc criteria. Analyses were conducted for men, women, and both sexes combined, and for dementia and AD separately. The age-specific incidence rates were similar in men and women, continued to increase after age 84 years, and remained stable over time for both dementia and AD. No birth cohort effect was present for either dementia or AD. The similar risks seen in men and women, the continuing increase in incidence after age 84 years, and the stability of incidence over time have important implications for etiologic research on AD.
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The incidence of dementia increases continually up to and above 90 years of age.
“The incidence of dementia increases continually up to (179-183) and above (139, 184) 90 years of age.”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [180]
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Incidence of Vascular Dementia in Rochester, Minn, 1985-1989
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Sex differences in chronic stress responses and Alzheimer's disease
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Time trends in the incidence of parkinsonism in Olmsted County, Minnesota
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Designing a large prevention trial: statistical issues
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A Mathematical Model of Alzheimer's Disease and the Apoe Gene
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1 Prevalence and projections of dementia
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- Authors
- Rocca, W. A., Cha, R. H., Waring, S. C., & Kokmen, E.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Rocca, W. A.
- ORCID
- Waring, S. C.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-07-01
- Volume
- 148
- Issue
- 1
- Pages
- 51-62
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2154275547
- Cited by
- 160
- References
- 28
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 1 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 13 · 2013: 8 · 2012: 9
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG-08031, P30AG008031, AG-06786, U01AG006786)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR030582, AR30582)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Keywords
- dementia, Alzheimer's disease, incidence rates, oldest old, age-specific incidence, temporal trends, birth cohort effects, sex differences, Rochester, Minnesota, dementia etiology
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Dementia, Female, Humans, Male, Middle Aged, Minnesota, Incidence, Age Distribution, Sex Distribution
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