Cited by 260Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchCerebrospinal fluid and hydrocephalus

Fluctuations of CSF amyloid-β levels: Implications for a diagnostic and therapeutic biomarker

Bateman, Randall J., Wen, Guolin, Morris, John C., Holtzman, David M.·2007·Neurology

Abstract

OBJECTIVE: To investigate the stability and time course of human CSF amyloid-beta (Abeta) levels over hours. METHODS: Fifteen nondemented participants had CSF sampled hourly for up to 36 hours via indwelling lumbar catheter. CSF Abeta(1-x), Abeta(1-40), and Abeta(1-42) were measured by ELISA in each hourly CSF sample. RESULTS: Significant variation in Abeta levels of 1.5- to fourfold was detected over 36 hours of serially sampling in individual subjects. Abeta(40), Abeta(42), and Abeta(1-X) are highly correlated over time indicating that similar processes likely regulate the level of these species. On average, the fluctuations of Abeta levels appear to be time of day or activity dependent. CONCLUSION: Diagnostic and therapeutic trials that measure Abeta should control for the time of CSF sampling to minimize variability.

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Crossref · 10.1212/01.wnl.0000256043.50901.e3

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17 of 17 references verified0 citation errors · 0 not checkable

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Authors
Bateman, R. J., Wen, G., Morris, J. C., & Holtzman, D. M.
Affiliations
Washington University in St. Louis (US)
Venue
Neurology
Published
2007-02-27
Volume
68
Issue
9
Pages
666-669
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
OpenAlex
W2129379145
Cited by
260
References
17
Citations by year
2026: 4 · 2025: 9 · 2024: 13 · 2023: 9 · 2022: 8 · 2021: 5 · 2020: 10 · 2019: 10 · 2018: 8 · 2017: 16 · 2016: 16 · 2015: 17 · 2014: 15 · 2013: 12 · 2012: 15
FWCI
15.34
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsches Krebsforschungszentrum
  • National Institute on Aging (L30 AG024455, K08AG027091, P50AG005681, P01AG003991)
  • National Center for Research Resources (MO1RR00036, M01RR000036)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
Keywords
cerebrospinal fluid, amyloid-beta, Aβ40, amyloid-beta 42, temporal variation, Alzheimer's disease biomarkers
MeSH terms
Adult, Aged, Alzheimer Disease, Female, Humans, Male, Middle Aged, Reference Values, Sensitivity and Specificity, Time Factors, Reproducibility of Results, Biomarkers, Amyloid beta-Peptides

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