BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1β administration
Abstract
The present study examined the modulating effects of an intrahippocampal injection of interleukin-1beta (IL-1beta) on brain-derived neurotrophic factor (BDNF) mRNA expression 0.5, 2, 4, and 6 h following contextual fear conditioning, a task known to increase BDNF mRNA, in rats. Contextual fear conditioning produced a time-dependent increase in BDNF mRNA that varied by region of hippocampus. IL-1beta blocked or reduced these increases in BDNF mRNA in the CA1, CA2, and dentate gyrus regions of the hippocampus, but had no effect in cortical regions. These data support the idea that IL-1beta-produced memory deficits may be mediated via BDNF mRNA reductions in hippocampus.
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IL-1β administration into the hippocampus induced memory impairments in a conditioning learning task in rats.
“However, in a study from 2004, IL-1β administration into the hippocampus induced memory impairments in a conditioning learning task in rats (204).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [204]
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- Authors
- Barrientos, R. M., Sprunger, D. B., Campeau, S., Watkins, L. R., Rudy, J. W., & Maier, S. F.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Barrientos, Ruth M.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 155
- Issue
- 1-2
- Pages
- 119-126
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2035717344
- Cited by
- 192
- References
- 58
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 7 · 2023: 5 · 2022: 14 · 2021: 11 · 2020: 14 · 2019: 8 · 2018: 5 · 2017: 12 · 2016: 11 · 2015: 11 · 2014: 11 · 2013: 18 · 2012: 9
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f32mh064339-03)
- National Institute of Mental Health (R01-MH65656, F32-MH64339, R01MH065656)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, BDNF mRNA expression, IL-1β, hippocampus, contextual fear conditioning, memory impairment, neuroinflammation, CA1, CA2, dentate gyrus, intrahippocampal injection
- MeSH terms
- Animals, Avoidance Learning, Drug Administration Routes, Fear, Hippocampus, Interleukin-1, Learning, Male, Memory Disorders, RNA, Messenger, Down-Regulation, Rats, Sprague-Dawley, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Rats
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