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Cited by 37Migraine and Headache StudiesTemporomandibular Joint DisordersTraumatic Brain Injury Research

The associations between preexisting mental disorders and subsequent onset of chronic headaches: a worldwide epidemiologic perspective

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Bruffaerts, Ronny, Demyttenaere, Koen, Kessler, Ronald C., Tachimori, Hisateru, Bunting, Brendan, Hu, Chiyi, Florescu, Silvia, Haro, Josep Maria +11 more·2015·The Journal of Pain
DOI 10.1016/j.jpain.2014.10.002
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Abstract

Unlabelled Although there is a significant association between preexisting depression and later onset of chronic headache, the extent to which other preexisting mental disorders are associated with subsequent onset of headache in the general population is not known. Also unknown is the extent to which these associations vary by gender or by life course. We report global data from the WHO's World Mental Health surveys (n = 52,095), in which, by means of the Composite International Diagnostic Interview-3.0, 16 mental disorders from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were retrospectively assessed in terms of lifetime prevalence and age of onset. Frequent or severe headaches were assessed using self-reports. After adjustment for covariates, survival models showed a moderate but consistent association between preexisting mood (odds ratios [ORs] = 1.3-1.4), anxiety (ORs = 1.2-1.7), and impulse-control disorders (ORs = 1.7-1.9) and the subsequent onset of headache. We also found a dose-response relationship between the number of preexisting mental disorders and subsequent headache onset (OR ranging from 1.9 for 1 preexisting mental disorder to 3.4 for ≥5 preexisting mental disorders). Our findings suggest a consistent and pervasive relationship between a wide range of preexisting mental disorders and the subsequent onset of headaches. This highlights the importance of assessing a broad range of mental disorders, not just depression, as specific risk factors for the subsequent onset of frequent or severe headaches.Perspective This study shows that there is a temporal association between a broad range of preexisting mental disorders and the subsequent onset of severe or frequent headaches in general population samples across the world.

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  • Depression, anxiety, and emotional distress contribute strongly, often more strongly than pain intensity, to long-term persistent pain outcomes including physical disability, work disability, healthcare costs, mortality, and suicide.

    “there is a wealth of evidence that symptoms of depression, anxiety, and emotional distress contribute strongly (more strongly than pain intensity, in many studies) to key long-term outcomes of persistent pain such as physical disability 35, 43–46, work disability 47, healthcare costs 48, 49, mortality 50–53, and suicide 22, 54, 55.”

    From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [45]

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Authors
Bruffaerts, R., Demyttenaere, K., Kessler, R. C., Tachimori, H., Bunting, B., Hu, C., Florescu, S., Haro, J. M., Lim, C. C. W., Kovess-Masfety, V., Levinson, D., Medina Mora, M. E., Piazza, M., Piotrowski, P., Posada-Villa, J., Salih Khalaf, M., ten Have, M., Xavier, M., & Scott, K. M.
Affiliations
  • KU Leuven (BE)
  • Harvard University (US)
  • National Center of Neurology and Psychiatry (JP)
  • University of Ulster (GB)
  • Shenzhen KangNing Hospital (CN)
  • National School of Public Health, Management and Professional Development (RO)
  • University of Otago (NZ)
  • Israel Ministry of Health (IL)
  • Universidad Peruana Cayetano Heredia (PE)
  • Wroclaw Medical University (PL)
  • Universidade Nova de Lisboa (PT)
Corresponding author
Bruffaerts, Ronny
ORCID
Venue
The Journal of Pain
Publisher
Elsevier BV
Published
2015-01
Volume
16
Issue
1
Pages
42-52
ISSN
1526-5900 (ISSN-L)
DOI
10.1016/j.jpain.2014.10.002
OpenAlex
W2022177047
Cited by
37
References
64
Citations by year
2025: 2 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 5
FWCI
3.03
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Pain (publishedVersion)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion)
Funders
  • National Institutes of Health (5r13mh066849-04, 5r01mh069864-04, 5r01mh070884-05)
  • National Institute of Mental Health (R13-MH-066849, R01‐MH070884, U01MH060220, R01‐MH069864)
  • National Institute on Drug Abuse (R01DA016558)
  • Fogarty International Center (R03TW006481)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
  • Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords
chronic headache, depression, anxiety, impulse control disorders, mood disorders, headache onset, comorbidities, dose-response relationship, gender differences, life course, risk factors
MeSH terms
Adolescent, Adult, Mental Disorders, Female, Humans, Male, Middle Aged, Retrospective Studies, Sex Factors, Time Factors, World Health Organization, Prevalence, Survival Analysis, Headache Disorders, Internationality, Young Adult, Self Report

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