Polyimide cuff electrodes for peripheral nerve stimulation
Abstract
This paper describes a new tripolar spiral cuff electrode, composed of a thin (10 microm) and flexible polyimide insulating carrier and three circumneural platinum electrodes, suitable for stimulation of peripheral nerves. The cuffs were implanted around the sciatic nerve of two groups of ten rats each, one in which the polyimide ribbon was attached to a plastic connector to characterize the in vivo stimulating properties of the electrode, and one without a connector for testing possible mechanical nerve damage by means of functional and histological methods. The polyimide cuff electrodes induced only a very mild foreign body reaction and did not change the nerve shape over a 2-6 month implantation period. There were no changes in the motor and sensory nerve conduction tests, nociceptive responses and walking track pattern over follow-up, and no morphological evidence of axonal loss or demyelination, except in one case with partial demyelination of some large fibers after 6 months. By delivering single electrical pulses through the cuff electrodes graded recruitment curves of alpha-motor nerve fibers were obtained. Recruitment of all motor units was achieved with a mean charge density lower than 4 microC/cm(2) for a pulse width of 50 micros at the time of implantation as well as 45 days thereafter. These data indicate that the polyimide cuff electrode is a stable stimulating device, with physical properties and dimensions that avoid nerve compression or activity-induced axonal damage.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Both types of intraneural electrodes, the LIFE and the TIME, are biocompatible and do not induce significant nerve damage after implantation, similar to the cuff electrodes.
“The results indicated that both types of intraneural electrodes, the LIFE (Lago et al 2007) and the TIME (Badia et al 2011) are biocompatible and do not induce significant nerve damage after implantation, similar to the cuff electrodes (Rodr´ ıguez et al 2000).”
From Comparative analysis of transverse intrafascicular multichannel, longitudinal intrafascicular and multipolar cuff electrodes for the selective stimulation of nerve fascicles (2011) · cites this paper as Rodríguez et al 2000
Cites
A spiral nerve cuff electrode for peripheral nerve stimulation
Naples, G. G., Mortimer, J. T., Scheiner, A., & Sweeney, J. D. (1988) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.8670 · Cited by 415 · see citing works
Waters, R. L., McNeal, D. R., Faloon, W., & Clifford, B. (1985) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-198567050-00016 · Cited by 156 · see citing works
Stieglitz, T., Beutel, H., & Meyer, J.-U. (1997) · Sensors and Actuators A: Physical · doi:10.1016/s0924-4247(97)01494-5 · Cited by 125 · see citing works
Self-citationGrill, W. M., & Mortimer, J. T. (1998) · IEEE Transactions on Rehabilitation Engineering · doi:10.1109/86.736150 · Cited by 103 · see citing works
Larsen, J. O., Thomsen, M., Haugland, M., & Sinkjær, T. (1998) · Acta Neuropathologica · doi:10.1007/s004010050907 · Cited by 96 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Yang, J. C., Mun, J., Kwon, S. Y., Park, S., Bao, Z., & Park, S. (2019) · Advanced Materials · doi:10.1002/adma.201904765 · Cited by 1,641 · see citing works
Navarro, X., Krueger, T. B., Lago, N., Micera, S., Stieglitz, T., & Dario, P. (2005) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2005.10303.x · Cited by 845 · see citing works
Self-citationImplanted Neural Interfaces: Biochallenges and Engineered Solutions
Grill, W. M., Norman, S. E., & Bellamkonda, R. V. (2009) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-061008-124927 · Cited by 488 · see citing works
A Materials Roadmap to Functional Neural Interface Design
Wellman, S. M., Eles, J. R., Ludwig, K. A., Seymour, J. P., Michelson, N. J., McFadden, W. E., Vazquez, A. L., & Kozai, T. D. Y. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201701269 · Cited by 389 · see citing works
Weiland, J. D., Liu, W., & Humayun, M. S. (2005) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.7.060804.100435 · Cited by 371 · see citing works
Selective Stimulation of Cat Sciatic Nerve Using an Array of Varying-Length Microelectrodes
Branner, A., Stein, R. B., & Normann, R. A. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.4.1585 · Cited by 358 · see citing works
Micromachined, Polyimide-Based Devices for Flexible Neural Interfaces
