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COVID-19 infection: Emergence, transmission, and characteristics of human coronaviruses

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Shereen, Muhammad Adnan, Khan, Suliman, Kazmi, Abeer, Bashir, Nadia, Siddique, Rabeea·2020·Journal of Advanced Research
DOI 10.1016/j.jare.2020.03.005
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Abstract

The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China and spread around the world. Genomic analysis revealed that SARS-CoV-2 is phylogenetically related to severe acute respiratory syndrome-like (SARS-like) bat viruses, therefore bats could be the possible primary reservoir. The intermediate source of origin and transfer to humans is not known, however, the rapid human to human transfer has been confirmed widely. There is no clinically approved antiviral drug or vaccine available to be used against COVID-19. However, few broad-spectrum antiviral drugs have been evaluated against COVID-19 in clinical trials, resulted in clinical recovery. In the current review, we summarize and comparatively analyze the emergence and pathogenicity of COVID-19 infection and previous human coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). We also discuss the approaches for developing effective vaccines and therapeutic combinations to cope with this viral outbreak.

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Metadata

Authors
Shereen, M. A., Khan, S., Kazmi, A., Bashir, N., & Siddique, R.
Venue
Journal of Advanced Research
Publisher
Elsevier BV
Published
2020-07
Volume
24
Pages
91-98
ISSN
  • 2090-1224 (ISSN-L)
  • 2090-1232
DOI
10.1016/j.jare.2020.03.005
OpenAlex
W3012189167
Cited by
3,536
References
10
FWCI
95.61
Type
journal article
Language
en
Open access
gold
Licence

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CoChat. (2026). Citation check: COVID-19 infection: Emergence, transmission, and characteristics of human coronaviruses. https://app.cochat.ai/papers/10.1016/j.jare.2020.03.005
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Shereen, M. A., Khan, S., Kazmi, A., Bashir, N., & Siddique, R. (2020). COVID-19 infection: Emergence, transmission, and characteristics of human coronaviruses. Journal of Advanced Research. https://doi.org/10.1016/j.jare.2020.03.005

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