The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)
Open accessAbstract
The present study reports elevated levels of endotoxin/lipopolysaccharide (LPS) concentrations in plasma from patients with sporadic amyotrophic lateral sclerosis (sALS) and Alzheimer's (AD) as compared to healthy controls. Levels of plasma LPS showed a significant positive correlation with degree of blood monocyte/macrophage activation in disease groups and was most elevated in patients with advanced sALS disease. There was a significant negative relationship between plasma LPS and levels of monocyte/macrophage IL-10 expression in sALS blood. These data suggest that systemic LPS levels and activated monocyte/macrophages may play significant roles in the pathogenesis of sALS.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“LPS is elevated in both the blood and brain of AD patients.25–29”
From TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice (2025) · cites this paper as [25]
Experimental — accuracy not yet measuredIn the citing paper
“Elevated blood LPS levels have been found in ALS patients (51), which may be attributable to gut inflammation and microbiota changes (64).”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [51]
In the citing paper
“Blood and brain endotoxin levels are elevated in Alzheimer’s disease”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [10]
In the citing paper
“but are elevated during infections, gut inflammation, gum disease and neurodegenerative disease.”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [10]
In the citing paper
“Serum endotoxin levels are elevated in patients with severe autism [30], liver cirrhosis [11], diabetes [31], cardiovascular disease [8], chronic infection and ageing [32], amyotrophic lateral sclerosis and Alzheimer’s disease [10].”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [10]
In the citing paper
“Blood endotoxin is elevated in amyotrophic lateral sclerosis”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [10]
In the citing paper
“Mean blood endotoxin levels are increased threefold in AD patients [10].”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [10]
In the citing paper
“Blood endotoxin levels are elevated in ALS patients [10], possibly as a result of gut inflammation and microbiome changes [102].”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
Cedarbaum, J. M., Stambler, N., Malta, E., Fuller, C., Hilt, D., Thurmond, B., & Nakanishi, A. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00210-5 · Cited by 3,307
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Beutler, B., Milsark, I. W., & Cerami, A. (1985) · Science · doi:10.1126/science.3895437 · Cited by 2,344
Brooks, B. R. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90191-0 · Cited by 2,171
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144
Okusawa, S., Gelfand, J. A., Ikejima, T., Connolly, R. J., & Dinarello, C. A. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113431 · Cited by 981
Gerard, C. M., Bruyns, C., Marchant, A., Abramowicz, D., Vandenabeele, P., Delvaux, A., Fiers, W., Goldman, M., & Velu, T. J. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.2.547 · Cited by 786
Cited by
Sorted by citations
Items 101–200 of 319
Bowerman, M., Vincent, T., Scamps, F., Perrin, F. E., Camu, W., & Raoul, C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00214 · Cited by 46
Amyotrophic lateral sclerosis: The complement and inflammatory hypothesis
Kjældgaard, A.-L., Pilely, K., Olsen, K. S., Pedersen, S. W., Lauritsen, A. Ø., Møller, K., & Garred, P. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.06.007 · Cited by 45
