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Depression and Risk for Diabetes: A Meta-Analysis
Abstract
Objective Many studies have reported the relationship between depression and diabetes, but the results have been inconsistent. Our aim was to conduct a systematic review through meta-analysis to assess the association of depression with the risk for developing diabetes. Methods We retrieved the studies concerning depression and the risk for diabetes. Meta-analysis was applied to calculate the combined effect values and their 95% confidence intervals. The risk for publication bias was assessed by the Egger regression asymmetry test. Results As many as 33 articles were included in the meta-analysis, for a total of 2 411 641 participants. The pooled relative risk for diabetes was 1.41 (95% CI, 1.25-1.59) for depression, and the combined relative risk for type 2 diabetes mellitus was 1.32 (95% CI, 1.18-1.47). Conclusions Depressed people have a 41% increased risk for developing diabetes mellitus and a 32% increased risk for developing type 2 diabetes. The mechanisms underlying this relationship are still unclear and need further research.
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Metadata
- Authors
- Yu, M., Zhang, X., Lu, F., & Fang, L.
- Affiliations
- Zhejiang Center for Disease Control and Prevention (CN)
- Hangzhou Center for Disease Control and Prevention (CN)
- Corresponding author
- Fang, Le
- Venue
- Canadian Journal of Diabetes
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 39
- Issue
- 4
- Pages
- 266-272
- ISSN
- 1499-2671 (ISSN-L)
- OpenAlex
- W1995900788
- Cited by
- 236
- References
- 64
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 41 · 2023: 31 · 2022: 28 · 2021: 25 · 2020: 25 · 2019: 22 · 2018: 16 · 2017: 7 · 2016: 7 · 2015: 5
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Canadian Journal of Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Major Special Project of Science and Technology (2011C13032-1)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- depression, type 2 diabetes, diabetes risk, relative risk
- MeSH terms
- Cross-Sectional Studies, Depression, Diabetes Mellitus, Type 2, Humans, Risk Factors, Cohort Studies, Case-Control Studies
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