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Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative
Abstract
Background: Numerous studies show that the cerebrospinal fluid biomarkers total tau (T‐tau), tau phosphorylated at threonine 181 (P‐tau 181P), and amyloid‐β (1‐42) (Aβ 1–42) have high diagnostic accuracy for Alzheimer's disease. Variability in concentrations for Aβ 1–42, T‐tau, and P‐tau 181P drives the need for standardization. Methods: Key issues were identified and discussed before the first meeting of the members of the Alzheimer's Biomarkers Standardization Initiative (ABSI). Subsequent ABSI consensus meetings focused on preanalytical issues. Results: Consensus was reached on preanalytical issues such as the effects of fasting, different tube types, centrifugation, time and temperature before storage, storage temperature, repeated freeze/thaw cycles, and length of storage on concentrations of Aβ 1–42, T‐tau, and P‐tau 181P in cerebrospinal fluid. Conclusions: The consensus reached on preanalytical issues and the recommendations put forward during the ABSI consensus meetings are presented in this paper.
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“A subset of ADRC participants (N = 70) underwent lumber puncture with standardized procedures, preanalytical preparation, and storage of cerebrospinal fluid in accordance with the recommended best practices [31].”
From Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status (2024) · cites this paper as [31]
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Metadata
- Authors
- Vanderstichele, H., Bibl, M., Engelborghs, S., Le Bastard, N., Lewczuk, P., Molinuevo, J. L., Parnetti, L., Perret‐Liaudet, A., Shaw, L. M., Teunissen, C., Wouters, D., & Blennow, K.
- Affiliations
- Fujirebio (Belgium) (BE)
- Kliniken Essen-Mitte (DE)
- University of Antwerp (BE)
- Department of Neurology and Memory Clinic, Middelheim and Hoge Beuken Hospital Network Antwerp (ZNA) Antwerp Belgium
- Universitätsklinikum Erlangen (DE)
- Alzheimer's Disease and Other Cognitive Disorders Unit Hospital Clinic i Universitari Barcelona Spain
- University of Perugia (IT)
- Lyon 1 Université (FR)
- University of Pennsylvania (US)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- Corresponding author
- Blennow, Kaj
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2011-11-03
- Volume
- 8
- Issue
- 1
- Pages
- 65-73
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W2141318707
- Cited by
- 358
- References
- 63
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 33 · 2023: 21 · 2022: 22 · 2021: 29 · 2020: 33 · 2019: 14 · 2018: 19 · 2017: 23 · 2016: 26 · 2015: 42 · 2014: 30 · 2013: 17 · 2012: 23
- FWCI
- 15.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Pure Amsterdam UMC (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Keywords
- Alzheimer's disease, cerebrospinal fluid biomarkers
- MeSH terms
- Alzheimer Disease, Humans, Peptide Fragments, Quality Control, Reproducibility of Results, Biomarkers, Amyloid beta-Peptides, tau Proteins, Guidelines as Topic
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