Stieglitz, T., Beutel, H., Schuettler, M., & Meyer, J.-U. (2000) · Biomedical Microdevices · doi:10.1023/a:1009955222114 · Cited by 343 · see citing works
Self-citationLong-term stimulation and recording with a penetrating microelectrode array in cat sciatic nerve
Branner, A., Stein, R. B., Fernandez, E., Aoyagi, Y., & Normann, R. A. (2004) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2003.820321 · Cited by 301 · see citing works
Badia, J., Boretius, T., Andreu, D., Azevedo-Coste, C., Stieglitz, T., & Navarro, X. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/3/036023 · Cited by 227 · see citing works
Self-citationLago, N., Yoshida, K., Koch, K. P., & Navarro, X. (2007) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2006.886617 · Cited by 227 · see citing works
Self-citationImplantable microscale neural interfaces
Cheung, K. C. (2007) · Biomedical Microdevices · doi:10.1007/s10544-006-9045-z · Cited by 202 · see citing works
Long-term usability and bio-integration of polyimide-based intra-neural stimulating electrodes
Wurth, S., Capogrosso, M., Raspopovic, S., Gandar, J., Federici, G., Kinany, N., Cutrone, A., Piersigilli, A., Pavlova, N., Guiet, R., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.014 · Cited by 176 · see citing works
Self-citationLago, N., Ceballos, D., J Rodrı́guez, F., Stieglitz, T., & Navarro, X. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.06.025 · Cited by 178 · see citing works
Self-citationA review for the peripheral nerve interface designer
Larson, C. E., & Meng, E. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108523 · Cited by 133 · see citing works
Ware, T., Simon, D., Hearon, K., Liu, C., Shah, S., Reeder, J., Khodaparast, N., Kilgard, M. P., Maitland, D. J., Rennaker, R. L., et al. (2012) · Macromolecular Materials and Engineering · doi:10.1002/mame.201200241 · Cited by 138 · see citing works
The foreign body response to the Utah Slant Electrode Array in the cat sciatic nerve
Christensen, M. B., Pearce, S. M., Ledbetter, N. M., Warren, D. J., Clark, G. A., & Tresco, P. A. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.07.010 · Cited by 135 · see citing works
Thin films and microelectrode arrays for neuroprosthetics
Ordonez, J., Schuettler, M., Boehler, C., Boretius, T., & Stieglitz, T. (2012) · MRS Bulletin · doi:10.1557/mrs.2012.117 · Cited by 118 · see citing works
Self-citationConformable hybrid systems for implantable bioelectronic interfaces
Fallegger, F., Schiavone, G., & Lacour, S. P. (2020) · Advanced Materials · doi:10.1002/adma.201903904 · Cited by 113 · see citing works
Human nerve stimulation thresholds and selectivity using a multi-contact nerve cuff electrode
Polasek, K. H., Hoyen, H. A., Keith, M. W., & Tyler, D. J. (2007) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2007.891383 · Cited by 111 · see citing works
Badia, J., Boretius, T., Pascual-Font, A., Udina, E., Stieglitz, T., & Navarro, X. (2011) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2011.2153850 · Cited by 103 · see citing works
Self-citationThin film multi-electrode softening cuffs for selective neuromodulation
González-González, M. A., Kanneganti, A., Joshi-Imre, A., Hernandez-Reynoso, A. G., Bendale, G., Modi, R., Ecker, M., Khurram, A., Cogan, S. F., Voit, W. E., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34566-6 · Cited by 97 · see citing works
Topographical distribution of motor fascicles in the sciatic‐tibial nerve of the rat
Badia, J., Pascual‐Font, A., Vivó, M., Udina, E., & Navarro, X. (2010) · Muscle & Nerve · doi:10.1002/mus.21652 · Cited by 98 · see citing works
Self-citationTissue-engineered peripheral nerve interfaces
Spearman, B. S., Desai, V. H., Mobini, S., McDermott, M. D., Graham, J. B., Otto, K. J., Judy, J. W., & Schmidt, C. E. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201701713 · Cited by 96 · see citing works
Fabrication and characteristics of an implantable, polymer-based, intrafascicular electrode
Lawrence, S. M., Dhillon, G. S., & Horch, K. W. (2003) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(03)00231-0 · Cited by 93 · see citing works
Fisher, L. E., Tyler, D. J., Anderson, J. S., & Triolo, R. J. (2009) · Journal of Neural Engineering · doi:10.1088/1741-2560/6/4/046010 · Cited by 89 · see citing works
Raspopovic, S., Carpaneto, J., Udina, E., Navarro, X., & Micera, S. (2010) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/1743-0003-7-17 · Cited by 81 · see citing works
Self-citationCompliant peripheral nerve interfaces.
