Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis
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A 25-gene expression signature associates with progression of fibrosing steatohepatitis in independent NAFLD cohorts.
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Bulk RNA-seq liver gene signatures from whole liver, isolated hepatocytes, non-parenchymal cells, or plasma correlate with disease features and sometimes predict transition from MASLD to MASH.
“Through the use of bulk RNA-seq, liver gene signatures were derived from whole liver, isolated hepatocytes, isolated non-parenchymal cells, or plasma that correlated with various disease features and, in some cases, predicted the transition from MASLD to MASH (44, 116-122).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [116]
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- Authors
- Govaere, O., Cockell, S., Tiniakos, D., Queen, R., Younes, R., Vacca, M., Alexander, L., Ravaioli, F., Palmer, J., Petta, S., Boursier, J., Rosso, C., Johnson, K., Wonders, K., Day, C. P., Ekstedt, M., Orešič, M., Darlay, R., Cordell, H. J., Marra, F., Vidal-Puig, A., Bedossa, P., Schattenberg, J. M., Clément, K., Allison, M., Bugianesi, E., Ratziu, V., Daly, A. K., & Anstee, Q. M.
- Affiliations
- Newcastle University (GB)
- National and Kapodistrian University of Athens (GR)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- University of Cambridge Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK.
- SomaLogic (United States) (US)
- University of Palermo (IT)
- Hepatology Department, Angers University Hospital, 49933 Angers, France.
- Linköping University (SE)
- Örebro University (SE)
- University of Florence (IT)
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Inserm (FR)
- University of Cambridge (GB)
- Sorbonne Université (FR)
- NIHR Newcastle Biomedical Research Centre (GB)
- Corresponding author
- Daly, Ann K.
- Anstee, Quentin M.
- ORCID
- Govaere, Olivier
- Cockell, Simon
- Tiniakos, Dina
- Queen, Rachel
- Younes, Ramy
- Vacca, Michele
- Alexander, Leigh
- Ravaioli, Federico
- Palmer, Jeremy
- Petta, Salvatore
- Rosso, Chiara
- Johnson, Katherine
- Wonders, Kristy
- Day, Christopher P.
- Ekstedt, Mattias
- Orešič, Matej
- Darlay, Rebecca
- Cordell, Heather J.
- Marra, Fabio
- Vidal-Puig, Antonio
- Schattenberg, Jörn M.
- Clément, Karine
- Allison, Michael
- Bugianesi, Elisabetta
- Ratziu, Vlad
- Daly, Ann K.
- Anstee, Quentin M.
- Venue
- Science Translational Medicine
- Published
- 2020-12-02
- Volume
- 12
- Issue
- 572
- Pages
- eaba4448
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W3109708108
- Cited by
- 479
- References
- 53
- Citations by year
- 2026: 101 · 2025: 101 · 2024: 91 · 2023: 73 · 2022: 66 · 2021: 43 · 2020: 4
- FWCI
- 33.31
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion, other-oa)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- HAL (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
- Lirias (KU Leuven) (submittedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by-nc-nd)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Horizon 2020 Framework Programme (634413)
- Innovative Medicines Initiative (777377)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- non-alcoholic fatty liver disease, steatohepatitis, liver fibrosis, gene expression profiling, gene expression signatures, disease progression, GDF15, macrophage inflammation, lipopolysaccharide, lipid loading, biomarkers
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Liver, Liver Cirrhosis, Transcriptome, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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