Advances in the Development of Disease-Modifying Treatments for Amyotrophic Lateral Sclerosis
Moujalled, D., & White, A. R. (2016) · CNS Drugs · doi:10.1007/s40263-016-0317-8 · Cited by 48
Pretorius, E., Bester, J., Pagé, M., & Kell, D. B. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00257 · Cited by 47
Intestinal barrier function and metabolic/liver diseases
Ghosh, S. S., Wang, J., Yannie, P. J., & Ghosh, S. (2020) · Liver Research · doi:10.1016/j.livres.2020.03.002 · Cited by 49
Soriano, S., Curry, K. D., Wang, Q., Chow, E., Treangen, T. J., & Villapol, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094476 · Cited by 42
Wasiak, J., & Gawlik-Kotelnicka, O. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114459 · Cited by 47
Keymoradzadeh, A., Hedayati, M., Abedinzade, M., Gazor, R., Rostampour, M., & Taleghani, B. K. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112814 · Cited by 43
Kar, F., Hacioglu, C., Kar, E., Donmez, D. B., & Kanbak, G. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00964-z · Cited by 42
Role of Stress, Depression, and Aging in Cognitive Decline and Alzheimer’s Disease
Daulatzai, M. A. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_350 · Cited by 42
Zhang, Y., Xia, Y., & Sun, J. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2363880 · Cited by 42
Agostini, A., Ding, Y., Bai, L., Kendall, D. A., & Pardon, M. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.019 · Cited by 43
Dhami, M., Raj, K., & Singh, S. (2023) · Aging and Health Research · doi:10.1016/j.ahr.2023.100128 · Cited by 44
Rusconi, M., Gerardi, F., Santus, W., Lizio, A., Sansone, V., Lunetta, C., Zanoni, I., & Granucci, F. (2017) · Scientific Reports · doi:10.1038/s41598-017-08233-1 · Cited by 40
Almulla, A. F., Supasitthumrong, T., Amrapala, A., Tunvirachaisakul, C., Jaleel, A.-K. K. A., Oxenkrug, G. F., Al‐Hakeim, H. K., & Maes, M. H. J. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220295 · Cited by 35
Hao, X., Ding, N., Zhang, Y., Yang, Y., Zhao, Y., Zhao, J. J., Li, Y., & Li, Z. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.960026 · Cited by 41
When the infectious environment meets the AD brain
Ganz, T., Fainstein, N., & Ben-Hur, T. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00559-3 · Cited by 39
Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38
Chen, S., Cai, X., Lao, L., Wang, Y., Su, H., & Sun, H. (2024) · Aging and Disease · doi:10.14336/ad.2023.0524 · Cited by 40
Salani, F., Sterbini, V., Sacchinelli, E., Garramone, M., & Bossù, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01768 · Cited by 37
Thymic involution, a co‐morbidity factor in amyotrophic lateral sclerosis
Seksenyan, A., Ron‐Harel, N., Azoulay, D., Cahalon, L., Cardon, M., Rogeri, P. S., Ko, M. K., Weil, M., Bulvik, S., Rechavi, G., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00863.x · Cited by 38
Schlegel, P., Novotný, M., Klímová, B., & Vališ, M. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190460 · Cited by 39
Akhgarjand, C., Vahabi, Z., Shab‐Bidar, S., Anoushirvani, A. A., & Djafarian, K. (2024) · Inflammopharmacology · doi:10.1007/s10787-023-01427-2 · Cited by 35
Grab, D. J., Chakravorty, S. J., van der Heyde, H., & Stins, M. F. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01661.x · Cited by 35
Wang, D., Dong, X., Wang, B., Liu, Y., & Li, S. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b03977 · Cited by 34
Gut microbiota immune cross-talk in amyotrophic lateral sclerosis
Kaul, M., Mukherjee, D., Weiner, H. L., & Cox, L. M. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00469 · Cited by 36
