Nrf2 participates in depressive disorders through an anti-inflammatory mechanism

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999 · see citing works

The tail suspension test: A new method for screening antidepressants in mice

Steru, L., Chermat, R., Thierry, B., & Simon, P. (1985) · Psychopharmacology · doi:10.1007/bf00428203 · Cited by 3,534 · see citing works

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

Schildkraut, J. J. (1965) · American Journal of Psychiatry · doi:10.1176/ajp.122.5.509 · Cited by 3,499 · see citing works

Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.

Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works

Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions

Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · see citing works

The mesolimbic dopamine reward circuit in depression

Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works

Cytokine-Associated Emotional and Cognitive Disturbances in Humans

Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365 · see citing works

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

Thimmulappa, R. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25790 · Cited by 1,028 · see citing works

The macrophage theory of depression

Smith, R. S. (1991) · Medical Hypotheses · doi:10.1016/0306-9877(91)90272-z · Cited by 931 · see citing works

Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects

Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875 · see citing works

IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress

Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works

Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)

Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00169-4 · Cited by 841 · see citing works

Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762 · see citing works

An Important Role of Nrf2-ARE Pathway in the Cellular Defense Mechanism

Lee, J., & Johnson, J. A. (2004) · BMB Reports · doi:10.5483/bmbrep.2004.37.2.139 · Cited by 746 · see citing works

INCREASED SERUM IL-6 AND IL-1 RECEPTOR ANTAGONIST CONCENTRATIONS IN MAJOR DEPRESSION AND TREATMENT RESISTANT DEPRESSION

Maes, M., Bosmans, E., De Jongh, R., Kenis, G., Vandoolaeghe, E., & Neels, H. (1997) · Cytokine · doi:10.1006/cyto.1997.0238 · Cited by 728 · see citing works

Depressive disorders and immunity: 20 years of progress and discovery

Irwin, M. R., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.01.010 · Cited by 676 · see citing works

Increased Levels of Glutamate in Brains from Patients with Mood Disorders

Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 609 · see citing works

Interferon-alpha–induced changes in tryptophan metabolism

Capuron, L., Neurauter, G., Musselman, D. L., Lawson, D. H., Nemeroff, C. B., Fuchs, D., & Miller, A. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00173-2 · Cited by 493 · see citing works

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

Innamorato, N. G., Rojo, A. I., García‐Yagüe, Á. J., Yamamoto, M. P., CEBALLOS, M. L. D., & Cuadrado, A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.680 · Cited by 479 · see citing works

VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants

Warner-Schmidt, J. L., & Duman, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610282104 · Cited by 438 · see citing works

Astroglial Plasticity in the Hippocampus is Affected by Chronic Psychosocial Stress and Concomitant Fluoxetine Treatment

Czéh, B., Simon, M., Schmelting, B., Hiemke, C., & Fuchs, E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300982 · Cited by 434 · see citing works

Induction of Cytoprotective Genes Through Nrf2 / Antioxidant Response Element Pathway: A New Therapeutic Approach for the Treatment of Inflammatory Diseases

Chen, X., & KUNSCH, C. A. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043452901 · Cited by 387 · see citing works

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

Rojo, A. I., Innamorato, N. G., Martín-Moreno, A. M., CEBALLOS, M. L. D., Yamamoto, M. P., & Cuadrado, A. (2009) · Glia · doi:10.1002/glia.20947 · Cited by 381 · see citing works

How Many Transcription Factors Does It Take to Turn On the Heme Oxygenase-1 Gene?

Alam, J., & Cook, J. L. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0340tr · Cited by 378 · see citing works

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

Jaźwa, A., Rojo, A. I., Innamorato, N. G., Hesse, M., Fernández‐Ruíz, J., & Cuadrado, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3731 · Cited by 329 · see citing works

Untitled work

(2008) · PubMed · Cited by 325 · see citing works

Increased serum tumor necrosis factor alpha concentrations in major depression and multiple sclerosis

Mikovа, O. E., Yakimova, R., Bosmans, E., Kenis, G., & Maes, M. H. J. (2001) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(01)00081-5 · Cited by 299 · see citing works

