Cited by 192Memory and Neural MechanismsNeuroinflammation and Neurodegeneration MechanismsNerve injury and regeneration

BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1β administration

Barrientos, Ruth M., Sprunger, David B., Campeau, Serge, Watkins, Linda R., Rudy, Jerry W., Maier, Steven F.·2004·Journal of Neuroimmunology

Abstract

The present study examined the modulating effects of an intrahippocampal injection of interleukin-1beta (IL-1beta) on brain-derived neurotrophic factor (BDNF) mRNA expression 0.5, 2, 4, and 6 h following contextual fear conditioning, a task known to increase BDNF mRNA, in rats. Contextual fear conditioning produced a time-dependent increase in BDNF mRNA that varied by region of hippocampus. IL-1beta blocked or reduced these increases in BDNF mRNA in the CA1, CA2, and dentate gyrus regions of the hippocampus, but had no effect in cortical regions. These data support the idea that IL-1beta-produced memory deficits may be mediated via BDNF mRNA reductions in hippocampus.

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Crossref · 10.1016/j.jneuroim.2004.06.009

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Authors
Barrientos, R. M., Sprunger, D. B., Campeau, S., Watkins, L. R., Rudy, J. W., & Maier, S. F.
Affiliations
University of Colorado Boulder (US)
Corresponding author
Barrientos, Ruth M.
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2004-10
Volume
155
Issue
1-2
Pages
119-126
ISSN
0165-5728 (ISSN-L)
OpenAlex
W2035717344
Cited by
192
References
58
Citations by year
2026: 4 · 2025: 2 · 2024: 7 · 2023: 5 · 2022: 14 · 2021: 11 · 2020: 14 · 2019: 8 · 2018: 5 · 2017: 12 · 2016: 11 · 2015: 11 · 2014: 11 · 2013: 18 · 2012: 9
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5f32mh064339-03)
  • National Institute of Mental Health (R01-MH65656, F32-MH64339, R01MH065656)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
brain-derived neurotrophic factor, BDNF mRNA expression, IL-1β, hippocampus, contextual fear conditioning, memory impairment, neuroinflammation, CA1, CA2, dentate gyrus, intrahippocampal injection
MeSH terms
Animals, Avoidance Learning, Drug Administration Routes, Fear, Hippocampus, Interleukin-1, Learning, Male, Memory Disorders, RNA, Messenger, Down-Regulation, Rats, Sprague-Dawley, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Rats

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