He, C., Huang, Z.-S., Yu, C.-C., Wang, X., Jiang, T., Wu, M., & Kong, L.-H. (2021) · PubMed Central · doi:10.22038/ijbms.2021.49147.11256 · Cited by 35
Circadian misalignment by environmental light/dark shifting causes circadian disruption in colon
Tran, L. B., Jochum, S. B., Shaikh, M. W., Wilber, S., Zhang, L., Hayden, D. M., Forsyth, C. B., Voigt, R. M., Bishehsari, F., Keshavarzian, A., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251604 · Cited by 34
Biotic/Abiotic Stress-Driven Alzheimer's Disease
Li, C., Zheng, Q., Wang, Q., & Zeng, Q.-P. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00269 · Cited by 33
Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease
Sfera, A., Gradini, R., Cummings, M., Diaz, E. L., Price, A. I., & Osorio, C. P. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01062 · Cited by 32
Andreadou, E. G., Katsipis, G., Tsolaki, M., & Pantazaki, A. A. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577561 · Cited by 31
C/EBPβ expression in activated microglia in amyotrophic lateral sclerosis
Valente, T., Mancera, P., Tusell, J. M., Serratosa, J., & Saura, J. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.019 · Cited by 30
Ganz, T., Fainstein, N., Elad, A., Lachish, M., Goldfarb, S., Einstein, O., & Ben‐Hur, T. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02369-8 · Cited by 31
Pathways to healing: Plants with therapeutic potential for neurodegenerative diseases
Tyler, S. E. B., & Tyler, L. D. K. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.01.006 · Cited by 33
Rhamnolipids, Microbial Virulence Factors, in Alzheimer’s Disease
Andreadou, E. G., Pantazaki, Α. A., Daniilidou, M., & Tsolaki, M. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161020 · Cited by 30
Chaiwiang, N., & Poyomtip, T. (2019) · Acta Microbiologica et Immunologica Hungarica · doi:10.1556/030.66.2019.038 · Cited by 29
Boeri, L., Perottoni, S., Izzo, L., Giordano, C., & Albani, D. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002043 · Cited by 28
Microglial cells: Sensors for neuronal activity and microbiota-derived molecules
D’Alessandro, G., Marrocco, F., & Limatola, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1011129 · Cited by 31
Mall, J. G., Tingö, L., Lindqvist, C. M., Algilani, S., Rasoal, D., Repsilber, D., Brummer, R. J., Keita, Å. V., & Schoultz, I. (2018) · BMC Geriatrics · doi:10.1186/s12877-018-0767-6 · Cited by 28
Bahar, B., & Singhrao, S. K. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-06024-y · Cited by 28
Sun, Z., Li, X., Liu, Y., Dong, X., Han, Y., Li, Y., Luo, J., & Li, W. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02717-y · Cited by 29
Towards early detection of neurodegenerative diseases: A gut feeling
Makdissi, S., Parsons, B., & Cara, F. D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1087091 · Cited by 28
Gut-Modulating Agents and Amyotrophic Lateral Sclerosis: Current Evidence and Future Perspectives
Eddin, A. N., Alfuwais, M., Eddin, R. N., AlKattan, K. M., & Yaqinuddin, A. (2024) · Nutrients · doi:10.3390/nu16050590 · Cited by 32
The HNRC Group, de Almeida, S. M., Rotta, I., Jiang, Y., Li, X., Raboni, S. M., Ribeiro, C. E., Smith, D. M., Potter, M., Vaida, F., et al. (2016) · Journal of NeuroVirology · doi:10.1007/s13365-016-0437-4 · Cited by 26
Inflammation, immunity, and amyotrophic lateral sclerosis: II. immune‐modulating therapies
Wosiski‐Kuhn, M., Lyon, M. S., Caress, J. B., & Milligan, C. (2018) · Muscle & Nerve · doi:10.1002/mus.26288 · Cited by 26
Review: Microglia in motor neuron disease
Ashford, B., Boche, D., Cooper‐Knock, J., Heath, P. R., Simpson, J. E., & Highley, J. R. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12640 · Cited by 27
