Assessment of rat sciatic nerve function following acute implantation of high density utah slanted electrode array (25 electrodes/mm2) based on neural recordings and evoked muscle activity
Abstract
Introduction: High density Utah slanted electrode arrays (HD‐USEAs) have been developed recently for intrafascicular access to submillimeter neural structures. Insertion of such high electrode density devices may cause nerve crush injury, counteracting the intended improved selective nerve fiber access. Methods: HD‐USEAs were implanted into sciatic nerves of anesthetized rats. Nerve function was assessed before and after HD‐USEA implantation by measuring changes in evoked muscle and nerve compound action potentials and single unit neuronal recordings. Results: Neural activity was recorded with over half of all implanted electrodes. Average decreases of 38%, 36%, and 13% in nerve, medial gastrocnemius, and tibialis anterior compound action potential amplitudes, respectively, were observed following array implantation. Only 1 of 8 implantations resulted in loss of all signals. Conclusions: These studies demonstrate that HD‐USEAs provide a useful neural interface without causing a nerve crush injury that would otherwise negate their use in acute preparations (<12 h). Muscle Nerve 50: 417–424, 2014
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The observed increase in CNAP peak potentials with increasing applied current amplitudes is consistent with the literature.
“which are consistent with the literature (10, 12, 54)”
From Climbing-inspired twining electrodes using shape memory for peripheral nerve stimulation and recording (2019) · cites this paper as [54]
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- Authors
- Mathews, K. S., Wark, H. A. C., & Normann, R. A.
- Affiliations
- University of Utah (US)
- Corresponding author
- Normann, Richard A.
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2014-05-14
- Volume
- 50
- Issue
- 3
- Pages
- 417-424
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W2109286850
- Cited by
- 26
- References
- 20
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2016: 2 · 2015: 6 · 2014: 3
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (CBET-1134545)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Undergraduate Neuroscience Education and Research
- Keywords
- high-density electrode arrays, sciatic nerve, nerve crush injury, compound action potential, single-unit recording, neural recording, neural interfaces, rats
- MeSH terms
- Action Potentials, Animals, Electrodes, Implanted, Evoked Potentials, Foot, Microelectrodes, Sciatic Nerve, Rats, Sprague-Dawley, Muscle, Skeletal, Rats, Electrophysiological Phenomena
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