Chronically implanted epineural electrodes for repeated assessment of nerve conduction velocity and compound action potential amplitude in rodents
Abstract
Implanted epineural electrodes were used for the longitudinal assessment of peripheral nerve conduction velocity (NCV) and compound action potential (CAP) amplitude in rats. Custom-fabricated stimulating and recording electrodes were sutured over the tibial and sciatic nerves, respectively, and were used for weekly recordings of CAP latency and amplitude. Intra-day variability of nerve conduction velocity measurements had coefficients of variation of less than 2% for same day recordings from individual subjects. A clear trend in recovery of the NCV values following implant was observed over the 7-week trial period. These results demonstrate that implanted epineural electrodes provide a reliable method for chronic, in vivo monitoring of nerve conduction parameters in rodents.
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After epineural electrode implantation, fibrous tissue grows around the electrode as part of a foreign body reaction, which stabilizes the electrode, and signals from the nerves become accurate and reproducible.
“After the implantation procedure, fibrous tissue grows around the electrode as part of a foreign body reaction and this is profitable since it stabilizes the electrode. Following this stabilization process, signals from the nerves are both accurate and reproducible [37, 45].”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [45]
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- Authors
- Murphy, B., Krieger, C., & Hoffer, J.-A.
- Affiliations
- Simon Fraser University (CA)
- University of British Columbia (CA)
- Corresponding author
- Krieger, Charles
- Venue
- Journal of Neuroscience Methods
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 132
- Issue
- 1
- Pages
- 25-33
- ISSN
- 0165-0270 (ISSN-L)
- OpenAlex
- W2016664265
- Cited by
- 13
- References
- 27
- Citations by year
- 2024: 2 · 2023: 2 · 2020: 1 · 2018: 1 · 2017: 1 · 2014: 3
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Methods (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- nerve conduction velocity, compound action potential, peripheral nerves, tibial nerve, sciatic nerve, electrode implantation, longitudinal assessment, rats, measurement variability
- MeSH terms
- Action Potentials, Animals, Electric Stimulation, Electrodes, Implanted, Electrophysiology, Male, Neural Conduction, Peripheral Nerves, Reaction Time, Time Factors, Rats, Sprague-Dawley, Rats
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