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Cognitive impairment following high fat diet consumption is associated with brain inflammation

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Pistell, Paul J., Morrison, Christopher D., Gupta, Sunita, Knight, Alecia G., Keller, Jeffrey N., Ingram, Donald K., Bruce-Keller, Annadora J.·2010·Journal of Neuroimmunology
DOI 10.1016/j.jneuroim.2009.11.010
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Abstract

C57Bl/6 mice were administered a high fat, Western diet (WD, 41% fat) or a very high fat lard diet (HFL, 60% fat), and evaluated for cognitive ability using the Stone T-maze and for biochemical markers of brain inflammation. WD consumption resulted in significantly increased body weight and astrocyte reactivity, but not impaired cognition, microglial reactivity, or heightened cytokine levels. HFL increased body weight, and impaired cognition, increased brain inflammation, and decreased BDNF. Collectively, these data suggest that while different diet formulations can increase body weight, the ability of high fat diets to disrupt cognition is linked to brain inflammation.

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Research works printed but not linked: 72

  1. Ahima, 2008, Adipokines in obesity, Front. Horm. Res., 36, 182, 10.1159/000115365 · DOI
  2. Aronis, 2008, Lipotoxic effects of triacylglycerols in J774.2 macrophages, Nutrition, 24, 167, 10.1016/j.nut.2007.10.017 · DOI
  3. Atzmon, 2002, Plasma HDL levels highly correlate with cognitive function in exceptional longevity, J. Gerontol. Med. Sci., 57, M712, 10.1093/gerona/57.11.M712 · DOI · Paper page
  4. Averill, 2009, Lipids versus glucose in inflammation and the pathogenesis of macrovascular disease in diabetes, Curr. Diab. Rep., 9, 18, 10.1007/s11892-009-0005-x · DOI
  5. Banks, 1996, Leptin enters the brain by a saturable system independent of insulin, Peptides, 17, 305, 10.1016/0196-9781(96)00025-3 · DOI · Paper page
  6. Baran, 2005, Combination of high fat diet and chronic stress retracts hippocampal dendrites, NeuroReport, 16, 39, 10.1097/00001756-200501190-00010 · DOI
  7. Barger, 2007, Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation, J. Neurochem., 101, 1205, 10.1111/j.1471-4159.2007.04487.x · DOI · Paper page
  8. Barrientos, 2006, Peripheral infection and aging interact to impair hippocampal memory consolidation, Neurobiol. Aging, 27, 723, 10.1016/j.neurobiolaging.2005.03.010 · DOI · Paper page
  9. Bellinger, 1995, Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6, Neurosci. Lett., 198, 95, 10.1016/0304-3940(95)11976-4 · DOI
  10. Benveniste, 2001, Immunological aspects of microglia: relevance to Alzheimer's disease, Neurochem. Int., 39, 381, 10.1016/S0197-0186(01)00045-6 · DOI · Paper page
  11. Brinton, 2008, Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease, Adv. Drug Deliv. Rev., 60, 1504, 10.1016/j.addr.2008.06.003 · DOI
  12. Bruce-Keller, 2001, Pro-inflammatory and pro-oxidant properties of the HIV protein Tat in a microglial cell line: attenuation by 17beta-estradiol, J. Neurochem., 78, 1315, 10.1046/j.1471-4159.2001.00511.x · DOI
  13. Chandalia, 2007, Metabolic complications of obesity: inflated or inflamed?, J. Diabetes its Complicat., 21, 128, 10.1016/j.jdiacomp.2006.10.004 · DOI
  14. Chen, 2009, Adiponectin protects against cerebral ischemia–reperfusion injury through anti-inflammatory action, Brain Res., 1273, 129, 10.1016/j.brainres.2009.04.002 · DOI