Paggi, V., Akouissi, O., Micera, S., & Lacour, S. P. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abcdbe · Cited by 60 · see citing works
“15 031001 [200] Rodri ́guez F J, Ceballos D, Schüttler M, Valero A, Valderrama E, Stieglitz T and Navarro X 2000 Polyimide cuff electrodes for peripheral nerve stimulation J.”
BackgroundA Parylene Self-Locking Cuff Electrode for Peripheral Nerve Stimulation and Recording
Yu, H., Xiong, W., Zhang, H., Wang, W., & Li, Z. (2014) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2014.2333733 · Cited by 56 · see citing works
Giagka, V., & Serdijn, W. A. (2018) · Bioelectronic Medicine · doi:10.1186/s42234-018-0010-y · Cited by 58 · see citing works
Schiefer, M. A., Freeberg, M., Pinault, G. J. C., Anderson, J., Hoyen, H., Tyler, D. J., & Triolo, R. J. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/5/056006 · Cited by 57 · see citing works
Pothof, F., Bonini, L., Lanzilotto, M., Livi, A., Fogassi, L., Orban, G. A., Paul, O., & Ruther, P. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/4/046006 · Cited by 56 · see citing works
The design of and chronic tissue response to a composite nerve electrode with patterned stiffness
Freeberg, M. J., Stone, M. A., Triolo, R. J., & Tyler, D. J. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa6632 · Cited by 54 · see citing works
Material considerations for peripheral nerve interfacing
Kim, Y.-T., & Romero-Ortega, M. I. (2012) · MRS Bulletin · doi:10.1557/mrs.2012.99 · Cited by 47 · see citing works
Biomechanical and functional variation in rat sciatic nerve following cuff electrode implantation
Restaino, S. M., Abliz, E., Wachrathit, K., Krauthamer, V., & Shah, S. B. (2014) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/1743-0003-11-73 · Cited by 44 · see citing works
Chronic histological effects of the flat interface nerve electrode
Leventhal, D. K., Cohen, M., & Durand, D. M. (2006) · Journal of Neural Engineering · doi:10.1088/1741-2560/3/2/004 · Cited by 43 · see citing works
Navarro, X., Lago, N., Vivo, M., Yoshida, K., Koch, K. P., Poppendieck, W., & Micera, S. (2007) · 2007 IEEE 10th International Conference on Rehabilitation Robotics · doi:10.1109/icorr.2007.4428492 · Cited by 36 · see citing works
Self-citationRecording nerve signals in canine sciatic nerves with a flexible penetrating microelectrode array
Byun, D., Cho, S.-J., Lee, B. H., Min, J., Lee, J.-H., & Kim, S. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa7493 · Cited by 23 · see citing works
Schuettler, M., Seetohul, V., Rijkhoff, N. J. M., Moeller, F. V., Donaldson, N., & Taylor, J. (2011) · 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society · doi:10.1109/iembs.2011.6090847 · Cited by 19 · see citing works
Murphy, B., Krieger, C., & Hoffer, J.-A. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2003.08.013 · Cited by 13 · see citing works
- Authors
- Rodri´guez, F. J., Ceballos, D., Schu¨ttler, M., Valero, A., Valderrama, E., Stieglitz, T., & Navarro, X.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Fraunhofer Institute for Biomedical Engineering (DE)
- Corresponding author
- Navarro, Xavier
- Venue
- Journal of Neuroscience Methods
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 98
- Issue
- 2
- Pages
- 105-118
- ISSN
- 0165-0270 (ISSN-L)
- OpenAlex
- W2014165332
- Cited by
- 207
- References
- 5
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 10 · 2020: 6 · 2019: 13 · 2018: 13 · 2017: 16 · 2016: 17 · 2015: 7 · 2014: 14 · 2013: 5 · 2012: 9
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Methods (publishedVersion)
- PubMed (publishedVersion)
- Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- peripheral nerve stimulation, sciatic nerve, platinum electrode, foreign body reaction, demyelination, axonal injury, charge density, motor unit recruitment, nerve conduction
- MeSH terms
- Animals, Electric Stimulation, Electrophysiology, Female, Microelectrodes, Motor Neurons, Movement, Nerve Fibers, Myelinated, Neural Conduction, Neurons, Afferent, Neurosciences, Peripheral Nervous System Diseases, Platinum, Resins, Synthetic, Sciatic Nerve, Rats, Sprague-Dawley, Muscle Fatigue, Prosthesis Implantation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