Depressive-like behavior induced by tumor necrosis factor-α in mice

Kaster, M. P., Gadotti, V. M., Calixto, J. B., Santos, A. R. S., & Rodrigues, A. L. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.018 · Cited by 294 · see citing works

Inflammation, Glutamate, and Glia in Depression:<i>A Literature Review</i>

McNally, L., Bhagwagar, Z., & Hannestad, J. (2008) · CNS Spectrums · doi:10.1017/s1092852900016734 · Cited by 289 · see citing works

Illness, Cytokines, and Depression

YIRMIYA, R., POLLAK, Y., MORAG, M., REICHENBERG, A., BARAK, O., AVITSUR, R., SHAVIT, Y., OVADIA, H., WEIDENFELD, J., MORAG, A., et al. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05412.x · Cited by 284 · see citing works

Enhancing Expression of Nrf2-Driven Genes Protects the Blood–Brain Barrier after Brain Injury

Zhao, J., Moore, A. N., Redell, J. B., & Dash, P. K. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1683-07.2007 · Cited by 274 · see citing works

Antidepressant actions of the exercise-regulated gene VGF

Hunsberger, J. G., Newton, S. S., Bennett, A., Duman, C. H., Russell, D., Salton, S. R., & Duman, R. S. (2007) · Nature Medicine · doi:10.1038/nm1669 · Cited by 267 · see citing works

Transcription Factor Nrf2 Protects the Brain From Damage Produced by Intracerebral Hemorrhage

Zhao, X., Sun, G., Zhang, J., Strong, R., Dash, P. K., Kan, Y. W., Grotta, J. C., & Aronowski, J. A. (2007) · Stroke · doi:10.1161/strokeaha.107.486506 · Cited by 227 · see citing works

Effects of interferon-alpha on rhesus monkeys: a nonhuman primate model of cytokine-induced depression

Felger, J. C., Alagbe, O., Hu, F., Mook, D., Freeman, A. A., Sanchez, M. M., Kalin, N. H., Ratti, E., Nemeroff, C. B., & Miller, A. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.026 · Cited by 214 · see citing works

BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1β administration

Barrientos, R. M., Sprunger, D. B., Campeau, S., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.06.009 · Cited by 192 · see citing works

Interferon-Induced Depression in Chronic Hepatitis C: A Review of Its Prevalence, Risk Factors, Biology, and Treatment Approaches

Asnis, G. M., & Garza, R. D. L. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000210099.36500.fe · Cited by 170 · see citing works

Vascular endothelial growth factor (VEGF) and its role in the central nervous system: A new element in the neurotrophic hypothesis of antidepressant drug action

Nowacka, M. M., & Obuchowicz, E. (2012) · Neuropeptides · doi:10.1016/j.npep.2011.05.005 · Cited by 157 · see citing works

VEGF as a potential target for therapeutic intervention in depression

Warner‐Schmidt, J. L., & Duman, R. S. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.013 · Cited by 150 · see citing works

Central Nervous System Concentrations of Cyclooxygenase-2 Inhibitors in Humans

Dembo, G. A., Park, S. B., & Kharasch, E. D. (2005) · Anesthesiology · doi:10.1097/00000542-200502000-00026 · Cited by 147 · see citing works

Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat

Gwak, Y. S., Crown, E. D., Unabia, G. C., & Hulsebosch, C. E. (2008) · Pain · doi:10.1016/j.pain.2008.01.021 · Cited by 143 · see citing works

Intrahippocampal Transplantation of Transgenic Neural Precursor Cells Overexpressing Interleukin-1 Receptor Antagonist Blocks Chronic Isolation-Induced Impairment in Memory and Neurogenesis

Menachem-Zidon, O. B., Goshen, I., Kreisel, T., Menahem, Y. B., Reinhartz, E., Hur, T. B., & Yirmiya, R. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301606 · Cited by 141 · see citing works

Different Susceptibility to the Parkinson's Toxin MPTP in Mice Lacking the Redox Master Regulator Nrf2 or Its Target Gene Heme Oxygenase-1