  15. Chen, 1997, The Tat protein of HIV-1 induces tumor necrosis factor-alpha production, J. Biol. Chem., 272, 22385, 10.1074/jbc.272.36.22385 · DOI · Paper page
  16. Combs, 2009, Inflammation and microglia actions in Alzheimer's disease, J. Neuroimmune Pharmacol., 4, 380, 10.1007/s11481-009-9165-3 · DOI
  17. Croll, 1998, Expression of BDNF and trkB as a function of age and cognitive performance, Brain Res., 812, 200, 10.1016/S0006-8993(98)00993-7 · DOI · Paper page
  18. de Vries, 2009, High-fat feeding redirects cytokine responses and decreases allergic airway eosinophilia, Clin. Exp. Allergy., 39, 731, 10.1111/j.1365-2222.2008.03179.x · DOI
  19. Elias, 2003, Lower cognitive function in the presence of obesity and hypertension: the Framingham Heart Study, Int. J. Obes. Relat. Metab. Disord., 27, 260, 10.1038/sj.ijo.802225 · DOI · Paper page
  20. Elmquist, 1998, Distributions of leptin receptor mRNA isoforms in the rat brain, J. Comp. Neurol., 395, 535, 10.1002/(SICI)1096-9861(19980615)395:4<535::AID-CNE9>3.0.CO;2-2 · doi:10.1002/(sici)1096-9861(19980615)395:4<535::aid-cne9>3.0.co;2-2
  21. Espey, 1998, Extracellular glutamate levels are chronically elevated in the brains of LP-BM5-infected mice: a mechanism of retrovirus-induced encephalopathy, J. Neurochem., 71, 2079, 10.1046/j.1471-4159.1998.71052079.x · DOI
  22. Fei, 1997, Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues, Proc. Natl. Acad. Sci. U.S.A., 94, 7001, 10.1073/pnas.94.13.7001 · DOI · Paper page
  23. Gemma, 2007, Interleukin-1beta and caspase-1: players in the regulation of age-related cognitive dysfunction, Rev. Neurosci., 18, 137, 10.1515/REVNEURO.2007.18.2.137 · DOI
  24. Granholm, 2008, Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat, J. Alzheimer's Dis., 14, 133, 10.3233/JAD-2008-14202 · DOI · Paper page
  25. Haslam, 2005, Obesity Lancet Neurol., 366, 1197
  26. Hilton, 2008, Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma, J. Cereb. Blood Flow Metab., 28, 1845, 10.1038/jcbfm.2008.75 · DOI
  27. Hooijmans, 2009, DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice, Neurobiol. Dis., 33, 482, 10.1016/j.nbd.2008.12.002 · DOI · Paper page
  28. Jagust, 2007, What can imaging reveal about obesity and the brain?, Curr. Alzheimer Res., 4, 135, 10.2174/156720507780362146 · DOI
  29. Jankowsky, 1999, Cytokine and growth factor involvement in long-term potentiation, Mol. Cell. Neurosci., 273, 10.1006/mcne.1999.0792 · DOI
  30. Jovanovic, 2000, Synapsins as mediators of BDNF-enhanced neurotransmitter release, Nat. Neurosci., 3, 323, 10.1038/73888 · DOI · Paper page
  31. Kadish, 2009, Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment, J. Neurosci., 29, 1805, 10.1523/JNEUROSCI.4599-08.2009 · DOI
  32. Kennedy, 2009, Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications, J. Nutr., 139, 1, 10.3945/jn.108.098269 · DOI · Paper page
  33. Laine, 2007, Palmitic acid induces IP-10 expression in human macrophages via NF-kappaB activation, Biochem. Biophys. Res. Commun., 358, 150, 10.1016/j.bbrc.2007.04.092 · DOI
  34. Lee, 2008, Differential immunoreactivity of microglial and astrocytic marker protein in the hippocampus of the seizure resistant and sensitive gerbils, J. Vet. Med. Sci., 70, 1405, 10.1292/jvms.70.1405 · DOI
