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Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study
Open accessAbstract
Introduction: The trends in prevalence and incidence of Alzheimer's disease (AD) dementia remain uncertain. Methods: A sample of 2794 participants with a clinical diagnosis for AD dementia were included. Results: The 2010 census standardized prevalence of AD dementia was 14.5% (95% CI = 13.7–15.3), and annual incidence was 2.3% (1.7–2.9). Both prevalence and incidence showed substantial variation over time, but no secular trends. The prevalence of AD dementia did not change significantly from 14.6% (95% CI = 13.0, 16.2) in 1994–1997 to 14.7% (95% CI = 13.2, 16.2) in 2010–2012 (P = .84). The annual incidence of AD dementia was 2.8% (95% CI = 2.2, 3.2) in 1998–2000 and 2.2% (95% CI = 1.6, 2.8) in 2004–2006 (P = .20) and remained steady in 2010–2012. The prevalence and incidence among African Americans were approximately twice than those among European Americans. Conclusions: The prevalence and incidence of AD dementia showed substantial variation between 1994 and 2012, but no secular trend.
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“in 2011 the average annual incidence in people age 65 to 74 was 0.4% (meaning four of every 1,000 people age 65 to 74 developed Alzheimer's dementia in 2011); in people age 75 to 84, the annual incidence was 3.2% (32 of every 1,000 people); and in people age 85 and older, the incidence was 7.6% (76 of every 1,000 people).259”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [259]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“approximately 910,000 people age 65 or older developed Alzheimer's dementia in the United States in 2011, a number that would be expected to be even higher in 2023 if CHAP estimates were available for that year.259”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [259]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Most other prevalence studies also indicate that Black older adults are about twice as likely to have Alzheimer's or other dementias as White older adults.”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [259]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“According to estimates using data from the CHAP study and the U.S. Census Bureau, approximately 910,000 people age 65 or older developed Alzheimer's dementia in the U.S. in 2011, a number that would be expected to be even higher in 2024 if CHAP estimates were available for that year.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [284]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The rate at which new cases of Alzheimer's develop increases dramatically with age: according to estimates from CHAP, in 2011 the average annual incidence in people age 65 to 74 was 0.4% (meaning four of every 1,000 people age 65 to 74 developed Alzheimer's dementia in 2011); in people age 75 to 84, the annual incidence was 3.2% (32 of every 1,000 people); and in people age 85 and older, the incid”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [284]
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“In line with these observations, most other prevalence studies indicate that Black older adults are about twice as likely to have Alzheimer's or other dementias as White older adults.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [284]
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Citations
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BackgroundDementia incidence declined in African‐Americans but not in Yoruba
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Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
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Metadata
- Authors
- Rajan, K. B., Weuve, J., Barnes, L. L., Wilson, R. S., & Evans, D. A.
- Affiliations
- University of California, Davis (US)
- Boston University (US)
- Rush University Medical Center (US)
- Rush University (US)
- Corresponding author
- Rajan, Kumar B.
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2018-09-06
- Volume
- 15
- Issue
- 1
- Pages
- 1-7
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC6531287
- OpenAlex
- W2891083286
- Cited by
- 245
- References
- 21
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 47 · 2023: 38 · 2022: 36 · 2021: 37 · 2020: 29 · 2019: 17 · 2018: 1
- FWCI
- 16.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (RF1-AG057532, R01-AG051635, R01-AG11101)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- Alzheimer's disease, dementia
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Black or African American, Female, Humans, Male, Prospective Studies, Risk Factors, United States, Incidence, Prevalence, White People
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