Cited by 479Liver Disease Diagnosis and TreatmentLiver physiology and pathologyAlcohol Consumption and Health Effects

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

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Govaere, Olivier, Cockell, Simon, Tiniakos, Dina, Queen, Rachel, Younes, Ramy, Vacca, Michele, Alexander, Leigh, Ravaioli, Federico +21 more·2020·Science Translational Medicine

Abstract

A 25-gene expression signature associates with progression of fibrosing steatohepatitis in independent NAFLD cohorts.

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Crossref · 10.1126/scitranslmed.aba4448

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  • Bulk RNA-seq liver gene signatures from whole liver, isolated hepatocytes, non-parenchymal cells, or plasma correlate with disease features and sometimes predict transition from MASLD to MASH.

    “Through the use of bulk RNA-seq, liver gene signatures were derived from whole liver, isolated hepatocytes, isolated non-parenchymal cells, or plasma that correlated with various disease features and, in some cases, predicted the transition from MASLD to MASH (44, 116-122).”

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Authors
Govaere, O., Cockell, S., Tiniakos, D., Queen, R., Younes, R., Vacca, M., Alexander, L., Ravaioli, F., Palmer, J., Petta, S., Boursier, J., Rosso, C., Johnson, K., Wonders, K., Day, C. P., Ekstedt, M., Orešič, M., Darlay, R., Cordell, H. J., Marra, F., Vidal-Puig, A., Bedossa, P., Schattenberg, J. M., Clément, K., Allison, M., Bugianesi, E., Ratziu, V., Daly, A. K., & Anstee, Q. M.
Affiliations
  • Newcastle University (GB)
  • National and Kapodistrian University of Athens (GR)
  • Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
  • University of Cambridge Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK.
  • SomaLogic (United States) (US)
  • University of Palermo (IT)
  • Hepatology Department, Angers University Hospital, 49933 Angers, France.
  • Linköping University (SE)
  • Örebro University (SE)
  • University of Florence (IT)
  • Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • University Medical Center of the Johannes Gutenberg University Mainz (DE)
  • Inserm (FR)
  • University of Cambridge (GB)
  • Sorbonne Université (FR)
  • NIHR Newcastle Biomedical Research Centre (GB)
Corresponding author
  • Daly, Ann K.
  • Anstee, Quentin M.
Venue
Science Translational Medicine
Published
2020-12-02
Volume
12
Issue
572
Pages
eaba4448
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W3109708108
Cited by
479
References
53
Citations by year
2026: 101 · 2025: 101 · 2024: 91 · 2023: 73 · 2022: 66 · 2021: 43 · 2020: 4
FWCI
33.31
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion, other-oa)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
  • HAL (submittedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
  • Lirias (KU Leuven) (submittedVersion)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by-nc-nd)
  • Newcastle University ePrints (Newcastle Univesity)
Funders
  • Horizon 2020 Framework Programme (634413)
  • Innovative Medicines Initiative (777377)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
non-alcoholic fatty liver disease, steatohepatitis, liver fibrosis, gene expression profiling, gene expression signatures, disease progression, GDF15, macrophage inflammation, lipopolysaccharide, lipid loading, biomarkers
MeSH terms
Diabetes Mellitus, Type 2, Humans, Liver, Liver Cirrhosis, Transcriptome, Non-alcoholic Fatty Liver Disease

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