  35. Luchsinger, 2009, Adiposity, type 2 diabetes, and Alzheimer's disease, J. Alzheimer's Dis., 16, 693, 10.3233/JAD-2009-1022 · DOI · Paper page
  36. Ma, 2008, Expression of free fatty xacid receptor GPR40 in the neurogenic niche of adult monkey hippocampus, Hippocampus, 18, 326, 10.1002/hipo.20393 · DOI
  37. Mankowski, 2004, Cerebrospinal fluid markers that predict SIV CNS disease, J. Neuroimmunol., 157, 66, 10.1016/j.jneuroim.2004.08.031 · DOI
  38. Mascarucci, 1998, Glutamate release in the nucleus tractus solitarius induced by peripheral lipopolysaccharide and interleukin-1 beta, Neuroscience, 86, 1285, 10.1016/S0306-4522(98)00105-5 · DOI
  39. McGeer, 1997, The role of the immune system in neurodegenerative disorders, Mov. Disord., 12, 855, 10.1002/mds.870120604 · DOI
  40. Milanski, 2009, Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity, J. Neurosci., 28, 359, 10.1523/JNEUROSCI.2760-08.2009 · DOI · Paper page
  41. Morrison, 2009, Leptin signaling in brain: a link between nutrition and cognition?, Biochim. Biophys. Acta, 1792, 401, 10.1016/j.bbadis.2008.12.004 · DOI · Paper page
  42. O'Callaghan, 2005, Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity, Expert Opin. Drug Safety, 4, 433, 10.1517/14740338.4.3.433 · DOI · Paper page
  43. Oomura, 2006, Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats, Peptides, 11, 2738, 10.1016/j.peptides.2006.07.001 · DOI · Paper page
  44. Ouchi, 2007, Adiponectin as an anti-inflammatory factor, Clin. Chim. Acta, 380, 24, 10.1016/j.cca.2007.01.026 · DOI · Paper page
  45. Parnet, 2002, Expression and regulation of interleukin-1 receptors in the brain. Role in cytokines-induced sickness behavior, J. Neuroimmunol., 125, 5, 10.1016/S0165-5728(02)00022-X · DOI
  46. Patil, 2005, Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons, Neurosci. Lett., 384, 288, 10.1016/j.neulet.2005.05.003 · DOI
  47. Perlmuter, 1998, Triglyceride levels affect cognitive function in non-insulin-dependent diabetes, J. Diabetes Complicat., 2, 210, 10.1016/S0891-6632(88)80011-4 · DOI
  48. Pickup, 1998, Is type II diabetes mellitus a disease of the innate immune system?, Diabetologia, 41, 1241, 10.1007/s001250051058 · DOI · Paper page
  49. Pinteaux, 2007, Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism, J. Neurochem., 102, 826, 10.1111/j.1471-4159.2007.04559.x · DOI
  50. Pistell, 2009, Striatal lesions interfere with acquisition of a complex maze task in rats, Behav. Brain Res., 197, 138, 10.1016/j.bbr.2008.08.015 · DOI
  51. Rader, 2000, Inflammatory markers of coronary risk, N. Engl. J. Med., 343, 1179, 10.1056/NEJM200010193431609 · DOI · Paper page
  52. Rasouli, 2008, Adipocytokines and the metabolic complications of obesity, J. Clin. Endocrinol. Metab., 93, S64, 10.1210/jc.2008-1613 · DOI · Paper page
  53. Reitz, 2005, Impact of plasma lipids and time on memory performance in healthy elderly without dementia, Neurology, 64, 1378, 10.1212/01.WNL.0000158274.31318.3C · DOI
  54. Rogers, 1989, Reducing hypertriglyceridemia in elderly patients with cerebrovascular disease stabilizes or improves cognition and cerebral perfusion, Angiology, 40, 260, 10.1177/0003319789040004043 · DOI
  55. Rogers, 2007, Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder?, Int. Rev. Neurobiol., 82, 235, 10.1016/S0074-7742(07)82012-5 · DOI · Paper page
  56. Sena, 1985, Brain myelin of genetically obese mice, J. Neurol. Sci., 68, 233, 10.1016/0022-510X(85)90104-2 · DOI
