Therapeutics, imaging and toxicity of nanomaterials in the central nervous system.

Malignant Gliomas in Adults

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The blood-brain barrier: Bottleneck in brain drug development

Pardridge, W. M. (2005) · NeuroRX · doi:10.1602/neurorx.2.1.3 · Cited by 2,798 · see citing works

Translocation of inhaled ultrafine particles to the brain

Oberdörster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., & Cox, C. (2004) · Inhalation Toxicology · doi:10.1080/08958370490439597 · Cited by 2,606 · see citing works

Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme

Maier-Hauff, K., Ulrich, F., Nestler, D., Niehoff, H., Wust, P., Thiesen, B., Orawa, H., Budach, V., & Jordan, A. (2010) · Journal of Neuro-Oncology · doi:10.1007/s11060-010-0389-0 · Cited by 1,447 · see citing works

Blood–brain barrier delivery

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Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds

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Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision

Ellis-Behnke, R. G., Liang, Y., You, S., Tay, D., Zhang, S., So, K., & Schneider, G. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600559103 · Cited by 796 · see citing works

Intracranial Thermotherapy using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme

Maier-Hauff, K., Rothe, R., Scholz, R., Gneveckow, U., Wust, P., Thiesen, B., Feussner, A., von Deimling, A., Waldöfner, N., Felix, R., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9195-0 · Cited by 772 · see citing works

Cerium and yttrium oxide nanoparticles are neuroprotective

Schubert, D. A., Dargusch, R., Raitano, J. M., & Chan, S. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.129 · Cited by 728 · see citing works

Carbon nanotube coating improves neuronal recordings

Keefer, E. W., Botterman, B. R., Romero, M. I., Rossi, A. F., & Gross, G. W. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.174 · Cited by 721 · see citing works

Self-Assembling Nanofibers Inhibit Glial Scar Formation and Promote Axon Elongation after Spinal Cord Injury

Tysseling, V. M., Sahni, V., Niece, K. L., Birch, D. V., Czeisler, C. M., Fehlings, M. G., Stupp, S. I., & Kessler, J. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0143-08.2008 · Cited by 680 · see citing works

Delivery of therapeutic agents to the central nervous system: the problems and the possibilities

Begley, D. J. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.08.001 · Cited by 679 · see citing works

Carbon Nanotube Substrates Boost Neuronal Electrical Signaling

Lovat, V., Pantarotto, D., Lagostena, L., Cacciari, B., Grandolfo, M., Righi, M., Spalluto, G., Prato, M., & Ballerini, L. (2005) · Nano Letters · doi:10.1021/nl050637m · Cited by 648 · see citing works

Molecular Functionalization of Carbon Nanotubes and Use as Substrates for Neuronal Growth

Mattson, M. P., Haddon, R. C., & Rao, A. M. (2000) · Journal of Molecular Neuroscience · doi:10.1385/jmn:14:3:175 · Cited by 636 · see citing works

Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)

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Significant Transport of Doxorubicin into the Brain with Polysorbate 80-Coated Nanoparticles

Gulyaev, A. E., Gelperina, S. E., Skidan, I. N., Antropov, A. S., Kivman, G. Y., & Kreuter, J. (1999) · Pharmaceutical Research · doi:10.1023/a:1018983904537 · Cited by 521 · see citing works

Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review

Weinstein, J. S., Varallyay, C. G., Dosa, E., Gahramanov, S., Hamilton, B., Rooney, W. D., Muldoon, L. L., & Neuwelt, E. A. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.192 · Cited by 500 · see citing works

Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging

Bhaskar, S. M. M., Tian, F., Stoeger, T., Kreyling, W. G., de la Fuente, J. M., Grazú, V., Borm, P. J. A., Estrada, G. G., Ntziachristos, V., & Razansky, D. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-3 · Cited by 497 · see citing works

Direct Evidence That Polysorbate-80-Coated Poly(Butylcyanoacrylate) Nanoparticles Deliver Drugs to the CNS via Specific Mechanisms Requiring Prior Binding of Drug to the Nanoparticles