Innamorato, N. G., Jaźwa, A., Rojo, A. I., García, C., Fernández‐Ruíz, J., Grochot‐Przeczek, A., Stachurska, A., Józkowicz, A., Dulak, J., & Cuadrado, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011838 · Cited by 138 · see citing works

Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal celldeath

Rojo, A. I., Rada, P., Egea, J., Rosa, A. O., López, M. G., & Cuadrado, A. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.06.007 · Cited by 132 · see citing works

Disturbances in acute phase plasma proteins during melancholia: Additional evidence for the presence of an inflammatory process during that illness

Maes, M. H. J., Scharpé, S., Bosmans, E., Vandewoude, M. F. J., Suy, E., Uyttenbroeck, W., Cooreman, W., Vandervorst, C., & Raus, J. (1992) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(92)90056-k · Cited by 130 · see citing works

Significantly increased expression of T-cell activation markers (interleukin-2 and HLA-DR) in depression: Further evidence for an inflamatory process during that illness

Maes, M. H. J., Stevens, W. J., DeClerck, L., Bridts, C. H., Peters, D., Schotte, C., & Cosyns, P. R. (1993) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(93)90045-t · Cited by 103 · see citing works

The catecholamine hypothesis of affective disorders: a review of supporting evidence. 1965 [classical article]

Schildkraut, J. J. (1995) · Journal of Neuropsychiatry · doi:10.1176/jnp.7.4.524 · Cited by 96 · see citing works

IFN- β 1b Induces Kynurenine Pathway Metabolism in Human Macrophages: Potential Implications for Multiple Sclerosis Treatment

Guillemin, G. J., Kerr, S. J., Pemberton, L. A., Smith, D. G., Smythe, G. A., Armati, P. J., & Brew, B. J. (2001) · Journal of Interferon & Cytokine Research · doi:10.1089/107999001317205231 · Cited by 95 · see citing works

Semi-automated Sholl analysis for quantifying changes in growth and differentiation of neurons and glia

Gensel, J. C., Schonberg, D. L., Alexander, J., McTigue, D. M., & Popovich, P. G. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.04.026 · Cited by 66 · see citing works

Cytokines Induce Indoleamine 2,3-Dioxygenase Expression in Human Atheroma-Associated Cells: Implications for Persistent Chlamydophila pneumoniae Infection

Sakash, J. B., Byrne, G. I., Lichtman, A. H., & Libby, P. (2002) · Infection and Immunity · doi:10.1128/iai.70.7.3959-3961.2002 · Cited by 66 · see citing works

The inhibition of different types of potassium channels underlies the antidepressant-like effect of adenosine in the mouse forced swimming test

Kaster, M. P., Budni, J., Binfaré, R. W., Santos, A. R. S., & Rodrigues, A. L. S. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.12.018 · Cited by 46 · see citing works

Lipopolysaccharide-mediated immobility in mice: Reversal by cyclooxygenase enzyme inhibitors

Jain, N., Kulkarni, S., & Singh, A. (2001) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2001.23.8.662131 · Cited by 43 · see citing works

Increased levels of alpha‐1‐acid glycoprotein and interleukin‐6 in refractory depression

Sluzewska, A., RYBAKOWSKI, J. K., Sobieska, M., Bosnians, E. E. N., Pollet, H., & Wiktorowicz, K. (1995) · Depression · doi:10.1002/depr.3050030403 · Cited by 29 · see citing works

Reversal of LPS‐induced immobility in mice by green tea polyphenols: possible COX‐2 mechanism

Singal, A., Tirkey, N., & Chopra, K. (2004) · Phytotherapy Research · doi:10.1002/ptr.1520 · Cited by 23 · see citing works

Studies on striatal neurotoxicity caused by the 3,4-methylenedioxymethamphetamine/ malonate combination: implications for serotonin/dopamine interactions

Goñi‐Allo, B., Ramos, M., Herv'as, I., Lasheras, B., & Aguirre, N. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106063264 · Cited by 22 · see citing works

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

Zhang, J.-C., Yao, W., & Hashimoto, K. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160119094646 · Cited by 538 · see citing works

