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Cited by 34

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex

Chen, Kai-En, Guo, Qian, Hill, Timothy A., Cui, Yi, Kendall, Amy K., Yang, Zhe, Hall, Ryan J., Healy, Michael D., Sacharz, Joanna, Norwood, Suzanne J., Fonseka, Sachini, Xie, Boyang, Reid, Robert C., Leneva, Natalya, Parton, Robert G., Ghai, Rajesh, Stroud, David A., Fairlie, David P., Suga, Hiroaki, Jackson, Lauren P., Teasdale, Rohan D., Passioura, Toby, Collins, Brett M.·2021·Science Advances
DOI 10.1126/sciadv.abg4007PMC PMC8635440
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Abstract

Novel macrocyclic peptides are found that bind and modulate the function of the retromer membrane trafficking complex.

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Crossref · 10.1126/sciadv.abg4007

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6 of 6 references verified0 citation errors · 0 not checkable

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  • This explains why synthetic macrocyclic peptides targeting the conserved pocket on VPS29 interact with Retromer but not Retriever.

    “which also explains why synthetic macrocyclic peptides targeting the conserved pocket on VPS29 interact with Retromer but not Retriever.44”

    From Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome (2023) · cites this paper as [44]

    The Results section reports that the macrocyclic peptides bind a conserved groove on VPS29 and interact with Retromer. The Discussion does not establish that they fail to interact with Retriever; it says the peptides may be useful for studying Retriever and that accessibility of the VPS29 binding site in that complex remains unconfirmed. Page numbers were not provided in our copy's passages. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • Stabilisation of Retromer expression is neuroprotective.

    “with stabilisation of Retromer expression being neuroprotective [49][50][51][52].”

    From Global identification of neuronal and astrocytic integral membrane proteins that require Retromer for their endosomal recycling (2026) · cites this paper as [49]

    The Introduction (page not provided) describes retromer as neuroprotective and reports that stabilizing it in cells reduces toxic-protein accumulation in disease models. It discusses stabilization of retromer’s structure and function, however, not stabilization of its expression; that specific part of the claim is unsupported. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Metadata

Authors
Chen, K.-E., Guo, Q., Hill, T. A., Cui, Y., Kendall, A. K., Yang, Z., Hall, R. J., Healy, M. D., Sacharz, J., Norwood, S. J., Fonseka, S., Xie, B., Reid, R. C., Leneva, N., Parton, R. G., Ghai, R., Stroud, D. A., Fairlie, D. P., Suga, H., Jackson, L. P., Teasdale, R. D., Passioura, T., & Collins, B. M.
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2021-12-03
Volume
7
Issue
49
ISSN
2375-2548
DOI
10.1126/sciadv.abg4007
PMC
PMC8635440
Cited by
34
References
6
Language
en

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