Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms
Open accessAbstract
Nutrition transition can be defined as shifts in food habits, and it is characterized by high-fat (chiefly saturated animal fat), hypercaloric and salty food consumption at the expense of dietary fibers, minerals and vitamins. Western dietary patterns serve as a model for studying the impact of nutrition transition on civilization diseases, such as obesity, which is commonly associated with oxidative stress and inflammation. In fact, reactive oxygen species (ROS) overproduction can be associated with nuclear factor-κB (NF-κB)-mediated inflammation in obesity. NF-κB regulates gene expression of several oxidant-responsive adipokines including tumor necrosis factor-α (TNF-α). Moreover, AMP-activated protein kinase (AMPK), which plays a pivotal role in energy homeostasis and in modulation of metabolic inflammation, can be downregulated by IκB kinase (IKK)-dependent TNF-α activation. On the other hand, adherence to a Mediterranean-style diet is highly encouraged because of its healthy dietary pattern, which includes antioxidant nutraceuticals such as polyphenols. Indeed, hydroxycinnamic derivatives, quercetin, resveratrol, oleuropein and hydroxytyrosol, which are well known for their antioxidant and anti-inflammatory activities, exert anti-obesity proprieties. In this review, we highlight the impact of the most common polyphenols from Mediterranean foods on molecular mechanisms that mediate obesity-related oxidative stress and inflammation. Hence, we discuss the effects of these polyphenols on a number of signaling pathways. We note that Mediterranean diet (MedDiet) dietary polyphenols can de-regulate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and NF-κB-mediated oxidative stress, and metabolic inflammation. MedDiet polyphenols are also effective in upregulating downstream effectors of several proteins, chiefly AMPK.
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Systemic oxidative stress is a hallmark of obesity and metabolic syndrome.
“Systemic oxidative stress is a hallmark of obesity and metabolic syndrome.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [4]
Obesity is generally considered a low-grade inflammation state affecting the whole body.
“Therefore, obesity is generally considered as a low-grade inflammation state affecting the whole body [4].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [4]
Activation of the NF-κB pathway results in increased expression of proinflammatory mediators such as TNFα, interleukin 6, and leptin while decreasing secretion of the protective adipokine adiponectin.
“Through the activation of the nuclear factor-kappa B (NF-κB) pathway, it results in an increased expression of the proinflammatory mediators such as tumor necrosis factor alpha (TNFα), interleukin 6 (IL6), leptin while decreasing the secretion of the protective adipokine, adiponectin [4,16].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [4]
Increased intake of high energy food rich in animal-saturated fat leads to oxidative stress at the cellular level and inflammation by increasing the expression of NADPH oxidase in adipocytes.
“An increased intake of high energy food rich in animal-saturated fat leads to oxidative stress at the cellular level and inflammation by increasing the expression of nicotinamide adenine dinucleuotide phosphate (NADPH) oxidase (NOX) in adipocytes.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [4]
Chronic inflammation contributes to increased rates of obesity and its complications, such as metabolic syndrome, nonalcoholic fatty liver disease, dyslipidemia, and diabetes, all conferring increased cardiovascular risk.
“Therefore, this chronic inflammation state contributes both to the increased rates of obesity and its complications, such as metabolic syndrome, nonalcoholic fatty liver disease, dyslipidemia, diabetes, all conferring an increased cardiovascular risk [4,14,15]”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [4]
Oxidative stress is crucially implicated in the chronic inflammation process that is an important component in obesity pathogenesis.
“As highlighted above, oxidative stress is crucially implicated in the chronic inflammation process that is an important component in obesity pathogenesis.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [4]
It is difficult to discern the specific effects of the different components of the Mediterranean diet on different expression patterns of inflammation and whether reduction in insulin resistance contributes to reduction in metabolic syndrome, type 2 diabetes, or nonalcoholic fatty liver disease, since these non-communicable diseases are interrelated with many common pathways.
“Therefore, the effects of MD on the prevention of obesity have simultaneously protective effects on its complications, and it is difficult to discern the specific effects of the different components of the MD on the different expression patterns of inflammation and whether the reduction in insulin resistance may rather contribute to the reduction in metabolic syndrome or merely of type 2 Diabetes,”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [4]
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Is there any association between dietary inflammatory index and quality of life? A systematic review
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- Authors
- Nani, A., Murtaza, B., Sayed Khan, A., Khan, N. A., & Hichami, A.
- Affiliations
- Inserm (FR)
- Physiologie de la Nutrition & Toxicologie, U1231 INSERM/Université de Bourgogne-Franche Comté (UBFC)/Agro-Sup, 21000 Dijon, France
- Corresponding author
- Nani, Abdelhafid
- Hichami, Aziz
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2021-02-12
- Volume
- 26
- Issue
- 4
- Pages
- 985
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC7918790
- OpenAlex
- W3131532488
- Cited by
- 321
- References
- 150
- Citations by year
- 2026: 70 · 2025: 63 · 2024: 53 · 2023: 69 · 2022: 51 · 2021: 15
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agence Nationale de la Recherche (ANR-11-LABX-0021)
- Institut National de la Santé et de la Recherche Médicale
- Université de Bourgogne
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- Mediterranean diet, dietary polyphenols, obesity, oxidative stress, metabolic inflammation, NF-κB signaling, AMPK, TNF-α, IκB kinase, NADPH oxidase, quercetin, resveratrol, oleuropein, hydroxytyrosol, hydroxycinnamic acid derivatives, nutraceuticals, nutrition transition, signaling pathways
- MeSH terms
- Resveratrol, Anti-Inflammatory Agents, Antioxidants, Dietary Fiber, Humans, Obesity, NF-kappa B, Diet, Mediterranean, Polyphenols
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