Kreuter, J., Ramge, P., Petrov, V. E., Hamm, S., Gelperina, S. E., Engelhardt, B., Alyautdin, R. N., von Briesen, H., & Begley, D. J. (2003) · Pharmaceutical Research · doi:10.1023/a:1022604120952 · Cited by 469 · see citing works

The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma

Jordan, A., Scholz, R., Maier-Hauff, K., van Landeghem, F. K. H., Waldoefner, N., Teichgraeber, U., Pinkernelle, J., Bruhn, H., Neumann, F., Thiesen, B., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-005-9059-z · Cited by 459 · see citing works

In Vivo Multiphoton Microscopy of Deep Brain Tissue

Levene, M. J., Dombeck, D. A., Kasischke, K. A., Molloy, R. P., & Webb, W. W. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01007.2003 · Cited by 457 · see citing works

Carbon nanofibers and carbon nanotubes in regenerative medicine

Tran, P. A., Zhang, L. G., & Webster, T. J. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.07.010 · Cited by 447 · see citing works

Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones

Zensi, A., Begley, D., Pontikis, C., Legros, C., Mihoreanu, L., Wagner, S., Büchel, C., von Briesen, H., & Kreuter, J. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.03.002 · Cited by 438 · see citing works

Chemotherapy of glioblastoma in rats using doxorubicin‐loaded nanoparticles

Steiniger, S. C. J., Kreuter, J., Khalansky, A. S., Skidan, I. N., Bobruskin, A. I., Smirnova, Z. S., Severin, E. S., Uhl, R., Kock, M., Geiger, K. D., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20048 · Cited by 434 · see citing works

The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2

Ren, J., Shen, S., Wang, D., Xi, Z., Guo, L., Pang, Z., Qian, Y. J., Sun, X., & Jiang, X. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.025 · Cited by 409 · see citing works

Neuroscience nanotechnology: progress, opportunities and challenges

Silva, G. A. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1827 · Cited by 383 · see citing works

Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease

Wilson, B., Samanta, M. K., Santhi, K., Kumar, K. P. S., Paramakrishnan, N., & Suresh, B. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.039 · Cited by 363 · see citing works

Post-mortem studies in glioblastoma patients treated with thermotherapy using magnetic nanoparticles

van Landeghem, F. K. H., Maier-Hauff, K., Jordan, A., Hoffmann, K., Gneveckow, U., Scholz, R., Thiesen, B., Brück, W., & von Deimling, A. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.044 · Cited by 354 · see citing works

Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma

Agemy, L., Friedmann‐Morvinski, D., Kotamraju, V. R., Roth, L., Sugahara, K. N., Girard, O. M., Mattrey, R. F., Verma, I. M., & Ruoslahti, E. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114518108 · Cited by 348 · see citing works

Covalent Linkage of Apolipoprotein E to Albumin Nanoparticles Strongly Enhances Drug Transport into the Brain

Michaelis, K., Hoffmann, M. M., Dreis, S., Herbert, E., Alyautdin, R. N., Michaelis, M., Kreuter, J., & Langer, K. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.097139 · Cited by 346 · see citing works

Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases

Wang, J., Chen, C., Liu, Y., Jiao, F., Li, W., Lao, F., Li, Y., Li, B., Ge, C., Zhou, G., et al. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.10.001 · Cited by 339 · see citing works

Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer

Ke, W., Shao, K., Huang, R., Han, L., Liu, Y., Li, J., Kuang, Y., Ye, L., Lou, J., & Jiang, C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.08.049 · Cited by 337 · see citing works

Microglial Response to Gold Nanoparticles

Hutter, E., Boridy, S., Labrecque, S., Lalancette–Hébert, M., Križ, J., Winnik, F. M., & Maysinger, D. (2010) · ACS Nano · doi:10.1021/nn901869f · Cited by 321 · see citing works

Pharmacological and toxicological target organelles and safe use of single-walled carbon nanotubes as drug carriers in treating alzheimer disease.