  57. Shoelson, 2007, Obesity, inflammation, and insulin resistance, Gastroenterology, 132, 2169, 10.1053/j.gastro.2007.03.059 · DOI · Paper page
  58. Silva, 2005, Transitory gliosis in the CA3 hippocampal region in rats fed on a ketogenic diet, Nutr. Neurosci., 8, 259, 10.1080/10284150500475032 · DOI
  59. Sparks, 2005, Atorvastatin for the treatment of mild to moderate Alzheimer disease preliminary results, Arch. Neurol., 62, 753, 10.1001/archneur.62.5.753 · DOI · Paper page
  60. Streit, 2008, Microglial degeneration in the aging brain—bad news for neurons?, Front. Biosci., 13, 3423, 10.2741/2937 · DOI · Paper page
  61. Studzinski, 2009, Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP×PS1 knock-in mice, J. Neurochem., 108, 860, 10.1111/j.1471-4159.2008.05798.x · DOI
  62. Tang, 2007, Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia, J. Immunol., 179, 1292, 10.4049/jimmunol.179.2.1292 · DOI · Paper page
  63. Tartaglia, 1995, Identification and expression cloning of a leptin receptor, OB-R Cell, 83, 1263, 10.1016/0092-8674(95)90151-5 · DOI · Paper page
  64. Vega-Avelaira, 2007, Age-related changes in the spinal cord microglial and astrocytic response profile to nerve injury, Brain Behav. Immun., 21, 617, 10.1016/j.bbi.2006.10.007 · DOI
  65. Waldstein, 2006, Interactive relations of central versus total obesity and blood pressure to cognitive function, Int. J. Obes. (Lond.), 30, 201, 10.1038/sj.ijo.0803114 · DOI · Paper page
  66. Ward, 2005, The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study, BMC Neurol., 23
  67. Wayner, 2004, Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo, Peptides, 25, 991, 10.1016/j.peptides.2004.03.018 · DOI · Paper page
  68. Willard, 2000, The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition, Exp. Brain Res., 134, 58, 10.1007/s002210000446 · DOI
  69. Winocur, 2005, Studies of the effects of high fat diets on cognitive function in a rat model, Neurobiol. Aging, 26, 46, 10.1016/j.neurobiolaging.2005.09.003 · DOI · Paper page
  70. Wu, 2004, The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition, Eur. J. NeuroSci., 19, 1699, 10.1111/j.1460-9568.2004.03246.x · DOI · Paper page
  71. Zecca, 2008, Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease, Acta Neuropathol., 116, 47, 10.1007/s00401-008-0361-7 · DOI · Paper page
  72. Zhao, 2004, Detrimental effects of the ketogenic diet on cognitive function in rats, Pediatr. Res., 55, 498, 10.1203/01.PDR.0000112032.47575.D1 · DOI

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Metadata

Authors
Pistell, P. J., Morrison, C. D., Gupta, S., Knight, A. G., Keller, J. N., Ingram, D. K., & Bruce-Keller, A. J.
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2010-02
Volume
219
Issue
1-2
Pages
25-32
ISSN
0165-5728 (ISSN-L)
DOI
10.1016/j.jneuroim.2009.11.010
OpenAlex
W2070381267
Cited by
596
References
13
FWCI
8.12
Type
journal article
Language
en
Open access
green
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)

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Pistell, P. J., Morrison, C. D., Gupta, S., Knight, A. G., Keller, J. N., Ingram, D. K., & Bruce-Keller, A. J. (2010). Cognitive impairment following high fat diet consumption is associated with brain inflammation. Journal of Neuroimmunology. https://doi.org/10.1016/j.jneuroim.2009.11.010

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