CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

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Multiplex Genome Engineering Using CRISPR/Cas Systems

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Genome engineering using the CRISPR-Cas9 system

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Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

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Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

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CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

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Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

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ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

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One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

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In vivo genome editing using Staphylococcus aureus Cas9

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Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

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Evolution and classification of the CRISPR–Cas systems

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An updated evolutionary classification of CRISPR–Cas systems

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Rationally engineered Cas9 nucleases with improved specificity

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Crystal structure of Cas9 in complex with guide RNA and target DNA

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Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412

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RNA targeting with CRISPR–Cas13

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CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

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The CRISPR tool kit for genome editing and beyond

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Engineered CRISPR-Cas9 nucleases with altered PAM specificities

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Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems

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Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

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Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

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Diversity, classification and evolution of CRISPR-Cas systems

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Gene therapy comes of age

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Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord

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Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

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In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

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A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

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Efficient genome editing in plants using a CRISPR/Cas system

Feng, Z., Zhang, B., Ding, W., Liu, X., Yang, D., Wei, P., Cao, F., Zhu, S., Zhang, F., Mao, Y., et al. (2013) · Cell Research · doi:10.1038/cr.2013.114 · Cited by 1,070 · see citing works

Diversity and evolution of class 2 CRISPR–Cas systems

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CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

Komor, A. C., Badran, A. H., & Liu, D. R. (2016) · Cell · doi:10.1016/j.cell.2016.10.044 · Cited by 1,011 · see citing works

A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes

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Correction of a pathogenic gene mutation in human embryos

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Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease

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Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi

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Gene Therapy Death Prompts Review of Adenovirus Vector

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Heritable genome editing in C. elegans via a CRISPR-Cas9 system

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Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

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Concerning RNA-guided gene drives for the alteration of wild populations

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Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant

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Targeted Mutagenesis, Precise Gene Editing, and Site-Specific Gene Insertion in Maize Using Cas9 and Guide RNA

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A prudent path forward for genomic engineering and germline gene modification

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Generation of knock-in primary human T cells using Cas9 ribonucleoproteins

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Substantial contribution of extrinsic risk factors to cancer development

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Programmable RNA recognition and cleavage by CRISPR/Cas9

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Conformational control of DNA target cleavage by CRISPR–Cas9

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The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations

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New CRISPR–Cas systems from uncultivated microbes

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A Critical Assessment of Vector Control for Dengue Prevention

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Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

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One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

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In vivo target gene activation via CRISPR/Cas9-mediated trans-epigenetic modulation

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CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

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CRISPR gene-editing tested in a person for the first time

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CRISPR-Cas Encoding of a Digital Movie into the Genomes of a Population of Living Bacteria

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A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

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CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations

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Detection of on-target and off-target mutations generated by CRISPR/Cas9 and other sequence-specific nucleases

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Safeguarding CRISPR-Cas9 gene drives in yeast

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Precise and efficient genome editing in zebrafish using the CRISPR/Cas9 system

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Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity

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CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing

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CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

Komor, A. C., Badran, A. H., & Liu, D. R. (2017) · Cell · doi:10.1016/j.cell.2017.04.005 · Cited by 276 · see citing works

Efficient targeted mutagenesis in soybean by TALENs and CRISPR/Cas9

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Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing

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Potential pitfalls of CRISPR /Cas9‐mediated genome editing

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Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells

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AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

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Generation of new glutinous rice by CRISPR/Cas9‐targeted mutagenesis of the Waxy gene in elite rice varieties

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Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes

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Non-model model organisms

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Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa: Recommendations of a Scientific Working Group †

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Embryology policy: Revisit the 14-day rule

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Genetic and environmental influences on height from infancy to early adulthood: an individual-based pooled analysis of 45 twin cohorts

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One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs

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Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics

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A global observatory for gene editing

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In vivo genome editing improves motor function and extends survival in a mouse model of ALS

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RNA-dependent RNA targeting by CRISPR-Cas9

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A comprehensive survey of the mutagenic impact of common cancer cytotoxics

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U.S. attitudes on human genome editing

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Genome editing of crops: A renewed opportunity for food security

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Macroevolutionary shifts of WntA function potentiate butterfly wing-pattern diversity

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Digits and fin rays share common developmental histories

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Pre-bilaterian origin of the blastoporal axial organizer

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