Yang, Z., Zhang, Y., Yang, Y., Sun, L., Han, D., Li, H., & Wang, C. (2010) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.11.007 · Cited by 311 · see citing works

Nanoparticles and Neurotoxicity

Win‐Shwe, T., & Fujimaki, H. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12096267 · Cited by 302 · see citing works

Manufactured Aluminum Oxide Nanoparticles Decrease Expression of Tight Junction Proteins in Brain Vasculature

Chen, L., Yokel, R. A., Hennig, B., & Toborek, M. J. (2008) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-008-9131-5 · Cited by 295 · see citing works

Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticles

WILSON, B., Samanta, M. K., Santhi, K., KUMAR, K., Paramakrishnan, N., & Suresh, B. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.03.009 · Cited by 279 · see citing works

Nanoparticle Technology for Delivery of Drugs Across the Blood–Brain Barrier

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Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia

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Brain-specific expression of an exogenous gene after i.v. administration

Shi, N., Zhang, Y., Zhu, C., Boado, R. J., & Pardridge, W. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221450098 · Cited by 273 · see citing works

Lipofection of cDNAs in the embryonic vertebrate central nervous system

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Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: Preparation, characterization and efficacy in Parkinson's disease

Hu, K., Shi, Y., Jiang, W., Han, J., Huang, S., & Jiang, X. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.05.062 · Cited by 261 · see citing works

Cellular uptake of magnetic fluid particles and their effects on human adenocarcinoma cells exposed to AC magnetic fieldsin vitro

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Nanoparticles aggravate heat stress induced cognitive deficits, blood–brain barrier disruption, edema formation and brain pathology

SHARMA, H. S., & Sharma, A. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)62013-x · Cited by 246 · see citing works

Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration

Wen, Z., Yan, Z., Hu, K., Pang, Z., Cheng, X., Guo, L., Zhang, Q., Jiang, X., Fang, L., & Lai, R. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.02.022 · Cited by 241 · see citing works

Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing

Al‐Jamal, K. T., Gherardini, L. M., Bardi, G., Nunes, A., Guo, C., Bussy, C., Herrero, M. A., Bianco, A., Prato, M., Kostarelos, K., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100930108 · Cited by 240 · see citing works

Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis

Basso, A. S., Frenkel, D., Quintana, F. J., Costa‐Pinto, F. A., Petrovic-Stojkovic, S., Puckett, L. L., Monsonego, A., Bar‐Shir, A., Engel, Y., Gozin, M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33464 · Cited by 237 · see citing works

Targeting the central nervous system: In vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123

Tosi, G., Costantino, L., Rivasi, F., Ruozi, B., Leo, E., Vergoni, A. V., Tacchi, R., Bertolini, A., Vandelli, M. A., & Forni, F. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.022 · Cited by 233 · see citing works

In vivo MRI of brain inflammation in human ischaemic stroke

Saleh, A., Schroeter, M., Jonkmanns, C., Hartung, H., Mödder, U., & Jander, S. (2004) · Brain · doi:10.1093/brain/awh191 · Cited by 228 · see citing works

Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model

Lee, H. J., Park, J., Yoon, O. J., Kim, H., Lee, D., Kim, D. H., Lee, W. B., Lee, N., Bonventre, J. V., & Kim, S. S. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.281 · Cited by 226 · see citing works

Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles

Kurakhmaeva, K. B., Djindjikhashvili, I. A., Petrov, V. E., Balabanyan, V. U., Voronina, T. A., Trofimov, S. S., Kreuter, J., Gelperina, S., Begley, D., & Alyautdin, R. N. (2009) · Journal of Drug Targeting · doi:10.1080/10611860903112842 · Cited by 221 · see citing works

Cationic Albumin–Conjugated Pegylated Nanoparticles Allow Gene Delivery into Brain Tumors via Intravenous Administration

Lü, W., Sun, Q. Q., Wan, J., She, Z., & Jiang, X. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2354 · Cited by 219 · see citing works

Imaging of iron oxide nanoparticles by MR and light microscopy in patients with malignant brain tumours

Neuwelt, E. A., Várallyay, P., Bagó, A. G., Muldoon, L. L., Nesbit, G. M., & Nixon, R. A. (2004) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2004.00557.x · Cited by 218 · see citing works