Mashaqi, S., Rangan, P., Saleh, A. A., Abraham, I. L., Gozal, D., Quan, S. F., & Parthasarathy, S. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101774 · Cited by 25
Matatall, K. A., Wathan, T. K., Nguyen, M., Chen, H., McDonald, A., Qi, G., Belk, J. A., Florez, M. A., Le, D. T., Olarinde, T., et al. (2025) · Cell Stem Cell · doi:10.1016/j.stem.2025.06.006 · Cited by 23
Effects of gut microbiota and probiotics on Alzheimer’s disease
Guo, L., Xu, J., Du, Y., Wu, W., Nie, W., Zhang, D., Luo, Y., Lu, H., Lei, M., Xiao, S., et al. (2021) · Translational Neuroscience · doi:10.1515/tnsci-2020-0203 · Cited by 25
Gut Microbiota as a Hidden Player in the Pathogenesis of Alzheimer’s Disease
Choi, H., Lee, D., & Mook‐Jung, I. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215235 · Cited by 24
Ashraf, H., Solla, P., & Sechi, L. A. (2022) · Pharmaceuticals · doi:10.3390/ph15091077 · Cited by 23
Association between dietary inflammatory index and cognitive impairment: A meta-analysis
Jia, Y., Yan, S., Sun, M., Yang, Y., Wang, L., Wu, C., & Li, P. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1007629 · Cited by 27
Patil, R. S., & Tupe, R. S. (2023) · Medicinal Research Reviews · doi:10.1002/med.21987 · Cited by 23
Lu, J., Guo, P., Liu, X., Zhang, Y., Guo, X., Gao, X. Y., & Chen, Y. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/8302950 · Cited by 23
André, P., Samieri, C., Buisson, C., Dartigues, J., Helmer, C., Laugerette, F., & Féart, C. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190295 · Cited by 26
Cheok, Y. Y., Lee, C. Y. Q., Cheong, H. C., Looi, C. Y., & Wong, W. F. (2020) · Microorganisms · doi:10.3390/microorganisms8010127 · Cited by 24
Kulkarni, R., Kumari, S., Dhapola, R., Sharma, P., Singh, S. K., Medhi, B., & HariKrishnaReddy, D. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04545-2 · Cited by 26
Immunology primer for neurosurgeons and neurologists part 2: Innate brain immunity
Blaylock, R. L. (2013) · Surgical Neurology International · doi:10.4103/2152-7806.118349 · Cited by 23
Microbiome influences on neuro-immune interactions in neurodegenerative disease
Menees, K. B., Otero, B. A., & Tansey, M. G. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.07.006 · Cited by 24
Fournier, C. N., Houser, M. C., Tansey, M. G., Glass, J. D., & Hertzberg, V. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.10.007 · Cited by 21
Does Alzheimer's disease stem in the gastrointestinal system?
Khodabakhsh, P., Bazrgar, M., Dargahi, L., Mohagheghi, F., Taei, A. A., Parvardeh, S., & Ahmadiani, A. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120088 · Cited by 21
Romo, E. Z., Hong, B. V., Patel, R. Y., Agus, J., Harvey, D. J., Maezawa, I., Jin, L., Lebrilla, C. B., & Zivkovic, A. M. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1408220 · Cited by 22
The blood–brain barrier as a treatment target for neurodegenerative disorders
Rust, R., Sagare, A. P., Zhang, M., Zloković, B. V., & Kisler, K. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2480654 · Cited by 21
Ayoub, S., Arabi, M., Al-Najjar, Y. A., Laswi, I., Outeiro, T. F., & Châari, A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05051-9 · Cited by 23
Barron, M. R., Gartlon, J. E., Dawson, L. A., Atkinson, P. J., & Pardon, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00293 · Cited by 19
Stephens, M., Liao, S., & von der Weid, P. (2021) · Scientific Reports · doi:10.1038/s41598-020-79145-w · Cited by 20
The Role of the Gut Microbiota and Microbial Metabolites in the Pathogenesis of Alzheimer’s Disease