Immune mechanisms linked to depression via oxidative stress and neuroprogression

Bakunina, N., Pariante, C. M., & Zunszain, P. A. (2015) · Immunology · doi:10.1111/imm.12443 · Cited by 444 · see citing works

The multifaceted role of Nrf2 in mitochondrial function

Holmström, K. M., Kostov, R. V., & Dinkova-Kostova, A. T. (2016) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2016.10.002 · Cited by 368 · see citing works

Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression

Bouvier, E., Brouillard, F., Molet, J., Claverie, D., Cabungcal, J.-H., Cresto, N., Doligez, N., Rivat, C., Do, K. Q., Bernard, C., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.144 · Cited by 248 · see citing works

Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus—A Mini Review

Lei, A. A., Phang, V. W. X., Lee, Y. Z., Kow, A. S. F., Tham, C. L., Ho, Y.-C., & Lee, M. T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072940 · Cited by 207 · see citing works

Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice

Yao, W., Zhang, J.-C., Ishima, T., Dong, C., Yang, C., Ren, Q., Ma, M., Han, M., Wu, J., Suganuma, H., et al. (2016) · Scientific Reports · doi:10.1038/srep30659 · Cited by 154 · see citing works

Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

Uddin, M. S., Mamun, A. A., Jakaria, M., Thangapandiyan, S., Ahmad, J., Rahman, M. A., Mathew, B., Abdel-Daim, M. M., & Aleya, L. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135624 · Cited by 154 · see citing works

Growth factors as clinical biomarkers of prognosis and diagnosis in psychiatric disorders

Galvez-Contreras, A. Y., Campos-Ordonez, T., Lopez-Virgen, V., Gomez-Plascencia, J., Ramos-Zuniga, R., & Gonzalez-Perez, O. (2016) · Cytokine &amp; Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.08.004 · Cited by 112 · see citing works

Sulforaphane produces antidepressant- and anxiolytic-like effects in adult mice

Wu, S., Gao, Q., Zhao, P., Gao, Y., Xi, Y., Wang, X., Liang, Y., Shi, H., & Ma, Y. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.12.030 · Cited by 97 · see citing works

Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective

Hashimoto, K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01182 · Cited by 98 · see citing works

Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants

Martín-Hernández, D., Caso, J. R., Javier Meana, J., Callado, L. F., Madrigal, J. L. M., García-Bueno, B., & Leza, J. C. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1294-2 · Cited by 80 · see citing works

AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks

Pittman, M. E., Edwards, S. W., Ives, C., & Mortensen, H. M. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.02.006 · Cited by 78 · see citing works

Keap1-Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress

Zhang, J.-C., Yao, W., Dong, C., Han, M., Shirayama, Y., & Hashimoto, K. (2018) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0848-0 · Cited by 66 · see citing works

ANTIDEPRESSANT ACTIVITY OF METHANOLIC EXTRACT OF VERBENA OFFICINALIS LINN. PLANT IN MICE

Kamal, M., Jawaid, T., & Imam, S. A. (2015) · Asian Journal of Pharmaceutical and Clinical Research · Cited by 9 · see citing works

Evaluation of the antidepressive property of β-hydroxybutyrate in mice

Pan, S., Hu, P., You, Q., Chen, J., Wu, J., Zhang, Y., Cai, Z., Ye, T., Xu, X., Chen, Z., et al. (2020) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000535 · Cited by 12 · see citing works

11-β hydroxysteroid type 1 knockout mice display an antidepressant-like phenotype in the forced swim test

Slattery, D. A., Uzunov, D. P., & Cryan, J. F. (2015) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.50 · Cited by 11 · see citing works

Rodent Models of Depression: Forced Swim and Tail Suspension Behavioral Despair Tests in Rats and Mice

Castagné, V., Moser, P., Roux, S., & Porsolt, R. D. (2011) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0810as55 · Cited by 702 · see citing works

Rodent Models of Depression: Forced Swim and Tail Suspension Behavioral Despair Tests in Rats and Mice

Castagné, V., Moser, P. C., Roux, S., & Porsolt, R. D. (2010) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph0508s49 · Cited by 468 · see citing works