Toxicity of Polyalkylcyanoacrylate Nanoparticles II: Doxorubicin-Loaded Nanoparticles

Couvreur, P., Kante, B., Grislain, L., Roland, M., & Speiser, P. P. (1982) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600710717 · Cited by 217 · see citing works

Rapid and effective labeling of brain tissue using TAT-conjugated CdS∶Mn/ZnS quantum dots

Santra, S., Yang, H., Stanley, J. T., Holloway, P. H., Moudgil, B. M., Walter, G. A., & Mericle, R. A. (2005) · Chemical Communications · doi:10.1039/b503234b · Cited by 215 · see citing works

Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity

Olivier, J.-C., Fenart, L., Chauvet, R., Pariat, C., Cecchelli, R., & Couet, W. (1999) · Pharmaceutical Research · doi:10.1023/a:1018947208597 · Cited by 213 · see citing works

Influence of Nanoparticles on Blood–Brain Barrier Permeability and Brain Edema Formation in Rats

Sharma, H. S., Hussain, S. M., Schlager, J. J., Ali, S. F., & Sharma, A. (2009) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-211-98811-4_65 · Cited by 213 · see citing works

A Macrophage−Nanozyme Delivery System for Parkinson's Disease

Batrakova, E. V., Li, S., Reynolds, A. D., Mosley, R. L., Bronich, T. K., Kabanov, A. V., & Gendelman, H. E. (2007) · Bioconjugate Chemistry · doi:10.1021/bc700184b · Cited by 209 · see citing works

Novel -penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer's and other CNS diseases

Cui, Z., Lockman, P. R., Atwood, C., Hsu, C. C., Gupte, A., ALLEN, D., & Mumper, R. J. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.07.009 · Cited by 203 · see citing works

In vivo imaging of the diseased nervous system

Misgeld, T., & Kerschensteiner, M. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1905 · Cited by 197 · see citing works

Multifunctional nanoparticle platforms for in vivo MRI enhancement and photodynamic therapy of a rat brain cancer

Kopelman, R., Koo, Y.-E. L., Philbert, M. A., Moffat, B. A., Reddy, G. R., McConville, P., Hall, D. E., Chenevert, T. L., Bhojani, M. S., Buck, S. M., et al. (2005) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2005.02.061 · Cited by 193 · see citing works

Evaluation of brain tumor vessels specific contrast agents for glioblastoma imaging

Tomanek, B., Iqbal, U. H., Błasiak, B., Abulrob, A., Albaghdadi, H., Matyas, J. R., Ponjevic, D., & Sutherland, G. R. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor183 · Cited by 192 · see citing works

Targeted brain delivery of AZT via transferrin anchored pegylated albumin nanoparticles

Mishra, V., Mahor, S., Rawat, A. K., Gupta, P. N., Dubey, P., Khatri, K., & Vyas, S. P. (2006) · Journal of drug targeting · doi:10.1080/10611860600612953 · Cited by 191 · see citing works

Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy?

Kateb, B., Chiu, K., Black, K. L., Yamamoto, V. N., Khalsa, B., Ljubimova, J. Y., Ding, H., Patil, R., Portilla‐Arias, J., Modo, M., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.105 · Cited by 189 · see citing works

A Nanomedicine Transports a Peptide Caspase-3 Inhibitor across the Blood–Brain Barrier and Provides Neuroprotection

Karataş, H., Aktaş, Y., Özdemir, Y., Bodur, E., Yemişçi, M., Caban-Toktas, S., Vural, A., Pınarbaşlı, O., Çapan, Y., Fernández-Megía, E., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4246-09.2009 · Cited by 187 · see citing works

Toxicological studies of doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma

Gelperina, S. E., Khalansky, A. S., Skidan, I. N., Smirnova, Z. S., Bobruskin, A. I., Severin, E. S., Turowski, B., Zanella, F., & Kreuter, J. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(01)00456-8 · Cited by 185 · see citing works

THE POTENTIAL OF FERUMOXYTOL NANOPARTICLE MAGNETIC RESONANCE IMAGING, PERFUSION, AND ANGIOGRAPHY IN CENTRAL NERVOUS SYSTEM MALIGNANCY: A PILOT STUDY

