Cited by 319Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)

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Zhang, Rongzhen, Miller, Robert G., Gascon, Ron, Champion, Stacey, Katz, Jonathan, Lancero, Mariselle, Narvaez, Amy, Honrada, Ronald, Ruvalcaba, David, McGrath, Michael S.·2009·Journal of Neuroimmunology

DOI 10.1016/j.jneuroim.2008.09.017PMC PMC2995297

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Abstract

The present study reports elevated levels of endotoxin/lipopolysaccharide (LPS) concentrations in plasma from patients with sporadic amyotrophic lateral sclerosis (sALS) and Alzheimer's (AD) as compared to healthy controls. Levels of plasma LPS showed a significant positive correlation with degree of blood monocyte/macrophage activation in disease groups and was most elevated in patients with advanced sALS disease. There was a significant negative relationship between plasma LPS and levels of monocyte/macrophage IL-10 expression in sALS blood. These data suggest that systemic LPS levels and activated monocyte/macrophages may play significant roles in the pathogenesis of sALS.

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Authors: Zhang, R., Miller, R. G., Gascon, R., Champion, S., Katz, J., Lancero, M., Narvaez, A., Honrada, R., Ruvalcaba, D., & McGrath, M. S.
Affiliations: University of California, San Francisco (US)
California Pacific Medical Center (US)
Corresponding author: McGrath, Michael S.
ORCID: Zhang, Rongzhen
Miller, Robert G.
Lancero, Mariselle
McGrath, Michael S.
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 2009-01
Volume: 206
Issue: 1-2
Pages: 121-124
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/j.jneuroim.2008.09.017
PMC: PMC2995297
OpenAlex: W2128492849
Cited by: 319
References: 35
Citations by year: 2026: 13 · 2025: 28 · 2024: 25 · 2023: 32 · 2022: 30 · 2021: 47 · 2020: 33 · 2019: 24 · 2018: 19 · 2017: 15 · 2016: 13 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 3
FWCI: 2.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (U01CA066529)
Topics: Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: sporadic ALS, endotoxin, lipopolysaccharide, systemic immune activation, monocyte/macrophage activation, IL-10, Alzheimer's disease, plasma biomarkers, neuroinflammation, disease progression
MeSH terms: Aged, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Analysis of Variance, Endotoxins, Female, Flow Cytometry, HLA-DR Antigens, Humans, Lipopolysaccharides, Macrophages, Male, Middle Aged, Monocytes, Interleukin-10

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Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)

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