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Cited by 192Skin Protection and AgingCollagen: Extraction and CharacterizationFacial Rejuvenation and Surgery Techniques

Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis

Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., Oesser, S.·2014·Skin Pharmacology and Physiology
DOI 10.1159/000355523
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Abstract

Dietary consumption of food supplements has been found to modulate skin functions and can therefore be useful in the treatment of skin aging. However, there is only a limited number of clinical studies supporting these claims. In this double-blind, placebo-controlled study, the effectiveness of the specific bioactive collagen peptide (BCP) VERISOL® on eye wrinkle formation and stimulation of procollagen I, elastin and fibrillin biosynthesis in the skin was assessed. A hundred and fourteen women aged 45-65 years were randomized to receive 2.5 g of BCP or placebo, once daily for 8 weeks, with 57 subjects being allocated to each treatment group. Skin wrinkles were objectively measured in all subjects, before starting the treatment, after 4 and 8 weeks as well as 4 weeks after the last intake (4-week regression phase). A subgroup was established for suction blister biopsies analyzing procollagen I, elastin and fibrillin at the beginning of the treatment and after 8 weeks of intake. The ingestion of the specific BCP used in this study promoted a statistically significant reduction of eye wrinkle volume (p < 0.05) in comparison to the placebo group after 4 and 8 weeks (20%) of intake. Moreover a positive long-lasting effect was observed 4 weeks after the last BCP administration (p < 0.05). Additionally, after 8 weeks of intake a statistically significantly higher content of procollagen type I (65%) and elastin (18%) in the BCP-treated volunteers compared to the placebo-treated patients was detected. For fibrillin, a 6% increase could be determined after BCP treatment compared to the placebo, but this effect failed to reach the level of statistical significance. In conclusion, our findings demonstrate that the oral intake of specific bioactive collagen peptides (Verisol®) reduced skin wrinkles and had positive effects on dermal matrix synthesis.

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Crossref · 10.1159/000355523

Cites

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  • Preclinical and pharmacokinetic studies indicate that triterpenoid-rich extracts exhibit dose-dependent biological activity despite inherently low bioavailability, supporting the rationale for a moderate dosing strategy.

    “In addition, preclinical and pharmacokinetic studies indicate that triterpenoid-rich extracts exhibit dose-dependent biological activity despite inherently low bioavailability, supporting the rationale for a moderate dosing strategy [25,53,54,55,56,57].”

    From A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. (2026) · cites this paper as [53]

    The Subjects section describes a single daily dose of bioactive collagen peptides versus placebo, and the Blister Suction Fluids section reports skin-matrix outcomes. Searches for triterpenoid-rich extracts, dose-dependent activity, bioavailability, and pharmacokinetics found no passage addressing the attributed claim. The copy therefore cannot verify it. (LLM, conf=0.75)

    Experimental — accuracy not yet measured

  • Eye wrinkle formation was reduced, and biosynthesis of procollagen I, elastin, and fibrillin in skin was significantly increased in the bioactive collagen peptide-treated group.

    “Eye wrinkle formation was reduced, and biosynthesis of procollagen I, elastin, and fibrillin in the skin was significantly increased in the bioactive collagen peptide-treated group [122].”

    From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [122]

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Cites

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Research works printed but not linked: 2

  1. Calleja-Agius J, Muscat-Baron Y, Brincat MP: Skin ageing. Menopause Int 2007; 13: 60-64.
  2. Manriquez JJ, Majerson Grinberg D, Nicklas Diaz C: Wrinkles. Clin Evid 2008;12:1-42.

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Authors
Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., & Oesser, S.
Affiliations
  • Christian-Albrechts-Universität zu Kiel (DE)
  • Universidade de São Paulo (BR)
ORCID
Proksch, E.
Venue
Skin Pharmacology and Physiology
Publisher
S. Karger AG
Published
2013-12-24
Volume
27
Issue
3
Pages
113-119
ISSN
  • 1422-2868 (ISSN-L)
  • 1660-5527
  • 1660-5535
DOI
10.1159/000355523
OpenAlex
W2045543071
Cited by
191
References
27
Citations by year
2026: 25 · 2025: 27 · 2024: 21 · 2023: 17 · 2022: 18 · 2021: 16 · 2020: 14 · 2019: 11 · 2018: 9 · 2017: 12 · 2016: 5 · 2015: 14 · 2014: 2
FWCI
8.22
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Skin Pharmacology and Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universität zu Kiel (Christian-Albrechts-Universität zu Kiel) (submittedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
  • Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
Keywords
skin aging, type I procollagen, elastin, fibrillin, dietary supplements, skin rejuvenation
MeSH terms
Fibrillins, Administration, Oral, Aged, Collagen, Double-Blind Method, Elastin, Female, Humans, Microfilament Proteins, Middle Aged, Peptides, Time Factors, Skin Aging, Treatment Outcome, Collagen Type I

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