Effect of aerobic exercise training dose on liver fat and visceral adiposity
Abstract
Background & aims Aerobic exercise reduces liver fat and visceral adipose tissue (VAT). However, there is limited data from randomized trials to inform exercise programming recommendations. This study examined the efficacy of commonly prescribed exercise doses for reducing liver fat and VAT using a randomized placebo-controlled design.Methods Inactive and overweight/obese adults received 8 weeks of either; i) low to moderate intensity, high volume aerobic exercise (LO:HI, 50% VO 2peak, 60 min, 4d/week); ii) high intensity, low volume aerobic exercise (HI:LO, 70% VO 2peak, 45 min, 3d/week); iii) low to moderate intensity, low volume aerobic exercise (LO:LO, 50% VO 2peak, 45 min, 3d/week); or iv) placebo (PLA). Liver fat (spectroscopy) and VAT (magnetic resonance imaging) were measured before and after intervention.Results Forty-seven of the 48 (n = 12 in each group) participants completed the trial. There were no serious adverse events. There was a significant change in group × time interaction in liver fat, which reduced in HI:LO by 2.38 ± 0.73%, in LO:HI by 2.62 ± 1.00%, and in LO:LO by 0.84 ± 0.47% but not in PLA (increase of 1.10 ± 0.62%) (p = 0.04). There was a significant reduction in VAT in HI:LO (-258.38 ± 87.78 cm(3)), in LO:HI (-386.80 ± 119.5 cm(3)), and in LO:LO (-212.96 ± 105.54 cm(3)), but not in PLA (92.64 ± 83.46 cm(3)) (p = 0.03). There were no significant differences between the dose or intensity of the exercise regimen and reductions in liver fat or VAT (p > 0.05).Conclusion The study found no difference in efficacy of liver fat reduction by either aerobic exercise dose or intensity. All of the aerobic exercise regimens employed reduced liver fat and VAT by a small amount without clinically significant weight loss.
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Very short or low-intensity exercises may be insufficient for improving hepatic steatosis, emphasizing the importance of exercise energy consumption.
“Also, very short or low-intensity exercises may be insufficient for improving hepatic steatosis, emphasizing the importance of exercise energy consumption (68, 69).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [69]
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- Authors
- Keating, S. E., Hackett, D. A., Parker, H. M., O’Connor, H. T., Gerofi, J. A., Sainsbury, A., Baker, M. K., Chuter, V. H., Caterson, I. D., George, J., & Johnson, N. A.
- Affiliations
- The University of Sydney (AU)
- Australian Catholic University (AU)
- University of Newcastle Australia (AU)
- Corresponding author
- George, Jacob
- ORCID
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 63
- Issue
- 1
- Pages
- 174-182
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2154852507
- Cited by
- 313
- References
- 50
- Citations by year
- 2026: 22 · 2025: 27 · 2024: 20 · 2023: 27 · 2022: 25 · 2021: 49 · 2020: 32 · 2019: 24 · 2018: 21 · 2017: 33 · 2016: 23 · 2015: 8 · 2014: 1
- FWCI
- 22.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- NOVA (University of Newcastle Australia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- aerobic exercise, exercise dose, exercise intensity, liver fat, visceral adipose tissue, non-alcoholic fatty liver disease, overweight and obesity, exercise programming, hepatic steatosis
- MeSH terms
- Adult, Exercise Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Weight Loss, Exercise, Treatment Outcome, Intra-Abdominal Fat, Resistance Training, Obesity, Abdominal
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