Neuwelt, E. A., Várallyay, C. G., Manninger, S., Solymosi, D., Haluska, M., Hunt, M. A., Nesbit, G., Stevens, A., Jerosch-Herold, M., Jacobs, P. M., et al. (2007) · Neurosurgery · doi:10.1227/01.neu.0000255350.71700.37 · Cited by 184 · see citing works

Carbon Nanotubes Enhance CpG Uptake and Potentiate Antiglioma Immunity

Zhao, D., Alizadeh, D., Zhang, L., Liu, W., Farrukh, O., Manuel, E. R., Diamond, D. J., & Badie, B. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2444 · Cited by 181 · see citing works

Enhanced brain targeting by synthesis of 3′,5′-dioctanoyl-5-fluoro-2′-deoxyuridine and incorporation into solid lipid nanoparticles

Wang, J.-X., Sun, X., & Zhang, Z.-R. (2002) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(02)00083-8 · Cited by 179 · see citing works

Nanoparticle iron chelators: A new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance

Liu, G., Men, P., Harris, P. L. R., Rolston, R. K., Perry, G. L., & Smith, M. A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.07.020 · Cited by 177 · see citing works

Targeted delivery of methotrexate to epidermal growth factor receptor–positive brain tumors by means of cetuximab (IMC-C225) dendrimer bioconjugates

Wu, G. J., Barth, R. F., Yang, W., Kawabata, S., Zhang, L., & Green‐Church, K. B. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0325 · Cited by 177 · see citing works

Lipid-Drug-Conjugate (LDC) Nanoparticles as Novel Carrier System for the Hydrophilic Antitrypanosomal Drug Diminazenediaceturate

Olbrich, C., Gessner, A., Kayser, O., & Müller, R. H. (2002) · Journal of drug targeting · doi:10.1080/1061186021000001832 · Cited by 175 · see citing works

Transport of nerve growth factor encapsulated into liposomes across the blood–brain barrier: In vitro and in vivo studies

Xie, Y., Ye, L., Zhang, X., Cui, W., Lou, J., Nagai, T., & Hou, X. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.03.005 · Cited by 168 · see citing works

Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model

Huang, R., Ke, W., Liu, Y., Wu, D., Feng, L., Jiang, C., & Pei, Y. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.09.032 · Cited by 157 · see citing works

The Olfactory Neuron and the Blood-Brain Barrier

de Lorenzo, A. J. D. (2008) · Novartis Foundation symposium · doi:10.1002/9780470715369.ch9 · Cited by 150 · see citing works

Polyhydroxylated fullerene derivative C60(OH)24 prevents mitochondrial dysfunction and oxidative damage in an MPP+‐induced cellular model of Parkinson's disease

Cai, X., Jia, H., Liu, Z., Hou, B., Luo, C. Y., Feng, Z., Li, W., & Liu, J. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21805 · Cited by 150 · see citing works

Nanoparticle–chelator conjugates as inhibitors of amyloid-β aggregation and neurotoxicity: A novel therapeutic approach for Alzheimer disease

Liu, G., Men, P., Kudo, W., Perry, G., & Smith, M. A. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.03.064 · Cited by 148 · see citing works

Transport of stavudine, delavirdine, and saquinavir across the blood–brain barrier by polybutylcyanoacrylate, methylmethacrylate-sulfopropylmethacrylate, and solid lipid nanoparticles

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Nanoparticles, a drug carrier system to pass the blood-brain barrier, permit central analgesic effects of i.v. dalargin injections

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Superoxide Dismutase-Loaded PLGA Nanoparticles Protect Cultured Human Neurons Under Oxidative Stress

Reddy, M. K., Wu, L., Kou, W., Ghorpade, A., & Labhasetwar, V. D. (2008) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-008-8232-1 · Cited by 142 · see citing works

Increase of the duration of the anticonvulsive activity of a novel NMDA receptor antagonist using poly(butylcyanoacrylate) nanoparticles as a parenteral controlled release system

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