Cited by 400Mindfulness and Compassion InterventionsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPersonality Disorders and Psychopathology

Examining psychological inflexibility as a transdiagnostic process across psychological disorders

Open access
Levin, Michael E., MacLane, Chelsea, Daflos, Susan, Seeley, John R., Hayes, Steven C., Biglan, Anthony, Pistorello, Jacqueline·2014·Journal of Contextual Behavioral Science

Abstract

The current cross-sectional study examined psychological inflexibility, a process in which behavior is rigidly guided by psychological reactions rather than direct contingencies or personal values, as a transdiagnostic process relevant to a range of depressive, anxiety, substance use and eating disorders. A sample of 972 first-year college students between 17 and 20 years of age completed self-report measures of psychological inflexibility and psychological distress as well as a structured diagnostic interview. Psychological inflexibility was significantly higher across a range of current and lifetime depressive and anxiety disorders as well as lifetime history of eating disorders, relative to students with no disorder, even after controlling for general psychological distress. Findings were mixed for substance use disorders, with a more consistent pattern for lifetime history than for current disorders. Psychological inflexibility was also related to having comorbid depressive, anxiety, and substance use disorders relative to only having one of these diagnoses. Results are discussed in relation to research on psychological inflexibility as a transdiagnostic pathological process and target for interventions. © 2014 Association for Contextual Behavioral Science.

Integrity signals

Registry

Crossref · 10.1016/j.jcbs.2014.06.003

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

1 of 2 cited sources checked · 1 supported · 0 flagged

  • Method

    The AAQ-II was used as a 7-item measure of psychological inflexibility and experiential avoidance.

    “The AAQ-II is a 7 item measure of psychological inflexibility and experiential avoidance.”
    Quote in the paperNot yet classified1 of 1 sources checked
    • cites Bond et al., 2011 source
  • Finding

    The AAQ-II was not significantly related to current substance use disorders or to alcohol abuse, drug abuse, or drug dependence.

    “The AAQ-II was not significantly related to having any current substance use disorder or specifically alcohol abuse, drug abuse, or drug dependence.”
    Quote in the paperNot yet classified
  • Finding

    For current depressive and anxiety disorders, comorbid cases were more psychologically inflexible than cases with only one of the two disorder classes.

    “participants with comorbid current depressive and anxiety disorders were significantly more psychologically inflexible than participants with only a current anxiety disorder”
    Quote in the paperNot yet classified
  • Finding

    After controlling for general psychological distress, current depressive-anxiety comorbidity was no longer significantly associated with AAQ-II scores.

    “There was no significant effect for current comorbidity status after controlling for general psychological distress as a covariate (p = .37).”
    Quote in the paperNot yet classified
  • Finding

    The authors argue that the findings provide preliminary support for psychological inflexibility as a transdiagnostic theoretical model, especially for depression and anxiety disorders.

    “The results from the current study provide preliminary support for this transdiagnostic theoretical model, particularly in the domain of depression and anxiety disorders, by demonstrating that individuals with a variety of specific psychological disorders report similarly elevated levels of psychological inflexibility.”
    Quote in the paperNot yet classified

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • EA predicts a range of specific anxiety disorders over and above general distress measures.

    “EA has been found to predict anxiety disorders up to two years later (Spinhoven et al., 2014), to predict a range of specific anxiety disorders over and above general distress measures (e.g., Levin, MacLane, et al., 2014) and over and above other known predictors such as anxiety sensitivity (e.g., Gloster et al., 2013).”

    From Examining the Role of Implicit Emotional Judgments in Social Anxiety and Experiential Avoidance (2017) · cites this paper as Levin, MacLane, et al., 2014

    The Results (Relationship of AAQ-II to Depressive, Anxiety, Substance Use and Eating Disorders; page unavailable) report associations between psychological inflexibility and several specific anxiety disorders after controlling for general distress (GHQ). The Discussion calls the study cross-sectional and describes these as relationships, not evidence that experiential avoidance predicts subsequent diagnoses. (LLM, conf=0.84)

    Experimental — accuracy not yet measured
  • PI is related to a range of current and lifetime depressive and anxiety disorders in a clinical sample of young adults (17-20 years old).

    “PI was also found to relate to a range of both current and lifetime depressive and anxiety disorders in a clinical sample of young adults (17–20 years old; Levin et al., 2014).”

    From Psychological inflexibility explains social anxiety over time: a mediation analyses with a clinical adolescent sample (2024) · cites this paper as Levin et al., 2014

    The Discussion reports that psychological inflexibility was related to a range of current and lifetime depressive and anxiety disorders, and the paper identifies participants as 17–20-year-old first-year college students. But the Discussion explicitly calls this a non-clinical sample and says it is unclear whether the findings generalize to treatment-seeking clinical populations. Page numbers were not supplied in the passages. (LLM, conf=0.94)

    Experimental — accuracy not yet measured
  • The negative influence of psychological inflexibility, such as avoidance and cognitive fusion, was verified, further supporting the adaptive aspect of psychological flexibility.