Wang, Y. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220417005115 · Cited by 21
Target Metabolites to Slow Down Progression of Amyotrophic Lateral Sclerosis in Mice
Ogbu, D., Zhang, Y., Claud, K., Xia, Y., & Sun, J. (2022) · Metabolites · doi:10.3390/metabo12121253 · Cited by 20
Psychobiotic Properties of Lactiplantibacillus plantarum in Neurodegenerative Diseases
Chiano, M. D., Sallustio, F., Fiocco, D., Rocchetti, M. T., Spano, G., Pontrelli, P., Moschetta, A., Gesualdo, L., Gadaleta, R. M., & Gallone, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179489 · Cited by 22
Mucus and mucin: changes in the mucus barrier in disease states
Fan, F., Guo, R., Pan, K., Xu, H., & Chu, X. (2025) · Tissue Barriers · doi:10.1080/21688370.2025.2499752 · Cited by 20
Fuke, N., Yamashita, T., Shimizu, S., Matsumoto, M., Sawada, K., Jung, S., Tokuda, I., Misawa, M., Suzuki, S., Ushida, Y., et al. (2023) · Metabolites · doi:10.3390/metabo13020250 · Cited by 22
Cai, M., Zhang, X., Gao, X., Huo, Q., Sun, Y., & Dai, X. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140683 · Cited by 20
Kwon, O.-Y., & Lee, S. H. (2022) · Antioxidants · doi:10.3390/antiox12010078 · Cited by 19
Dong, W., Peng, Y., Chen, G., Xie, Z., Xu, W., Zhou, W., Mi, J., Lu, L., Sun, Y., Zeng, X., et al. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250020 · Cited by 18
The Effects of Sleep on the Commensal Microbiota
Parekh, P. J., Oldfield, E. C., & Johnson, D. A. (2017) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000965 · Cited by 18
Environmental Subconcussive Injury, Axonal Injury, and Chronic Traumatic Encephalopathy
Morley, W. A. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00166 · Cited by 18
Zhang, R., Bracci, P. M., Azhir, A., Forrest, B. D., & McGrath, M. S. (2022) · Biomedicines · doi:10.3390/biomedicines10112907 · Cited by 17
Self-citationMichalovicz, L. T., Lally, B. E., & Konat, G. W. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.06.003 · Cited by 19
Miranda-Ribera, A., Serena, G., Liu, J., Fasano, A., Kingsbury, M. A., & Fiorentino, M. R. (2021) · Tissue Barriers · doi:10.1080/21688370.2021.2000299 · Cited by 18
Effect of Food Endotoxin on Infant Health
Wu, H., Wang, Y., Li, H., Meng, L., Zheng, N., & Wang, J. (2021) · Toxins · doi:10.3390/toxins13050298 · Cited by 18
Schirmbeck, G. H., Seady, M., Fróes, F. T., Taday, J., Ré, C. D., Souza, J. M., Gonçalves, C. A., & Leite, M. C. (2023) · NeuroToxicology · doi:10.1016/j.neuro.2023.11.009 · Cited by 18
Zhan, X., Hakoupian, M., Jin, L., & Sharp, F. R. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.705594 · Cited by 16
Syk inhibitors protect against microglia-mediated neuronal loss in culture
Birkle, T. J. Y., & Brown, G. C. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1120952 · Cited by 15
Ruminal Lipopolysaccharides Analysis: Uncharted Waters with Promising Signs
Sarmikasoglou, E., & Faciola, A. P. (2021) · Animals · doi:10.3390/ani11010195 · Cited by 15
Mehboodi, M., Namdari, M. P., Abdollahi, Z., Mobarezi, Z., Kiani, M., Chamani, F., Khanbabaie, H., Rabiei, S., Maleki, M. H., Sanati, H., et al. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107905 · Cited by 15
Bacteria-Derived Protein Aggregates Contribute to the Disruption of Host Proteostasis
Walker, A. C., Bhargava, R., Dove, A. S., Brust, A. S., Owji, A. A., & Czyż, D. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094807 · Cited by 15
An inclusive study of recent advancements in Alzheimer's disease: A comprehensive review
Singh, S., Mahajan, M., Kumar, D., Singh, K., Chowdhary, M., & Amit (2023) · Neuropeptides · doi:10.1016/j.npep.2023.102369 · Cited by 15
