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Cited by 1,060

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management

Open access
McPherson, Stuart, Hardy, Tim, Henderson, Elsbeth, Burt, Alastair D., Day, Christopher P., Anstee, Quentin M.·2015·Journal of Hepatology
DOI 10.1016/j.jhep.2014.11.034
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Abstract

BACKGROUND AND AIMS: There remains uncertainty about the natural history of non-alcoholic fatty liver disease (NAFLD). The spectrum of NAFLD includes non-alcoholic fatty liver (NAFL; steatosis without hepatocellular injury) and steatohepatitis (NASH; steatosis with hepatocyte ballooning degeneration±fibrosis). Our aim was to assess the histological severity of NAFLD in a cohort with serial biopsy data, and determine factors predicting progression. METHODS: Patients with two liver biopsies more than a year apart were identified. Clinical and laboratory data were collected from the time of liver biopsy. RESULTS: 108 patients had serial biopsies (median interval 6.6years, range 1.3-22.6). 81 (75%) patients had NASH and 27 had NAFL. Overall, 45 (42%) patients had fibrosis progression, 43 (40%) had no change in fibrosis, while 20 (18%) had fibrosis regression. Importantly, no significant difference in the proportion exhibiting fibrosis progression was found between those with NAFL or NASH at index biopsy (37% vs. 43%, p=0.65). Progression to NASH was seen in 44% of patients with baseline NAFL. Of 10 patients with NAFL who had fibrosis progression, 3 progressed by 1 stage, 5 by 2 stages and 2 by 3 stages; all had NASH on follow-up biopsy. Of concern, 6 of 27 (22%) patients with baseline NAFL, reached stage 3 fibrosis at follow-up biopsy. Among the patients with NAFL, 80% of those having fibrosis progression were diabetic at the follow-up liver biopsy compared with 25% of non-progressors (p=0.005). CONCLUSIONS: Contrary to current dogma, this study suggests that steatosis can progress to NASH and clinically significant fibrosis.

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Metadata

Authors
McPherson, S., Hardy, T., Henderson, E., Burt, A. D., Day, C. P., & Anstee, Q. M.
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2015-05
Volume
62
Issue
5
Pages
1148-1155
ISSN
0168-8278 (ISSN-L)
DOI
10.1016/j.jhep.2014.11.034
OpenAlex
W2105359426
Cited by
1,060
References
8
FWCI
43.59
Type
journal article
Language
en
Open access
hybrid

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