    “the negative influence of psychological inflexibility, such as avoidance and cognitive fusion, was verified, further supporting the adaptive aspect of psychological flexibility”

    From Acceptance and commitment therapy reduces psychological distress in patients with cancer: a systematic review and meta-analysis of randomized controlled trials (2024) · cites this paper as Levin et al., 2014

    The Discussion reports elevated psychological inflexibility among people with several disorders, supporting an association with poorer psychological functioning. But it describes the findings as preliminary and says the cross-sectional design cannot establish whether inflexibility contributed to psychopathology. It also notes that the measure emphasized experiential avoidance rather than cognitive fusion; the study did not separately verify cognitive fusion’s negative influence or directly test the adaptive effects of flexibility. (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • Psychological inflexibility is a transdiagnostic dimension associated with psychological distress and poor mental health and quality of life.

    “Psychological inflexibility is a transdiagnostic dimension associated to psychological distress and poor mental health and quality of life.”

    From Spanish adaptation of the experiential approach scale (Eas) (2021) · cites this paper as [11]

    The Discussion describes psychological inflexibility as a dimensional, transdiagnostic process associated with a variety of psychological disorders, even after controlling for general psychological distress. The Methods identify distress as a measured covariate. The passages do not report an association with quality of life, so that part of the claim is unsupported. (LLM, conf=0.85)

    Experimental — accuracy not yet measured
  • Psychological inflexibility underlies a range of psychopathologies, including anxiety and mood disorders.

    “PI underlies a range of psychopathologies, including anxiety and mood disorders (Bluett et al., 2014; Levin et al., 2014)”

    From Associations between psychological inflexibility processes, pre‐sleep arousal and sleep quality. (2025) · cites this paper as Levin et al., 2014

    The Discussion reports preliminary support for psychological inflexibility as a process relevant to multiple disorders, particularly depression and anxiety. But it says the cross-sectional study cannot establish whether inflexibility contributes to psychopathology or results from it, so “underlies” is stronger than the findings establish. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

Statistics recomputed

Every reported test result, recomputed from its test statistic and degrees of freedom. A result shows as not adding up only once an independent check has confirmed it.

  • ConsistentF(2, 153) = 5.95reported p = .003 · recomputed p = .003

    “F(2, 153) = 5.95, p = .003”

  • ConsistentF(2, 382) = 8.15reported p < .001 · recomputed p < .001

    “F(2, 382) = 8.15, p < .001”

  • ConsistentF(2, 379) = 7.54reported p = .001 · recomputed p < .001

    “F(2, 379) = 7.54, p = .001”

  • ConsistentF(2, 193) = 8.62reported p < .001 · recomputed p < .001

    “F(2, 193) = 8.62, p < .001”

  • ConsistentF(2, 191) = 8.26reported p < .001 · recomputed p < .001

    “F(2, 191) = 8.26, p < .001”

  • ConsistentF(2, 437) = 7.43reported p = .001 · recomputed p < .001

    “F(2, 437) = 7.43, p = .001”

  • ConsistentF(2, 434) = 5.94reported p = .003 · recomputed p = .003

    “F(2, 434) = 5.94, p = .003”

7 of 7

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • An effect size of .08 is labeled small despite the paper's stated threshold

    Minor

    The paper defines partial η2 of .06 as a medium effect, but later describes a range extending to .08 as small.

1 of 1

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Authors
Levin, M. E., MacLane, C., Daflos, S., Seeley, J. R., Hayes, S. C., Biglan, A., & Pistorello, J.
Affiliations
  • Utah State University (US)
  • University of Nevada, Reno (US)
  • Oregon Research Institute (US)
Corresponding author
Levin, Michael E.
Venue
Journal of Contextual Behavioral Science
Publisher
Elsevier BV
Published
2014-07
Volume
3
Issue
3
Pages
155-163
ISSN
2212-1447 (ISSN-L)
OpenAlex
W2033922058
Cited by
400
References
49
Citations by year
2026: 42 · 2025: 60 · 2024: 58 · 2023: 58 · 2022: 43 · 2021: 50 · 2020: 35 · 2019: 13 · 2018: 21 · 2017: 7 · 2016: 7 · 2015: 6
FWCI
7.87
Type
journal article
Language
en
Open access
Locations
  • Journal of Contextual Behavioral Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Commons - USU (Utah State University) (submittedVersion)
Funders
National Institute of Mental Health
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords
psychological inflexibility, transdiagnostic mechanisms, depression, anxiety disorders, substance use disorders, eating disorders, comorbidities, psychological distress, university students, behavioral inflexibility

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