Cited by 236Diabetes Management and EducationDiabetes, Cardiovascular Risks, and LipoproteinsCardiac Health and Mental Health

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Depression and Risk for Diabetes: A Meta-Analysis

Yu, Min, Zhang, Xingliang, Lu, Feng, Fang, Le·2015·Canadian Journal of Diabetes

DOI 10.1016/j.jcjd.2014.11.006

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Abstract

Objective Many studies have reported the relationship between depression and diabetes, but the results have been inconsistent. Our aim was to conduct a systematic review through meta-analysis to assess the association of depression with the risk for developing diabetes. Methods We retrieved the studies concerning depression and the risk for diabetes. Meta-analysis was applied to calculate the combined effect values and their 95% confidence intervals. The risk for publication bias was assessed by the Egger regression asymmetry test. Results As many as 33 articles were included in the meta-analysis, for a total of 2 411 641 participants. The pooled relative risk for diabetes was 1.41 (95% CI, 1.25-1.59) for depression, and the combined relative risk for type 2 diabetes mellitus was 1.32 (95% CI, 1.18-1.47). Conclusions Depressed people have a 41% increased risk for developing diabetes mellitus and a 32% increased risk for developing type 2 diabetes. The mechanisms underlying this relationship are still unclear and need further research.

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Authors: Yu, M., Zhang, X., Lu, F., & Fang, L.
Affiliations: Zhejiang Center for Disease Control and Prevention (CN)
Hangzhou Center for Disease Control and Prevention (CN)
Corresponding author: Fang, Le
ORCID: Yu, Min
Zhang, Xingliang
Lu, Feng
Fang, Le
Venue: Canadian Journal of Diabetes
Publisher: Elsevier BV
Published: 2015-08
Volume: 39
Issue: 4
Pages: 266-272
ISSN: 1499-2671 (ISSN-L)
DOI: 10.1016/j.jcjd.2014.11.006
OpenAlex: W1995900788
Cited by: 236
References: 64
Citations by year: 2026: 12 · 2025: 17 · 2024: 41 · 2023: 31 · 2022: 28 · 2021: 25 · 2020: 25 · 2019: 22 · 2018: 16 · 2017: 7 · 2016: 7 · 2015: 5
FWCI: 1.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Canadian Journal of Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: Major Special Project of Science and Technology (2011C13032-1)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords: depression, type 2 diabetes, diabetes risk, relative risk
MeSH terms: Cross-Sectional Studies, Depression, Diabetes Mellitus, Type 2, Humans, Risk Factors, Cohort Studies, Case-Control Studies

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Depression and Risk for Diabetes: A Meta-Analysis

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