Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection
Open accessAbstract
We previously reported that aging F344XBN rats are more vulnerable to disruptions of memory consolidation processes following an injection of Escherichia coli than are young rats. Furthermore, this disruption was specific to hippocampal-dependent memory. In the present study we examined the time course of the proinflammatory cytokine IL-1 beta in young and old rats following a peripheral injection of E. coli. Compared to young rats, aging rats treated with E. coli showed an exaggerated and prolonged up-regulation of IL-1 beta protein in the hippocampus, but not in hypothalamus, parietal cortex, prefrontal cortex, serum or spleen. Aging rats showed greater hippocampal IL-1 beta protein levels than their young counterparts 4h after E. coli, and these levels remained significantly elevated for 8 but not 14 days after E. coli. In a second experiment, aging rats exhibited anterograde memory consolidation impairments 4 and 8 days after an E. coli injection, but not after 14 days. A third experiment revealed that following an E. coli injection, bacterial clearance from the spleen and peritoneum was not impaired in aged rats, suggesting that elevations in hippocampal IL-1 beta were not mediated by impaired clearance in the periphery in aging rats. These data suggest that the exaggerated and prolonged elevation of IL-1 beta, specifically in the hippocampus, may be responsible for hippocampal-dependent memory impairments observed in aging rats following a bacterial infection.
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Elevated IL-1β was reported in some studies and not others; aged Wistar and Fisher 344 rats were reported to show elevated brain IL-1β, whereas other strains did not exhibit increased baseline levels of brain IL-1β.
“For instance, aged (~22 month old) Wistar and Fisher 344 rats (Gemma et al, 2005;Lynch, 1999) were reported to show elevated brain IL-1β, whereas (23-26 month old) Fisher 344 × BN F1 and Fisher 344 rats (Barrientos et al, 2009;Gee, Ding, and Keller, 2006) and (18-22 month old) BALB/c and C57BL/6 mice did not exhibit increased baseline levels of brain IL-1β (Hascup et al, 2016;Huang et al, 2008;Wyn”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Barrientos et al, 2009
Acute challenge, such as Escherichia coli in aged rats, induced exaggerated neuroinflammatory response and memory impairments that were completely resolved by 14 days.
“Acute challenge, such as Escherichia coli in aged rats (discussed above) induced exaggerated neuroinflammatory response and memory impairments that were completely resolved by 14 days (Barrientos et al, 2009).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Barrientos et al, 2009
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- Authors
- Barrientos, R. M., Frank, M. G., Hein, A. M., Higgins, E. A., Watkins, L. R., Rudy, J. W., & Maier, S. F.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Barrientos, Ruth M.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 23
- Issue
- 1
- Pages
- 46-54
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC2630971
- OpenAlex
- W2029300652
- Cited by
- 226
- References
- 57
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 12 · 2023: 9 · 2022: 12 · 2021: 12 · 2020: 19 · 2019: 12 · 2018: 17 · 2017: 14 · 2016: 18 · 2015: 15 · 2014: 14 · 2013: 13 · 2012: 13
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5f32mh064339-03)
- National Institute on Aging (R01AG028271)
- National Institute of Mental Health (F32 MH064339)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- memory consolidation, aging, hippocampal-dependent memory, Escherichia coli infection, peripheral infection, inflammatory cytokines, neuroinflammation, bacterial clearance
- MeSH terms
- Aging, Animals, Conditioning, Psychological, Enzyme-Linked Immunosorbent Assay, Escherichia coli, Escherichia coli Infections, Fear, Hippocampus, Hypothalamus, Male, Memory, Parietal Lobe, Rats, Inbred BN, Rats, Inbred F344, Spleen, Prefrontal Cortex, Amnesia, Anterograde, Rats, Interleukin-1beta, Host-Pathogen Interactions
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