Oluwagbemigun, K., Anesi, A., Vrhovšek, U., Mattivi, F., Adami, P. V. M., Pentzek, M., Scherer, M., Riedel-Heller, S. G., Weyerer, S. B., Bickel, H., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03513-6 · Cited by 16
Correlating the Gut Microbiome to Health and Disease
Marques, T. M., Holster, S., Wall, R., König, J., Brummer, R. J., & de Vos, W. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802304-4.00012-8 · Cited by 13
Huo, J.-Y., Jiang, W., Lyu, Y.-T., Zhu, L., Liu, H., Chen, Y., Chen, M., Geng, J., Jiang, Z., & Shan, Q. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.650140 · Cited by 22
The role of the microbiome on immune homeostasis of the host nervous system
Zhao, S., Fu, D., Lin, Y., Sun, X., Wang, X., Wu, X., & Zhang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1609960 · Cited by 13
Systemic Lipopolysaccharide Exposure Exacerbates Choroidal Neovascularization in Mice
Tsioti, I., Steiner, B. L., Escher, P., Zinkernagel, M. S., Benz, P. M., & Kokona, D. (2022) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2022.2147547 · Cited by 14
Chandra, S., & Vassar, R. J. (2024) · Immunological Reviews · doi:10.1111/imr.13412 · Cited by 17
Eo, H., Lee, S.-M., Kim, S. H., Ju, I. G., Huh, E., Lim, J., Park, S., & Oh, M. S. (2022) · Food & Function · doi:10.1039/d2fo01989b · Cited by 14
Intestinal Barrier Function and Neurodegenerative Disease
Wu, S., Yang, L., Fu, Y., Liao, Z., Cai, D., & Liu, Z. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273264097231116103948 · Cited by 13
García‐Carpintero, S., Domínguez-Bértalo, J., Pedrero-Prieto, C. M., Frontiñán-Rubio, J., Amo‐Salas, M., Durán‐Prado, M., Pérez, E. G., Vaamonde, J., & Alcain, F. J. (2021) · Antioxidants · doi:10.3390/antiox10020143 · Cited by 12
Waller, E. S., Yardeny, B. J., Fong, W. Y., Gan, X. Y., Jimenez, S. V., Pan, Y., Abasszade, J. H., & Nicolazzo, J. A. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114282 · Cited by 12
Zhang, Y., Robinson, K., Xia, Y., & Sun, J. (2025) · Comprehensive physiology · doi:10.1002/cph4.70009 · Cited by 11
Lachish, M., Fainstein, N., Ganz, T., Sofer, L., & Ben‐Hur, T. (2022) · Cells · doi:10.3390/cells11050876 · Cited by 13
Immune Responses to Non-Tumor Antigens in the Central Nervous System
Huber, A. K., Duncker, P. C., & Irani, D. N. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00328 · Cited by 11
Metadata
- Authors
- Zhang, R., Miller, R. G., Gascon, R., Champion, S., Katz, J., Lancero, M., Narvaez, A., Honrada, R., Ruvalcaba, D., & McGrath, M. S.
- Affiliations
- University of California, San Francisco (US)
- California Pacific Medical Center (US)
- Corresponding author
- McGrath, Michael S.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 206
- Issue
- 1-2
- Pages
- 121-124
- ISSN
- 0165-5728 (ISSN-L)
- PMC
- PMC2995297
- OpenAlex
- W2128492849
- Cited by
- 319
- References
- 35
- Citations by year
- 2026: 13 · 2025: 28 · 2024: 25 · 2023: 32 · 2022: 30 · 2021: 47 · 2020: 33 · 2019: 24 · 2018: 19 · 2017: 15 · 2016: 13 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 3
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (U01CA066529)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- sporadic ALS, endotoxin, lipopolysaccharide, systemic immune activation, monocyte/macrophage activation, IL-10, Alzheimer's disease, plasma biomarkers, neuroinflammation, disease progression
- MeSH terms
- Aged, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Analysis of Variance, Endotoxins, Female, Flow Cytometry, HLA-DR Antigens, Humans, Lipopolysaccharides, Macrophages, Male, Middle Aged, Monocytes, Interleukin-10
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
