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Improved mammalian retromer cryo-EM structures reveal a new assembly interface

Kendall, Amy K., Chandra, Mintu, Xie, Boyang, Wan, William, Jackson, Lauren P.·2022·Journal of Biological Chemistry
DOI 10.1016/j.jbc.2022.102523PMC PMC9636581

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Crossref · 10.1016/j.jbc.2022.102523

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  • This interaction is unique to Retriever, as Retromer uses distinct surfaces to interact with adaptors, such as SNX3 and SNX27, or directly with cargoes, such as DMT1.

    “This interaction is unique to Retriever, as Retromer uses distinct surfaces to interact with adaptors, such as SNX3 and SNX27, or directly with cargoes, such as DMT126,29,34”

    From Structural basis for Retriever-SNX17 assembly and endosomal sorting (2024) · cites this paper as [34]

    The paper’s introductory text (labeled Abstract in our copy; no page number available) says retromer binds SNX3 and SNX27 and has been implicated in direct cargo recognition. It does not identify DMT1 as a directly bound cargo or establish that retromer uses distinct surfaces for those interactions. Nor does it establish that the interaction described by the citing paper is unique to Retriever. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • The precise mechanisms of cargo selection by Retriever have remained elusive.

    “Unlike the well-studied Retromer25,26,34, the precise mechanisms of cargo selection by Retriever have remained elusive37.”

    From Structural basis for Retriever-SNX17 assembly and endosomal sorting (2024) · cites this paper as [34]

    The paper’s introductory discussion (page unavailable) mentions Retriever only to identify VPS26C as a subunit of that complex. A search for Retriever and cargo-selection mechanisms found no passage in our copy saying whether those mechanisms remain elusive; the paper’s cargo-recognition discussion concerns Retromer instead. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Metadata

Authors
Kendall, A. K., Chandra, M., Xie, B., Wan, W., & Jackson, L. P.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2022-11
Volume
298
Issue
11
Pages
102523
ISSN
0021-9258
DOI
10.1016/j.jbc.2022.102523
PMC
PMC9636581
Cited by
18
References
2
Language
en
Licence
Funders
  • NIH (U24 GM129539, R35GM119525, DP2GM146321)
  • Vanderbilt University
  • Simons Foundation (SF349247, R35GM119525, DP2GM146321)

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